{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:51:57Z","timestamp":1767862317530,"version":"3.49.0"},"reference-count":80,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0030614","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T22:35:19Z","timestamp":1329345319000},"page":"e30614","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Functional Redundancy of Two Pax-Like Proteins in Transcriptional Activation of Cyst Wall Protein Genes in Giardia lamblia"],"prefix":"10.1371","volume":"7","author":[{"given":"Shen-Fung","family":"Chuang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Hsin","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Cheng","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jiao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Hung","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/CMR.14.3.447-475.2001","article-title":"Biology of <italic>Giardia lamblia<\/italic>.","volume":"14","author":"RD Adam","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrmicro2317","article-title":"Behind the smile: cell biology and disease mechanisms of <italic>Giardia<\/italic> species.","volume":"8","author":"J Ankarklev","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pt.2009.11.010","article-title":"Giardiasis\u2013why do the symptoms sometimes never stop?","volume":"26","author":"LJ Robertson","year":"2010","journal-title":"Trends Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijpara.2006.09.009","article-title":"Irritable bowel syndrome: a review on the role of intestinal protozoa and the importance of their detection and diagnosis.","volume":"37","author":"D Stark","year":"2007","journal-title":"Int J Parasitol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-230X-9-27","article-title":"Development of functional gastrointestinal disorders after <italic>Giardia lamblia<\/italic> infection.","volume":"9","author":"K Hanevik","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1080\/00365520802588091","article-title":"Subjective health complaints and quality of life in patients with irritable bowel syndrome following <italic>Giardia lamblia<\/italic> infection: a case control study.","volume":"44","author":"MH Morken","year":"2009","journal-title":"Scand J Gastroenterol"},{"key":"ref7","first-page":"925","article-title":"Host parasite interactions and pathophysiology in <italic>Giardia<\/italic> infections.","volume":"41","author":"JA Cotton","year":"2011"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1442-200x.2005.02110.x","article-title":"Effects of giardiasis on school success, weight and height indices of primary school children in Turkey.","volume":"47","author":"A Celiks\u00f6z","year":"2005","journal-title":"Pediatr Int"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1369-5274(00)00229-0","article-title":"Encystation in parasitic protozoa.","volume":"4","author":"D Eichinger","year":"2001","journal-title":"Curr Opin Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1146\/annurev.micro.50.1.679","article-title":"Cell biology of the primitive eukaryote <italic>Giardia lamblia<\/italic>.","volume":"50","author":"FD Gillin","year":"1996","journal-title":"Annu Rev Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.micinf.2009.09.008","article-title":"New insights regarding the biology of <italic>Giardia lamblia<\/italic>.","volume":"12","author":"PG Carranza","year":"2010","journal-title":"Microbes Infect"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"29307","DOI":"10.1074\/jbc.270.49.29307","article-title":"Identification of a novel <italic>Giardia lamblia<\/italic> cyst wall protein with leucine-rich repeats. Implications for secretory granule formation and protein assembly into the cyst wall.","volume":"270","author":"HD Lujan","year":"1995","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1365-2958.1995.tb02364.x","article-title":"Developmentally regulated expression of a <italic>Giardia lamblia<\/italic> cyst wall protein gene.","volume":"15","author":"MR Mowatt","year":"1995","journal-title":"Mol Microb"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"21701","DOI":"10.1074\/jbc.M302023200","article-title":"Mining the <italic>Giardia lamblia<\/italic> genome for new cyst wall proteins.","volume":"278","author":"CH Sun","year":"2003","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1365-2958.1999.01602.x","article-title":"Developmental gene regulation in <italic>Giardia lamblia<\/italic>: first evidence for an encystation-specific promoter and differential 5\u2032 mRNA processing.","volume":"34","author":"LA Knodler","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1550-7408.1998.tb04560.x","article-title":"Cloning of two putative <italic>Giardia lamblia<\/italic> glucosamine 6-phosphate isomerase genes only one of which is transcriptionally activated during encystment.","volume":"45","author":"H Van Keulen","year":"1998","journal-title":"J Eukaryot Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1128\/.61.3.294-304.1997","article-title":"Mechanisms of <italic>Giardia lamblia<\/italic> differentiation into cysts.","volume":"61","author":"HD Lujan","year":"1997","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"17975","DOI":"10.1074\/jbc.M109.012047","article-title":"A novel WRKY-like protein involved in