{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:44:46Z","timestamp":1790779486693,"version":"4.1.0"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T00:00:00Z","timestamp":1327017600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0030406","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T21:56:30Z","timestamp":1327096590000},"page":"e30406","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Metabolic State Determines Sensitivity to Cellular Stress in Huntington Disease: Normalization by Activation of PPAR\u03b3"],"prefix":"10.1371","volume":"7","author":[{"given":"Youngnam N.","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong Y.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulman","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail V. W.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1523\/JNEUROSCI.11-12-03877.1991","article-title":"Proliferative and degenerative changes in striatal spiny neurons in Huntington&apos;s disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry.","volume":"11","author":"RJ Ferrante","year":"1991","journal-title":"J Neurosci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington&apos;s disease chromosomes.","volume":"72","year":"1993","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1212\/01.WNL.0000031791.10922.CF","article-title":"Weight loss in early stage of Huntington&apos;s disease.","volume":"59","author":"L Djousse","year":"2002","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1111\/j.1460-9568.2008.06310.x","article-title":"Mechanisms of neurodegeneration in Huntington&apos;s disease.","volume":"27","author":"JM Gil","year":"2008","journal-title":"Eur J Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10863-010-9286-7","article-title":"The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease.","volume":"42","author":"YN Jin","year":"2010","journal-title":"J Bioenerg Biomembr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"25628","DOI":"10.1074\/jbc.M804291200","article-title":"Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease.","volume":"283","author":"RA Quintanilla","year":"2008","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"34785","DOI":"10.1074\/jbc.M603845200","article-title":"Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences.","volume":"281","author":"T Milakovic","year":"2006","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1750-3639.1999.tb00216.x","article-title":"Oxidative stress in Huntington&apos;s disease.","volume":"9","author":"SE Browne","year":"1999","journal-title":"Brain Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.freeradbiomed.2010.05.016","article-title":"Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism.","volume":"49","author":"MA Sorolla","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1074\/mcp.M500090-MCP200","article-title":"Proteomic analysis of protein expression and oxidative modification in r6\/2 transgenic mice: a model of Huntington disease.","volume":"4","author":"M Perluigi","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/nm1106-1239","article-title":"Transcription meets metabolism in neurodegeneration.","volume":"12","author":"CA Ross","year":"2006","journal-title":"Nat Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.","volume":"127","author":"L Cui","year":"2006","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nri1748","article-title":"Combinatorial roles of nuclear receptors in inflammation and immunity.","volume":"6","author":"CK Glass","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1093\/hmg\/ddq322","article-title":"Modulation of energy deficiency in Huntington&apos;s disease via activation of the peroxisome proliferator-activated receptor gamma.","volume":"19","author":"MC Chiang","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/brain\/awh452","article-title":"Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1\u201342 levels in APPV717I transgenic mice.","volume":"128","author":"MT Heneka","year":"2005","journal-title":"Brain"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1046\/j.1471-4159.2002.00990.x","article-title":"Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson&apos;s disease.","volume":"82","author":"T Breidert","year":"2002","journal-title":"J Neurochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.expneurol.2004.10.007","article-title":"Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis.","volume":"191","author":"M Kiaei","year":"2005","journal-title":"Exp Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1471-4159.2006.03758.x","article-title":"Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone.","volume":"97","author":"Y Luo","year":"2006","journal-title":"J Neurochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0165-5728(01)00285-5","article-title":"Amelioration of experimental autoimmune encephalomyelitis in C57BL\/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma.","volume":"116","author":"M Niino","year":"2001","journal-title":"J Neuroimmunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"30773","DOI":"10.1074\/jbc.M504749200","article-title":"Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin.","volume":"280","author":"T Milakovic","year":"2005","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1093\/hmg\/ddi319","article-title":"HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.","volume":"14","author":"IS Seong","year":"2005","journal-title":"Human Molecular