{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:08:16Z","timestamp":1785902896554,"version":"3.56.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T00:00:00Z","timestamp":1327017600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0030678","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T21:58:21Z","timestamp":1327096701000},"page":"e30678","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Copper Deficiency Induced Emphysema Is Associated with Focal Adhesion Kinase Inactivation"],"prefix":"10.1371","volume":"7","author":[{"given":"Shiro","family":"Mizuno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Yasuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm J.","family":"Bogaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatas","family":"Kraskauskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysar","family":"Alhussaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Gomez-Arroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert F.","family":"Voelkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1172\/JCI31811","article-title":"Molecular pathogenesis of emphysema.","volume":"118","author":"L Taraseviciene-Stewart","year":"2008","journal-title":"J Clin Invest"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1513\/pats.200605-124SF","article-title":"Role of lung maintenance program in the heterogeneity of lung destruction in emphysema.","volume":"3","author":"RM Tuder","year":"2006","journal-title":"Proc Am Thorac Soc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(09)61303-9","article-title":"Chronic obstructive pulmonary disease in non-smokers.","volume":"374","author":"SS Salvi","year":"2009","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1378\/chest.128.3.1239","article-title":"Mild and moderate-to-severe COPD in nonsmokers: distinct demographic profiles.","volume":"128","author":"CE Behrendt","year":"2005","journal-title":"Chest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/ajmg.a.31001","article-title":"Severe bilateral panlobular emphysema and pulmonary arterial hypoplasia: unusual manifestations of Menkes disease.","volume":"139A","author":"DK Grange","year":"2005","journal-title":"Am J Med Genet A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/249852a0","article-title":"Primary defect in copper transport underlies mottled mutants in the mouse.","volume":"249","author":"DM Hunt","year":"1974","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3109\/01902148309055014","article-title":"Morphologic and phenotypic analysis of an outcross line of blotchy mouse.","volume":"4","author":"V Ranga","year":"1983","journal-title":"Exp Lung Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"70S","DOI":"10.1378\/chest.85.6_Supplement.70S","article-title":"Mechanisms of lung injury in the copper deficient hamster model of emphysema.","volume":"85","author":"NT Soskel","year":"1984","journal-title":"Chest"},{"key":"ref9","first-page":"413","article-title":"The lung of the copper-deficient rat. A model for developmental pulmonary emphysema.","volume":"91","author":"BL O'Dell","year":"1978","journal-title":"Am J Pathol"},{"key":"ref10","first-page":"693","article-title":"The effects of beta-aminopropionitrile on the growing rat lung.","volume":"101","author":"K Kida","year":"1980","journal-title":"Am J Pathol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1164\/ajrccm.157.1.9704038","article-title":"Intrapulmonary gas mixing in panacinar- and centriacinar-induced emphysema in rats.","volume":"157","author":"ML Rubio","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1164\/ajrccm.163.3.2002117","article-title":"Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema.","volume":"163","author":"Y Kasahara","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI10259","article-title":"Inhibition of VEGF receptors causes lung cell apoptosis and emphysema.","volume":"106","author":"Y Kasahara","year":"2000","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1183\/09031936.00022910","article-title":"Hypoxia inducible factor-1a in human emphysema lung tissue.","volume":"37","author":"M Yasuo","year":"2011","journal-title":"Eur Respir J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1015312119693","article-title":"Molecular mechanisms of \u201cdetachment-induced apoptosis\u2014Anoikis\u201d.","volume":"7","author":"J Grossmann","year":"2002","journal-title":"Apoptosis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature04323","article-title":"Potentiation of neuroblastoma metastasis by loss of caspase-8.","volume":"439","author":"DG Stupack","year":"2006","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molcel.2007.11.031","article-title":"Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.","volume":"29","author":"ST Lim","year":"2008","journal-title":"Mol Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1021\/jm800483v","article-title":"A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.","volume":"51","author":"VM Golubovskaya","year":"2008","journal-title":"J Med Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1182\/blood-2004-10-3980","article-title":"Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.","volume":"105","author":"F Martin","year":"2005","journal-title":"Blood"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1124\/mol.108.051516","article-title":"Copper regulation of hypoxia-inducible factor-1 activity.","volume":"75","author":"W Feng","year":"2009","journal-title":"Mol Pharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1128\/MCB.21.20.7025-7034.2001","article-title":"Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice.","volume":"21","author":"G Kostka","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ppul.20174","article-title":"Splicing mutation in the fibrillin-1 gene associated with neonatal Marfan syndrome and severe pulmonary emphysema with tracheobronchomalacia.","volume":"39","author":"M Shinawi","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/abbi.1993.1151","article-title":"Expression and accumulation of lysyl oxidase, elastin, and type I procollagen in human Menkes and mottled mouse fibroblasts.","volume":"301","author":"S Gacheru","year":"1993","journal-title":"Arch Biochem Biophys"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"35624","DOI":"10.1074\/jbc.M006124200","article-title":"Integrin activation and focal complex formation in cardiac hypertrophy.","volume":"275","author":"M Laser","year":"2000","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10495-008-0192-y","article-title":"B1 integrin\/Fak\/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms.","volume":"13","author":"V Bouchard","year":"2008","journal-title":"Apoptosis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jcb.20240","article-title":"Doxazosin inhibits human vascular endothelial cell adhesion, migration, and invasion.","volume":"94","author":"K Keledjian","year":"2005","journal-title":"J Cell Biochem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.exer.2008.11.034","article-title":"Focal adhesion kinase signaling pathway participates in the formation of choroidal neovascularization and regulates the proliferation and migration of choroidal microvascular endothelial cells by acting through HIF-1 and VEGF expression in RPE cells.","volume":"88","author":"J Zhu","year":"2009","journal-title":"Exp Eye Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/stem.302","article-title":"Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex.","volume":"28","author":"H Song","year":"2010","journal-title":"Stem Cells"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"11429","DOI":"10.1158\/0008-5472.CAN-05-1274","article-title":"Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism.","volume":"65","author":"SL Payne","year":"2005","journal-title":"Cancer Res"},{"key":"ref30","first-page":"287","article-title":"Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol.","volume":"3","author":"T Noda","year":"2009","journal-title":"Possible role of Bim, focal adhesion kinase and endonuclease G. Apoptosis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.yjmcc.2008.10.017","article-title":"FAK regulates cardiomyocyte survival following ischemia\/reperfusion.","volume":"46","author":"ZS Hakim","year":"2009","journal-title":"J Mol Cell Cardiol;"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1073\/pnas.0802319105","article-title":"Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice.","volume":"105","author":"X Peng","year":"2008","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0030678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T17:37:11Z","timestamp":1640540231000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0030678"}},"subtitle":[],"editor":[{"given":"Marcia B.","family":"Aguila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,1,20]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0030678","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,20]]}}}