{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T15:29:31Z","timestamp":1748964571954},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T00:00:00Z","timestamp":1332720000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0034272","type":"journal-article","created":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T21:21:11Z","timestamp":1332796871000},"page":"e34272","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Monoclonal Antibodies to Meningococcal Factor H Binding Protein with Overlapping Epitopes and Discordant Functional Activity"],"prefix":"10.1371","volume":"7","author":[{"given":"Serena","family":"Giuntini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Beernink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald C.","family":"Reason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan M.","family":"Granoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1086\/648966","article-title":"Review of meningococcal group B vaccines.","volume":"50","author":"DM Granoff","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.4049\/jimmunol.138.12.4402","article-title":"An IgG monoclonal antibody to group B meningococci cross-reacts with developmentally regulated polysialic acid units of glycoproteins in neural and extraneural tissues.","volume":"138","author":"J Finne","year":"1987","journal-title":"J Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(83)90340-9","article-title":"Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis.","volume":"2","author":"J Finne","year":"1983","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.4049\/jimmunol.137.5.1708","article-title":"Induction of meningococcal group B polysaccharide-specific IgG antibodies in mice by using an N-propionylated B polysaccharide-tetanus toxoid conjugate vaccine.","volume":"137","author":"HJ Jennings","year":"1986","journal-title":"J Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1093\/cid\/cir500","article-title":"Comparative long-term adverse effects elicited by invasive group B and C meningococcal infections.","volume":"53","author":"M Gottfredsson","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"17871","DOI":"10.1073\/pnas.1114489108","article-title":"Capsular polysaccharide vaccine for Group B Neisseria meningitidis, Escherichia coli K1, and Pasteurella haemolytica A2.","volume":"108","author":"JB Robbins","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S1473-3099(09)70324-X","article-title":"Serogroup B meningococcal vaccines-an unfinished story.","volume":"10","author":"M Sadarangani","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1073\/pnas.0603940103","article-title":"A universal vaccine for serogroup B meningococcus.","volume":"103","author":"MM Giuliani","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1128\/IAI.72.4.2088-2100.2004","article-title":"Vaccine potential of the <italic>Neisseria meningitidis<\/italic> 2086 lipoprotein.","volume":"72","author":"LD Fletcher","year":"2004","journal-title":"Infect Immun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4049\/jimmunol.177.1.501","article-title":"The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance.","volume":"177","author":"G Madico","year":"2006","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.tim.2007.03.005","article-title":"Interactions between <italic>Neisseria meningitidis<\/italic> and the complement system.","volume":"15","author":"MC Schneider","year":"2007","journal-title":"Trends Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.4049\/jimmunol.176.12.7566","article-title":"Functional significance of factor H binding to <italic>Neisseria meningitidis<\/italic>.","volume":"176","author":"MC Schneider","year":"2006","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1128\/IAI.01191-08","article-title":"Binding of complement factor H (fH) to <italic>Neisseria meningitidis<\/italic> is specific for human fH and inhibits complement activation by rat and rabbit sera.","volume":"77","author":"DM Granoff","year":"2009","journal-title":"Infect Immun"},{"key":"ref14","article-title":"Enhanced bacteremia in human factor H transgenic rats infected by <italic>Neisseria meningitidis<\/italic>.","author":"DM Vu","year":"2011","journal-title":"Infect Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1097\/INF.0b013e3181f59f6d","article-title":"Immunogenicity of two investigational serogroup B meningococcal vaccines in the first year of life: a randomized comparative trial.","volume":"29","author":"MD Snape","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1086\/656741","article-title":"Multicenter, open-label, randomized phase II controlled trial of an investigational recombinant meningococcal serogroup B vaccine with and without outer membrane vesicles, administered in infancy.","volume":"51","author":"J Findlow","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref17","article-title":"Prediction of broad vaccine coverage for a bivalent rLP2086 based vaccine which elicits serum bactericidal