{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:31:43Z","timestamp":1791945103627,"version":"4.3.4"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T00:00:00Z","timestamp":1330905600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0032643","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T03:37:30Z","timestamp":1331005050000},"page":"e32643","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Wolbachia Infection Decreased the Resistance of Drosophila to Lead"],"prefix":"10.1371","volume":"7","author":[{"given":"Ling","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Guang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1574-6968.2008.01110.x","article-title":"How many species are infected with <italic>Wolbachia<\/italic>? - a statistical analysis of current data.","volume":"281","author":"K Hilgenboecker","year":"2008","journal-title":"FEMS Microbiol Lett"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.genet.41.110306.130354","article-title":"The Genetic and Cell Biology of Wolbachia-host Interactions.","volume":"42","author":"LR Serbus","year":"2008","journal-title":"Annu Rev Genet"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s11434-009-0183-6","article-title":"Infection of <italic>Wolbachia<\/italic> may improve the olfactory response of <italic>Drosophila<\/italic>.","volume":"54","author":"Y Peng","year":"2009","journal-title":"Chinese Sci Bull"},{"issue":"20","key":"ref4","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.1073\/pnas.94.20.10792","article-title":"Wolbachia, normally a symbiont of Drosophila, can be virulent, causing degeneration and early death.","volume":"94","author":"KT Min","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1126\/science.1177531","article-title":"Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.","volume":"326","author":"Z Kambris","year":"2009","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1126\/science.1165326","article-title":"The stable introduction of a life-shortening <italic>Wolbachia<\/italic> infection into the mosquito <italic>Aedes aegypti<\/italic>.","volume":"323","author":"CJ McMeniman","year":"2009","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1126\/science.1162418","article-title":"Wolbachia and virus protection in insects.","volume":"322","author":"LM Hedges","year":"2008","journal-title":"Science"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"e1000002","DOI":"10.1371\/journal.pbio.1000002","article-title":"The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster.","volume":"6","author":"L Teixeira","year":"2008","journal-title":"PLoS Biol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"e1000833","DOI":"10.1371\/journal.ppat.1000833","article-title":"The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti.","volume":"6","author":"G Bian","year":"2010","journal-title":"PLoS Pathog"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"e1001143","DOI":"10.1371\/journal.ppat.1001143","article-title":"<italic>Wolbachia<\/italic> stimulates immune gene expression and inhibits plasmodium development in <italic>Anopheles gambiae<\/italic>.","volume":"6","author":"Z Kambris","year":"2010","journal-title":"PLoS Pathog"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"e1002043","DOI":"10.1371\/journal.ppat.1002043","article-title":"<italic>Wolbachia<\/italic> infections are virulent and inhibit the human malaria parasite <italic>Plasmodium falciparum<\/italic> in <italic>Anopheles gambiae<\/italic>.","volume":"7","author":"GL Hughes","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref12","first-page":"217","article-title":"Evaluation of glutathionerelated enzyme activities in the liver and kidney of rats exposed to lead and ethanol.","volume":"59","author":"J Moniuszko-Jakoniuk","year":"2007","journal-title":"Pharmacol Rep"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/1071576031000076277","article-title":"Alpha tocopherol protects against immunosuppressive and immunotoxic effects of lead.","volume":"37","author":"MJ Fernandez-Cabezudo","year":"2003","journal-title":"Free Radic Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/10799890802305217","article-title":"Integrated approach to immunotoxicity: electron transfer, reactive oxygen species, antioxidants, cell signaling, and receptors.","volume":"28","author":"P Kovacic","year":"2008","journal-title":"J Recept Signal Transduct Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2478\/s11687-008-0013-4","article-title":"The effect of chronic lead acetate trihydrate intoxication in Wistar rats on experimental Ascaris suum infestation and immunity.","volume":"45","author":"J Pistl","year":"2008","journal-title":"Helminthologia"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1382-6689(01)00064-3","article-title":"Combined administration of a chelating agent and an antioxidant in the prevention and treatment of acute lead intoxication in rats.","volume":"9","author":"M Pande","year":"2001","journal-title":"Environ Toxicol Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0300-483X(02)00380-3","article-title":"Antioxidant nutrients and lead toxicity.","volume":"180","author":"PC Hsu","year":"2002","journal-title":"Toxicology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/(SICI)1096-8652(199910)62:2<122::AID-AJH14>3.0.CO;2-R","article-title":"Vancomycin-induced thrombocytopenia.","volume":"62","author":"R Govindarajan","year":"1999","journal-title":"Am J Hematol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0887-2333(99)00089-2","article-title":"The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro.","volume":"14","author":"Z Krocova","year":"2000","journal-title":"Toxicol In Vitro"},{"key":"ref20","first-page":"405","article-title":"Mutagenicity testing with <italic>Drosophila<\/italic> as a method for detecting potential carcinogens.","volume":"95","author":"E Vogel","year":"1976","journal-title":"Biol Zent Bl"},{"issue":"146","key":"ref21","first-page":"427","article-title":"The results of assays in <italic>Drosophila<\/italic> as indicators