{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:56:31Z","timestamp":1773777391871,"version":"3.50.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T00:00:00Z","timestamp":1333497600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0033505","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T21:06:00Z","timestamp":1333573560000},"page":"e33505","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Differential Inflammatory Response to Inhaled Lipopolysaccharide Targeted Either to the Airways or the Alveoli in Man"],"prefix":"10.1371","volume":"7","author":[{"given":"Winfried","family":"M\u00f6ller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Heimbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P. J.","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclnaz","family":"Khadem Saba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Neiswirth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Frankenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00f6ms","family":"Ziegler-Heitbrock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,4,4]]},"reference":[{"key":"ref1","first-page":"167","article-title":"Bacterial lipopolysaccharides and innate immunity.","volume":"7","author":"C Alexander","year":"2001","journal-title":"J Endotoxin Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1034\/j.1600-065X.2000.917306.x","article-title":"Innate immunity and pulmonary host defense.","volume":"173","author":"P Zhang","year":"2000","journal-title":"Immunol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1183\/09031936.06.00010806","article-title":"Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin.","volume":"28","author":"NA Maris","year":"2006","journal-title":"Eur Respir J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00024382-199911001-00064","article-title":"Bacterial endotoxins: Bioactive conformation and specific host-recognition.","volume":"12","author":"ET Rietschel","year":"1999","journal-title":"Shock"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1289\/ehp.6552","article-title":"Ambient Endotoxin Concentrations in PM10 from Southern California.","volume":"112","author":"L Mueller-Anneling","year":"2004","journal-title":"Environ Health Perspect"},{"key":"ref6","first-page":"241","article-title":"Endotoxin in the environment\u2013exposure and effects.","volume":"8","author":"R Rylander","year":"2002","journal-title":"J Endotoxin Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00204-008-0290-1","article-title":"Health effects due to endotoxin inhalation.","volume":"82","author":"V Liebers","year":"2008","journal-title":"Arch Toxicol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1046\/j.1365-2222.2003.01665.x","article-title":"Early endotoxin exposure and atopy development in infants: results of a birth cohort study.","volume":"33","author":"G Bolte","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1183\/09031936.02.01182001","article-title":"Traffic-related air pollution and respiratory health during the first 2 yrs of life.","volume":"19","author":"U Gehring","year":"2002","journal-title":"Eur Respir J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1289\/ehp.0901178","article-title":"Chronic Lung Function Decline in Cotton Textile Workers: Roles of Historical and Recent Exposures to Endotoxin.","volume":"118","author":"J Shi","year":"2010","journal-title":"Environ Health Perspect"},{"key":"ref11","first-page":"1204","article-title":"Exacerbations of chronic obstructive pulmonary disease.","volume":"48","author":"JA Wedzicha","year":"2003","journal-title":"Respir Care"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000107056","article-title":"Lipopolysaccharide challenge of humans as a model for chronic obstructive lung disease exacerbations.","volume":"14","author":"SA Kharitonov","year":"2007","journal-title":"Contrib Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/76048","article-title":"TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.","volume":"25","author":"NC Arbour","year":"2000","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s000110050751","article-title":"The inflammatory response in humans after inhalation of bacterial endotoxin: a review.","volume":"50","author":"J Thorn","year":"2001","journal-title":"Inflamm Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1289\/ehp.8006","article-title":"Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells.","volume":"113","author":"M Geiser","year":"2005","journal-title":"Environ Health Perspect"},{"key":"ref16","first-page":"347","article-title":"The organization of ciliary activity and mucus transport in pulmonary airways.","volume":"46","author":"A van As","year":"1972","journal-title":"S Afr Med J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1164\/rccm.200602-301OC","article-title":"Deposition, retention and translocation of ultrafine particles from the central airways and lung periphery.","volume":"177","author":"W M\u00f6ller","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e21827","DOI":"10.1371\/journal.pone.0021827","article-title":"Innate Immune Responses to Bacterial