{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:50:25Z","timestamp":1791309025277,"version":"4.3.1"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0032947","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T16:08:24Z","timestamp":1330963704000},"page":"e32947","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":77,"title":["Critical Role of Constitutive Type I Interferon Response in Bronchial Epithelial Cell to Influenza Infection"],"prefix":"10.1371","volume":"7","author":[{"given":"Alan C-Y.","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Lowther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Hansbro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A. B.","family":"Wark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,3,2]]},"reference":[{"key":"ref1","article-title":"Pandemic Potential of a Strain of Influenza A (H1N1) : Early Findings.","author":"C Fraser","year":"2009","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9300","DOI":"10.1128\/JVI.74.19.9300-9305.2000","article-title":"Recognition of N-glycolylneuraminic acid linked to galactose by the alpha2,3 linkage is associated with intestinal replication of influenza A virus in ducks.","volume":"74","author":"T Ito","year":"2000","journal-title":"J Virol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1128\/JVI.71.4.3357-3362.1997","article-title":"Differences in sialic acid-galactose linkages in the chicken egg amnion and allantois influence human influenza virus receptor specificity and variant selection.","volume":"71","author":"T Ito","year":"1997","journal-title":"J Virol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0168-1702(98)00067-7","article-title":"Changes in H3 influenza A virus receptor specificity during replication in humans.","volume":"56","author":"K Ryan-Poirier","year":"1998","journal-title":"Virus Res"},{"key":"ref5","first-page":"2559","article-title":"[Influenza viruses and their receptor sugar recognition].","volume":"43","author":"Y Suzuki","year":"1998","journal-title":"Tanpakushitsu Kakusan Koso"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.4049\/jimmunol.164.8.4220","article-title":"Type I IFN modulates innate and specific antiviral immunity.","volume":"164","author":"JE Durbin","year":"2000","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ni873","article-title":"IL-28, IL-29 and their class II cytokine receptor IL-28R.","volume":"4","author":"P Sheppard","year":"2003","journal-title":"Nat Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ni921","article-title":"IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.","volume":"4","author":"KA Fitzgerald","year":"2003","journal-title":"Nat Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1126\/science.1081315","article-title":"Triggering the interferon antiviral response through an IKK-related pathway.","volume":"300","author":"S Sharma","year":"2003","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ni875","article-title":"IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.","volume":"4","author":"SV Kotenko","year":"2003","journal-title":"Nat Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact.","volume":"3","author":"DE Levy","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1128\/MMBR.00027-06","article-title":"Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action.","volume":"70","author":"MA Garcia","year":"2006","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1009664109241","article-title":"Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action.","volume":"5","author":"J Gil","year":"2000","journal-title":"Apoptosis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"8192","DOI":"10.1128\/JVI.00426-07","article-title":"Protein kinase PKR plays a stimulus- and virus-dependent role in apoptotic death and virus multiplication in human cells.","volume":"81","author":"P Zhang","year":"2007","journal-title":"J Virol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","article-title":"How cells respond to interferons.","volume":"67","author":"GR Stark","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1093\/emboj\/18.8.2273","article-title":"Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3\u2032-end processing machinery.","volume":"18","author":"Z Chen","year":"1999","journal-title":"Embo J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/j.1462-5822.2006.00841.x","article-title":"IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.","volume":"9","author":"B Opitz","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.micinf.2006.02.028","article-title":"Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines.","volume":"8","author":"J Siren","year":"2006","journal-title":"Microbes Infect"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cell.2009.12.018","article-title":"A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection.","volume":"139","author":"SD Shapira","year":"2009","journal-title":"Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"11515","DOI":"10.1128\/JVI.01703-09","article-title":"Interferon-{lambda} is the predominant interferon induced by influenza A virus infection in vivo.","volume":"84","author":"NA Jewell","year":"2010","journal-title":"J Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.immuni.2007.07.013","article-title":"Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.","volume":"27","author":"Y Kumagai","year":"2007","journal-title":"Immunity"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1000709","DOI":"10.1371\/journal.ppat.1000709","article-title":"Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host.","volume":"5","author":"Y Gao","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1128\/JVI.01712-07","article-title":"Avian