transcriptional activation of cyst wall protein genes in <italic>Giardia lamblia<\/italic>.","volume":"284","author":"YJ Pan","year":"2009","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1074\/jbc.M509673200","article-title":"The <italic>Giardia duodenalis<\/italic> 14-3-3 protein is post-translationally modified by phosphorylation and polyglycylation of the C-terminal tail.","volume":"281","author":"M Lalle","year":"2006","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijpara.2009.07.010","article-title":"Involvement of 14-3-3 protein post-translational modifications in <italic>Giardia duodenalis<\/italic> encystation.","volume":"40","author":"M Lalle","year":"2010","journal-title":"Int J Parasitol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1126\/science.1143837","article-title":"Genomic minimalism in the early diverging intestinal parasite <italic>Giardia lamblia<\/italic>.","volume":"317","author":"HG Morrison","year":"2007","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1101\/gr.2256604","article-title":"Evolution of eukaryotic transcription: insights from the genome of <italic>Giardia lamblia<\/italic>.","volume":"14","author":"AA Best","year":"2004","journal-title":"Genome Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1093\/nar\/gkn349","article-title":"Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex.","volume":"36","author":"HM Bourbon","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"27804","DOI":"10.1074\/jbc.M303316200","article-title":"<italic>Giardia lamblia<\/italic> RNA polymerase II: amanitin-resistant transcription.","volume":"278","author":"V Seshadri","year":"2003","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0166-6851(01)00211-0","article-title":"Initiator and upstream elements in the alpha2-tubulin promoter of <italic>Giardia lamblia<\/italic>.","volume":"113","author":"HG Elmendorf","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"19699","DOI":"10.1074\/jbc.274.28.19699","article-title":"Identification and characterization of a <italic>ran<\/italic> gene promoter in the primitive protozoan pathogen <italic>Giardia lamblia<\/italic>.","volume":"274","author":"CH Sun","year":"1999","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11432","DOI":"10.1074\/jbc.275.15.11432","article-title":"Transcriptional analysis of the glutamate dehydrogenase gene in the primitive eukaryote, <italic>Giardia lamblia<\/italic>. Identification of a primordial gene promoter.","volume":"275","author":"J Yee","year":"2000","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1093\/nar\/23.15.2945","article-title":"Analysis of consensus sequence patterns in <italic>Giardia<\/italic> cytoskeleton gene promoters.","volume":"23","author":"DV Holberton","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1046\/j.1365-2958.2002.03233.x","article-title":"A novel Myb-related protein involved in transcriptional activation of encystation genes in <italic>Giardia lamblia<\/italic>.","volume":"46","author":"CH Sun","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0020-7519(03)00177-2","article-title":"Encystation-specific regulation of the cyst wall protein 2 gene in <italic>Giardia lamblia<\/italic> by multiple cis-acting elements.","volume":"33","author":"SR Davis-Hayman","year":"2003","journal-title":"Int J Parasitol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"8905","DOI":"10.1074\/jbc.M611170200","article-title":"A novel ARID\/Bright-like protein involved in transcriptional activation of cyst wall protein 1 gene in <italic>Giardia lamblia<\/italic>.","volume":"282","author":"CH Wang","year":"2007","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molbiopara.2005.10.017","article-title":"Novel plant-GARP-like transcription factors in <italic>Giardia lamblia<\/italic>.","volume":"146","author":"CH Sun","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"31021","DOI":"10.1074\/jbc.M805023200","article-title":"Regulation of Cyst Wall Protein Promoters by Myb2 in <italic>Giardia lamblia<\/italic>.","volume":"283","author":"YC Huang","year":"2008","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"32213","DOI":"10.1074\/jbc.M110.156620","article-title":"A Novel Pax-like Protein Involved in Transcriptional activation of Cyst Wall Protein Genes in <italic>Giardia lamblia<\/italic>. The Journal of Biological Chemistry.","volume":"285","author":"YT Wang","year":"2010","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"34101","DOI":"10.1074\/jbc.M111.280206","article-title":"A novel E2F-like protein involved in transcriptional activation of cyst wall protein genes in <italic>Giardia lamblia<\/italic>.","volume":"286","author":"LH Su","year":"2011","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1369-5266(00)00107-2","article-title":"A genomic perspective on plant transcription factors.","volume":"3","author":"JL Riechmann","year":"2000","journal-title":"Curr Opin Plant Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0955-0674(96)80087-1","article-title":"Pax genes and their roles in cell differentiation and development.","volume":"8","author":"A Mansouri","year":"1996","journal-title":"Curr Opin Cell Biol"},{"key":"ref38","first-page":"405","article-title":"PAX: developmental control genes in cell growth and differentiation.","volume":"7","author":"ET