Ligands in the Peripheral Human Lung \u2013 Role of Alveolar Epithelial TLR Expression and Signalling.","volume":"6","author":"AJ Thorley","year":"2011","journal-title":"PLoS ONE"},{"key":"ref19","first-page":"1","article-title":"Epidemiology Standardization Project (American Thoracic Society).","volume":"118","author":"BG Ferris","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"ref20","first-page":"5","article-title":"Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society.","volume":"16","author":"PH Quanjer","year":"1993","journal-title":"Eur Respir J"},{"key":"ref21","first-page":"53","article-title":"Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society.","volume":"Suppl 6","author":"PJ Sterk","year":"1993","journal-title":"Eur Respir J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/(SICI)1520-6017(200006)89:6<724::AID-JPS3>3.0.CO;2-B","article-title":"Total deposition of therapeutic particles during spontaneous and controlled inhalations.","volume":"89","author":"P Brand","year":"2000","journal-title":"J Pharm Sci"},{"key":"ref23","first-page":"1","article-title":"Human respiratory tract model for radiological protection. A report of a Task Group of the International Commission on Radiological Protection.","volume":"24","year":"1994","journal-title":"Ann ICRP"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1089\/jamp.2009.0764","article-title":"Fractionated Exhaled Breath Condensate Collection Shows High Hydrogen Peroxide Release in the Airways.","volume":"23","author":"W M\u00f6ller","year":"2010","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.rmed.2005.02.020","article-title":"Validation of a new method to measure hydrogen peroxide in exhaled breath condensate.","volume":"99","author":"WB Gerritsen","year":"2005","journal-title":"Respir Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1183\/09031936.05.00029705","article-title":"Exhaled breath condensate: methodological recommendations and unresolved questions.","volume":"26","author":"I Horvath","year":"2005","journal-title":"Eur Respir J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.pupt.2008.02.002","article-title":"Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: A randomized placebo-controlled trial.","volume":"21","author":"JM Hohlfeld","year":"2008","journal-title":"Pulm Pharmacol Ther"},{"key":"ref28","first-page":"165","article-title":"Regional drug targeting within the lungs by controlled inhalation with the AKITA inhalation system.","author":"G Scheuch","year":"2002"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1164\/ajrccm.156.4.97-02002","article-title":"Dose-response relationship to inhaled endotoxin in normal subjects.","volume":"156","author":"O Michel","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1136\/thx.53.7.563","article-title":"Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects.","volume":"53","author":"JA Nightingale","year":"1998","journal-title":"Thorax"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1067\/mai.2001.114249","article-title":"Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy.","volume":"107","author":"O Michel","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1179\/096805106X153934","article-title":"Systemic and bronchial inflammation following LPS inhalation in asthmatic and healthy subjects.","volume":"12","author":"R Kitz","year":"2006","journal-title":"J Endotoxin Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/thx.2005.049403","article-title":"Inhalation of stable dust extract prevents allergen induced airway inflammation and hyperresponsiveness.","volume":"61","author":"M Peters","year":"2006","journal-title":"Thorax"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1084\/jem.86.1.29","article-title":"Tolerance to Bacterial Pyrogens: I. Factors Influencing Its Development.","volume":"86","author":"PB Beeson","year":"1947","journal-title":"J Exp Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"17001","DOI":"10.1016\/S0021-9258(17)32510-3","article-title":"Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.","volume":"269","author":"HW Ziegler-Heitbrock","year":"1994","journal-title":"J Biol Chem"},{"key":"ref36","first-page":"201","article-title":"Review: Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed.","volume":"10","author":"CA Dinarello","year":"2004","journal-title":"J Endotoxin Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1004","article-title":"Innate immune sensing and its roots: the story of endotoxin.","volume":"3","author":"B Beutler","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/1753425909104782","article-title":"Endotoxin-induced translocation of interleukin-6 from lungs to the systemic circulation.","volume":"15","author":"E Tamagawa","year":"2009","journal-title":"Innate Immunity"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00062752-200701000-00003","article-title":"Regulation of neutrophil homeostasis.","volume":"14","author":"MJ Christopher","year":"2007","journal-title":"Curr Opin Hematol"},{"key":"ref40","first-page":"L360","article-title":"Corticosteroids differentially regulate secretion