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Gaskin","year":"1978","journal-title":"Neurosci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/S0006-291X(80)80095-7","article-title":"Tubulin assembly induced by cobalt and zinc.","volume":"95","author":"KM Haskins","year":"1980","journal-title":"Biochem Biophys Res Commun"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/0020-711X(84)90236-2","article-title":"Microtubule assembly in rat brain extracts: Further characterization of the effects of zinc on assembly and cold stability.","volume":"16","author":"JE Hesketh","year":"1984","journal-title":"Int J Biochem"},{"key":"ref48","article-title":"Zinc Deficiency and Microtubule Function in Prostate Cells.","author":"BN Ames","year":"2006","journal-title":"DTIC"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0006-8993(75)90650-2","article-title":"Small amounts of zinc stimulate rapid axonal transport in vitro.","volume":"86","author":"A Edstr\u00f6m","year":"1975","journal-title":"Brain Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1021\/bi00508a043","article-title":"In vitro microtubule assembly regulation by divalent cations and nucleotides.","volume":"20","author":"F Gaskin","year":"1981","journal-title":"Biochem"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0006-8993(81)90217-1","article-title":"Effects of zinc on the cytoskeletal proteins in the central nervous system of the rat.","volume":"220","author":"Y Kress","year":"1981","journal-title":"Brain Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/0020-711X(82)90059-3","article-title":"Zinc-stimulated microtubule assembly and evidence for zinc binding to tubulin.","volume":"14","author":"JE Hesketh","year":"1982","journal-title":"Int J Biochem"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/tera.1420410110","article-title":"Influence of maternal dietary zinc intake on in vitro tubulin polymerization in fetal rat brain.","volume":"41","author":"PI Oteiza","year":"1990","journal-title":"Teratology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF02789137","article-title":"Effects of marginal zinc deficiency on microtubule polymerization in the developing rat brain.","volume":"24","author":"PI Oteiza","year":"1990","journal-title":"Biol Trace Elem Res"},{"key":"ref55","first-page":"495","article-title":"Effect of dietary zinc on microtubule-associated protein 2 expression in the brain of mice.","volume":"51","author":"FD Wang","year":"1999","journal-title":"Acta Physiologica Sinica"},{"key":"ref56","first-page":"156","article-title":"Mechanism of impairment to microtubule polymerization resulting from zinc deficiency during pregnancy and lactation in mice,","volume":"30","author":"F Wang","year":"2000","journal-title":"J Hygiene Research"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1021\/bi00270a032","article-title":"Tubulin-zinc interactions: binding and polymerizaton studies.","volume":"22","author":"GR Eagle","year":"1983","journal-title":"Biochem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0020-711X(83)90202-1","article-title":"Zinc binding to tubulin.","volume":"15","author":"JE Hesketh","year":"1983","journal-title":"Int J Biochem"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1021\/bi00064a026","article-title":"Thermodynamics of tubulin polymerization into zinc sheets: Assembly is not regulated by GTP hydrolysis.","volume":"32","author":"R Melki","year":"1993","journal-title":"Biochem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/0006-291X(82)90958-5","article-title":"Zinc-induced self-assembly of goat brain tubulin: Some novel aspects.","volume":"105","author":"A Banerjee","year":"1982","journal-title":"Biochem Biophys Res Commun"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0014-5793(83)80341-X","article-title":"Characterization of acid and alkaline phosphatase activity in preparations of tubulin and microtubule-associated proteins,","volume":"151","author":"K Prus","year":"1983","journal-title":"FEBS Lett"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0022-2836(77)80200-3","article-title":"The Protein Data Bank: A Computer-based Archival File For Macromolecular Structures.","volume":"112","author":"FC Bernstein","year":"1977","journal-title":"J Mol Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints.","volume":"234","author":"A Sali","year":"1993","journal-title":"J Mol Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","article-title":"Scalable molecular dynamics with NAMD.","volume":"26","author":"JC Phillips","year":"2005","journal-title":"J Comp Chem"},{"key":"ref65","article-title":"PyMOL Release 0.99","author":"W DeLano","year":"2002"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0969-2126(02)00827-4","article-title":"Microtubule Structure at 8 \u00c5 Resolution.","volume":"10","author":"H Li","year":"2002","journal-title":"Structure"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1110\/ps.03187503","article-title":"The physical basis of microtubule structure and stability.","volume":"12","author":"D