{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:21:41Z","timestamp":1786616501770,"version":"build-2736575974"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0031978","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T22:51:49Z","timestamp":1329864709000},"page":"e31978","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Mature and Precursor Brain-Derived Neurotrophic Factor Have Individual Roles in the Mouse Olfactory Bulb"],"prefix":"10.1371","volume":"7","author":[{"given":"Thomas Gerald","family":"Mast","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra Ann","family":"Fadool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1749-6632.1998.tb10551.x","article-title":"Compensatory responses to early olfactory restriction.","volume":"855","author":"M Leon","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1177\/112067210301303S07","article-title":"Apoptosis in the mechanisms of neuronal plasticity in the developing visual system.","volume":"13","author":"C Nucci","year":"2003","journal-title":"Eur J Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuroscience.2008.08.065","article-title":"The influence of chronic lithium administration on deafferentation-induced cellular changes in the chick cochlear nucleus.","volume":"157","author":"A Bush","year":"2008","journal-title":"Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1523\/JNEUROSCI.1526-05.2005","article-title":"Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury.","volume":"25","author":"J Scholz","year":"2005","journal-title":"J Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0006-8993(94)01448-Q","article-title":"Olfactory experience modulated apoptosis in the developing olfactory bulb.","volume":"674","author":"J Najbauer","year":"1995","journal-title":"Brain Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"9548","DOI":"10.1523\/JNEUROSCI.1727-06.2006","article-title":"Odorant deprivation reversibly modulates transsynaptic changes in the NR2B-mediated CREB pathway in mouse piriform cortex.","volume":"26","author":"H Kim","year":"2006","journal-title":"J Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"9697","DOI":"10.1073\/pnas.0406082102","article-title":"Critical period for sensory experience-dependent survival of newly generated granule cells in the adult mouse olfactory bulb.","volume":"102","author":"M Yamaguchi","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0006-8993(74)90844-0","article-title":"Denervation in the primary olfactory pathway of mice: biochemical and morphological effects.","volume":"81","author":"F Margolis","year":"1974","journal-title":"Brain Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-3806(85)90063-X","article-title":"Unilateral odor deprivation: effects on the development of olfactory bulb catecholamines and behavior.","volume":"354","author":"P Brunjes","year":"1985","journal-title":"Brain Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"11852","DOI":"10.1523\/JNEUROSCI.2406-09.2009","article-title":"A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis.","volume":"29","author":"W Kelsch","year":"2009","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0006-8993(76)90243-2","article-title":"Effects of olfactory deprivation on postnatal growth of the rat olfactory bulb utilizing a new method for production of neonatal unilateral anosmia.","volume":"107","author":"E Meisami","year":"1976","journal-title":"Brain Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0006-8993(93)91023-L","article-title":"Adult naris closure profoundly reduces tyrosine hydroxylase expression in mouse olfactory bulb.","volume":"614","author":"H Baker","year":"1993","journal-title":"Brain Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neulet.2008.09.050","article-title":"Olfactory sensory deprivation increases the number of proBDNF-immunoreactive mitral cells in the olfactory bulb of mice.","volume":"447","author":"K Biju","year":"2008","journal-title":"Neurosci Lett"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0006-8993(88)91545-4","article-title":"Differential afferent regulation of dopaminergic and GABAergic neurons in the mouse main olfactory bulb.","volume":"450","author":"H Baker","year":"1988","journal-title":"Brain Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.biopsych.2006.09.010","article-title":"Methamphetamine administration causes death of dopaminergic neurons in the mouse olfactory bulb.","volume":"61","author":"X Deng","year":"2007","journal-title":"Biol Psychiatry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.cub.2007.04.040","article-title":"Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo.","volume":"17","author":"L Cao","year":"2007","journal-title":"Curr Biol"},{"key":"ref17","first-page":"159","article-title":"Olfactory bulb.","author":"GM Shepherd","year":"1998"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1126\/science.1065057","article-title":"Regulation of cell survival by secreted proneurotrophins.","volume":"294","author":"R