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Wilke","year":"2005","journal-title":"BMC Evol Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0042-6822(80)90532-2","article-title":"Generation of defective interfering particles in picornaviruses.","volume":"100","author":"MA McClure","year":"1980","journal-title":"Virology"},{"key":"ref65","first-page":"180","article-title":"Defective interfering (di) particles of poliovirus.","volume":"20","author":"CN Cole","year":"1975","journal-title":"Prog Med Virol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/viro.1996.0450","article-title":"Long-term, large-population passage of aphthovirus can generate and amplify defective noninterfering particles deleted in the leader protease gene.","volume":"223","author":"N Charpentier","year":"1996","journal-title":"Virology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"11678","DOI":"10.1128\/JVI.78.21.11678-11685.2004","article-title":"Evolutionary transition toward 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The making of a picornavirus genome. 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Bruns","year":"1988","journal-title":"Virology"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1099\/vir.0.83041-0","article-title":"Superinfection exclusion in BHK-21 cells persistently infected with Junin virus.","volume":"88","author":"P Ellenberg","year":"2007","journal-title":"J Gen Virol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00705-003-0227-1","article-title":"Resistance to superinfection of Vero cells persistently infected with Junin virus.","volume":"149","author":"P Ellenberg","year":"2004","journal-title":"Arch Virol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2005.05.008","article-title":"Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection.","volume":"338","author":"N Tapia","year":"2005","journal-title":"Virology"},{"key":"ref91","first-page":"139","article-title":"Arenaviruses: genomic RNAs 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