{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:49:32Z","timestamp":1791308972275,"version":"4.3.1"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T00:00:00Z","timestamp":1331510400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0032863","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T21:21:25Z","timestamp":1331587285000},"page":"e32863","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":82,"title":["Innate Immune Deficiency of Extremely Premature Neonates Can Be Reversed by Interferon-\u03b3"],"prefix":"10.1371","volume":"7","author":[{"given":"Pierre","family":"Tissi\u00e8res","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Ochoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ir\u00e8ne","family":"Dunn-Siegrist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Drifte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Berner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Pugin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1542\/peds.110.2.285","article-title":"Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network.","volume":"110","author":"BJ Stoll","year":"2002","journal-title":"Pediatrics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1053\/j.spid.2006.06.005","article-title":"Coagulase-negative staphylococcal infections in the neonate and child: an update.","volume":"17","author":"MP Venkatesh","year":"2006","journal-title":"Semin Pediatr Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1001\/jama.292.19.2357","article-title":"Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection.","volume":"292","author":"BJ Stoll","year":"2004","journal-title":"Jama"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1080\/08035250410027363","article-title":"Host defence lectins in preterm neonates.","volume":"94","author":"A Hilgendorff","year":"2005","journal-title":"Acta Paediatr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1440-1754.1994.tb00563.x","article-title":"Plasma fibronectin levels in extremely preterm infants in the first 8 weeks of life.","volume":"30","author":"MP Dyke","year":"1994","journal-title":"J Paediatr Child Health"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1182\/blood-2006-06-032961","article-title":"Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria.","volume":"109","author":"G Elson","year":"2007","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/1074-7613(94)90093-0","article-title":"CD14 is a pattern recognition receptor.","volume":"1","author":"J Pugin","year":"1994","journal-title":"Immunity"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1203\/00006450-200104000-00023","article-title":"Evidence for an innate immune response in the immature human intestine: toll-like receptors on fetal enterocytes.","volume":"49","author":"RD Fusunyan","year":"2001","journal-title":"Pediatr Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.4049\/jimmunol.173.7.4627","article-title":"Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.","volume":"173","author":"O Levy","year":"2004","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1203\/01.PDR.0000163397.53466.0F","article-title":"Monocyte toll-like receptor 4 expression and LPS-induced cytokine production increase during gestational aging.","volume":"58","author":"E Forster-Waldl","year":"2005","journal-title":"Pediatr Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1086\/509892","article-title":"Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling.","volume":"195","author":"K Sadeghi","year":"2007","journal-title":"J Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1016\/j.molimm.2008.02.014","article-title":"Increased release of sMD-2 during human endotoxemia and sepsis: a role for endothelial cells.","volume":"45","author":"TG Wolfs","year":"2008","journal-title":"Mol Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nm0697-678","article-title":"Monocyte deactivation in septic patients: restoration by IFN-gamma treatment.","volume":"3","author":"WD Docke","year":"1997","journal-title":"Nat Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.clim.2005.10.012","article-title":"Innate cellular immune responses in newborns.","volume":"118","author":"L Marodi","year":"2006","journal-title":"Clin Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/QCO.0b013e32832ae2fc","article-title":"The role of MD-2 in the opsonophagocytosis of Gram-negative bacteria.","volume":"22","author":"P Tissieres","year":"2009","journal-title":"Curr Opin Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJMoa012657","article-title":"Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants.","volume":"347","author":"BJ Stoll","year":"2002","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1056\/NEJMoa073059","article-title":"Intensive care for extreme prematurity\u2013moving beyond gestational age.","volume":"358","author":"JE Tyson","year":"2008","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/ibd.20995","article-title":"Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gut.","volume":"16","author":"TG Wolfs","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1164\/ajrccm.163.2.2007102","article-title":"Normal responses to injury prevent systemic inflammation and can be immunosuppressive.","volume":"163","author":"RS Munford","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/cyto.2002.0880","article-title":"Endotoxin-stimulated production of IL-6 and IL-8 is increased in short-term cultures of whole blood from healthy term neonates.","volume":"18","author":"J Dembinski","year":"2002","journal-title":"Cytokine"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1053\/jpsu.2001.26359","article-title":"Intracellular cytokine production by fetal and adult monocytes.","volume":"36","author":"A Hebra","year":"2001","journal-title":"J Pediatr Surg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1203\/00006450-200203000-00009","article-title":"Enhanced interleukin-6 and interleukin-8 synthesis in term and preterm infants.","volume":"51","author":"C Schultz","year":"2002","journal-title":"Pediatr Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000112541","article-title":"Cytokine expression in response to bacterial antigens in preterm and term infant cord blood monocytes.","volume":"94","author":"AM Tatad","year":"2008","journal-title":"Neonatology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1203\/PDR.0b013e3181568105","article-title":"Postnatal development of monocyte cytokine responses to bacterial lipopolysaccharide.","volume":"62","author":"ST Yerkovich","year":"2007","journal-title":"Pediatr Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1046\/j.1365-2141.2000.01992.x","article-title":"Neutrophil production and function in newborn infants.","volume":"110","author":"R Carr","year":"2000","journal-title":"Br J Haematol"},{"key":"ref26","article-title":"PI3K\u03b3 kinase activity contributes to sepsis and organ damage by altering neutrophil recruitment.","author":"EL Martin","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1073\/pnas.0900196106","article-title":"Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis.","volume":"106","author":"JC Alves-Filho","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"S474","DOI":"10.1007\/BF01743727","article-title":"Monocyte deactivation\u2013rationale for a new therapeutic