{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:45:54Z","timestamp":1787165154866,"version":"build-2736575974"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0033148","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T18:02:28Z","timestamp":1332871348000},"page":"e33148","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":53,"title":["Dietary Lactoferrin Alleviates Age-Related Lacrimal Gland Dysfunction in Mice"],"prefix":"10.1371","volume":"7","author":[{"given":"Motoko","family":"Kawashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kawakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Shimmura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shinmura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1515\/CCLM.1999.049","article-title":"Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process.","volume":"37","author":"S Baveye","year":"1999","journal-title":"Clin Chem Lab Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1002817226110","article-title":"Lactoferrin and its biological functions.","volume":"66","author":"TG Kanyshkova","year":"2001","journal-title":"Biochemistry (Mosc)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1007\/s00018-005-5370-2","article-title":"Lactoferrin: a modulator of immune and inflammatory responses.","volume":"62","author":"D Legrand","year":"2005","journal-title":"Cell Mol Life Sc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"389S","DOI":"10.1080\/07315724.2001.10719173","article-title":"Antiinflammatory activities of lactoferrin.","volume":"20","author":"OM Conneely","year":"2001","journal-title":"J Am Coll Nutr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1292\/jvms.66.149","article-title":"Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis.","volume":"66","author":"K Hayashida","year":"2004","journal-title":"J Vet Med.Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jhep.2007.11.013","article-title":"Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats.","volume":"48","author":"A Tsubota","year":"2008","journal-title":"J Hepatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1017\/S0007114500002324","article-title":"Antioxidative factors in milk.","volume":"84","author":"H Lindmark-M\u00e5nsson","year":"2000","journal-title":"Br J Nutr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1073\/pnas.85.17.6465","article-title":"Normal oxidative damage to mitochondrial and nuclear DNA is extensive.","volume":"85","author":"C Richter","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0891-5849(95)02184-1","article-title":"Association between 8-hydroxy-2\u2032-deoxyguanosine formation and DNA strand breaks mediated by copper and iron.","volume":"20","author":"S Toyokuni","year":"1996","journal-title":"Free Radic Biol Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/10715769800300611","article-title":"Age-associated change in mitochondrial DNA damage.","volume":"29","author":"EK Hudson","year":"1998","journal-title":"Free Radic Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1755-3768.1994.tb02791.x","article-title":"Ocular surface damage and tear lactoferrin in dry eye syndrome.","volume":"72","author":"Y Danjo","year":"1994","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00003226-199413060-00007","article-title":"Rapid assay of lactoferrin in keratoconjunctivitis sicca.","volume":"13","author":"CJ McCollum","year":"1994","journal-title":"Cornea"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1755-3768.1986.tb06877.x","article-title":"The concentration of lactoferrin in tears of normals and of diabetics.","volume":"64","author":"OL Jensen","year":"1986","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/bjo.68.5.316","article-title":"Normal tear protein profiles and age-related changes.","volume":"68","author":"JI McGill","year":"1984","journal-title":"The British journal of ophthalmology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0002-9394(14)75074-3","article-title":"Lactoferrin in human ocular tissues.","volume":"90","author":"TE Gillette","year":"1980","journal-title":"Am J Ophthalmol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biochi.2008.07.007","article-title":"Role of lactoferrin in the tear film.","volume":"91","author":"JL Flanagan","year":"2009","journal-title":"Biochimie"},{"key":"ref17","first-page":"1346","article-title":"Reoxygenation injury in a cultured corneal epithelial cell line protected by the uptake of lactoferrin.","volume":"39","author":"S Shimmura","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.bbrc.2010.06.018","article-title":"Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats.","volume":"397","author":"M Kawashima","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e2264","DOI":"10.1371\/journal.pone.0002264","article-title":"A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.","volume":"3","author":"JL Barger","year":"2008","journal-title":"PloS one"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cmet.2008.06.011","article-title":"Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.","volume":"8","author":"KJ Pearson","year":"2008","journal-title":"Cell metabolism"},{"key":"ref21","first-page":"111","article-title":"A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD.","volume":"42","author":"Y Ogawa","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.ophtha.2007.06.027","article-title":"Lactoferrin in Sj\u00f6gren&apos;s syndrome.","volume":"114","author":"M Dogru","year":"2007","journal-title":"Ophthalmology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00003226-200003000-00015","article-title":"Lactoferrin protects against UV-B irradiation-induced corneal epithelial damage in rats.","volume":"19","author":"T Fujihara","year":"2000","journal-title":"Cornea"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/jop.1998.14.99","article-title":"Lactoferrin suppresses loss of corneal epithelial integrity in a rabbit short-term dry eye model.","volume":"14","author":"T Fujihara","year":"1998","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biochi.2008.07.007","article-title":"Role of lactoferrin in the tear film.","volume":"91","author":"JL Flanagan","year":"2009","journal-title":"Biochimie"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1167\/iovs.08-1882","article-title":"Bovine lactoferrin stimulates human corneal epithelial alkali wound healing in vitro.","volume":"50","author":"U Pattamatta","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1139\/o01-212","article-title":"The physiology of lactoferrin.","volume":"80","author":"JH