activity against a diverse collection of serogroup B Meningococci.","author":"H-Q Jiang"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.vaccine.2010.12.039","article-title":"A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression.","volume":"29","author":"PB Keiser","year":"2011","journal-title":"Vaccine"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.20021911","article-title":"Vaccination against <italic>Neisseria meningitidis<\/italic> using three variants of the lipoprotein GNA1870.","volume":"197","author":"V Masignani","year":"2003","journal-title":"J Exp Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1099\/mic.0.029876-0","article-title":"The modular architecture of meningococcal factor H-binding protein.","volume":"155","author":"PT Beernink","year":"2009","journal-title":"Microbiology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.vaccine.2009.12.027","article-title":"Frequency of factor H-binding protein modular groups and susceptibility to cross-reactive bactericidal activity in invasive meningococcal isolates.","volume":"28","author":"R Pajon","year":"2010","journal-title":"Vaccine"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.4049\/jimmunol.172.9.5606","article-title":"Protective activity of monoclonal antibodies to genome-derived neisserial antigen 1870, a <italic>Neisseria meningitidis<\/italic> candidate vaccine.","volume":"172","author":"JA Welsch","year":"2004","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1086\/528994","article-title":"Complement-dependent synergistic bactericidal activity of antibodies against factor H-binding protein, a sparsely distributed meningococcal vaccine antigen.","volume":"197","author":"JA Welsch","year":"2008","journal-title":"J Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1302","DOI":"10.1371\/journal.pntd.0001302","article-title":"Meningococcal factor H binding proteins in epidemic strains from Africa: Implications for vaccine development.","volume":"5","author":"R Pajon","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/IAI.05956-11","article-title":"Combined roles of human IgG subclass, alternative complement pathway activation, and epitope density in the bactericidal activity of antibodies to meningococcal factor h binding protein.","volume":"80","author":"S Giuntini","year":"2012","journal-title":"Infect Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1128\/IAI.00033-08","article-title":"Bactericidal antibody responses induced by meningococcal recombinant chimeric factor H-binding protein vaccines.","volume":"76","author":"PT Beernink","year":"2008","journal-title":"Infect Immun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1128\/IAI.05182-11","article-title":"Complement-mediated bactericidal activity of anti-factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding.","volume":"79","author":"S Giuntini","year":"2011","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1128\/IAI.73.2.1151-1160.2005","article-title":"The region comprising amino acids 100 to 255 of <italic>Neisseria meningitidis<\/italic> lipoprotein GNA 1870 elicits bactericidal antibodies.","volume":"73","author":"MM Giuliani","year":"2005","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jmb.2008.12.005","article-title":"Epitope mapping of a bactericidal monoclonal antibody against the factor H binding protein of <italic>Neisseria meningitidis<\/italic>.","volume":"386","author":"M Scarselli","year":"2009","journal-title":"J Mol Biol"},{"key":"ref30","article-title":"Complement-mediated bactericidal activity of anti-fHbp monoclonal antibodies against the meningococcus relies upon blocking factor H binding.","author":"S Giuntini","year":"2011","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1086\/600141","article-title":"Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B <italic>Neisseria meningitidis<\/italic>.","volume":"200","author":"E Murphy","year":"2009","journal-title":"J Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1128\/IAI.00367-08","article-title":"Fine antigenic specificity and cooperative bactericidal activity of monoclonal antibodies directed at the meningococcal vaccine candidate, factor H-binding protein.","volume":"76","author":"PT Beernink","year":"2008","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/molbev\/msj030","article-title":"Application of phylogenetic networks in evolutionary studies.","volume":"23","author":"DH Huson","year":"2006","journal-title":"Mol Biol Evol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e1001027","DOI":"10.1371\/journal.ppat.1001027","article-title":"The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement.","volume":"6","author":"LA Lewis","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.0300-9475.2004.01362.x","article-title":"The four mouse IgG isotypes differ extensively in bactericidal and opsonophagocytic activity when reacting with the P1.16 epitope on the outer membrane PorA protein of <italic>Neisseria meningitidis<\/italic>.","volume":"59","author":"TE