{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:07:23Z","timestamp":1790626043455,"version":"4.1.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T00:00:00Z","timestamp":1330905600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0030984","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T03:38:31Z","timestamp":1331005111000},"page":"e30984","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of Deletion of Macrophage ABCA7 on Lipid Metabolism and the Development of Atherosclerosis in the Presence and Absence of ABCA1"],"prefix":"10.1371","volume":"7","author":[{"given":"Illiana","family":"Meurs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Calpe-Berdiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim L. L.","family":"Habets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne J. A.","family":"Korporaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Mieke","family":"Mommaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Josselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reeni B.","family":"Hildebrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud","family":"Out","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Kuiper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo J. C.","family":"Van Berkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Chimini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Van Eck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-2275(20)43114-1","article-title":"The plasma lecithins:cholesterol acyltransferase reaction.","volume":"9","author":"JA Glomset","year":"1968","journal-title":"J Lipid Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1161\/01.ATV.21.1.13","article-title":"High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport.","volume":"21","author":"A von Eckardstein","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.cb.08.110192.000435","article-title":"ABC transporters: from microorganisms to man.","volume":"8","author":"CF Higgins","year":"1992","journal-title":"Annu Rev Cell Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1161\/01.ATV.0000104029.74961.f5","article-title":"Formation and metabolism of prebeta-migrating, lipid-poor apolipoprotein A-I.","volume":"24","author":"KA Rye","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1006\/bbrc.2000.4219","article-title":"Apolipoprotein specificity for lipid efflux by the human ABCAI transporter.","volume":"280","author":"AT Remaley","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/11905","article-title":"Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency.","volume":"22","author":"A Brooks-Wilson","year":"1999","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/11914","article-title":"The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease.","volume":"22","author":"M Bodzioch","year":"1999","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/11921","article-title":"Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1.","volume":"22","author":"S Rust","year":"1999","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0021-9150(94)90144-9","article-title":"Homozygous Tangier disease and cardiovascular disease.","volume":"107","author":"C Serfaty-Lacrosniere","year":"1994","journal-title":"Atherosclerosis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"9774","DOI":"10.1073\/pnas.0403506101","article-title":"ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins.","volume":"101","author":"N Wang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cmet.2005.01.002","article-title":"ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.","volume":"1","author":"MA Kennedy","year":"2005","journal-title":"Cell Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/00041433-200010000-00007","article-title":"ABC transporters in cellular lipid trafficking.","volume":"11","author":"G Schmitz","year":"2000","journal-title":"Curr Opin Lipidol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/01.mol.0000169351.28019.04","article-title":"Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis.","volume":"16","author":"M Van Eck","year":"2005","journal-title":"Curr Opin Lipidol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1006\/bbrc.2000.2954","article-title":"Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7).","volume":"273","author":"WE Kaminski","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbrc.2003.10.002","article-title":"Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release.","volume":"311","author":"Y Ikeda","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000056914","article-title":"Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter.","volume":"92","author":"C Broccardo","year":"2001","journal-title":"Cytogenet Cell Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1194\/jlr.M600127-JLR200","article-title":"ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis.","volume":"47","author":"N Iwamoto","year":"2006","journal-title":"J Lipid Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/bbrc.1999.0406","article-title":"Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.","volume":"257","author":"T Langmann","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1073\/pnas.97.2.817","article-title":"ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.","volume":"97","author":"J Klucken","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1074\/jbc.M309888200","article-title":"Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.","volume":"279","author":"S Abe-Dohmae","year":"2004","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1194\/jlr.M500092-JLR200","article-title":"Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7.","volume":"46","author":"M Hayashi","year":"2005","journal-title":"J Lipid Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"42906","DOI":"10.1074\/jbc.M307831200","article-title":"ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux.","volume":"278","author":"N Wang","year":"2003","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1194\/jlr.M400247-JLR200","article-title":"Potential role of ABCA7 in cellular lipid efflux to apoA-I.","volume":"46","author":"P Linsel-Nitschke","year":"2005","journal-title":"J Lipid Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1074\/jbc.M412602200","article-title":"Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.","volume":"280","author":"WS Kim","year":"2005","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbrc.2010.04.027","article-title":"Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice.","volume":"395","author":"D Ye","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0003-2697(78)90046-5","article-title":"Lipid extraction of tissues with a low-toxicity solvent.","volume":"90","author":"A Hara","year":"1978","journal-title":"Anal Biochem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.exphem.2005.07.004","article-title":"HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes.","volume":"33","author":"I Meurs","year":"2005","journal-title":"Exp Hematol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1194\/jlr.M300110-JLR200","article-title":"Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1.","volume":"44","author":"CL Wellington","year":"2003","journal-title":"J Lipid Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1161\/01.ATV.0000208364.22732.16","article-title":"Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice.","volume":"26","author":"M Van Eck","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1073\/pnas.092327399","article-title":"Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.","volume":"99","author":"M van Eck","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1172\/JCI18730","article-title":"Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta\/delta, and gamma.","volume":"114","author":"AC Li","year":"2004","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1016\/j.febslet.2006.08.022","article-title":"Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development.","volume":"580","author":"M Pennings","year":"2006","journal-title":"FEBS Lett"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1161\/01.ATV.0000242275.92915.43","article-title":"Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1\u2212\/\u2212 bone marrow.","volume":"26","author":"M Ranalletta","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1161\/01.ATV.18.10.1519","article-title":"Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects.","volume":"18","author":"MM Kockx","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/01.CIR.97.23.2307","article-title":"Apoptosis and related proteins in different stages of human atherosclerotic plaques.","volume":"97","author":"MM Kockx","year":"1998","journal-title":"Circulation"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200601030","article-title":"ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages.","volume":"174","author":"AW Jehle","year":"2006","journal-title":"J Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/11878","article-title":"The ABCs of cholesterol efflux.","volume":"22","author":"SG Young","year":"1999","journal-title":"Nat Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/35017029","article-title":"ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.","volume":"2","author":"Y Hamon","year":"2000","journal-title":"Nat Cell Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.97.8.4245","article-title":"High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1.","volume":"97","author":"J McNeish","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1152\/jappl.1999.87.5.1901","article-title":"Role of the spleen in the exaggerated polycythemic response to hypoxia in chronic mountain sickness in rats.","volume":"87","author":"HY Kam","year":"1999","journal-title":"J Appl Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1006\/bbrc.2000.3880","article-title":"Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene.","volume":"278","author":"WE Kaminski","year":"2000","journal-title":"Biochem Biophys Res Commun"}],"updated-by":[{"DOI":"10.1371\/annotation\/577d9009-baf4-46ea-b44e-eda094b604db","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T00:00:00Z","timestamp":1337817600000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0030984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T13:26:45Z","timestamp":1641043605000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0030984"}},"subtitle":[],"editor":[{"given":"Leon J.","family":"de Windt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,5]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0030984","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,5]]}}}