influenza virus A\/HK\/483\/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells.","volume":"82","author":"WY Lam","year":"2008","journal-title":"J Virol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1743-422X-7-102","article-title":"5\u2032PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication.","volume":"7","author":"P Ranjan","year":"2010","journal-title":"Virol J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"8112","DOI":"10.1128\/JVI.00006-07","article-title":"The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells.","volume":"81","author":"KY Twu","year":"2007","journal-title":"J Virol"},{"key":"ref26","article-title":"Human Influenza is More Effective than Avian Influenza at Antiviral Suppression in Airway Cells.","author":"AC Hsu","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref27","article-title":"X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus.","author":"ZA Bornholdt","year":"2008","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1073\/pnas.0800482105","article-title":"A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity.","volume":"105","author":"D Jackson","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1128\/JVI.01698-07","article-title":"A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice.","volume":"82","author":"P Jiao","year":"2008","journal-title":"J Virol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1023\/A:1023668705040","article-title":"Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.","volume":"8","author":"M Chawla-Sarkar","year":"2003","journal-title":"Apoptosis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1089\/107999003766628124","article-title":"Interferons and apoptosis.","volume":"23","author":"MJ Clemens","year":"2003","journal-title":"J Interferon Cytokine Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1017\/S0007114508025798","article-title":"Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells.","volume":"101","author":"A Saedisomeolia","year":"2009","journal-title":"The British journal of nutrition"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"L373","DOI":"10.1152\/ajplung.00300.2003","article-title":"Resistance of differentiated human airway epithelium to infection by rhinovirus.","volume":"286","author":"N Lopez-Souza","year":"2004","journal-title":"American journal of physiology Lung cellular and molecular physiology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jaci.2007.04.046","article-title":"IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations.","volume":"120","author":"PA Wark","year":"2007","journal-title":"The Journal of allergy and clinical immunology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.20041901","article-title":"Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus.","volume":"201","author":"PA Wark","year":"2005","journal-title":"J Exp Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1165\/rcmb.2010-0157OC","article-title":"Human influenza is more effective than avian influenza at antiviral suppression in airway cells.","volume":"44","author":"AC Hsu","year":"2011","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e3965","DOI":"10.1371\/journal.pone.0003965","article-title":"RIG-I and dsRNA-induced IFNbeta activation.","volume":"3","author":"S Hausmann","year":"2008","journal-title":"PLoS ONE"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.1132505","article-title":"5\u2032-Triphosphate RNA is the ligand for RIG-I.","volume":"314","author":"V Hornung","year":"2006","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature04734","article-title":"Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.","volume":"441","author":"H Kato","year":"2006","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1128\/JVI.01080-07","article-title":"Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.","volume":"82","author":"YM Loo","year":"2008","journal-title":"J Virol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000101411","article-title":"Role of RIG-I, MDA-5, and PKR on the expression of inflammatory chemokines induced by synthetic dsRNA in airway epithelial cells.","volume":"143","author":"S Matsukura","year":"2007","journal-title":"Int Arch Allergy Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.coi.2008.01.002","article-title":"MDA5\/RIG-I and virus recognition.","volume":"20","author":"O Takeuchi","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1165\/rcmb.2006-0283RC","article-title":"NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I.","volume":"36","author":"Z Guo","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1128\/JVI.78.4.1706-1717.2004","article-title":"Innate cellular response to virus particle entry requires IRF3 but not virus replication.","volume":"78","author":"SE Collins","year":"2004","journal-title":"J Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chom.2009.04.006","article-title":"Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.","volume":"5","author":"MU Gack","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"11166","DOI":"10.1128\/JVI.76.21.11166-11171.2002","article-title":"The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors.","volume":"76","author":"S Ludwig","year":"2002","journal-title":"J Virol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"7989","DOI":"10.1128\/JVI.74.17.7989-7996.2000","article-title":"Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.","volume":"74","author":"J Talon","year":"2000","journal-title":"J Virol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"11566","DOI":"10.1128\/JVI.74.24.11566-11573.2000","article-title":"Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha\/beta