Lee","year":"2001","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1152\/physiol.00042.2004","article-title":"Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions.","volume":"20","author":"R Blum","year":"2005","journal-title":"Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"12660","DOI":"10.1074\/jbc.M008104200","article-title":"Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor.","volume":"276","author":"SJ Mowla","year":"2001","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1126\/science.1100135","article-title":"Cleavage of proBDNF by tPA\/plasmin is essential for long-term hippocampal plasticity.","volume":"306","author":"P Pang","year":"2004","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/jnr.20432","article-title":"The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC.","volume":"80","author":"B Fayard","year":"2005","journal-title":"J Neurosci Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.tins.2004.11.003","article-title":"The protean actions of neurotrophins and their receptors on the life and death of neurons.","volume":"28","author":"R Kalb","year":"2005","journal-title":"Trends Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1098\/rstb.2006.1894","article-title":"Neurotrophin-regulated signalling pathways.","volume":"361","author":"L Reichardt","year":"2006","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0896-6273(02)01005-X","article-title":"ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury.","volume":"36","author":"M Beattie","year":"2002","journal-title":"Neuron"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1523\/JNEUROSCI.5123-04.2005","article-title":"ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.","volume":"25","author":"H Teng","year":"2005","journal-title":"J Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e6729","DOI":"10.1371\/journal.pone.0006729","article-title":"Dendritic branching of olfactory bulb mitral and tufted cells: regulation by TrkB.","volume":"4","author":"F Imamura","year":"2009","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuroscience.2006.09.055","article-title":"Neurotrophin B receptor kinase increases Kv subfamily member 1.3 (Kv1.3) ion channel half-life and surface expression.","volume":"144","author":"BS Colley","year":"2007","journal-title":"Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/10606820490270870","article-title":"Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodents.","volume":"10","author":"B Colley","year":"2004","journal-title":"Receptors Channels"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1113\/jphysiol.2002.017376","article-title":"Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent.","volume":"542","author":"K Tucker","year":"2002","journal-title":"J Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2202-10-8","article-title":"Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc.","volume":"10","author":"B Colley","year":"2009","journal-title":"BMC Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0896-6273(03)00844-4","article-title":"Kv1.3 channel gene-targeted deletion produces \u201cSuper-Smeller Mice\u201d with altered glomeruli, interacting scaffolding proteins, and biophysics.","volume":"41","author":"D Fadool","year":"2004","journal-title":"Neuron"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e24921","DOI":"10.1371\/journal.pone.0024921","article-title":"Mitral Cells of the Olfactory Bulb Perform Metabolic Sensing and Are Disrupted by Obesity at the Level of the Kv1.3 Ion Channel.","volume":"6","author":"DA Fadool","year":"2011","journal-title":"PLoS ONE"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1152\/jn.00016.2004","article-title":"Phasic stimuli evoke precisely timed spikes in intermittently discharging mitral cells.","volume":"92","author":"R Balu","year":"2004","journal-title":"J Neurophysiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1523\/JNEUROSCI.18-16-06126.1998","article-title":"Modulation of olfactory bulb neuron potassium current by tyrosine phosphorylation.","volume":"18","author":"D Fadool","year":"1998","journal-title":"J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e6770","DOI":"10.1371\/journal.pone.0006770","article-title":"Predominant functional expression of Kv1.3 by activated microglia of the hippocampus after status epilepticus.","volume":"4","author":"A Menteyne","year":"2009","journal-title":"PLoS ONE"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"37675","DOI":"10.1074\/jbc.M605617200","article-title":"Association of Kv1.5 and Kv1.3 contributes to the major voltage-dependent K+ channel in macrophages.","volume":"281","author":"R Vicente","year":"2006","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1756-6606-2-27","article-title":"Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival.","volume":"2","author":"H Koshimizu","year":"2009","journal-title":"Mol Brain"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.nbd.2004.10.025","article-title":"Expression time