{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:13:58Z","timestamp":1790140438644,"version":"4.0.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0031967","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T22:51:37Z","timestamp":1329864697000},"page":"e31967","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":75,"title":["Epicutaneous Immunotherapy (EPIT) Blocks the Allergic Esophago-Gastro-Enteropathy Induced by Sustained Oral Exposure to Peanuts in Sensitized Mice"],"prefix":"10.1371","volume":"7","author":[{"given":"Lucie","family":"Mondoulet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Dioszeghy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Larcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Ligouis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Dhelft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Puteaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cherel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Letourneur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Henri","family":"Benhamou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"key":"ref1","first-page":"694","article-title":"Interactions between food antigens and the immune system in the pathogenesis of gastrointestinal diseases.","volume":"55","author":"AM Saavedra-Delgado","year":"1985","journal-title":"Ann Allergy"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jaci.2003.10.047","article-title":"Eosinophilic gastrointestinal disorders (EGID).","volume":"113","author":"ME Rothenberg","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0091-6749(99)70411-2","article-title":"Food allergy. Part 1: immunopathogenesis and clinical disorders.","volume":"103","author":"HA Sampson","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S1081-1206(10)61151-9","article-title":"Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests.","volume":"95","author":"JM Spergel","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S1542-3565(05)00885-2","article-title":"Eosinophilic esophagitis: a 10-year experience in 381 children.","volume":"3","author":"CA Liacouras","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2010.01.055","article-title":"Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract.","volume":"126","author":"D Simon","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cgh.2007.11.008","article-title":"Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in children.","volume":"6","author":"ET Schaefer","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1365-2222.2009.03430.x","article-title":"Epicutaneous immunotherapy on intact skin using a new delivery system in a murine model of allergy.","volume":"40","author":"L Mondoulet","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1159\/000321822","article-title":"Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanut.","volume":"154","author":"L Mondoulet","year":"2011","journal-title":"Int Arch Allergy Immunol"},{"key":"ref10","article-title":"Epicutaneous allergen administration as a novel method of allergen-specific immunotherapy.","author":"G Senti","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.jaci.2010.02.029","article-title":"Cow&apos;s milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity.","volume":"125","author":"C Dupont","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaci.2009.06.025","article-title":"Open-label maintenance after milk oral immunotherapy for IgE-mediated cow&apos;s milk allergy.","volume":"124","author":"SD Narisety","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"AB28","DOI":"10.1016\/j.jaci.2010.12.121","article-title":"Peanut Oral Immunotherapy (OIT) of Food Allergy (FA) Carries a Significant Risk of Eosinophilic Esophagitis (EoE).","volume":"127","author":"RL Wasserman","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.jaci.2005.08.033","article-title":"A pilot study of the usefulness and safety of a ready-to-use atopy patch test (Diallertest) versus a comparator (Finn Chamber) during cow&apos;s milk allergy in children.","volume":"116","author":"N Kalach","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1172\/JCI10224","article-title":"An etiological role for aeroallergens and eosinophils in experimental esophagitis.","volume":"107","author":"A Mishra","year":"2001","journal-title":"J Clin Invest"},{"key":"ref16","first-page":"1419","article-title":"Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism.","volume":"125","author":"A Mishra","year":"2003","journal-title":"Gastroenterology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1189\/jlb.1106653","article-title":"Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice.","volume":"81","author":"A Mishra","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1053\/j.gastro.2007.10.002","article-title":"Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia.","volume":"134","author":"A Mishra","year":"2008","journal-title":"Gastroenterology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.4049\/jimmunol.168.5.2464","article-title":"IL-5 promotes eosinophil trafficking to the esophagus.","volume":"168","author":"A Mishra","year":"2002","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2222.2007.02866.x","article-title":"Modulation of mucosal immunity in a murine model of food-induced intestinal inflammation.","volume":"38","author":"CR Cardoso","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"ref21","article-title":"Eosinophilic esophagitis: Updated consensus recommendations for children and adults.","author":"CA Liacouras","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1172\/JCI26679","article-title":"Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis.","volume":"116","author":"C Blanchard","year":"2006","journal-title":"J Clin Invest"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.4049\/jimmunol.1000471","article-title":"IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway.","volume":"185","author":"L Zuo","year":"2010","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.4049\/jimmunol.0903069","article-title":"Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.","volume":"184","author":"C Blanchard","year":"2010","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.giec.2007.09.016","article-title":"Basic pathogenesis of eosinophilic esophagitis.","volume":"18","author":"C Blanchard","year":"2008","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1084\/jem.182.4.1169","article-title":"Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.","volume":"182","author":"PD Collins","year":"1995","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1097\/00005176-200001001-00010","article-title":"Food-induced malabsorption syndromes.","volume":"30","author":"E Savilahti","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref28","first-page":"509","article-title":"CD25+CD4+Tregs mediate the protection from oral peanut-induced esophageal lesions of sensitised mice treated by epicutaneous immunotherapy.","volume":"66","author":"V Dioszeghy","year":"2011","journal-title":"Allergy"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1053\/j.gastro.2005.06.027","article-title":"Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice.","volume":"129","author":"HS Akei","year":"2005","journal-title":"Gastroenterology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jaci.2008.12.1107","article-title":"Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells.","volume":"123","author":"KD Srivastava","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1172\/JCI25575","article-title":"IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking.","volume":"116","author":"RT Strait","year":"2006","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1067\/mai.2000.104575","article-title":"The role of lymphocytes in allergic disease.","volume":"105","author":"S Romagnani","year":"2000","journal-title":"JJ Clin InvestAllergy Clin Immunol"},{"key":"ref33","article-title":"Epicutaneous immunitherapy results in rapid allergen uptake by dendritic cells through intact skin and down-regulates the allergen specific response in sensitized mice.","author":"V Dioszeghy","year":"2011","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1053\/j.gastro.2009.03.055","article-title":"Sequential role of plasmacytoid dendritic cells and regulatory T cells in oral tolerance.","volume":"137","author":"B Dubois","year":"2009","journal-title":"Gastroenterology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0031967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T05:21:40Z","timestamp":1713590500000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0031967"}},"subtitle":[],"editor":[{"given":"Marco","family":"Idzko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,21]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0031967","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,21]]}}}