{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:06:27Z","timestamp":1759741587393},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T00:00:00Z","timestamp":1328572800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0030557","type":"journal-article","created":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T22:20:38Z","timestamp":1328653238000},"page":"e30557","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Neovascular Niche for Human Myeloma Cells in Immunodeficient Mouse Bone"],"prefix":"10.1371","volume":"7","author":[{"given":"Hirono","family":"Iriuchishima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiyo","family":"Takubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Miyakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Nakamura-Ishizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiteru","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Nojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Suda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,2,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1056\/NEJMra041875","article-title":"Multiple myeloma.","volume":"351","author":"RA Kyle","year":"2004","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2174\/138920109787847493","article-title":"Multiple myeloma bone marrow niche.","volume":"10","author":"GW Basak","year":"2009","journal-title":"Curr Pharm Biotechnol"},{"key":"ref3","first-page":"1227","article-title":"The role of the bone marrow microenvironment in multiple myeloma.","volume":"20","author":"HR De Raeve","year":"2005","journal-title":"Histol Histopathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11899-010-0057-7","article-title":"Improving induction therapy in multiple myeloma.","volume":"5","author":"A Nooka","year":"2010","journal-title":"Curr Hematol Malig Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1200\/JCO.2008.18.7252","article-title":"Bendamustine: rebirth of an old drug.","volume":"27","author":"BD Cheson","year":"2009","journal-title":"J Clin Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1158\/1078-0432.CCR-07-1061","article-title":"Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents.","volume":"14","author":"LM Leoni","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/sonc.2002.34872","article-title":"Metabolism and mechanisms of action of bendamustine: rationales for combination therapies.","volume":"29","author":"V Gandhi","year":"2002","journal-title":"Semin Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1200\/JCO.2007.12.5070","article-title":"Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: results from a phase II multicenter, single-agent study.","volume":"26","author":"JW Friedberg","year":"2008","journal-title":"J Clin Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1182\/blood-2010-11-314708","article-title":"The combination of bendamustine, bortezomib and rituximab for patients with relapsed\/refractory indolent and mantle cell non-Hodgkin lymphoma.","volume":"117","author":"JW Friedberg","year":"2011","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00432-005-0074-4","article-title":"Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone\u2013a randomized phase III study of the East German Study Group of Hematology and Oncology (OSHO).","volume":"132","author":"W Ponisch","year":"2006","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref11","first-page":"1287","article-title":"The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy.","volume":"90","author":"S Knop","year":"2005","journal-title":"Haematologica"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1182\/blood-2001-12-0207","article-title":"NOD\/SCID\/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.","volume":"100","author":"M Ito","year":"2002","journal-title":"Blood"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbrc.2003.11.120","article-title":"Establishment of a new model of human multiple myeloma using NOD\/SCID\/gammac(null) (NOG) mice.","volume":"313","author":"Y Miyakawa","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"ref14","first-page":"2210","article-title":"Bone marrow angiogenesis in 400 patients with monoclonal gammopathy of undetermined significance, multiple myeloma, and primary amyloidosis.","volume":"8","author":"SV Rajkumar","year":"2002","journal-title":"Clin Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00277-010-0919-z","article-title":"Bone marrow angiogenesis in multiple myeloma and its correlation with clinicopathological factors.","volume":"89","author":"C Rana","year":"2010","journal-title":"Ann Hematol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1182\/blood-2002-09-2907","article-title":"Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma.","volume":"101","author":"G Bisping","year":"2003","journal-title":"Blood"},{"key":"ref17","first-page":"728","article-title":"Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.","volume":"59","author":"WT Bellamy","year":"1999","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1007\/s00018-004-4200-2","article-title":"Spontaneous fusion between cancer cells and endothelial cells.","volume":"61","author":"K Mortensen","year":"2004","journal-title":"Cell Mol Life Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.stem.2010.06.020","article-title":"Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.","volume":"7","author":"K Takubo","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"7480","DOI":"10.1038\/sj.onc.1210566","article-title":"HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites.","volume":"26","author":"A Le