{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:34:36Z","timestamp":1791056076258,"version":"4.1.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T00:00:00Z","timestamp":1332374400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0033413","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T13:09:54Z","timestamp":1332508194000},"page":"e33413","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Invariant NKT Cells Drive Hepatic Cytokinic Microenvironment Favoring Efficient Granuloma Formation and Early Control of Leishmania donovani Infection"],"prefix":"10.1371","volume":"7","author":[{"given":"Florence","family":"Robert-Gangneux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Drogoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavie","family":"Rostan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Piquet-Pellorce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome","family":"Cayon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariette","family":"Lisbonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Herbelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Gascan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Guiguen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Samson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Gangneux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-5699(99)01549-2","article-title":"Organ-specific immune responses associated with infectious disease.","volume":"21","author":"CR Engwerda","year":"2000","journal-title":"Immunol Today"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.4049\/jimmunol.148.6.1858","article-title":"Acquired resistance and granuloma formation in experimental visceral leishmaniasis. Differential T cell and lymphokine roles in initial versus established immunity.","volume":"148","author":"HW Murray","year":"1992","journal-title":"J Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1365-2613.2001.00199.x","article-title":"Tissue granuloma structure-function in experimental visceral leishmaniasis.","volume":"82","author":"HW Murray","year":"2001","journal-title":"Int J Exp Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-065X.1997.tb00994.x","article-title":"Cytokines in the induction and expression of T-cell-mediated granuloma formation and protection in the murine model of listeriosis.","volume":"158","author":"ME Mielke","year":"1997","journal-title":"Immunol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1046\/j.1440-1711.2000.00933.x","article-title":"Restraining mycobacteria: role of granulomas in mycobacterial infections.","volume":"78","author":"BM Saunders","year":"2000","journal-title":"Immunol Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1000805","DOI":"10.1371\/journal.ppat.1000805","article-title":"Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells.","volume":"6","author":"L Beattie","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1084\/jem.189.4.741","article-title":"Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani.","volume":"189","author":"HW Murray","year":"1999","journal-title":"J Exp Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.181.1.387","article-title":"Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis.","volume":"181","author":"HW Murray","year":"1995","journal-title":"J Exp Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"768","DOI":"10.4049\/jimmunol.153.2.768","article-title":"Role and effect of TNF-alpha in experimental visceral leishmaniasis.","volume":"153","author":"MC Tumang","year":"1994","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.4049\/jimmunol.143.12.4244","article-title":"Experimental visceral leishmaniasis: role of endogenous IFN-gamma in host defense and tissue granulomatous response.","volume":"143","author":"KE Squires","year":"1989","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.0105-2896.2004.00188.x","article-title":"The immunopathology of experimental visceral leishmaniasis.","volume":"201","author":"PM Kaye","year":"2004","journal-title":"Immunol Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1128\/IAI.68.11.6289-6293.2000","article-title":"Visceral leishmaniasis in mice devoid of tumor necrosis factor and response to treatment.","volume":"68","author":"HW Murray","year":"2000","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1128\/IAI.71.8.4804-4807.2003","article-title":"Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity.","volume":"71","author":"S Stager","year":"2003","journal-title":"Infect Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1128\/IAI.68.11.6294-6299.2000","article-title":"Mononuclear cell recruitment, granuloma assembly, and response to treatment in experimental visceral leishmaniasis: intracellular adhesion molecule 1-dependent and -independent regulation.","volume":"68","author":"HW Murray","year":"2000","journal-title":"Infect Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.4049\/jimmunol.140.11.3971","article-title":"Role of L3T4+ and LyT-2+ cells in experimental visceral leishmaniasis.","volume":"140","author":"JJ Stern","year":"1988","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/(SICI)1521-4141(199901)29:01<203::AID-IMMU203>3.0.CO;2-B","article-title":"Leishmania donovani infection initiates T cell-independent chemokine responses, which are subsequently amplified