{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:25:57Z","timestamp":1768271157014,"version":"3.49.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T00:00:00Z","timestamp":1333497600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0034415","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T21:06:46Z","timestamp":1333573606000},"page":"e34415","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses"],"prefix":"10.1371","volume":"7","author":[{"given":"Donata","family":"De Marco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Clementi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicasio","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Solforosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guisella J.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrence M.","family":"Tumpey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa V.","family":"Gubareva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliy","family":"Mishin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Clementi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Burioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/jama.292.11.1333","article-title":"Influenza-associated hospitalizations in the United States.","volume":"292","author":"WW Thompson","year":"2004","journal-title":"Jama"},{"key":"ref2","first-page":"1","article-title":"Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008.","volume":"57","author":"AE Fiore","year":"2008","journal-title":"MMWR Recomm Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1126\/science.1176062","article-title":"Pandemic potential of a strain of influenza A (H1N1): early findings.","volume":"324","author":"C Fraser","year":"2009","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1038\/nm1141","article-title":"Influenza: old and new threats.","volume":"10","author":"P Palese","year":"2004","journal-title":"Nat Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJMp0904572","article-title":"Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus.","volume":"361","author":"V Trifonov","year":"2009","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1073\/pnas.96.4.1164","article-title":"1918 Spanish influenza: the secrets remain elusive.","volume":"96","author":"RG Webster","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","first-page":"1","article-title":"Prevention and Control of Influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP).","volume":"55","author":"NM Smith","year":"2006","journal-title":"MMWR Recomm Rep"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1016\/j.vaccine.2009.06.032","article-title":"Influenza control in the 21st century: Optimizing protection of older adults.","volume":"27","author":"AS Monto","year":"2009","journal-title":"Vaccine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3201\/eid1506.081357","article-title":"Oseltamivir- and amantadine-resistant influenza viruses A (H1N1).","volume":"15","author":"PK Cheng","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3201\/eid1702.100897","article-title":"Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, Mexico.","volume":"17","author":"JE Ramirez-Gonzalez","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1001\/jama.295.8.joc60020","article-title":"Adamantane resistance among influenza A viruses isolated early during the 2005\u20132006 influenza season in the United States.","volume":"295","author":"RA Bright","year":"2006","journal-title":"Jama"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.antiviral.2007.08.007","article-title":"Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China.","volume":"77","author":"G He","year":"2008","journal-title":"Antiviral Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1126\/science.323.5918.1162","article-title":"Drug resistance. A \u2018wimpy\u2019 flu strain mysteriously turns scary.","volume":"323","author":"M Enserink","year":"2009","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1056\/NEJMp0900648","article-title":"Global transmission of oseltamivir-resistant influenza.","volume":"360","author":"A Moscona","year":"2009","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/nature06956","article-title":"Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.","volume":"453","author":"PJ Collins","year":"2008","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1056\/NEJMoa054512","article-title":"Oseltamivir resistance during treatment of influenza A (H5N1) infection.","volume":"353","author":"MD de Jong","year":"2005","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.med.59.061506.213121","article-title":"Medical management of influenza infection.","volume":"59","author":"A Moscona","year":"2008","journal-title":"Annu Rev Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1465-9921-7-126","article-title":"Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice.","volume":"7","author":"BJ Hanson","year":"2006","journal-title":"Respir Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1073\/pnas.79.15.4800","article-title":"Evolution of influenza A and B viruses: conservation of structural features in the hemagglutinin genes.","volume":"79","author":"M Krystal","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1172\/JCI41902","article-title":"Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine.","volume":"120","author":"D Corti","year":"2010","journal-title":"J Clin Invest"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.1204839","article-title":"A highly conserved neutralizing epitope on group 2 influenza A viruses.","volume":"333","author":"DC Ekiert","year":"2011","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e9106","DOI":"10.1371\/journal.pone.0009106","article-title":"New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets.","volume":"5","author":"RH Friesen","year":"2010","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e1000990","DOI":"10.1371\/journal.ppat.1000990","article-title":"Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries.","volume":"6","author":"AK Kashyap","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nsmb.1566","article-title":"Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses.","volume":"16","author":"J Sui","year":"2009","journal-title":"Nat Struct Mol Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e3942","DOI":"10.1371\/journal.pone.0003942","article-title":"Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells.","volume":"3","author":"M Throsby","year":"2008","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.virol.2009.12.014","article-title":"Monoclonal antibodies isolated from human B cells neutralize a broad range of H1 subtype influenza A viruses including swine-origin Influenza virus (S-OIV).","volume":"399","author":"R Burioni","year":"2010","journal-title":"Virology"},{"key":"ref27","first-page":"319","article-title":"Molecular cloning of the first human monoclonal antibodies neutralizing with high potency swine-origin influenza A pandemic virus (S-OIV).","volume":"32","author":"R Burioni","year":"2009","journal-title":"New Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1128\/JVI.01986-07","article-title":"Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein.","volume":"82","author":"M Perotti","year":"2008","journal-title":"J Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1128\/JVI.67.5.2552-2558.1993","article-title":"A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains.","volume":"67","author":"Y Okuno","year":"1993","journal-title":"J Virol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.2471267","article-title":"High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis.","volume":"244","author":"BC Cunningham","year":"1989","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1096\/fasebj.10.1.8566545","article-title":"Structural and genetic analysis of the folding and function of T4 lysozyme.","volume":"10","author":"BW Matthews","year":"1996","journal-title":"FASEB J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"8950","DOI":"10.1073\/pnas.160252097","article-title":"Rapid mapping of protein functional epitopes by combinatorial alanine scanning.","volume":"97","author":"GA Weiss","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.4049\/jimmunol.154.8.3975","article-title":"Protection from lethal coronavirus infection by immunoglobulin fragments.","volume":"154","author":"A Lamarre","year":"1995","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1128\/IAI.58.10.3407-3414.1990","article-title":"An investigation into the mechanism of protection by local passive immunization with monoclonal antibodies against Streptococcus mutans.","volume":"58","author":"JK Ma","year":"1990","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF01314232","article-title":"Is bivalent binding of monoclonal antibodies to different antigenic areas on the hemagglutinin of influenza virus required for neutralization of viral infectivity?","volume":"85","author":"S Yoden","year":"1985","journal-title":"Arch Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"9233","DOI":"10.1128\/JVI.78.17.9233-9242.2004","article-title":"Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody.","volume":"78","author":"MY Zhang","year":"2004","journal-title":"J Virol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1417; author reply 1417","DOI":"10.1016\/S0140-6736(09)61853-5","article-title":"Pregnancy and H1N1 infection.","volume":"374","author":"R Burioni","year":"2009","journal-title":"Lancet"},{"key":"ref38","first-page":"28","year":"2002"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e28001","DOI":"10.1371\/journal.pone.0028001","article-title":"A Human Monoclonal Antibody with Neutralizing Activity against Highly Divergent Influenza Subtypes.","volume":"6","author":"N Clementi","year":"2011","journal-title":"PloS one"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0034415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T19:24:06Z","timestamp":1687375446000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0034415"}},"subtitle":[],"editor":[{"given":"Sylvie","family":"Alonso","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,4]]},"references-count":39,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0034415","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,4]]}}}