Bras","year":"2007","journal-title":"Oncogene"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.","volume":"466","author":"S Mendez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1046\/j.1365-2141.1997.4503260.x","article-title":"Bone marrow fibrosis and disease activity in multiple myeloma monitored by the aminoterminal propeptide of procollagen III in serum.","volume":"99","author":"N Abildgaard","year":"1997","journal-title":"Br J Haematol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e17336","DOI":"10.1371\/journal.pone.0017336","article-title":"Three-dimensional characterization of the vascular bed in bone metastasis of the rat by microcomputed tomography (MicroCT).","volume":"6","author":"H Nyangoga","year":"2011","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1182\/blood-2010-08-303800","article-title":"The relationship between bone, hemopoietic stem cells, and vasculature.","volume":"118","author":"SL Ellis","year":"2011","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1182\/blood-2009-05-219840","article-title":"On the adaptation of endosteal stem cell niche function in response to stress.","volume":"114","author":"Y Jiang","year":"2009","journal-title":"Blood"},{"key":"ref26","first-page":"264","article-title":"Hematological malignancies and the bone (myeloma excluded).","volume":"67","author":"S Roux","year":"2000","journal-title":"Joint Bone Spine"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"15638","DOI":"10.1073\/pnas.242590799","article-title":"Measurements of endothelial cell-to-cell and cell-to-substrate gaps and micromechanical properties of endothelial cells during monocyte adhesion.","volume":"99","author":"N Kataoka","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.ejca.2006.02.017","article-title":"Angiogenesis in multiple myeloma.","volume":"42","author":"C Jakob","year":"2006","journal-title":"Eur J Cancer"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000046612","article-title":"Bone marrow angiogenesis and plasma cell angiogenic and invasive potential in patients with active multiple myeloma.","volume":"106","author":"A Vacca","year":"2001","journal-title":"Acta Haematol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mvr.2008.08.003","article-title":"The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions.","volume":"77","author":"L Lu","year":"2009","journal-title":"Microvasc Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09624","article-title":"Glioblastoma stem-like cells give rise to tumour endothelium.","volume":"468","author":"R Wang","year":"2010","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nature09557","article-title":"Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.","volume":"468","author":"L Ricci-Vitiani","year":"2010","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1359\/jbmr.2003.18.3.482","article-title":"Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival.","volume":"18","author":"PI Croucher","year":"2003","journal-title":"J Bone Miner Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/002215549804600311","article-title":"Immunofluorescence characterization of key extracellular matrix proteins in murine bone marrow in situ.","volume":"46","author":"SK Nilsson","year":"1998","journal-title":"J Histochem Cytochem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/10428190500051448","article-title":"Extracellular matrix in bone marrow can mediate drug resistance in myeloma.","volume":"46","author":"T Vincent","year":"2005","journal-title":"Leuk Lymphoma"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1182\/blood-2003-07-2340","article-title":"Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines.","volume":"103","author":"Y Nefedova","year":"2004","journal-title":"Blood"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bone.2010.06.016","article-title":"Osteoblast function in myeloma.","volume":"48","author":"GD Roodman","year":"2011","journal-title":"Bone"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1182\/blood-2004-12-4986","article-title":"Myeloma cells block RUNX2\/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation.","volume":"106","author":"N Giuliani","year":"2005","journal-title":"Blood"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/sj.leu.2403285","article-title":"Effect of thalidomide therapy on bone marrow angiogenesis in multiple myeloma.","volume":"18","author":"S Kumar","year":"2004","journal-title":"Leukemia"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/sj.bjc.6600607","article-title":"Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects.","volume":"87","author":"K Dredge","year":"2002","journal-title":"Br J Cancer"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1158\/0008-5472.CAN-05-1195","article-title":"Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells.","volume":"66","author":"AM Roccaro","year":"2006","journal-title":"Cancer Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.stem.2007.10.023","article-title":"Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest.","volume":"2","author":"K Takubo","year":"2008","journal-title":"Cell Stem Cell"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0030557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T09:09:39Z","timestamp":1540285779000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0030557"}},"subtitle":[],"editor":[{"given":"Wolfgang","family":"Wagner","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,7]]},"references-count":42,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0030557","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,7]]}}}