in a T cell-dependent manner.","volume":"29","author":"SE Cotterell","year":"1999","journal-title":"Eur J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.femsim.2004.01.003","article-title":"Hepatic cellular immune responses in mice with &quot;cure&quot; and &quot;non-cure&quot; phenotype to Leishmania infantum infection: importance of CD8+ T cells and TGF-beta production.","volume":"41","author":"S Gomes-Pereira","year":"2004","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.4049\/jimmunol.164.7.3681","article-title":"B cell-deficient mice are highly resistant to Leishmania donovani infection, but develop neutrophil-mediated tissue pathology.","volume":"164","author":"SC Smelt","year":"2000","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1073\/pnas.96.9.5141","article-title":"Murine natural killer T(NKT) cells [correction of natural killer cells] contribute to the granulomatous reaction caused by mycobacterial cell walls.","volume":"96","author":"I Apostolou","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.clim.2007.12.005","article-title":"Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections.","volume":"127","author":"JS Im","year":"2008","journal-title":"Clin Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1000239","DOI":"10.1371\/journal.ppat.1000239","article-title":"Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria.","volume":"4","author":"I Sada-Ovalle","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/hep.20433","article-title":"To be or not to be NKT: natural killer T cells in the liver.","volume":"40","author":"MA Exley","year":"2004","journal-title":"Hepatology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.22034","article-title":"Liver: An organ with predominant innate immunity.","volume":"47","author":"B Gao","year":"2008","journal-title":"Hepatology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0020-7519(01)00197-7","article-title":"Function and assembly of the Leishmania surface coat.","volume":"31","author":"SC Ilgoutz","year":"2001","journal-title":"Int J Parasitol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/eji.201040981","article-title":"Leishmania donovani glycosphingolipid facilitates antigen presentation by inducing relocation of CD1d into lipid rafts in infected macrophages.","volume":"41","author":"S Karmakar","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1084\/jem.20040704","article-title":"A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan.","volume":"200","author":"JL Amprey","year":"2004","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0167-5699(00)01735-7","article-title":"NKT cells: facts, functions and fallacies.","volume":"21","author":"DI Godfrey","year":"2000","journal-title":"Immunol Today"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/hep.22813","article-title":"Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride.","volume":"49","author":"O Park","year":"2009","journal-title":"Hepatology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijpara.2003.09.007","article-title":"Regulation of immunity and pathogenesis in infectious diseases by CD1d-restricted NKT cells.","volume":"34","author":"DS Hansen","year":"2004","journal-title":"Int J Parasitol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4049\/jimmunol.0900690","article-title":"Cutting edge: B and T lymphocyte attenuator signaling on NKT cells inhibits cytokine release and tissue injury in early immune responses.","volume":"183","author":"ML Miller","year":"2009","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1053\/j.gastro.2008.02.037","article-title":"Critical role for CD1d-restricted invariant NKT cells in stimulating intrahepatic CD8 T-cell responses to liver antigen.","volume":"134","author":"D Sprengers","year":"2008","journal-title":"Gastroenterology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.4049\/jimmunol.178.9.5435","article-title":"The Pro-Th1 cytokine IL-12 enhances IL-4 production by invariant NKT cells: relevance for T cell-mediated hepatitis.","volume":"178","author":"R Zhu","year":"2007","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1000028","DOI":"10.1371\/journal.ppat.1000028","article-title":"Activation of invariant NKT cells exacerbates experimental visceral leishmaniasis.","volume":"4","author":"AC Stanley","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/intimm\/12.9.1267","article-title":"CD4(+) v(alpha)14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major.","volume":"12","author":"H Ishikawa","year":"2000","journal-title":"Int Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.micinf.2005.07.002","article-title":"NKT cells mediate organ-specific resistance against Leishmania major infection.","volume":"8","author":"J Mattner","year":"2006","journal-title":"Microbes Infect"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/eji.200939863","article-title":"Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation.","volume":"40","author":"L Beattie","year":"2010","journal-title":"Eur J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.","volume":"117","author":"CL Tsou","year":"2007","journal-title":"J Clin Invest"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1182\/blood.V90.3.909","article-title":"Chemokines.","volume":"90","author":"BJ Rollins","year":"1997","journal-title":"Blood"},{"key":"ref39","first-page":"119","article-title":"Regulation of Leishmania populations within the host. I. the variable course of Leishmania donovani infections in mice.","volume":"30","author":"DJ Bradley","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/107999000312748","article-title":"The capacity to produce IFN-gamma rather than the presence of interleukin-4 determines the resistance and the degree of susceptibility to Leishmania donovani infection in mice.","volume":"20","author":"J Lehmann","year":"2000","journal-title":"J Interferon Cytokine Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1002\/1521-4141(200007)30:7<1919::AID-IMMU1919>3.0.CO;2-3","article-title":"Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide.","volume":"30","author":"Y Osman","year":"2000","journal-title":"Eur J Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1002\/eji.201041006","article-title":"Invariant natural killer T-cell-deficient mice display increased CCl -induced hepatitis associated with CXCL1 over-expression and neutrophil infiltration.","volume":"41","author":"M Lisbonne","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.4049\/jimmunol.171.8.4020","article-title":"Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells.","volume":"171","author":"NY Crowe","year":"2003","journal-title":"J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1365-3024.2011.01328.x","article-title":"Enrichment of invariant natural killer T cells in the bone marrow of visceral leishmaniasis patients.","volume":"33","author":"AK Rai","year":"2011","journal-title":"Parasite Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.ijpara.2011.05.010","article-title":"Early activated Th-1 type and dominantly diverse natural killer T (CD3CD161Valpha24) cells in bone marrow among visceral leishmaniasis patients.","volume":"41","author":"AK Rai","year":"2011","journal-title":"Int J Parasitol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.4049\/jimmunol.157.10.4421","article-title":"Early production of IL-4 and induction of Th2 responses in the lymph node originate from an MHC class I-independent CD4+NK1.1- T cell population.","volume":"157","author":"T von der Weid","year":"1996","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1084\/jem.185.7.1231","article-title":"Intracellular antimicrobial activity in the absence of interferon-gamma: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-gamma gene-disrupted mice.","volume":"185","author":"AP Taylor","year":"1997","journal-title":"J Exp Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/1521-4141(200003)30:3<834::AID-IMMU834>3.0.CO;2-9","article-title":"IL-12 gene-deficient C57BL\/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology.","volume":"30","author":"AR Satoskar","year":"2000","journal-title":"Eur J Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.4049\/jimmunol.163.9.4647","article-title":"Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells.","volume":"163","author":"C Carnaud","year":"1999","journal-title":"J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4049\/jimmunol.0900873","article-title":"Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Valpha24 invariant NKT cells.","volume":"183","author":"Y Uemura","year":"2009","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"7541","DOI":"10.1128\/IAI.73.11.7541-7547.2005","article-title":"Invariant NKT cells are essential for the regulation of hepatic CXCL10 gene expression during Leishmania donovani infection.","volume":"73","author":"M Svensson","year":"2005","journal-title":"Infect Immun"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/hep.22761","article-title":"Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice.","volume":"49","author":"T Santodomingo-Garzon","year":"2009","journal-title":"Hepatology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.humimm.2010.09.002","article-title":"Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis.","volume":"71","author":"AP Campanelli","year":"2010","journal-title":"Hum Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte-mediated defense against microbial pathogens.","volume":"26","author":"NV Serbina","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1128\/IAI.01388-07","article-title":"Neutrophils contribute to development of a protective immune response during onset of infection with Leishmania donovani.","volume":"76","author":"E McFarlane","year":"2008","journal-title":"Infect Immun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/eji.200939594","article-title":"Alpha-GalCer ameliorates listeriosis by accelerating infiltration of Gr-1+ cells into the liver.","volume":"40","author":"M Emoto","year":"2010","journal-title":"Eur J Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.","volume":"3","author":"J Vandesompele","year":"2002","journal-title":"Genome Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0033413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T22:46:03Z","timestamp":1713739563000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0033413"}},"subtitle":[],"editor":[{"given":"Laurent","family":"R\u00e9nia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,22]]},"references-count":57,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0033413","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,22]]}}}