Genetics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"11174","DOI":"10.1523\/JNEUROSCI.3004-06.2006","article-title":"Mitochondrial-dependent Ca2+ handling in Huntington&apos;s disease striatal cells: effect of histone deacetylase inhibitors.","volume":"26","author":"JM Oliveira","year":"2006","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1158\/0008-5472.CAN-03-1101","article-title":"Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells.","volume":"64","author":"R Rossignol","year":"2004","journal-title":"Cancer Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jcla.1860090402","article-title":"Use of pyruvate oxidase to overcome pyruvate inhibition during the lactate to pyruvate reaction for assaying lactate dehydrogenase in serum.","volume":"9","author":"VV Murthy","year":"1995","journal-title":"J Clin Lab Anal"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e6123","DOI":"10.1371\/journal.pone.0006123","article-title":"Intracellular localization and conformational state of transglutaminase 2: implications for cell death.","volume":"4","author":"S Gundemir","year":"2009","journal-title":"PLoS ONE"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.nbd.2008.02.010","article-title":"Beneficial effects of rolipram in the R6\/2 mouse model of Huntington&apos;s disease.","volume":"30","author":"Z DeMarch","year":"2008","journal-title":"Neurobiol Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/hmg\/ddg046","article-title":"Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington&apos;s disease knock-in mice.","volume":"12","author":"S Gines","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mam.2010.03.002","article-title":"VDAC, a multi-functional mitochondrial protein regulating cell life and death.","volume":"31","author":"V Shoshan-Barmatz","year":"2010","journal-title":"Mol Aspects Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.2337\/db10-0638","article-title":"Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha.","volume":"59","author":"Z Zheng","year":"2010","journal-title":"Diabetes"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/nprot.2007.405","article-title":"Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometry.","volume":"2","author":"L Troiano","year":"2007","journal-title":"Nat Protoc"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"9763","DOI":"10.1128\/MCB.24.22.9763-9770.2004","article-title":"Calcium binding of ARC mediates regulation of caspase 8 and cell death.","volume":"24","author":"DG Jo","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref32","first-page":"1483","article-title":"Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac\/Diablo and Omi\/HtrA2 release from mitochondria.","volume":"63","author":"H Yamaguchi","year":"2003","journal-title":"Cancer Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncb735","article-title":"Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.","volume":"4","author":"FG Gervais","year":"2002","journal-title":"Nat Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.mad.2005.09.011","article-title":"Huntingtin fragmentation and increased caspase 3, 8 and 9 activities in lymphoblasts with heterozygous and homozygous Huntington&apos;s disease mutation.","volume":"127","author":"V Maglione","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1046\/j.1471-4159.2003.02105.x","article-title":"Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington&apos;s disease.","volume":"87","author":"Y Zhang","year":"2003","journal-title":"Journal of Neurochemistry"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1152\/ajprenal.00735.2009","article-title":"Thiazolidinediones alter growth and epithelial cell integrity, independent of PPAR{gamma} and MAPK activation, in mouse M1 Cortical Collecting Duct Cells.","volume":"298","author":"R Nasrallah","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.freeradbiomed.2010.01.028","article-title":"Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth.","volume":"48","author":"J Zielonka","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1471-4159.2009.05995.x","article-title":"Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.","volume":"109","author":"F Doonan","year":"2009","journal-title":"J Neurochem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ana.410130116","article-title":"Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain.","volume":"13","author":"S Sorbi","year":"1983","journal-title":"Ann Neurol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0022-510X(85)90112-1","article-title":"Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and gamma-glutamyl transpeptidase in post-mortem brain from Huntington&apos;s disease and agonal cases.","volume":"67","author":"J Butterworth","year":"1985","journal-title":"J Neurol Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1074\/mcp.M500090-MCP200","article-title":"Proteomic analysis of protein expression and oxidative modification in r6\/2 transgenic mice: a model of Huntington disease.","volume":"4","author":"M Perluigi","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.yjmcc.2008.10.020","article-title":"Increased expression and intramitochondrial translocation of cyclophilin-D associates with increased vulnerability of the permeability transition pore to stress-induced opening during compensated ventricular hypertrophy.","volume":"46","author":"J Matas","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"G954","DOI":"10.1152\/ajpgi.00246.2010","article-title":"Chronic ethanol