Sept","year":"2003","journal-title":"Prot Sci"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1110\/ps.073138508","article-title":"Robust recognition of zinc binding sites in proteins.","volume":"17","author":"JC Ebert","year":"2008","journal-title":"Prot Sci"},{"key":"ref69","first-page":"226","article-title":"A density-based algorithm for discovering clusters in large spatial databases with noise.","author":"M Ester","year":"1996"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/prot.20660","article-title":"Very Fast Empirical Prediction and Interpretation of Protein pKa Values.","volume":"61","author":"H Li","year":"2005","journal-title":"Proteins"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"W665","DOI":"10.1093\/nar\/gkh381","article-title":"PDB2PQR: an automated pipeline for the setup, execution, and analysis of Poisson-Boltzmann electrostatics calculations.","volume":"32","author":"TJ Dolinsky","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"W522","DOI":"10.1093\/nar\/gkm276","article-title":"PDB2PQR: Expanding and upgrading automated preparation of biomolecular structures for 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Sci"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/prot.1138","article-title":"Successful molecular dynamics simulation of two zinc complexes bridged by a hydroxide in phosphotriesterase using the cationic dummy atom method.","volume":"45","author":"YP Pang","year":"2001","journal-title":"Proteins"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.","volume":"274","author":"K Hsiao","year":"1996","journal-title":"Science"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"10332","DOI":"10.1016\/S0021-9258(18)67528-3","article-title":"Phosphorylation of tubulin by a calmodulin-dependent protein kinase.","volume":"261","author":"F Wandosell","year":"1986","journal-title":"J Biol Chem"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/bioinformatics\/btm618","article-title":"Prediction of zinc-binding sites in proteins from sequence.","volume":"24","author":"N Shu","year":"2008","journal-title":"Bioinformatics"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"34648","DOI":"10.1074\/jbc.M109.058883","article-title":"Low Micromolar Zinc Accelerates the Fibrillization of Human Tau via Bridging of Cys-291 and Cys-322.","volume":"284","author":"ZY Mo","year":"2009","journal-title":"J Biol Chem"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"12910","DOI":"10.1073\/pnas.0402928101","article-title":"Tau induces cooperative Taxol binding to microtubules.","volume":"101","author":"JL Ross","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/emboj\/cdg001","article-title":"Repeat motifs of tau bind to the insides of microtubules in the 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Kim","year":"2011","journal-title":"Neuroreport"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1111\/j.1582-4934.2008.00509.x","article-title":"mTOR-dependent signalling in Alzheimer&apos;s disease.","volume":"12","author":"JJ Pei","year":"2008","journal-title":"J Cell Mol Med"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1074\/jbc.M704292200","article-title":"Coupling of Mammalian Target of Rapamycin with Phosphoinositide 3-Kinase Signaling Pathway Regulates Protein Phosphatase 2A- and Glycogen Synthase Kinase-3\u03b2-dependent Phosphorylation of Tau.","volume":"283","author":"V Meske","year":"2008","journal-title":"J Biol Chem"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"13107","DOI":"10.1074\/jbc.M110.100420","article-title":"Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-\u03b2, and Tau.","volume":"285","author":"A Caccamo","year":"2010","journal-title":"J Biol Chem"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3233\/JAD-2008-14405","article-title":"p70 S6 kinase and tau in Alzheimer&apos;s disease.","volume":"14","author":"JJ Pei","year":"2008","journal-title":"Alzheimers Dis"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0002-9440(10)63687-5","article-title":"Up-Regulation of Phosphorylated\/Activated p70 S6 Kinase and Its Relationship to Neurofibrillary Pathology in Alzheimer&apos;s Disease.","volume":"163","author":"WL An","year":"2003","journal-title":"Am J Pathol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1471-4159.2004.02948.x","article-title":"Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells.","volume":"92","author":"WL An","year":"2005","journal-title":"J Neurochem"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/jnr.21039","article-title":"The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide.","volume":"84","author":"C Lafay-Chebassier","year":"2006","journal-title":"J Neurosci Res"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1038\/sj.onc.1204751","article-title":"Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase.","volume":"20","author":"A Calastretti","year":"2001","journal-title":"Oncogene"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuron.2008.06.018","article-title":"Rapid Restoration of Cognition in