Stuart","year":"1996","journal-title":"Cell Growth Differ"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0168-9525(01)02594-X","article-title":"Getting your Pax straight: Pax proteins in development and disease.","volume":"18","author":"N Chi","year":"2002","journal-title":"Trends Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.gde.2005.05.001","article-title":"Pax genes in eye development and evolution.","volume":"15","author":"Z Kozmik","year":"2005","journal-title":"Curr Opin Genet Dev"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nrc1778","article-title":"A PANorama of PAX genes in cancer and development.","volume":"6","author":"EJ Robson","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2006.06.024","article-title":"PAX genes: roles in development, pathophysiology, and cancer.","volume":"73","author":"D Lang","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"26914","DOI":"10.1074\/jbc.271.43.26914","article-title":"Zebrafish Pax9 encodes two proteins with distinct C-terminal transactivating domains of different potency negatively regulated by adjacent N-terminal sequences.","volume":"271","author":"S Nornes","year":"1996","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0925-4773(94)90086-8","article-title":"Dissection of the <italic>Drosophila<\/italic> paired protein: Functional requirements for conserved motifs.","volume":"47","author":"J Cai","year":"1994","journal-title":"Mech Dev"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1101\/gad.7.10.2048","article-title":"DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.","volume":"7","author":"T Czerny","year":"1993","journal-title":"Genes Dev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/0092-8674(91)90434-Z","article-title":"The molecular basis of the undulated\/Pax-1 mutation.","volume":"66","author":"G Chalepakis","year":"1991","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1093\/emboj\/19.10.2292","article-title":"Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.","volume":"19","author":"D Eberhard","year":"2000","journal-title":"EMBO J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1002\/j.1460-2075.1996.tb00548.x","article-title":"C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.","volume":"15","author":"P D\u00f6rfler","year":"1996","journal-title":"EMBO J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1074\/jbc.M209274200","article-title":"Potential involvement of extracellular signal-regulated kinase 1 and 2 in encystation of a primitive eukaryote, <italic>Giardia lamblia<\/italic>. Stage-specific activation and intracellular localization.","volume":"278","author":"4th Ellis JG","year":"2003","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0035-9203(83)90120-7","article-title":"Axenic culture of <italic>Giardia lamblia<\/italic> in TYI-S-33 medium supplemented with bile.","volume":"77","author":"DB Keister","year":"1983","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.molbiopara.2007.07.015","article-title":"Neomycin and puromycin affect gene expression in <italic>Giardia lamblia<\/italic> stable transfection.","volume":"156","author":"LH Su","year":"2007","journal-title":"Mol Biochem Parasitol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1574-6968.2000.tb09242.x","article-title":"The <italic>Giardia<\/italic> genome project database.","volume":"189","author":"AG McArthur","year":"2000","journal-title":"FEMS Microbiol Lett"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0166-6851(97)00225-9","article-title":"Episomal and integrated maintenance of foreign DNA in <italic>Giardia lamblia<\/italic>.","volume":"92","author":"SM Singer","year":"1998","journal-title":"Mol Biochem Parasitol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.ijpara.2008.02.006","article-title":"Incomplete nonsense-mediated mRNA decay in <italic>Giardia lamblia<\/italic>.","volume":"38","author":"YH Chen","year":"2008","journal-title":"Int J Parasitol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molbiopara.2010.11.008","article-title":"An atypical proprotein convertase in <italic>Giardia lamblia<\/italic> differentiation.","volume":"175","author":"BJ Davids","year":"2011","journal-title":"Mol Biochem Parasitol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"32979","DOI":"10.1074\/jbc.M403171200","article-title":"Mitotic cyclins stimulate the activity of c-Myb-like factors for transactivation of G2\/M phase-specific genes in tobacco.","volume":"279","author":"S Araki","year":"2004","journal-title":"J Biol Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1101\/gad.13.10.1263","article-title":"Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding.","volume":"13","author":"HE Xu","year":"1999","journal-title":"Genes Dev"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1006\/jmbi.1993.1413","article-title":"Prediction of protein secondary structure at better than 70% accuracy.","volume":"232","author":"B Rost","year":"1993","journal-title":"J Mol Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0166-6851(97)00239-9","article-title":"Stable DNA transfection of the primitive protozoan pathogen <italic>Giardia lamblia<\/italic>.","volume":"92","author":"CH Sun","year":"1998","journal-title":"Mol Biochem Parasitol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0888-7543(05)80111-9","article-title":"A