strategy in sepsis.","volume":"22","author":"HD Volk","year":"1996","journal-title":"Intensive Care Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/09680519050110050901","article-title":"Reprogramming of circulatory cells in sepsis and SIRS.","volume":"11","author":"JM Cavaillon","year":"2005","journal-title":"J Endotoxin Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1164\/rccm.200903-0363OC","article-title":"Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial.","volume":"180","author":"C Meisel","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/9780470059593.ch3","article-title":"Immunostimulation is a rational therapeutic strategy in sepsis.","volume":"280","author":"J Pugin","year":"2007","journal-title":"Novartis Found Symp"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1182\/blood.V90.8.3187","article-title":"Increased phagocyte Fc gammaRI expression and improved Fc gamma-receptor-mediated phagocytosis after in vivo recombinant human interferon-gamma treatment of normal human subjects.","volume":"90","author":"DE Schiff","year":"1997","journal-title":"Blood"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"20431","DOI":"10.1074\/jbc.M110333200","article-title":"TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells.","volume":"277","author":"MT Abreu","year":"2002","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000073638","article-title":"Age-related changes in intracellular TH1\/TH2 cytokine production, immunoproliferative T lymphocyte response and natural killer cell activity in newborns, children and adults.","volume":"84","author":"A Gasparoni","year":"2003","journal-title":"Biol Neonate"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0167-5699(93)90235-D","article-title":"Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?","volume":"14","author":"TG Wegmann","year":"1993","journal-title":"Immunol Today"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/eji.1830250112","article-title":"Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E2 critically depends on interleukin-2.","volume":"25","author":"CM Hilkens","year":"1995","journal-title":"Eur J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1084\/jem.184.2.539","article-title":"Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.","volume":"184","author":"I Roth","year":"1996","journal-title":"J Exp Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.4049\/jimmunol.0804111","article-title":"Local production of IFN-gamma by invariant NKT cells modulates acute Lyme carditis.","volume":"182","author":"CM Olson Jr","year":"2009","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1128\/IAI.73.6.3445-3452.2005","article-title":"Gamma interferon enhances internalization and early nonoxidative killing of Salmonella enterica serovar Typhimurium by human macrophages and modifies cytokine responses.","volume":"73","author":"MA Gordon","year":"2005","journal-title":"Infect Immun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1084\/jem.173.3.767","article-title":"Human recombinant interferon gamma enhances neonatal polymorphonuclear leukocyte activation and movement, and increases free intracellular calcium.","volume":"173","author":"HR Hill","year":"1991","journal-title":"J Exp Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1128\/IAI.68.4.2167-2170.2000","article-title":"Survival of group B streptococcus type III in mononuclear phagocytes: differential regulation of bacterial killing in cord macrophages by human recombinant gamma interferon and granulocyte-macrophage colony-stimulating factor.","volume":"68","author":"L Marodi","year":"2000","journal-title":"Infect Immun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1056\/NEJM199102213240801","article-title":"A controlled trial of interferon gamma to prevent infection in chronic granulomatous disease. .","volume":"324","year":"1991","journal-title":"N Engl J Med"},{"key":"ref43","first-page":"CD003935","article-title":"Repeat doses of prenatal corticosteroids for women at risk of preterm birth for preventing neonatal respiratory disease.","author":"CA Crowther","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jsgi.2003.08.004","article-title":"Effects of interferon-gamma and tumor necrosis factor-alpha on survival and differentiation of oligodendrocyte progenitors.","volume":"11","author":"B Feldhaus","year":"2004","journal-title":"J Soc Gynecol Investig"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1750-3639.2004.tb00063.x","article-title":"Interferon-gamma expression in periventricular leukomalacia in the human brain.","volume":"14","author":"RD Folkerth","year":"2004","journal-title":"Brain Pathol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0140-6736(09)60071-4","article-title":"Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial.","volume":"373","author":"R Carr","year":"2009","journal-title":"Lancet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1203\/01.PDR.0000156500.13600.B5","article-title":"Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor have differential effects on neonatal and adult neutrophil survival and function.","volume":"57","author":"EJ Molloy","year":"2005","journal-title":"Pediatr Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1542\/peds.2008-1222","article-title":"Differential patterns of 27 cord blood immune biomarkers across gestational age.","volume":"123","author":"N Matoba","year":"2009","journal-title":"Pediatrics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.leukres.2007.06.011","article-title":"Increased responsiveness to TLR2 and TLR4 ligands during dimethylsulfoxide-induced neutrophil-like differentiation of HL-60 myeloid leukemia cells.","volume":"31","author":"T Shuto","year":"2007","journal-title":"Leuk Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1182\/blood-2003-04-1290","article-title":"Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock.","volume":"104","author":"J Pugin","year":"2004","journal-title":"Blood"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1182\/blood-2007-06-097782","article-title":"Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria.","volume":"111","author":"P Tissieres","year":"2008","journal-title":"Blood"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"34817","DOI":"10.1074\/jbc.M706440200","article-title":"Pivotal involvement of Fcgamma receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1.","volume":"282","author":"I Dunn-Siegrist","year":"2007","journal-title":"J Biol Chem"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nature735","article-title":"Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli.","volume":"416","author":"M Ramet","year":"2002","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What&apos;s wrong with Bonferroni adjustments.","volume":"316","author":"TV Perneger","year":"1998","journal-title":"Bmj"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0032863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T03:10:14Z","timestamp":1593832214000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0032863"}},"subtitle":[],"editor":[{"given":"Samithamby","family":"Jeyaseelan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,12]]},"references-count":54,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0032863","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,12]]}}}