{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:34:11Z","timestamp":1791189251359,"version":"4.1.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0031083","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T22:48:22Z","timestamp":1329864502000},"page":"e31083","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":63,"title":["Cortical Gyrification and Sulcal Spans in Early Stage Alzheimer's Disease"],"prefix":"10.1371","volume":"7","author":[{"given":"Tao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren M.","family":"Lipnicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacheng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse S.","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perminder S.","family":"Sachdev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0404.1996.tb05866.x","article-title":"Evolution of the neuropathology of Alzheimer's disease.","volume":"165","author":"H Braak","year":"1996","journal-title":"Acta Neurol Scand Suppl"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/153331750201700106","article-title":"Alzheimer's disease and other dementias: a review.","volume":"17","author":"S Rogan","year":"2002","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/cercor\/1.1.103","article-title":"The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease.","volume":"1","author":"SE Arnold","year":"1991","journal-title":"Cereb Cortex"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0079-6123(02)36039-4","article-title":"Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease.","volume":"136","author":"JH Morrison","year":"2002","journal-title":"Prog Brain Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.neuroimage.2006.11.042","article-title":"Regional coherence changes in the early stages of Alzheimer's disease: a combined structural and resting-state functional MRI study.","volume":"35","author":"Y He","year":"2007","journal-title":"Neuroimage"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/hipo.20573","article-title":"Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies.","volume":"19","author":"F Shi","year":"2009","journal-title":"Hippocampus"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/brain\/awm112","article-title":"3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease.","volume":"130","author":"JL Whitwell","year":"2007","journal-title":"Brain"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1212\/01.WNL.0000154530.72969.11","article-title":"Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD.","volume":"64","author":"AF Fotenos","year":"2005","journal-title":"Neurology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1148\/radiol.2482070938","article-title":"Whole-brain atrophy rate and cognitive decline: longitudinal MR study of memory clinic patients.","volume":"248","author":"JD Sluimer","year":"2008","journal-title":"Radiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1523\/JNEUROSCI.23-03-00994.2003","article-title":"Dynamics of gray matter loss in Alzheimer's disease.","volume":"23","author":"PM Thompson","year":"2003","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.neuroimage.2005.05.015","article-title":"Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study.","volume":"27","author":"G Chetelat","year":"2005","journal-title":"Neuroimage"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.neuroimage.2007.06.016","article-title":"Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment.","volume":"37","author":"A Hamalainen","year":"2007","journal-title":"Neuroimage"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S1053-8119(03)00041-7","article-title":"A comprehensive study of gray matter loss in patients with Alzheimer's disease using optimized voxel-based morphometry.","volume":"18","author":"GB Karas","year":"2003","journal-title":"Neuroimage"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/02841850701627181","article-title":"Regional white matter decreases in Alzheimer's disease using optimized voxel-based morphometry.","volume":"49","author":"S Li","year":"2008","journal-title":"Acta Radiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuroimage.2005.08.057","article-title":"Gray matter reduction is correlated with white matter hyperintensity volume: a voxel-based morphometric study in a large epidemiological sample.","volume":"29","author":"W Wen","year":"2006","journal-title":"Neuroimage"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/cercor\/bhn113","article-title":"The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals.","volume":"19","author":"BC Dickerson","year":"2009","journal-title":"Cereb Cortex"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neulet.2008.03.032","article-title":"Variations in cortical thickness with dementia severity in Alzheimer's disease.","volume":"436","author":"K Im","year":"2008","journal-title":"Neurosci Lett"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrneurol.2009.215","article-title":"The clinical use of structural MRI in Alzheimer disease.","volume":"6","author":"GB Frisoni","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/WCO.0b013e32833a0afc","article-title":"In-vivo measurement of cortical morphology: means and meanings.","volume":"23","author":"JF Mangin","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"ref20","first-page":"132","article-title":"Why does cerebral cortex fissure and fold? A review of determinants of gyri and sulci.","volume":"8","author":"W Welker","year":"1988","journal-title":"Cerebral Cortex"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/385313a0","article-title":"A tension-based theory of morphogenesis and compact wiring in the central nervous system.","volume":"385","author":"DC Van Essen","year":"1997","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1093\/cercor\/bhm225","article-title":"Cortical folding patterns and predicting cytoarchitecture.","volume":"18","author":"B Fischl","year":"2008","journal-title":"Cereb Cortex"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/cercor\/bhp074","article-title":"Mapping surface variability of the central sulcus in musicians.","volume":"20","author":"S Li","year":"2010","journal-title":"Cereb Cortex"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.neuroimage.2007.08.049","article-title":"Cortical