{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:42:00Z","timestamp":1783996920991,"version":"3.55.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T00:00:00Z","timestamp":1331856000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0033084","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T21:18:41Z","timestamp":1331932721000},"page":"e33084","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Incremental Effects of Endocrine and Metabolic Biomarkers and Abdominal Obesity on Cardiovascular Mortality Prediction"],"prefix":"10.1371","volume":"7","author":[{"given":"Harald J\u00f6rn","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Wallaschofski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello Ricardo Paulista","family":"Markus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Doerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan B.","family":"Felix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Nauck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/01.CIR.83.1.356","article-title":"An updated coronary risk profile. A statement for health professionals.","author":"KM Anderson","year":"1991","journal-title":"Circulation"},{"key":"ref2","first-page":"2486","article-title":"Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP).","year":"2001","journal-title":"JAMA"},{"key":"ref3","first-page":"A2","article-title":"The Munster Heart Study (PROCAM). Results of follow-up at 8 years.","volume":"19","author":"G Assmann","year":"1998","journal-title":"Eur Heart J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0195-668X(03)00114-3","article-title":"Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project.","author":"RM Conroy","year":"2003","journal-title":"Eur Heart"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories.","author":"PW Wilson","year":"1998","journal-title":"Circulation"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/CIRCULATIONAHA.105.590927","article-title":"Comparative impact of multiple biomarkers and N-Terminal pro-brain natriuretic peptide in the context of conventional risk factors for the prediction of recurrent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study.","author":"S Blankenberg","year":"2006","journal-title":"Circulation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1161\/CIRCULATIONAHA.109.901413","article-title":"Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project.","author":"S Blankenberg","year":"2010","journal-title":"Circulation"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jama.2009.943","article-title":"Novel and conventional biomarkers for prediction of incident cardiovascular events in the community.","author":"O Melander","year":"2009","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/jama.297.6.611","article-title":"Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score.","author":"PM Ridker","year":"2007","journal-title":"JAMA"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1056\/NEJMoa055373","article-title":"Multiple biomarkers for the prediction of first major cardiovascular events and death.","author":"TJ Wang","year":"2006","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1056\/NEJMoa0707064","article-title":"Use of multiple biomarkers to improve the prediction of death from cardiovascular causes.","author":"B Zethelius","year":"2008","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"832","DOI":"10.7326\/0003-4819-148-11-200806030-00225","article-title":"Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality.","author":"N Ochs","year":"2008","journal-title":"Ann Intern Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1210\/jc.2003-030967","article-title":"The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study.","author":"GA Laughlin","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1210\/jc.2008-2138","article-title":"Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.","author":"N Friedrich","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/aje\/kwm124","article-title":"Insulin-like growth factors and subsequent risk of mortality in the United States.","author":"S Saydah","year":"2007","journal-title":"Am J Epidemiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1093\/eurheartj\/ehq009","article-title":"Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20\u201379.","author":"R Haring","year":"2010","journal-title":"Eur Heart J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1001\/archinte.166.15.1660","article-title":"Low serum testosterone and mortality in male veterans.","author":"MM Shores","year":"2006","journal-title":"Arch Intern Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/jc.2007-1792","article-title":"Low serum testosterone and mortality in older men.","author":"GA Laughlin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/oby.2008.592","article-title":"Independent association of HbA(1c) and incident cardiovascular disease in people without diabetes.","author":"RJ Adams","year":"2009","journal-title":"Obesity"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1001\/archinte.168.15.1699","article-title":"The hemoglobin A1c level as a progressive risk factor for cardiovascular death, hospitalization for heart failure, or death in patients with chronic heart failure: an analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program.","author":"HC Gerstein","year":"2008","journal-title":"Arch Intern Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/bmj.322.7277.15","article-title":"Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of european prospective investigation of cancer and nutrition (EPIC-Norfolk).","author":"KT Khaw","year":"2001","journal-title":"BMJ"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.numecd.2009.02.007","article-title":"Glycosylated hemoglobin and the risk of death and cardiovascular mortality in the elderly.","author":"M Chonchol","year":"2010","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jacc.2008.03.066","article-title":"Measures of obesity and cardiovascular risk among men and women.","volume":"2008; 52","author":"RP Gelber","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1210\/jc.2009-1584","article-title":"The predictive value of different measures of obesity for incident cardiovascular events and mortality.","author":"HJ Schneider","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/BF01324255","article-title":"Study of Health In Pomerania (SHIP): a health examination survey in an east German region: objectives and design.","author":"U John","year":"2001","journal-title":"Soz Praventivmed"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/ije\/dyp394","article-title":"Cohort Profile: The Study of Health in Pomerania.","author":"H V\u00f6lzke","year":"2011","journal-title":"Int J Epidemiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/thy.2005.15.279","article-title":"Reference intervals of serum thyroid function tests in a previously iodine-deficient area.","author":"H V\u00f6lzke","year":"2005","journal-title":"Thyroid"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/sim.1802","article-title":"Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation.","author":"MJ Pencina","year":"2004","journal-title":"Stat Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/1536867X1001000303","article-title":"Comparing the predictive power of survival models using Harrell&apos;s C or Somers&apos; D.","author":"RB Newson","year":"2010","journal-title":"The Stata Journal"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.2337\/db09-0031","article-title":"Prediction of metabolic syndrome by low serum testosterone levels in men: Results from the Study of Health in Pomerania.","author":"R Haring","year":"2009","journal-title":"Diabetes"},{"key":"ref31","first-page":"446","article-title":"Prevalence of low male testosterone levels in primary care in Germany: cross-sectional results from the DETECT study.","author":"HJ Schneider","year":"200","journal-title":"Clin Endocrinol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1210\/jc.2007-0179","article-title":"Review: The association of thyroid dysfunction with all-cause and circulatory mortality: is there a causal relationship?","author":"H Volzke","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref33","first-page":"3","article-title":"The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes.","author":"SN Rajpathak","year":"200","journal-title":"Diabetes Metab Res Rev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1096-6374(03)00038-8","article-title":"Serum levels of insulin-like growth factor I and its binding proteins in health and disease.","author":"A Juul","year":"2003","journal-title":"Growth Horm IGF Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1530\/EJE-10-0563","article-title":"Association of serum insulin-like growth factor I with endothelial function: Results from the population-based Study of Health in Pomerania (SHIP).","author":"K Empen","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.2337\/dc10-1794","article-title":"Measuring abdominal obesity: effects of height on distribution of cardiometabolic risk factors risk using waist circumference and waist-to-height ratio.","volume":"34","author":"HJ Schneider","year":"2011","journal-title":"Diabetes Care"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1001\/jama.298.17.2028","article-title":"Cause-specific excess deaths associated with underweight, overweight, and obesity.","author":"KM Flegal","year":"2007","journal-title":"JAMA"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0140-6736(06)69251-9","article-title":"Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies.","author":"A Romero-Corral","year":"2006","journal-title":"Lancet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0735-1097(01)01802-2","article-title":"The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox?","author":"L Gruberg","year":"2002","journal-title":"J Am Coll Cardiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0033084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T14:20:58Z","timestamp":1561472458000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0033084"}},"subtitle":[],"editor":[{"given":"Christian","family":"Schulz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,16]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0033084","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,16]]}}}