of IL-6, IL-8, and G-CSF by a human bronchial epithelial cell line.","volume":"265","author":"SJ Levine","year":"1993","journal-title":"Am J Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/00043426-199124000-00004","article-title":"Human granulocyte colony-stimulating factor: its basic aspects and clinical applications.","volume":"13","author":"S Asano","year":"1991","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1439-0442.1994.tb00079.x","article-title":"Hematological, Blood Biochemical, and Cytological Bronchoalveolar Lavage Studies in Prepubertal Gilts after Endotoxin Inhalation and Ingestion.","volume":"41","author":"H Holst","year":"1994","journal-title":"Journal of Veterinary Medicine Series A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.4049\/jimmunol.146.9.3032","article-title":"Effects of cytokine combinations on acute phase protein production in two human hepatoma cell lines.","volume":"146","author":"A Mackiewicz","year":"1991","journal-title":"J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1385\/IR:24:2:163","article-title":"C-reactive protein, inflammation, and innate immunity.","volume":"24","author":"RF Mortensen","year":"2001","journal-title":"Immunol Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S1357-2725(02)00259-5","article-title":"Airway smooth muscle: contraction and beyond.","volume":"35","author":"Y Amrani","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1378\/chest.110.1.263","article-title":"Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects.","volume":"110","author":"PJ Jagielo","year":"1996","journal-title":"Chest"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/76048","article-title":"TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.","volume":"25","author":"NC Arbour","year":"2000","journal-title":"Nat Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00418-004-0679-8","article-title":"Assembly of the phagocyte NADPH oxidase.","volume":"122","author":"WM Nauseef","year":"2004","journal-title":"Histochem Cell Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0891-5849(97)00375-4","article-title":"Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro.","volume":"24","author":"LG Rochelle","year":"1998","journal-title":"Free Radic Biol Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbrc.2005.02.144","article-title":"Cigarette smoke condensate induces MMP-12 gene expression in airway- like epithelia.","volume":"330","author":"MC Lavigne","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/10408449991349276","article-title":"Glutathione Redox System in Oxidative Lung Injury.","volume":"29","author":"Q Rahman","year":"1999","journal-title":"Crit Rev Toxicol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0022-1759(95)00210-3","article-title":"Influence of specimen age and anticoagulant on flow cytometric evaluation of granulocyte oxidative burst generation.","volume":"188","author":"HE Prince","year":"1995","journal-title":"J Immunol Methods"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12013-009-9054-7","article-title":"Antioxidant Activity of Sulfur and Selenium: A Review of Reactive Oxygen Species Scavenging, Glutathione Peroxidase, and Metal-Binding Antioxidant Mechanisms.","volume":"55","author":"E Battin","year":"2009","journal-title":"Cell Biochem Biophys"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.4049\/jimmunol.150.7.2885","article-title":"Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages.","volume":"150","author":"MA Dentener","year":"1993","journal-title":"J Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1073\/pnas.97.4.1778","article-title":"Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis.","volume":"97","author":"N Kaminski","year":"2000","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature01413","article-title":"Loss of integrin [alpha]v[beta]6-mediated TGF-[beta] activation causes Mmp12-dependent emphysema.","volume":"422","author":"DG Morris","year":"2003","journal-title":"Nature"},{"key":"ref57","first-page":"1","article-title":"Time Course of Endotoxin-Induced Airways&apos; Inflammation in Healthy Subjects.","author":"V Doyen","year":"2011","journal-title":"Inflammation"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1164\/rccm.200503-451OC","article-title":"Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers.","volume":"172","author":"NA Maris","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref59","first-page":"1","article-title":"Exacerbations of asthma and COPD: definitions, clinical manifestations and epidemiology.","volume":"14","author":"PM O'Byrne","year":"2007","journal-title":"Contrib Microbiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0033505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T19:24:11Z","timestamp":1687375451000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0033505"}},"subtitle":[],"editor":[{"given":"Dominik","family":"Hartl","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,4]]},"references-count":59,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0033505","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,4]]}}}