of exposure to carcinogens.","author":"EW Vogel","year":"1999","journal-title":"IARC Sci Publ"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mrgentox.2011.05.008","article-title":"Genotoxicity testing of two lead-compounds in somatic cells of <italic>Drosophila melanogaster<\/italic>.","volume":"724","author":"ER Carmona","year":"2011","journal-title":"Mutat Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.cub.2005.06.069","article-title":"Evidence for a global <italic>Wolbachia<\/italic> replacement in <italic>Drosophila melanogaster<\/italic>.","volume":"15","author":"M Riegler","year":"2005","journal-title":"Curr Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.fct.2009.10.006","article-title":"Oxidative stress and immunotoxic effects of lead and their amelioration with myrrh (Commiphora molmol) emulsion.","volume":"48","author":"KM Ashry","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.cell.2009.11.042","article-title":"A <italic>Wolbachia<\/italic> symbiont in <italic>Aedes aegypti<\/italic> limits infection with dengue, Chikungunya, and Plasmodium.","volume":"139","author":"LA Moreira","year":"2009","journal-title":"Cell"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"e25430","DOI":"10.1371\/journal.pone.0025430","article-title":"<italic>Wolbachia<\/italic>-Mediated Antibacterial Protection and Immune Gene Regulation in <italic>Drosophila<\/italic>.","volume":"6","author":"ZS Wong","year":"2011","journal-title":"PLoS ONE"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0300-483X(01)00345-6","article-title":"Antioxidant effects of <italic>\u03b1<\/italic> tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats.","volume":"162","author":"RC Patra","year":"2001","journal-title":"Toxicology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/009841099157737","article-title":"A study on oxidative stress in lead-exposed workers.","volume":"57","author":"XB Ye","year":"1999","journal-title":"J Toxicol Environ Health A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"457327","DOI":"10.4061\/2011\/457327","article-title":"Oxidative stress in lead and cadmium toxicity and its amelioration.","volume":"2011","author":"RC Patra","year":"2011","journal-title":"Vet Med Int"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.tim.2008.02.001","article-title":"Staying alive: bacterial inhibition of apoptosis during infection.","volume":"16","author":"CS Faherty","year":"2008","journal-title":"Trends Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1210\/me.2010-0189","article-title":"Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta\/p66shc signaling cascade: counter regulation by estrogens or androgens.","volume":"24","author":"M Almeida","year":"2010","journal-title":"Mol Endocrinol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.freeradbiomed.2004.09.010","article-title":"Metal-induced oxidative stress and signal transduction.","volume":"37","author":"SS Leonard","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1000630","DOI":"10.1371\/journal.ppat.1000630","article-title":"<italic>Wolbachia<\/italic> interferes with ferritin expression and iron metabolism in insects.","volume":"5","author":"N Kremer","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref34","first-page":"457","article-title":"Ferritin, iron homeostasis, and oxidative damage.","volume":"33","author":"P Arosio","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"267","DOI":"10.5483\/BMBRep.2008.41.4.267","article-title":"Positive and negative regulation of the <italic>Drosophila<\/italic> immune response.","volume":"41","author":"K Aggarwal","year":"2008","journal-title":"BMB Rep"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nrmicro1870","article-title":"Bacterial strategies to overcome insect defences.","volume":"6","author":"I Vallet-Gely","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"14715","DOI":"10.1073\/pnas.1009473107","article-title":"Heterodimers of NF-kappaB transcription factors DIF and Relish regulate antimicrobial peptide genes in <italic>Drosophila<\/italic>.","volume":"107","author":"T Tanji","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-9-1","article-title":"Genome-wide analysis of the interaction between the endosymbiotic bacterium <italic>Wolbachia<\/italic> and its <italic>Drosophila<\/italic> host.","volume":"9","author":"Z Xi","year":"2008","journal-title":"BMC Genomics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1365-2583.2000.00224.x","article-title":"<italic>Wolbachia<\/italic> neither induces nor suppresses transcripts encoding antimicrobial peptides.","volume":"9","author":"K Bourtzis","year":"2000","journal-title":"Insect Mol Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1534\/genetics.106.068486","article-title":"Male development time influences the strength of <italic>Wolbachia<\/italic>-induced cytoplasmic incompatibility expression in <italic>Drosophila melanogaster<\/italic>.","volume":"177","author":"R Yamada","year":"2007","journal-title":"Genetics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/genetics\/119.2.435","article-title":"Unidirectional incompatibility in <italic>Drosophila simulans<\/italic>: inheritance, geographic variation and fitness effects.","volume":"119","author":"AA Hoffmann","year":"1988","journal-title":"Genetics"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.jinsphys.2010.08.006","article-title":"Antioxidant responses of citrus red mite, <italic>Panonychus citri<\/italic> (McGregor) (Acari: Tetranychidae), exposed to thermal stress.","volume":"56","author":"LH Yang","year":"2010","journal-title":"J Insect Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0032643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T03:53:46Z","timestamp":1713671626000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0032643"}},"subtitle":[],"editor":[{"given":"Hitoshi","family":"Okazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,5]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0032643","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,5]]}}}