course and spatial distribution of activated caspase-3 after experimental status epilepticus: contribution of delayed neuronal cell death to seizure-induced neuronal injury.","volume":"18","author":"J Weise","year":"2005","journal-title":"Neurobiol Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0168-0102(98)00040-6","article-title":"Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3.","volume":"31","author":"R Katoh-Semba","year":"1998","journal-title":"Neurosci Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1002\/jnr.21704","article-title":"Age-dependent time course of cerebral brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 in APP23 transgenic mice.","volume":"86","author":"O Schulte-Herbr\u00fcggen","year":"2008","journal-title":"J Neurosci Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1523\/JNEUROSCI.17-07-02295.1997","article-title":"Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport.","volume":"17","author":"JM Conner","year":"1997","journal-title":"J Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1085\/jgp.99.2.217","article-title":"Mechanism of 4-aminopyridine action on voltage-gated potassium channels in lymphocytes.","volume":"99","author":"D Choquet","year":"1992","journal-title":"J Gen Physiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.68.5.519","article-title":"Dynamics of aminopyridine block of potassium channels in squid axon membrane.","volume":"68","author":"JZ Yeh","year":"1976","journal-title":"J Gen Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0006-8993(96)01150-X","article-title":"Membrane and synaptic properties of mitral cells in slices of rat olfactory bulb.","volume":"745","author":"W Chen","year":"1997","journal-title":"Brain Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrn2148","article-title":"The action potential in mammalian central neurons.","volume":"8","author":"B Bean","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"18866","DOI":"10.1016\/S0021-9258(17)46707-X","article-title":"Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.","volume":"268","author":"M Garcia-Calvo","year":"1993","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"R733","DOI":"10.1152\/ajpregu.00077.2008","article-title":"Kv1.3 channels in postganglionic sympathetic neurons: expression, function, and modulation.","volume":"295","author":"MA Doczi","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00424-001-0734-4","article-title":"Recombinant Kv1.3 potassium channels stabilize tonic firing of cultured rat hippocampal neurons.","volume":"443","author":"J Kupper","year":"2002","journal-title":"Pflugers Arch"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"27577","DOI":"10.1074\/jbc.272.44.27577","article-title":"Complex Subunit Assembly of Neuronal Voltage-gated K+Channels.","volume":"272","author":"RO Koch","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/pr.57.4.10","article-title":"International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels.","volume":"57","author":"GA Gutman","year":"2005","journal-title":"Pharmacological Reviews"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"C611","DOI":"10.1152\/ajpcell.00292.2003","article-title":"Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying K+ conductance in rat choroid plexus epithelial cells.","volume":"286","author":"T Speake","year":"2004","journal-title":"American Journal of Physiology - Cell Physiology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuroscience.2004.11.004","article-title":"Increase of delayed rectifier potassium currents in large aspiny neurons in the neostriatum following transient forebrain ischemia.","volume":"131","author":"P Deng","year":"2005","journal-title":"Neurosci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1113\/jphysiol.2007.128702","article-title":"Developmental changes in potassium currents at the rat calyx of Held presynaptic terminal.","volume":"581","author":"Y Nakamura","year":"2007","journal-title":"The Journal of Physiology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1111\/j.1471-4159.2007.04870.x","article-title":"Post-synaptic density perturbs insulin-induced Kv1.3 channel modulation via a clustering mechanism involving the SH3 domain.","volume":"103","author":"DR Marks","year":"2007","journal-title":"J Neurochem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/nn.2630","article-title":"Intrinsic biophysical diversity decorrelates neuronal firing while increasing information content.","volume":"13","author":"K Padmanabhan","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/cne.20120","article-title":"Caspase-3 and caspase-9 mediate developmental apoptosis in the mouse olfactory system.","volume":"474","author":"CM Cowan","year":"2004","journal-title":"J Comp Neurol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/cdd.2009.180","article-title":"Neuronal caspase-3 signaling: not only cell death.","volume":"17","author":"M D'Amelio","year":"2010","journal-title":"Cell Death