{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T18:55:28Z","timestamp":1648666528654},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0032460","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T16:07:26Z","timestamp":1330963646000},"page":"e32460","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Contrasting Relationships between Betaine and Homocysteine in Two Clinical Cohorts are Associated with Plasma Lipids and Drug Treatments"],"prefix":"10.1371","volume":"7","author":[{"given":"Michael","family":"Lever","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane L.","family":"Elmslie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Slow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L.","family":"Molyneux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Troughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Mark","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Frampton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen T.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.clinbiochem.2010.03.009","article-title":"The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism.","volume":"43","author":"M Lever","year":"2010","journal-title":"Clin Biochem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10545-010-9088-4","article-title":"Choline and betaine in health and disease.","volume":"34","author":"PM Ueland","year":"2011","journal-title":"J Inherit Metab Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/ajcn\/80.3.539","article-title":"Betaine in human nutrition.","volume":"80","author":"SAS Craig","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1515\/CCLM.2005.187","article-title":"Betaine: a key modulator of one-carbon metabolism and homocysteine status.","volume":"43","author":"PM Ueland","year":"2005","journal-title":"Clin Chem Lab Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/jn\/138.5.914","article-title":"Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women.","volume":"138","author":"SV Konstantinova","year":"2008","journal-title":"J Nutr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2004.07.007","article-title":"Homocysteine, glycine betaine, and <italic>N,N<\/italic>-dimethylglycine in patients attending a lipid clinic.","volume":"54","author":"M Lever","year":"2005","journal-title":"Metabolism"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.clinbiochem.2006.10.029","article-title":"Inter- and intra-individual variations in normal urinary glycine betaine excretion.","volume":"40","author":"M Lever","year":"2007","journal-title":"Clin Biochem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.clinbiochem.2007.05.021","article-title":"Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic.","volume":"40","author":"M Lever","year":"2007","journal-title":"Clin Biochem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.nutres.2010.06.017","article-title":"Dietary intake of S-(\u03b4-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.","volume":"30","author":"J Strakova","year":"2010","journal-title":"Nutr Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"36258","DOI":"10.1074\/jbc.M111.265348","article-title":"Deletion of betaine-homocysteine <italic>S<\/italic>-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.","volume":"286","author":"Y-W Teng","year":"2011","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e21666","DOI":"10.1371\/journal.pone.0021666","article-title":"Plasma lipids and betaine are related in an Acute Coronary Syndrome Cohort.","volume":"6","author":"M Lever","year":"2011","journal-title":"PLoS ONE"},{"key":"ref12","article-title":"Development of laboratory tests for assessing vitamin status.","author":"MK Storer","year":"2006"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10557-009-6188-1","article-title":"Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine.","volume":"23","author":"M Lever","year":"2009","journal-title":"Cardiovasc Drugs Ther"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.clinbiochem.2011.10.021","article-title":"Betaine excretion correlates with plasma homocysteine when plasma lipids are elevated,","volume":"45","author":"M Lever","year":"2012","journal-title":"Clin Biochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1056\/NEJMoa011053","article-title":"The prognostic value of B-type natriuretic peptides in patients with acute coronary syndromes.","volume":"345","author":"JA De Lemos","year":"2001","journal-title":"New Engl Med J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.aca.2005.10.060","article-title":"Aracyl triflates for preparing fluorescent and UV absorbing derivatives of unreactive carboxylates, amines and other metabolites.","volume":"558","author":"MK Storer","year":"2006","journal-title":"Anal Chim Acta"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.chroma.2005.11.123","article-title":"Separation of cationic aracyl derivatives of betaines and related compounds.","volume":"1104","author":"MK Storer","year":"2006","journal-title":"J Chromatog A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1373\/clinchem.2007.085480","article-title":"Homocysteine and cardiovascular risk: considering the evidence in the context of study design, folate fortification, and statistical power.","volume":"53","author":"PM Ueland","year":"2007","journal-title":"Clin Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2174\/138920007779315008","article-title":"Hyperhomocysteinaemia: a critical review of old and new aspects.","volume":"8","author":"W Herrmann","year":"2007","journal-title":"Curr Drug Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"a3083","DOI":"10.1136\/bmj.a3083","article-title":"Use of framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study.","volume":"338","author":"W de Ruijter","year":"2009","journal-title":"Brit Med J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction.","volume":"354","author":"KH B\u00f8naa","year":"2006","journal-title":"New Engl J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease.","volume":"354","year":"2006","journal-title":"New Engl J Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1001\/jama.299.17.2027","article-title":"Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial.","volume":"299","author":"CM Albert","year":"2008","journal-title":"JAMA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10545-010-9151-1","article-title":"The homocysteine controversy.","volume":"34","author":"YM Smulders","year":"2011","journal-title":"J Inherit Metab Dis"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"e16473","DOI":"10.1371\/journal.pone.0016473","article-title":"Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis.","volume":"6","author":"DS Wald","year":"2011","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1161\/01.ATV.0000114569.54976.31","article-title":"Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation.","volume":"24","author":"PI Holm","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.33549\/physiolres.931569","article-title":"Plasma dependent and independent accumulation of betaine in male and female rat tissues.","volume":"58","author":"S Slow","year":"2009","journal-title":"Physiol Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0009-8981(94)90090-6","article-title":"Abnormal glycine betaine content of the blood and urine of diabetic and renal patients.","volume":"230","author":"M Lever","year":"1994","journal-title":"Clin Chim Acta"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0168-8227(98)00115-6","article-title":"Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia.","volume":"43","author":"WJ Dellow","year":"1999","journal-title":"Diab Res Clin Pract"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00216-009-3054-8","article-title":"<sup>1<\/sup>H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet.","volume":"395","author":"S Kim","year":"2009","journal-title":"Anal Bioanal Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0032460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T06:18:32Z","timestamp":1641017912000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0032460"}},"subtitle":[],"editor":[{"given":"Qi","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,2]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0032460","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,2]]}}}