folding abnormalities in schizophrenia patients with resistant auditory hallucinations.","volume":"39","author":"A Cachia","year":"2008","journal-title":"Neuroimage"},{"key":"ref25","first-page":"127","article-title":"Cortical folding in patients with bipolar disorder or unipolar depression.","volume":"34","author":"J Penttila","year":"2009","journal-title":"J Psychiatry Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/brain\/awn129","article-title":"Cortical changes in cerebral small vessel diseases: a 3D MRI study of cortical morphology in CADASIL.","volume":"131","author":"E Jouvent","year":"2008","journal-title":"Brain"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1212\/WNL.0b013e31821810a4","article-title":"Apathy is related to cortex morphology in CADASIL. A sulcal-based morphometry study.","volume":"76","author":"E Jouvent","year":"2011","journal-title":"Neurology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/hbm.20198","article-title":"Age-related morphology trends of cortical sulci.","volume":"26","author":"P Kochunov","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuroimage.2010.02.016","article-title":"The effects of age and sex on cortical sulci in the elderly.","volume":"51","author":"T Liu","year":"2010","journal-title":"Neuroimage"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neuroimage.2011.03.015","article-title":"The relationship between cortical sulcal variability and cognitive performance in the elderly.","volume":"56","author":"T Liu","year":"2011","journal-title":"Neuroimage"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuroimage.2008.07.016","article-title":"Sulcal morphology changes and their relationship with cortical thickness and gyral white matter volume in mild cognitive impairment and Alzheimer's disease.","volume":"43","author":"K Im","year":"2008","journal-title":"Neuroimage"},{"key":"ref32","first-page":"189","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician.","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1001\/jama.297.21.2391","article-title":"Does this patient have dementia?","volume":"297","author":"T Holsinger","year":"2007","journal-title":"JAMA"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1162\/jocn.2007.19.9.1498","article-title":"Open Access Series of Imaging Studies (OASIS): cross-sectional MRI data in young, middle aged, nondemented, and demented older adults.","volume":"19","author":"DS Marcus","year":"2007","journal-title":"J Cogn Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules.","volume":"43","author":"JC Morris","year":"1993","journal-title":"Neurology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/archneur.58.3.397","article-title":"Mild cognitive impairment represents early-stage Alzheimer disease.","volume":"58","author":"JC Morris","year":"2001","journal-title":"Arch Neurol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry\u2013the methods.","volume":"11","author":"J Ashburner","year":"2000","journal-title":"Neuroimage"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1016\/j.neuroimage.2004.07.019","article-title":"A framework to study the cortical folding patterns.","volume":"23","author":"JF Mangin","year":"2004","journal-title":"Neuroimage"},{"key":"ref39","first-page":"153","article-title":"Deformable topological models for segmentation of 3D medical images.","volume":"3","author":"JF Mangin","year":"1995","journal-title":"Information Processing in Medical Imaging"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1361-8415(02)00052-X","article-title":"Automatic recognition of cortical sulci of the human brain using a congregation of neural networks.","volume":"6","author":"D Riviere","year":"2002","journal-title":"Med Image Anal"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/hbm.20369","article-title":"Relationship among neuroimaging indices of cerebral health during normal aging.","volume":"29","author":"P Kochunov","year":"2008","journal-title":"Hum Brain Mapp"},{"key":"ref42","article-title":"A Library of Cortical Morphology Analysis Tools to Study Development, Aging and Genetics of Cerebral Cortex.","author":"P Kochunov","year":"2011","journal-title":"Neuroinformatics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cercor\/bhg087","article-title":"Automatically parcellating the human cerebral cortex.","volume":"14","author":"B Fischl","year":"2004","journal-title":"Cereb Cortex"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest.","volume":"31","author":"RS Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuroimage.2010.06.050","article-title":"Fractal dimension analysis of the cortical ribbon in mild Alzheimer's disease.","volume":"53","author":"RD King","year":"2010","journal-title":"Neuroimage"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1212\/01.wnl.0000340981.97664.2f","article-title":"The cortical signature of prodromal AD: regional thinning predicts mild AD dementia.","volume":"72","author":"A Bakkour","year":"2009","journal-title":"Neurology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroimage.2011.06.041","article-title":"Age-related changes in the surface morphology of the central sulcus.","volume":"58","author":"S Li","year":"2011","journal-title":"Neuroimage"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.neuroimage.2008.10.030","article-title":"Regional white matter volume differences in nondemented aging and Alzheimer's disease.","volume":"44","author":"DH Salat","year":"2009","journal-title":"Neuroimage"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neubiorev.2011.06.009","article-title":"Parietal cortex matters in Alzheimer's disease: An overview of structural, functional and metabolic findings.","volume":"36","author":"HI Jacobs","year":"2012","journal-title":"Neurosci Biobehav Rev"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0031083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T06:10:38Z","timestamp":1640844638000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0031083"}},"subtitle":[],"editor":[{"given":"Stephen D.","family":"Ginsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,21]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0031083","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,21]]}}}