Michaelsen","year":"2004","journal-title":"Scand J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"8738","DOI":"10.1074\/jbc.M808831200","article-title":"Structural basis for the immunogenic properties of the meningococcal vaccine candidate LP2086.","volume":"284","author":"A Mascioni","year":"2009","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1074\/jbc.M508595200","article-title":"Solution structure of the immunodominant domain of protective antigen GNA1870 of <italic>Neisseria meningitidis<\/italic>.","volume":"281","author":"F Cantini","year":"2006","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/nature07769","article-title":"<italic>Neisseria meningitidis<\/italic> recruits factor H using protein mimicry of host carbohydrates.","volume":"458","author":"MC Schneider","year":"2009","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.molimm.2009.02.021","article-title":"A region of the N-terminal domain of meningococcal factor H-binding protein that elicits bactericidal antibody across antigenic variant groups.","volume":"46","author":"PT Beernink","year":"2009","journal-title":"Mol Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1086\/597806","article-title":"Meningococcal factor H-binding protein variants expressed by epidemic capsular group A, W-135, and X strains from Africa.","volume":"199","author":"PT Beernink","year":"2009","journal-title":"J Infect Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1016\/j.vaccine.2010.06.083","article-title":"Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal disease.","volume":"28","author":"HQ Jiang","year":"2010","journal-title":"Vaccine"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"91ra62","DOI":"10.1126\/scitranslmed.3002234","article-title":"Rational design of a meningococcal antigen inducing broad protective immunity.","volume":"3","author":"M Scarselli","year":"2011","journal-title":"Sci Transl Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.4049\/jimmunol.1003470","article-title":"A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination.","volume":"186","author":"PT Beernink","year":"2011","journal-title":"J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1128\/IAI.62.5.1776-1786.1994","article-title":"Variable region sequences and idiotypic expression of a protective human immunoglobulin M antibody to capsular polysaccharides of <italic>Neisseria meningitidis<\/italic> group B and <italic>Escherichia coli<\/italic> K1.","volume":"62","author":"FH Azmi","year":"1994","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nbt0697-553","article-title":"Yeast surface display for screening combinatorial polypeptide libraries.","volume":"15","author":"ET Boder","year":"1997","journal-title":"Nat Biotechnol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jmb.2004.07.053","article-title":"Fine epitope mapping of anti-epidermal growth factor receptor antibodies through random mutagenesis and yeast surface display.","volume":"342","author":"G Chao","year":"2004","journal-title":"J Mol Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00216-005-0065-y","article-title":"Chemoinformatics: a new field with a long tradition.","volume":"384","author":"J Gasteiger","year":"2006","journal-title":"Anal Bioanal Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/IAI.00849-10","article-title":"Effect of factor H-binding protein sequence variation on factor H binding and survival of <italic>Neisseria meningitidis<\/italic> in human blood.","volume":"79","author":"KY Dunphy","year":"2011","journal-title":"Infect Immun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1128\/CVI.00097-06","article-title":"Rapid genetic grouping of factor H-binding protein (genome-derived neisserial antigen 1870), a promising group B meningococcal vaccine candidate.","volume":"13","author":"PT Beernink","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1073\/pnas.95.6.3140","article-title":"Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.","volume":"95","author":"MC Maiden","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1099\/mic.0.027995-0","article-title":"Variation of the factor H-binding protein of Neisseria meningitidis.","volume":"155","author":"C Brehony","year":"2009","journal-title":"Microbiology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1128\/CVI.00036-08","article-title":"Vaccine-induced opsonophagocytic immunity to <italic>Neisseria meningitidis<\/italic> group B.","volume":"15","author":"JS Plested","year":"2008","journal-title":"Clin Vaccine Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0034272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T13:06:57Z","timestamp":1687352817000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0034272"}},"subtitle":[],"editor":[{"given":"Nicholas J.","family":"Mantis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,3,26]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0034272","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,26]]}}}