{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:14:21Z","timestamp":1791242061268,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T00:00:00Z","timestamp":1331856000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0033688","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T21:08:09Z","timestamp":1331932089000},"page":"e33688","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Research on the Stability of a Rabbit Dry Eye Model Induced by Topical Application of the Preservative Benzalkonium Chloride"],"prefix":"10.1371","volume":"7","author":[{"given":"Chaoyang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyue","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohong","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengxia","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiju","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,3,16]]},"reference":[{"key":"ref1","first-page":"221","article-title":"Report of the National Eye Institute\/Industry workshop on Clinical Trials in Dry Eyes.","volume":"21","author":"MA Lemp","year":"1995","journal-title":"Clao J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/BF00404705","article-title":"Prevalence of dry eye in Japanese eye centers.","volume":"233","author":"T Hikichi","year":"1995","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0002-9394(14)71688-5","article-title":"Prevalence of dry eye among the elderly.","volume":"124","author":"OD Schein","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0161-6420(03)00262-8","article-title":"Prevalence of dry eye among an elderly chinese population in Taiwan - The Shihpai eye study.","volume":"110","author":"PY Lin","year":"2003","journal-title":"Ophthalmology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop.","volume":"5","year":"2007","journal-title":"Ocul Surf"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000055537","article-title":"Development of a simple dry eye model in the albino rabbit and evaluation of some tear substitutes[J].","volume":"31","author":"B Susi","year":"1999","journal-title":"Ophthalmic Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1167\/iovs.04-1326","article-title":"The controlled-environment chamber: a new mouse model of dry eye.","volume":"46","author":"S Barabino","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.exer.2007.02.003","article-title":"Exposure to a dry environment induces strain-specific responses in mice.","volume":"84","author":"S Barabino","year":"2007","journal-title":"Exp Eye Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.exer.2009.03.003","article-title":"Corneal epithelial proliferation and thickness in a mouse model of dry eye.","volume":"89","author":"C Fabiani","year":"2009","journal-title":"Exp Eye Res"},{"key":"ref10","first-page":"632","article-title":"A mouse model of keratoconjunctivitis sicca.","volume":"43","author":"D Dursun","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.4049\/jimmunol.176.7.3950","article-title":"Desiccating stress induces T cell-mediated Sjogren's Syndrome-like lacrimal keratoconjunctivitis.","volume":"176","author":"JY Niederkorn","year":"2006","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1167\/iovs.02-0581","article-title":"Apoptosis of ocular surface cells in experimentally induced dry eye.","volume":"44","author":"S Yeh","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/01.ICL.0000161705.19602.C9","article-title":"Effect of experimental dry eye on tear sodium concentration in the mouse.","volume":"31","author":"P Stewart","year":"2005","journal-title":"Eye Contact Lens"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1167\/iovs.03-1145","article-title":"Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface.","volume":"45","author":"L Luo","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1167\/iovs.07-0744","article-title":"A Murine Model of Dry Eye Induced by an Intelligently Controlled Environmental System.","volume":"49","author":"Jia Qu","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.exer.2009.03.015","article-title":"Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis.","volume":"89","author":"W Chen","year":"2009","journal-title":"Exp Eye Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1167\/iovs.07-0720","article-title":"A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride.","volume":"49","author":"C Xiong","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0014-4835(86)90037-0","article-title":"Allansmith MR. Hormonal modulation of tear volume in the rat.","volume":"42","author":"DA Sullivan","year":"1986","journal-title":"Exp Eye Res"},{"key":"ref19","first-page":"234","article-title":"Hormonal influence on the secretory immune system of the eye: androgen regulation of secretory component levels in rat tears.","volume":"52","author":"DA Sullivan","year":"1984","journal-title":"Immunology"},{"key":"ref20","first-page":"374","article-title":"Tear film osmolarity and ocular surface disease in two rabbit models for keratoconjunctivitis sicca.","volume":"29","author":"JP Gilbard","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1001\/archopht.1989.01070020276038","article-title":"Spontaneous