{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:14:49Z","timestamp":1769202889180,"version":"3.49.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0033702","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T21:05:05Z","timestamp":1332191105000},"page":"e33702","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Role of Fibrocytes in Sickle Cell Lung Disease"],"prefix":"10.1371","volume":"7","author":[{"given":"Joshua J.","family":"Field","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie D.","family":"Burdick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"DeBaun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett A.","family":"Strieter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borna","family":"Mehrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Edward","family":"Rose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Linden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Strieter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/oxfordjournals.aje.a010288","article-title":"Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review.","volume":"151","author":"A Ashley-Koch","year":"2000","journal-title":"American Journal of Epidemiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00005792-198801000-00005","article-title":"Sickle cell chronic lung disease: prior morbidity and the risk of pulmonary failure.","volume":"67","author":"D Powars","year":"1988","journal-title":"Medicine (Baltimore)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/01.md.0000189089.45003.52","article-title":"Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients.","volume":"84","author":"DR Powars","year":"2005","journal-title":"Medicine (Baltimore)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1056\/NEJMra0804411","article-title":"Pulmonary complications of sickle cell disease.","volume":"359","author":"MT Gladwin","year":"2008","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1056\/NEJMoa035477","article-title":"Pulmonary hypertension as a risk factor for death in patients with sickle cell disease.","volume":"350","author":"MT Gladwin","year":"2004","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1164\/rccm.200601-125OC","article-title":"Abnormal pulmonary function in adults with sickle cell anemia.","volume":"173","author":"ES Klings","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1164\/rccm.200708-1184OC","article-title":"Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus.","volume":"177","author":"TR McMillan","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"77S","DOI":"10.1378\/chest.120.1_suppl.S77-a","article-title":"Mechanisms of pulmonary fibrosis: conference summary.","volume":"120","author":"RM Strieter","year":"2001","journal-title":"Chest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1513\/pats.200710-160DR","article-title":"What differentiates normal lung repair and fibrosis? Inflammation, resolution of repair, and fibrosis.","volume":"5","author":"RM Strieter","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1172\/JCI30562","article-title":"The role of CXC chemokines in pulmonary fibrosis.","volume":"117","author":"RM Strieter","year":"2007","journal-title":"J Clin Invest"},{"key":"ref11","first-page":"171","article-title":"The role of intraalveolar fibrosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage.","volume":"126","author":"Y Fukuda","year":"1987","journal-title":"Am J Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/thx.53.10.815","article-title":"The acute respiratory distress syndrome: fibrosis in the fast lane.","volume":"53","author":"R Marshall","year":"1998","journal-title":"Thorax"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI200420997","article-title":"Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis.","volume":"114","author":"RJ Phillips","year":"2004","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1007\/s00018-003-2328-0","article-title":"Fibrocytes: a unique cell population implicated in wound healing.","volume":"60","author":"CN Metz","year":"2003","journal-title":"Cell Mol Life Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03403533","article-title":"Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair.","volume":"1","author":"R Bucala","year":"1994","journal-title":"Mol Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1755-1536-4-2","article-title":"The role of fibrocytes in fibrotic diseases of the lungs and heart.","volume":"4","author":"EC Keeley","year":"2011","journal-title":"Fibrogenesis Tissue Repair"},{"key":"ref17","article-title":"The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis.","author":"RM Strieter","year":"2009","journal-title":"J Leukoc Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.biocel.2009.10.014","article-title":"Fibrocytes: bringing new insights into mechanisms of inflammation and fibrosis.","volume":"42","author":"EC Keeley","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1189\/jlb.0906587","article-title":"Fibrocytes in lung disease.","volume":"82","author":"BN Gomperts","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0002-9440(10)62289-4","article-title":"CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury.","volume":"166","author":"BB Moore","year":"2005","journal-title":"Am J Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2353\/ajpath.2008.070732","article-title":"C-C chemokine receptor 5 on pulmonary fibrocytes facilitates migration and promotes metastasis via matrix metalloproteinase 9.","volume":"173","author":"HW van Deventer","year":"2008","journal-title":"Am J Pathol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.4049\/jimmunol.179.6.4035","article-title":"Reduction of bleomycin-induced pulmonary fibrosis by serum amyloid P.","volume":"179","author":"D Pilling","year":"2007","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bbrc.2006.11.149","article-title":"Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease.","volume":"353","author":"B Mehrad","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.biocel.2008.02.012","article-title":"Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis.","volume":"40","author":"A Andersson-Sjoland","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1164\/rccm.200810-1534OC","article-title":"Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis.","volume":"179","author":"A Moeller","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1164\/rccm.200301-071OC","article-title":"The stromal derived factor-1\/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases.","volume":"167","author":"RJ Phillips","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0002-9440(10)64867-5","article-title":"Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma.","volume":"160","author":"K Blease","year":"2002","journal-title":"Am J Pathol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.4049\/jimmunol.163.10.5686","article-title":"IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis.","volume":"163","author":"MP Keane","year":"1999","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"22910","DOI":"10.1074\/jbc.M703597200","article-title":"Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma.","volume":"282","author":"KM Hong","year":"2007","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.biocel.2009.02.020","article-title":"Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis.","volume":"41","author":"B Mehrad","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1182\/blood-2009-02-205492","article-title":"NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines.","volume":"114","author":"KL Wallace","year":"2009","journal-title":"Blood"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"22473","DOI":"10.1074\/jbc.M500963200","article-title":"Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase\/PTEN\/AKT\/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha.","volume":"280","author":"RJ Phillips","year":"2005","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1164\/rccm.200409-1164OC","article-title":"CXCL11 attenuates bleomycin-induced pulmonary fibrosis via inhibition of vascular remodeling.","volume":"171","author":"MD Burdick","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1378\/chest.109.3.780","article-title":"Increased expression of platelet-derived growth factor A and insulin-like growth factor-I in BAL cells during the development of bleomycin-induced pulmonary fibrosis in mice.","volume":"109","author":"A Maeda","year":"1996","journal-title":"Chest"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1164\/rccm.200609-1279OC","article-title":"Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis.","volume":"176","author":"CP Baran","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1172\/JCI9225","article-title":"Hypoxia\/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice.","volume":"106","author":"DK Kaul","year":"2000","journal-title":"J Clin Invest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1182\/blood.V96.1.314","article-title":"Reperfusion injury pathophysiology in sickle transgenic mice.","volume":"96","author":"UR Osarogiagbon","year":"2000","journal-title":"Blood"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ajh.21058","article-title":"Pulmonary hypertension associated with sickle cell disease: clinical and laboratory endpoints and disease outcomes.","volume":"83","author":"LM De Castro","year":"2008","journal-title":"Am J Hematol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2141.2006.06110.x","article-title":"Pulmonary hypertension in patients with sickle cell disease: a longitudinal study.","volume":"134","author":"KI Ataga","year":"2006","journal-title":"Br J Haematol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1164\/rccm.200610-1498OC","article-title":"Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension.","volume":"175","author":"A Anthi","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJM199107043250103","article-title":"Pain in sickle cell disease. Rates and risk factors.","volume":"325","author":"OS Platt","year":"1991","journal-title":"N Engl J Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0033702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T08:27:25Z","timestamp":1687336045000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0033702"}},"subtitle":[],"editor":[{"given":"Neeraj","family":"Vij","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,19]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0033702","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,19]]}}}