Differ"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2011.01.068","article-title":"Sensory experience selectively regulates transmitter synthesis enzymes in interglomerular circuits.","volume":"1382","author":"S Parrish-Aungst","year":"2011","journal-title":"Brain Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0306-4522(03)00172-6","article-title":"Deprivation of sensory inputs to the olfactory bulb up-regulates cell death and proliferation in the subventricular zone of adult mice.","volume":"119","author":"N Mandairon","year":"2003","journal-title":"Neuroscience"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/chemse\/bjm079","article-title":"Sensory deafferentation transsynaptically alters neuronal GluR1 expression in the external plexiform layer of the adult mouse main olfactory bulb.","volume":"33","author":"KA Hamilton","year":"2008","journal-title":"Chem Senses"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"16865","DOI":"10.1073\/pnas.0808946106","article-title":"Experience-dependent maturation of the glomerular microcircuit.","volume":"106","author":"BJ Maher","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0165-0173(94)90007-8","article-title":"Unilateral naris closure and olfactory system development.","volume":"19","author":"PC Brunjes","year":"1994","journal-title":"Brain Res Brain Res Rev"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/cne.1121","article-title":"Expression of active caspase-3 in mitotic and postmitotic cells of the rat forebrain.","volume":"433","author":"XX Yan","year":"2001","journal-title":"J Comp Neurol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neulet.2009.08.049","article-title":"Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice.","volume":"465","author":"Q Shi","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/STROKEAHA.106.477331","article-title":"Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis.","volume":"38","author":"W Sch\u00e4bitz","year":"2007","journal-title":"Stroke"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF02674671","article-title":"Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat.","volume":"12","author":"K Yamashita","year":"1997","journal-title":"Metab Brain Dis"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1471-4159.2005.03135.x","article-title":"Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease.","volume":"93","author":"S Peng","year":"2005","journal-title":"J Neurochem"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0169-328X(03)00003-2","article-title":"Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease.","volume":"111","author":"B Michalski","year":"2003","journal-title":"Brain Res Mol Brain Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2174\/156720507783018316","article-title":"Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms.","volume":"4","author":"F Longo","year":"2007","journal-title":"Curr Alzheimer Res"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1212\/WNL.52.7.1427","article-title":"A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III).","volume":"52","author":"W Bradley","year":"1999","journal-title":"Neurol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1073\/pnas.0913572107","article-title":"A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.","volume":"107","author":"S Jang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1523\/JNEUROSCI.2439-06.2007","article-title":"Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.","volume":"27","author":"D De Saint Jan","year":"2007","journal-title":"J Neurosci"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0361-9230(95)02042-X","article-title":"Orthodromic synaptic activation of rat olfactory bulb mitral cells in isolated slices.","volume":"39","author":"W Nickell","year":"1996","journal-title":"Brain Res Bull"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1523\/JNEUROSCI.1350-09.2009","article-title":"Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors.","volume":"29","author":"D Marks","year":"2009","journal-title":"J Neurosci"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuroscience.2004.05.029","article-title":"Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration.","volume":"127","author":"R Thorne","year":"2004","journal-title":"Neurosci"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1023\/A:1010209925783","article-title":"Genetic dissection of the olfactory bulbs of mice: QTLs on four chromosomes modulate bulb size.","volume":"31","author":"R Williams","year":"2001","journal-title":"Behav Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0031978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T06:12:27Z","timestamp":1640844747000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0031978"}},"subtitle":[],"editor":[{"given":"Silvana","family":"Allodi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,2,21]]},"references-count":77,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0031978","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,21]]}}}