{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:42:43Z","timestamp":1785195763991,"version":"3.55.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T00:00:00Z","timestamp":1329696000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0031573","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T22:12:40Z","timestamp":1329775960000},"page":"e31573","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Role of Histone Acetylation in the Stimulatory Effect of Valproic Acid on Vascular Endothelial Tissue-Type Plasminogen Activator Expression"],"prefix":"10.1371","volume":"7","author":[{"given":"Pia","family":"Larsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Ulfhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Bergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Lunke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assam","family":"El-Osta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Medcalf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Arne","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverker","family":"Jern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,2,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1161\/01.ATV.0000222011.13026.25","article-title":"Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk.","volume":"26","author":"S Kathiresan","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-0037-1612951","article-title":"Tissue-type plasminogen activator \u22127,351C\/T enhancer polymorphism is associated with a first myocardial infarction.","volume":"87","author":"P Ladenvall","year":"2002","journal-title":"Thromb Haemost"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1161\/01.HYP.0000137380.91476.fb","article-title":"Impaired endothelial release of tissue-type plasminogen activator in patients with chronic kidney disease and hypertension.","volume":"44","author":"T Hrafnkelsdottir","year":"2004","journal-title":"Hypertension"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(05)61044-6","article-title":"Impaired capacity for endogenous fibrinolysis in essential hypertension.","volume":"352","author":"T Hrafnkelsdottir","year":"1998","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/01.HYP.0000210540.35296.62","article-title":"Impaired capacity for stimulated fibrinolysis in primary hypertension is restored by antihypertensive therapy.","volume":"47","author":"W Ridderstrale","year":"2006","journal-title":"Hypertension"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"E807","DOI":"10.1152\/ajpendo.00072.2005","article-title":"Endothelial t-PA release is impaired in overweight and obese adults but can be improved with regular aerobic exercise.","volume":"289","author":"GP Van Guilder","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/j.1399-6576.2008.01741.x","article-title":"Impaired myocardial t-PA release in patients with coronary artery disease.","volume":"52","author":"B Osterlund","year":"2008","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1161\/01.CIR.103.15.1936","article-title":"Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis.","volume":"103","author":"DE Newby","year":"2001","journal-title":"Circulation"},{"issue":"Pt 1","key":"ref9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/bj3100171","article-title":"Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation.","volume":"310","author":"J Arts","year":"1995","journal-title":"Biochem J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1042\/bj2470605","article-title":"Butyrate stimulates tissue-type plasminogen-activator synthesis in cultured human endothelial cells.","volume":"247","author":"T Kooistra","year":"1987","journal-title":"Biochem J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/cvr\/cvr028","article-title":"Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells.","volume":"90","author":"S Dunoyer-Geindre","year":"2011","journal-title":"Cardiovasc Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1146\/annurev.biochem.76.052705.162114","article-title":"Functions of site-specific histone acetylation and deacetylation.","volume":"76","author":"MD Shahbazian","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.","volume":"20","author":"M Gottlicher","year":"2001","journal-title":"EMBO J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.","volume":"276","author":"CJ Phiel","year":"2001","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1124\/mol.65.3.520","article-title":"Valproic acid inhibits angiogenesis in vitro and in vivo.","volume":"65","author":"M Michaelis","year":"2004","journal-title":"Mol Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1172\/JCI107470","article-title":"Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.","volume":"52","author":"EA Jaffe","year":"1973","journal-title":"J Clin Invest"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1160\/TH05-02-0092","article-title":"Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid.","volume":"97","author":"JA Muldowney 3rd","year":"2007","journal-title":"Thromb Haemost"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0014-5793(92)81080-6","article-title":"TATA box-independent transcription of the human tissue plasminogen activator gene initiates within a sequence conserved in related genes.","volume":"309","author":"BR Henderson","year":"1992","journal-title":"FEBS Lett"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"468","DOI":"10.4161\/cc.7.4.5405","article-title":"Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments.","volume":"7","author":"KN Harikrishnan","year":"2008","journal-title":"Cell Cycle"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications.","volume":"403","author":"BD Strahl","year":"2000","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1124000","article-title":"Histone H4-K16 acetylation controls chromatin structure and protein interactions.","volume":"311","author":"M Shogren-Knaak","year":"2006","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1158\/0008-5472.CAN-03-0799","article-title":"Histone deacetylase is a target of valproic acid-mediated cellular differentiation.","volume":"64","author":"N Gurvich","year":"2004","journal-title":"Cancer Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.RES.0000037983.07158.B1","article-title":"Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis.","volume":"91","author":"L Rossig","year":"2002","journal-title":"Circ Res"},{"key":"ref24","first-page":"4561","article-title":"Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer.","volume":"60","author":"JM Mariadason","year":"2000","journal-title":"Cancer Res"},{"key":"ref25","first-page":"245","article-title":"The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.","volume":"5","author":"C Van Lint","year":"1996","journal-title":"Gene Expr"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/bbrc.1997.7786","article-title":"Histone deacetylase inhibitor activates the WAF1\/Cip1 gene promoter through the Sp1 sites.","volume":"241","author":"Y Sowa","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.bbrc.2006.02.081","article-title":"Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites.","volume":"342","author":"S Kim","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"33431","DOI":"10.1074\/jbc.M204417200","article-title":"Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex.","volume":"277","author":"Y Zhang","year":"2002","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1093\/nar\/29.14.3006","article-title":"Telomerase activation by histone deacetylase inhibitor in normal cells.","volume":"29","author":"M Takakura","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/nar\/25.2.311","article-title":"Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro.","volume":"25","author":"J Arts","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"14618","DOI":"10.1016\/S0021-9258(18)77347-X","article-title":"A DNA motif related to the cAMP-responsive element and an exon-located activator protein-2 binding site in the human tissue-type plasminogen activator gene promoter cooperate in basal expression and convey activation by phorbol ester and cAMP.","volume":"265","author":"RL Medcalf","year":"1990","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1128\/MCB.19.8.5504","article-title":"Histone deacetylase 1 can repress transcription by binding to Sp1.","volume":"19","author":"A Doetzlhofer","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1471-4159.2009.06385.x","article-title":"Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation.","volume":"111","author":"Z Marinova","year":"2009","journal-title":"J Neurochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.1074\/jbc.M408680200","article-title":"Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF\/p300 to a Sp1.NF-Y complex.","volume":"280","author":"W Huang","year":"2005","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/479364","article-title":"Molecular and therapeutic potential and toxicity of valproic acid.","volume":"2010","author":"S Chateauvieux","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1111\/j.1538-7836.2004.00948.x","article-title":"Regulation of local availability of active tissue-type plasminogen activator in vivo in man.","volume":"2","author":"T Hrafnkelsdottir","year":"2004","journal-title":"J Thromb Haemost"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/pds.2073","article-title":"Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study.","volume":"20","author":"JB Olesen","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0031573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T02:59:29Z","timestamp":1640833169000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0031573"}},"subtitle":[],"editor":[{"given":"Pieter H.","family":"Reitsma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,20]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0031573","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,20]]}}}