Alzheimer&apos;s Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial A\u03b2.","volume":"59","author":"PA Adlard","year":"2008","journal-title":"Neuron"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3233\/JAD-2010-1390","article-title":"PBT2 Rapidly Improves Cognition in Alzheimer&apos;s Disease: Additional Phase II Analyses.","volume":"20","author":"NG Faux","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1523\/JNEUROSCI.5255-09.2010","article-title":"Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer&apos;s Disease?","volume":"30","author":"PA Adlard","year":"2010","journal-title":"J Neurosci"},{"issue":"3","key":"ref100","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000328951","article-title":"Transcranial magnetic stimulation in the management of mood disorders.","volume":"64","author":"CL Allan","year":"2011","journal-title":"Neuropsychobiology"},{"issue":"2","key":"ref101","doi-asserted-by":"crossref","first-page":"e16655","DOI":"10.1371\/journal.pone.0016655","article-title":"Facilitate Insight by Non-Invasive Brain Stimulation.","volume":"6","author":"RP Chi","year":"2011","journal-title":"PLoS ONE"},{"issue":"5","key":"ref102","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2010.05.008","article-title":"Transcranial pulsed ultrasound stimulates intact brain circuits.","volume":"66","author":"Y Tufail","year":"2010","journal-title":"Neuron"},{"issue":"3","key":"ref103","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.neuroimage.2011.02.058","article-title":"Focused ultrasound modulates region-specific brain activity.","volume":"56","author":"SS Yoo","year":"2011","journal-title":"Neuroimage"},{"key":"ref104","article-title":"Radio-frequency-induced ultrafast assembly of microtubules and their length-independent electronic properties.","author":"S Sahu","year":"2012","journal-title":"Nature Mater"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02736834","article-title":"Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration.","volume":"8","author":"J Nunez","year":"1997","journal-title":"J Mol Neurosci"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/gb-2006-7-6-224","article-title":"The MAP1 family of microtubule-associated proteins.","volume":"7","author":"S Halpain","year":"2006","journal-title":"Genome Biol"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/neu.10283","article-title":"Microtubule-associated protein 1B function during normal development, regeneration, and pathological condition in the nervous system.","volume":"58","author":"C Gonzalez-Billaut","year":"2004","journal-title":"J Neurobiol"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.brainresbull.2006.11.012","article-title":"Microtubule-associated protein 1B, growth-associated and phosphorylated scaffold protein.","volume":"71","author":"BM Riederer","year":"2007","journal-title":"Brain Res Bull"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/gb-2004-6-1-204","article-title":"The MAP2\/Tau family of microtubule-associated proteins.","volume":"6","author":"L Dehmelt","year":"2005","journal-title":"Genome Biol"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0301-0082(99)00046-5","article-title":"Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function.","volume":"61","author":"C S\u00e1nchez","year":"2000","journal-title":"Prog Neurobiol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0166-2236(91)90105-4","article-title":"Molecular characterization of microtubule-associated proteins tau and MAP2.","volume":"14","author":"M Godert","year":"1991","journal-title":"Trends Neurosci"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/MOP.0b013e328010542d","article-title":"Cerebral development disorders.","volume":"18","author":"G Lian","year":"2006","journal-title":"Curr Opin Pediatr"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/bies.10402","article-title":"LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome.","volume":"26","author":"CC Hoogenraad","year":"2004","journal-title":"Bioessays"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.conb.2004.08.011","article-title":"Molecular motors in neuronal development, intracellular transport and diseases.","volume":"14","author":"N Hirokawa","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.neuro.23.1.39","article-title":"Microtubule-based transport systems in neurons: the roles of kinesins and dyneins.","volume":"23","author":"LS Goldstein","year":"2000","journal-title":"Annu Rev Neurosci"}],"updated-by":[{"DOI":"10.1371\/annotation\/57c710a6-83ba-444c-a352-b9f60125f2fa","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T00:00:00Z","timestamp":1333411200000}},{"DOI":"10.1371\/annotation\/e83fbf22-647f-496f-b27d-5aff26898083","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T00:00:00Z","timestamp":1367798400000}},{"DOI":"10.1371\/annotation\/866da844-12ad-4fef-a57e-92a4549e035c","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T00:00:00Z","timestamp":1339718400000}}],"container-title":["PLoS 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