{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:11:09Z","timestamp":1791418269471,"version":"4.3.3"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T00:00:00Z","timestamp":1327276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0030616","type":"journal-article","created":{"date-parts":[[2012,1,23]],"date-time":"2012-01-23T17:00:39Z","timestamp":1327338039000},"page":"e30616","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":66,"title":["Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis"],"prefix":"10.1371","volume":"7","author":[{"given":"B\u00e9reng\u00e8re","family":"Coup\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Grit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Hulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwena\u00eblle","family":"Randuineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Parnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,1,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"R813","DOI":"10.1152\/ajpregu.00201.2009","article-title":"The timing of \u201ccatch-up growth\u201d affects metabolism and appetite regulation in male rats born with intrauterine growth restriction.","volume":"297","author":"B Coupe","year":"2009","journal-title":"American Journal of Physiology-Regulatory Integrative and Comparative Physiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1210\/en.2009-0893","article-title":"Nutritional programming affects hypothalamic organization and early response to leptin.","volume":"151","author":"B Coup\u00e9","year":"2010","journal-title":"Endocrinology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.1095004","article-title":"Trophic action of leptin on hypothalamic neurons that regulate feeding.","volume":"304","author":"S Bouret","year":"2004","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0031-9384(03)00104-5","article-title":"Ontogeny of the hypothalamic neuropeptide Y system.","volume":"79","author":"K Grove","year":"2003","journal-title":"Physiol Behav"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/1933719107303983","article-title":"Programmed hyperphagia due to reduced anorexigenic mechanisms in intrauterine growth-restricted offspring.","volume":"14","author":"M Desai","year":"2007","journal-title":"Reprod Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1740-8709.2005.00020.x","article-title":"The developmental origins of adult disease.","volume":"1","author":"P Gluckman","year":"2005","journal-title":"Matern Child Nutr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/bmb\/60.1.5","article-title":"The thrifty phenotype hypothesis.","volume":"60","author":"C Hales","year":"2001","journal-title":"Br Med Bull"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1021\/pr2003193","article-title":"Offspring Metabolomic Response to Maternal Protein Restriction in a Rat Model of Intrauterine Growth Restriction (IUGR).","volume":"10","author":"MC Alexandre-Gouabau","year":"2011","journal-title":"Journal of Proteome Research"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nm0995-953","article-title":"Increased obese mRNA expression in omental fat cells from massively obese humans.","volume":"1","author":"B Hamilton","year":"1995","journal-title":"Nat Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.physiol.70.113006.100707","article-title":"Mechanisms of leptin action and leptin resistance.","volume":"70","author":"M Myers","year":"2008","journal-title":"Annu Rev Physiol"},{"key":"ref11","article-title":"Recent Advances in Understanding Leptin Signaling and Leptin Resistance.","author":"D Morris","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.physiol.62.1.413","article-title":"Leptin.","volume":"62","author":"R Ahima","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1210\/endo.138.2.5033","article-title":"Leptin activates neurons in ventrobasal hypothalamus and brainstem.","volume":"138","author":"JK Elmquist","year":"1997","journal-title":"Endocrinology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/(SICI)1096-9861(19980615)395:4<535::AID-CNE9>3.0.CO;2-2","article-title":"Distributions of leptin receptor mRNA isoforms in the rat brain.","volume":"395","author":"J Elmquist","year":"1998","journal-title":"J Comp Neurol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1073\/pnas.95.2.741","article-title":"Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei.","volume":"95","author":"J Elmquist","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1210\/rp.59.1.287","article-title":"Leptin receptor signaling and the regulation of mammalian physiology.","volume":"59","author":"MJ Myers","year":"2004","journal-title":"Recent Prog Horm Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature02440","article-title":"AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.","volume":"428","author":"Y Minokoshi","year":"2004","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000326785","article-title":"Intracellular Leptin-Signaling Pathways in Hypothalamic Neurons: The Emerging Role of Phosphatidylinositol-3 Kinase-Phosphodiesterase-3B-cAMP Pathway.","volume":"93","author":"A Sahu","year":"2011","journal-title":"Neuroendocrinology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1126\/science.1124147","article-title":"Hypothalamic mTOR signaling regulates food intake.","volume":"312","author":"D Cota","year":"2006","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(00)80062-3","article-title":"Identification of SOCS-3 as a potential mediator of central leptin resistance.","volume":"1","author":"C Bj\u00f8rbaek","year":"1998","journal-title":"Mol Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"16064","DOI":"10.1073\/pnas.0405041101","article-title":"Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.","volume":"101","author":"E Zhang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"R813","DOI":"10.1152\/ajpregu.00201.2009","article-title":"The timing of \u201ccatch-up growth\u201d affects metabolism and appetite regulation in male rats born with intrauterine growth restriction.","volume":"297","author":"B Coup\u00e9","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref23","article-title":"The rat brain in strereotaxic coordinates. 5 ed","author":"G Paxinos","year":"2005"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"K Livak","year":"2001","journal-title":"Methods"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and obese humans.","volume":"334","author":"R Considine","year":"1996","journal-title":"N Engl J Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/physrev.00053.2003","article-title":"Developmental origins of the metabolic syndrome: prediction, plasticity, and programming.","volume":"85","author":"I McMillen","year":"2005","journal-title":"Physiol Rev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/bmj.320.7240.967","article-title":"Association between postnatal catch-up growth and obesity in childhood: prospective cohort study.","volume":"320","author":"K Ong","year":"2000","journal-title":"BMJ"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/ajcn\/70.5.811","article-title":"Obesity at the age of 50 y in men and women exposed to famine prenatally.","volume":"70","author":"A Ravelli","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1053\/meta.2001.21693","article-title":"Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity.","volume":"50","author":"S Smith","year":"2001","journal-title":"Metabolism"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"R291","DOI":"10.1152\/ajpregu.90497.2008","article-title":"Forced catch-up growth after fetal protein restriction alters the adipose tissue gene expression program leading to obesity in adult mice.","volume":"297","author":"V Bol","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref31","article-title":"Nutritional Programming in the Rat Is Linked to Long-Lasting Changes in Nutrient Sensing and Energy Homeostasis in the Hypothalamus.","volume":"5","author":"R Orozco-Solis","year":"2011","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.tem.2010.08.002","article-title":"Obesity and leptin resistance: distinguishing cause from effect.","volume":"21","author":"MG Myers","year":"2010","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1210\/en.2007-1307","article-title":"Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB\/N mice.","volume":"149","author":"A Metlakunta","year":"2008","journal-title":"Endocrinology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1210\/en.2007-0945","article-title":"Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein\/neuropeptide Y neurons for normal energy homeostasis.","volume":"149","author":"L Gong","year":"2008","journal-title":"Endocrinology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1210\/en.2006-1119","article-title":"Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding.","volume":"148","author":"AW Xu","year":"2007","journal-title":"Endocrinology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"7202","DOI":"10.1523\/JNEUROSCI.1389-08.2008","article-title":"The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.","volume":"28","author":"D Cota","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"18933","DOI":"10.1074\/jbc.M512831200","article-title":"Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.","volume":"281","author":"TL Martin","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.cmet.2009.03.005","article-title":"Critical role for hypothalamic mTOR activity in energy balance.","volume":"9","author":"H Mori","year":"2009","journal-title":"Cell Metab"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0030616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T16:47:27Z","timestamp":1561222047000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0030616"}},"subtitle":[],"editor":[{"given":"Olivier","family":"Baud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,23]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0030616","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,23]]}}}