interferon.","volume":"74","author":"X Wang","year":"2000","journal-title":"J Virol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1128\/JVI.68.4.2425-2432.1994","article-title":"The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A).","volume":"68","author":"Y Qiu","year":"1994","journal-title":"J Virol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/jbiol61","article-title":"Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress.","volume":"6","author":"M Ralser","year":"2007","journal-title":"Journal of biology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e1000193","DOI":"10.1371\/journal.ppat.1000193","article-title":"Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus.","volume":"4","author":"H Phipps-Yonas","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1128\/MMBR.64.2.239-280.2000","article-title":"Translational Control of Viral Gene Expression in Eukaryotes.","volume":"64","author":"M Gale Jr","year":"2000","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0014-5793(97)01161-7","article-title":"Mechanisms of cycloheximide-induced apoptosis in liver cells.","volume":"416","author":"AV Alessenko","year":"1997","journal-title":"FEBS Letters"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.cellbi.2006.06.016","article-title":"Analysis of cycloheximide-induced apoptosis in human leukocytes: fluorescence microscopy using annexin V\/propidium iodide versus acridin orange\/ethidium bromide.","volume":"30","author":"D Baskic","year":"2006","journal-title":"Cell Biology International"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1073\/pnas.81.13.3964","article-title":"Inhibition of protein synthesis stimulates the transcription of human beta-interferon genes in Chinese hamster ovary cells.","volume":"81","author":"GM Ringold","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref56","first-page":"405","article-title":"The physiological interferon response. V. Antiviral activity present in rat lymph is neutralized by anti-mouse interferon-gamma antibodies.","volume":"8","author":"V Bocci","year":"1985","journal-title":"Microbiologica"},{"key":"ref57","first-page":"151","article-title":"The physiologic interferon response. VI. Interferon activity in human plasma after a meal and drinking.","volume":"4","author":"V Bocci","year":"1985","journal-title":"Lymphokine Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0769-2617(88)80005-4","article-title":"Identification by in situ hybridization of IFN-beta-producing murine macrophages obtained from high and low interferon producers.","volume":"139","author":"J De Maeyer-Guignard","year":"1988","journal-title":"Ann Inst Pasteur Virol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1074-7613(00)00053-4","article-title":"Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha\/beta gene induction.","volume":"13","author":"M Sato","year":"2000","journal-title":"Immunity"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.4049\/jimmunol.0804277","article-title":"Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo.","volume":"183","author":"S Lienenklaus","year":"2009","journal-title":"J Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/35073080","article-title":"A weak signal for strong responses: interferon-alpha\/beta revisited.","volume":"2","author":"T Taniguchi","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0140-6736(02)11772-7","article-title":"Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?","volume":"360","author":"CY Cheung","year":"2002","journal-title":"Lancet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1128\/JVI.00978-07","article-title":"A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens.","volume":"82","author":"Q Zhu","year":"2008","journal-title":"J Virol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3201\/eid1201.051186","article-title":"Antiviral response in pandemic influenza viruses.","volume":"12","author":"A Garcia-Sastre","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1125676","article-title":"Type 1 interferons and the virus-host relationship: a lesson in detente.","volume":"312","author":"A Garcia-Sastre","year":"2006","journal-title":"Science"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0166-0934(80)90020-8","article-title":"A simplified plaque assay for influenza viruses in Madin-Darby kidney (MDCK) cells.","volume":"1","author":"J Huprikar","year":"1980","journal-title":"J Virol Methods"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0091-6749(91)90189-U","article-title":"Workshop summary and guidelines: investigative use of bronchoscopy.","volume":"88","author":"SZ Hurd","year":"1991","journal-title":"J Allergy Clin immunol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e21183","DOI":"10.1371\/journal.pone.0021183","article-title":"Avian influenza viruses infect primary human bronchial epithelial cells unconstrained by sialic acid alpha2,3 residues.","volume":"6","author":"CM Oshansky","year":"2011","journal-title":"PLoS ONE"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"10702","DOI":"10.1074\/jbc.M110.185793","article-title":"Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.","volume":"286","author":"A Watanabe","year":"2011","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0032947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T16:31:54Z","timestamp":1593793914000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0032947"}},"subtitle":[],"editor":[{"given":"Volker","family":"Thiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,2]]},"references-count":69,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0032947","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,2]]}}}