knowledge base for predicting protein localization sites in eukaryotic cells.","volume":"14","author":"K Nakai","year":"1992","journal-title":"Genomics"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0092-8674(95)90518-9","article-title":"Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations.","volume":"80","author":"W Xu","year":"1995","journal-title":"Cell"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0092-8674(92)90432-C","article-title":"A tissue-specific MAR\/SAR DNA-binding protein with unusual binding site recognition.","volume":"70","author":"LA Dickinson","year":"1992","journal-title":"Cell"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"18101","DOI":"10.1073\/pnas.0608849103","article-title":"The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity.","volume":"103","author":"MA Emrick","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature01198","article-title":"Role of duplicate genes in genetic robustness against null mutations.","volume":"421","author":"Z Gu","year":"2003","journal-title":"Nature"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"35024","DOI":"10.1074\/jbc.M702795200","article-title":"Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.","volume":"282","author":"Y Gosmain","year":"2007","journal-title":"J Biol Chem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e677","DOI":"10.1371\/journal.pntd.0000677","article-title":"A novel family of cyst proteins with epidermal growth factor repeats in <italic>Giardia lamblia<\/italic>.","volume":"4","author":"PW Chiu","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"8355","DOI":"10.1016\/S0021-9258(17)37201-0","article-title":"Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes.","volume":"269","author":"J Epstein","year":"1994","journal-title":"J Biol Chem"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/bj3370253","article-title":"Co-operation between the PAI and RED subdomains of Pax-8 in the interaction with the thyroglobulin promoter.","volume":"337","author":"L Pellizzari","year":"1999","journal-title":"Biochem J"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"7978","DOI":"10.1074\/jbc.271.14.7978","article-title":"Identification of novel Pax-2 binding sites by chromatin precipitation.","volume":"271","author":"DE Phelps","year":"1996","journal-title":"J Biol Chem"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0952-7915(94)90095-7","article-title":"Regulation of gene expression at early stages of B-cell differentiation.","volume":"6","author":"J Hagman","year":"1994","journal-title":"Curr Opin Immunol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1093\/hmg\/9.13.1907","article-title":"Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome.","volume":"9","author":"N Bondurand","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1128\/MCB.11.12.6166","article-title":"Positive autoregulation of c-myb expression via Myb binding sites in the 5\u2032 flanking region of the human c-myb gene.","volume":"11","author":"NC Nicolaides","year":"1991","journal-title":"Mol Cell Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1101\/gad.222702","article-title":"Targets of AtWRKY6 regulation during plant senescence and pathogen defense.","volume":"16","author":"S Robatzek","year":"2002","journal-title":"Genes Dev"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/10409230802486208","article-title":"Self-regulated Pax gene expression and modulation by the TGFbeta superfamily.","volume":"43","author":"V Frost","year":"2008","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"ref76","first-page":"1531","article-title":"Nuclear localization signals, DNA binding, and transactivation properties of quail Pax-6 (Pax-QNR) isoforms.","volume":"6","author":"C Carri\u00e8re","year":"1995","journal-title":"Cell Growth Differ"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"15115","DOI":"10.1074\/jbc.274.21.15115","article-title":"Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase.","volume":"274","author":"I Mikkola","year":"1999","journal-title":"J Biol Chem"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.ijpara.2011.06.001","article-title":"Mining the <italic>Giardia<\/italic> genome and proteome for conserved and unique basal body proteins.","volume":"41","author":"T Lauwaet","year":"2011","journal-title":"Int J Parasitol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ydbio.2009.05.538","article-title":"A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm.","volume":"331","author":"NM Amin","year":"2009","journal-title":"Dev Biol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1093\/nar\/gkg500","article-title":"Multiple sequence alignment with the Clustal series of programs.","volume":"31","author":"R Chenna","year":"2003","journal-title":"Nucleic Acids Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0030614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T11:54:01Z","timestamp":1640778841000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0030614"}},"subtitle":[],"editor":[{"given":"Ira","family":"Blader","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,15]]},"references-count":80,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0030614","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,15]]}}}