consumption enhances sensitivity to Ca(2+)-mediated opening of the mitochondrial permeability transition pore and increases cyclophilin D in liver.","volume":"299","author":"AL King","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.febslet.2010.02.022","article-title":"Signal transduction to the permeability transition pore.","volume":"584","author":"A Rasola","year":"2010","journal-title":"FEBS Lett"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1093\/hmg\/ddq247","article-title":"Mitochondrial calcium uptake capacity as a therapeutic target in the R6\/2 mouse model of Huntington&apos;s disease.","volume":"19","author":"GM Perry","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"37006","DOI":"10.1074\/jbc.M700447200","article-title":"Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis.","volume":"282","author":"K Fuenzalida","year":"2007","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1007\/s10495-010-0526-4","article-title":"Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells.","volume":"15","author":"JA Martinez","year":"2010","journal-title":"Apoptosis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/jb\/mvn063","article-title":"Nicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cells.","volume":"144","author":"H Sasaya","year":"2008","journal-title":"J Biochem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release.","volume":"13","author":"YS Choo","year":"2004","journal-title":"Hum Mol Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington&apos;s disease are a direct effect of polyglutamines.","volume":"5","author":"AV Panov","year":"2002","journal-title":"Nat Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.taap.2007.05.002","article-title":"Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress.","volume":"223","author":"X Zhang","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"E1256","DOI":"10.1152\/ajpendo.00218.2007","article-title":"Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study.","volume":"293","author":"BM Jucker","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1089\/ars.2009.2427","article-title":"Superoxide anion regulates the mitochondrial free Ca2+ through uncoupling proteins.","volume":"11","author":"Z Wu","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/CIRCRESAHA.109.199018","article-title":"Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension.","volume":"105","author":"SH Chan","year":"2009","journal-title":"Circ Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/415096a","article-title":"Superoxide activates mitochondrial uncoupling proteins.","volume":"415","author":"KS Echtay","year":"2002","journal-title":"Nature"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1172\/JCI200319774","article-title":"Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.","volume":"112","author":"S Krauss","year":"2003","journal-title":"J Clin Invest"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.freeradbiomed.2007.08.011","article-title":"Mitochondrial uncoupling proteins\u2013what is their physiological role?","volume":"43","author":"KS Echtay","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12035-010-8103-y","article-title":"Anti-apoptotic actions of PPAR-gamma against ischemic stroke.","volume":"41","author":"WH Fong","year":"2010","journal-title":"Mol Neurobiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"12433","DOI":"10.1523\/JNEUROSCI.2897-08.2008","article-title":"Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4.","volume":"28","author":"SC Schock","year":"2008","journal-title":"J Neurosci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.nbd.2009.05.015","article-title":"Oxidative damage to the promoter region of SQSTM1\/p62 is common to neurodegenerative disease.","volume":"35","author":"Y Du","year":"2009","journal-title":"Neurobiol Dis"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1073\/pnas.95.8.4333","article-title":"ADD1\/SREBP1 activates PPARgamma through the production of endogenous ligand.","volume":"95","author":"JB Kim","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.1073\/pnas.1232352100","article-title":"An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle.","volume":"100","author":"C Handschin","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1210\/en.2006-0070","article-title":"Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation.","volume":"147","author":"E Hondares","year":"2006","journal-title":"Endocrinology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1073\/pnas.232688199","article-title":"Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.","volume":"100","author":"XF Qin","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","article-title":"Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells.","volume":"9","author":"F Trettel","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1523\/JNEUROSCI.22-14-05848.2002","article-title":"The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes.","volume":"22","author":"GJ Kress","year":"2002","journal-title":"J Neurosci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0030406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T19:26:49Z","timestamp":1561231609000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0030406"}},"subtitle":[],"editor":[{"given":"Janine","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,20]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0030406","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,20]]}}}