canine keratoconjunctivitis sicca: a useful model for human keratoconjunctivitis sicca: treatment with cyclosporine eye drops.","volume":"107","author":"RL Kaswan","year":"1989","journal-title":"Arch Ophthalmol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1001\/archopht.118.2.246","article-title":"Tear production after unilateral removal of the main lacrimal gland insquirrel monkeys.","volume":"118","author":"DY Maitchouk","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1089\/jop.1995.11.503","article-title":"Establishment of a rabbit short-term dry eye model.","volume":"11","author":"T Fujihara","year":"1995","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1001\/archopht.120.3.330","article-title":"Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine.","volume":"120","author":"KS Kunert","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.preteyeres.2010.03.001","article-title":"Preservatives in eyedrops: the good, the bad and the ugly.","volume":"29","author":"C Baudouin","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1159\/000109986","article-title":"Acute corneal epithelial change after instillation of BAC evaluated using a newly developed in vivo cornea.","volume":"39","author":"Masafumi Uematsu","year":"2007","journal-title":"Ophthalmic Res"},{"key":"ref27","first-page":"435","article-title":"Corneal epithelial fluorescein staining.","volume":"66","author":"G Wilson","year":"1995","journal-title":"J Am Optom Assoc"},{"key":"ref28","first-page":"1458","article-title":"Flow cytometry in impression cytology specimens: a new method for evaluation of conjunctival inflammation.","volume":"38","author":"C Baudouin","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/bjo.76.9.545","article-title":"Immunopathological findings in conjunctival cells using immunofluorescence staining of impression cytology specimens.","volume":"76","author":"C Baudouin","year":"1992","journal-title":"BrJ Ophthalmol"},{"key":"ref30","first-page":"865","article-title":"Effect of anti-glaucoma eyedrops on cell differentiation of the conjunctiva.","volume":"88","author":"KP Steuhl","year":"1991","journal-title":"Fortschr Ophthalmol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/00061198-200312000-00008","article-title":"Comparison of the short-term effects on the human corneal surface of topical timolo maleate with and without benzalkonium chloride.","volume":"12","author":"T Ishibashi","year":"2003","journal-title":"J Glaucoma"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1016\/j.ophtha.2004.06.023","article-title":"Conjunctival epithelial cell expression of interleukins and inflammatory markers in glaucoma patients treated over the long term.","volume":"111","author":"C Baudouin","year":"2004","journal-title":"Ophthalmology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ophtha.2007.01.036","article-title":"The ocular surface of glaucoma patients treated over the long term expresses inflammatory markers related to both T-helper 1 and T-helper 2 pathways.","volume":"115","author":"C Baudouin","year":"2008","journal-title":"Ophthalmology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1167\/iovs.03-1067","article-title":"Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study.","volume":"45","author":"PJ Pisella","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref35","first-page":"619","article-title":"Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells.","volume":"40","author":"M De Saint Jean","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/15569528709052168","article-title":"Detergent penetration into young and adult rabbit eyes: comparative pharmacokinetics.","volume":"6","author":"K Green","year":"1987","journal-title":"Toxicol Cut Ocul Toxicol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00003226-200203001-00005","article-title":"Significance of mucin on the ocular surface.","volume":"21","author":"H Watanabe","year":"2002","journal-title":"Cornea"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/02713689808951223","article-title":"Histopathological effects of topical ophthalmic preservatives on ratcorneoconjunctival surface.","volume":"17","author":"F Becquet","year":"1998","journal-title":"Curr Eye Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.exer.2007.01.018","article-title":"Assay of mucins in human tear fluid.","volume":"84","author":"S Spurr-Michaud","year":"2007","journal-title":"Exp Eye Res"}],"updated-by":[{"DOI":"10.1371\/annotation\/f2df1a21-1df3-4c2d-a99a-b054dfbc6443","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T00:00:00Z","timestamp":1341878400000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0033688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T23:34:41Z","timestamp":1540251281000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0033688"}},"subtitle":[],"editor":[{"given":"Michael E.","family":"Boulton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,16]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0033688","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/f2df1a21-1df3-4c2d-a99a-b054dfbc6443","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,16]]}}}