Brock","year":"2002","journal-title":"Biochem Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.exer.2004.10.012","article-title":"Age-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response.","volume":"80","author":"JD Rios","year":"2005","journal-title":"Exp Eye Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0165-1838(98)00026-5","article-title":"Age-related changes in morphology and secretory responses of male rat lacrimal gland.","volume":"69","author":"CE Draper","year":"1998","journal-title":"J Auton Nerv Syst"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/exer.1998.0605","article-title":"Evidence to suggest morphological and physiological alterations of lacrimal gland acini with ageing.","volume":"68","author":"CE Draper","year":"1999","journal-title":"Exp Eye Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj3340321","article-title":"The survival of ingested lactoferrin in the gastrointestinal tract of adult mice.","volume":"334","author":"H Kuwata","year":"1998","journal-title":"Biochem J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1017\/S0007114510003259","article-title":"Effects of pepsin and trypsin on the anti-adipogenic action of lactoferrin against pre-adipocytes derived from rat mesenteric fat.","volume":"105","author":"T Ono","year":"2011","journal-title":"Br J Nutr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.intimp.2007.05.019","article-title":"Uptake of ingested bovine lactoferrin and its accumulation in adult mouse tissues.","volume":"7","author":"R Fischer","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0161-6420(95)30971-2","article-title":"Histopathologic study of human lacrimal gland. Statistical analysis with special reference to aging.","volume":"102","author":"H Obata","year":"1995","journal-title":"Ophthalmology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.freeradbiomed.2011.09.025","article-title":"Corneal damage and lacrimal gland dysfunction in a smoking rat model.","volume":"51","author":"A Higuchi","year":"2011","journal-title":"Free radical biology & medicine"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1079\/BJN20041090","article-title":"Bovine lactoferrin reduces plasma triacylglycerol and NEFA accompanied by decreased hepatic cholesterol and triacylglycerol contents in rodents.","volume":"91","author":"T Takeuchi","year":"2004","journal-title":"Br J Nutr"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1740-0929.2009.00642.x","article-title":"Influence of orally administered bovine lactoferrin on lipid metabolism in lipopolysaccharide-injected preruminant calves.","volume":"80","author":"S Kushibiki","year":"2009","journal-title":"Anim Sci J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1161\/01.ATV.0000193626.22269.45","article-title":"Low-density lipoprotein cholesterol determines oxidative stress and endothelial dysfunction in saphenous veins from patients with coronary artery disease.","volume":"26","author":"S Al-Benna","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMoa050461","article-title":"Intensive lipid lowering with atorvastatin in patients with stable coronary disease.","volume":"352","author":"JC LaRosa","year":"2005","journal-title":"N Engl J Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.3168\/jds.S0022-0302(93)77520-7","article-title":"Iron-binding properties of bovine lactoferrin in iron-rich solution.","volume":"76","author":"Y Nagasako","year":"1993","journal-title":"J Dairy Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2362.2010.02429.x","article-title":"High risk of cardiovascular disease in iron overload patients.","volume":"41","author":"T Mero\u00f1o","year":"2011","journal-title":"Eur J Clin Invest"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1167\/iovs.10-6207","article-title":"The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.","volume":"52","author":"M Hadziahmetovic","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1042\/bj1990259","article-title":"Inhibition of lipid peroxidation by the iron-binding protein lactoferrin.","volume":"199","author":"JM Gutteridge","year":"1981","journal-title":"Biochem J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1203\/01.pdr.0000250198.22735.20","article-title":"Effects of iron-unsaturated human lactoferrin on hydrogen peroxide-induced oxidative damage in intestinal epithelial cells.","volume":"61","author":"H Shoji","year":"2007","journal-title":"Pediatr Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2174\/157340611795564286","article-title":"Antioxidant enzyme activities of iron-saturated bovine lactoferrin (Fe-bLf) in human gut epithelial cells under oxidative stress.","volume":"7","author":"H Burrow","year":"2011","journal-title":"Med Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1113\/expphysiol.2006.034876","article-title":"Enteric-formulated lactoferrin was more effectively transported into blood circulation from gastrointestinal tract in adult rats.","volume":"91","author":"T Takeuchi","year":"2006","journal-title":"Exp Physiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1021\/pr0501970","article-title":"Characterization of human tear proteome using multiple proteomic analysis techniques.","volume":"4","author":"N Li","year":"2005","journal-title":"J Proteome Res"},{"key":"ref48","first-page":"456","article-title":"Investigation of the human tear film proteome using multiple proteomic approaches.","volume":"14","author":"KB Green-Church","year":"2008","journal-title":"Mol Vis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0002-9394(03)00203-4","article-title":"Abnormal protein profiles in tears with dry eye syndrome.","volume":"136","author":"Y Ohashi","year":"2003","journal-title":"Am J Ophthalomol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1136\/bjo.2004.055822","article-title":"Decreased tear lipocalin concentration in patients with meibomian gland dysfunction.","volume":"89","author":"M Yamada","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1167\/iovs.09-4573","article-title":"Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells.","volume":"51","author":"A Morimoto-Tochigi","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0033148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:42:35Z","timestamp":1561509755000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0033148"}},"subtitle":[],"editor":[{"given":"Rajendra S.","family":"Apte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,27]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0033148","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,27]]}}}