{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:50:18Z","timestamp":1778878218076,"version":"3.51.4"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T00:00:00Z","timestamp":1333929600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0034519","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T20:51:41Z","timestamp":1334004701000},"page":"e34519","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Gestational High Protein Diet Affects the Abundance of Muscle Transcripts Related to Cell Cycle Regulation throughout Development in Porcine Progeny"],"prefix":"10.1371","volume":"7","author":[{"given":"Michael","family":"Oster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Murani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia C.","family":"Metges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriluck","family":"Ponsuksili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Wimmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,4,9]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2527\/jas1977.4551061x","article-title":"Effect of feeding various gestation and lactation dietary protein sequences on long-term reproductive performance in swine.","volume":"45","author":"D Mahan","year":"1977","journal-title":"J Anim Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2527\/jas.2010-2970","article-title":"Low and excess dietary protein levels during gestation affect growth and compositional traits in gilts and impair offspring fetal growth.","volume":"329\u201341","author":"C Rehfeldt","year":"2011","journal-title":"J Anim Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.2527\/jas.2006-156","article-title":"Board-invited review: intrauterine growth retardation: implications for the animal sciences.","volume":"84","author":"G Wu","year":"2006","journal-title":"J Anim Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.livprodsci.2004.09.009","article-title":"Inuence of piglet birth weight on postnatal growth performance, tissue lipogenic capacity and muscle histological traits at market weight.","volume":"93","author":"F Gondret","year":"2005","journal-title":"Livest Prod Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"E113","DOI":"10.2527\/2006.8413_supplE113x","article-title":"Consequences of birth weight for postnatal growth performance and carcass quality in pigs as related to myogenesis.","volume":"84:","author":"C Rehfeldt","year":"2006","journal-title":"J Anim Sci"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.2527\/jas.2010-2856","article-title":"Effects of gestation and transition diets, piglet birth weight, and fasting time on depletion of glycogen pools in liver and 3 muscles of newborn piglets.","volume":"89","author":"P Theil","year":"2011","journal-title":"J Anim Sci"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jnutbio.2010.08.015","article-title":"Maternal malnutrition programs pancreatic islet mitochondrial dysfunction in the adult offspring.","volume":"22","author":"N Theys","year":"2011","journal-title":"J Nutr Biochem"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1017\/S0007114509993795","article-title":"Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats.","volume":"103","author":"K Lillycrop","year":"2010","journal-title":"Br J Nutr"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"e21691","DOI":"10.1371\/journal.pone.0021691","article-title":"A high protein diet during pregnancy affects hepatic gene expression of energy sensing pathways along ontogenesis in a porcine model.","volume":"6","author":"M Oster","year":"2011","journal-title":"PlosOne"},{"issue":"1\u20132","key":"ref10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.mce.2010.10.018","article-title":"Protein intake during gestation affects postnatal bovine skeletal muscle growth and relative expression of igf1, igf1r, igf2 and igf2r.","volume":"332","author":"G Micke","year":"2011","journal-title":"Mol Cell Endocrinol"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"e28745","DOI":"10.1371\/journal.pone.0028745","article-title":"Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age.","volume":"6","author":"A Watkins","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1530\/REP-10-0332","article-title":"Heifer nutrient intake during early-and mid-gestation programs adult offspring adiposity and mrna expression of growth-related genes in adipose depots.","volume":"141","author":"G Micke","year":"2011","journal-title":"Reproduction"},{"key":"ref13","article-title":"Limited and excess protein intake of pregnant gilts differently affects body composition and cellularity of skeletal muscle and subcutaneous adipose tissue of newborn and weanling piglets.","author":"C Rehfeldt","year":"2011","journal-title":"Eur J Nutr [Epub ahead of print]"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2527\/jas.2011-4234","article-title":"Effects of limited and excess protein intakes of pregnant gilts on carcass quality and cellular properties of skeletal muscle and subcutaneous adipose tissue in fattening pigs.","volume":"90","author":"C Rehfeldt","year":"2012","journal-title":"J Anim Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.5194\/aab-53-230-2010","article-title":"Annotation and in silico localization of the affymetrix genechip porcine genome array.","volume":"53","author":"W Naraballobh","year":"2010","journal-title":"Arch Anim Breed"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1471-213X-7-109","article-title":"Identification of genes differentially expressed during prenatal development of skeletal muscle in two pig breeds differing in muscularity.","volume":"7","author":"E Murani","year":"2007","journal-title":"BMC Dev Biol"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2052.2010.02164.x","article-title":"Muscle transcriptome profiling in divergent phenotype swine breeds during growth using microarray and rt-pcr tools.","volume":"42","author":"M D'Andrea","year":"2011","journal-title":"Anim Genet"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"e11541","DOI":"10.1371\/journal.pone.0011541","article-title":"Micrornaome of porcine pre- and postnatal development.","volume":"5","author":"M Li","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1079\/BJN19960065","article-title":"Organ-selective growth in the offspring of protein-restricted mothers.","volume":"76","author":"M Desai","year":"1996","journal-title":"Br J Nutr"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"R813","DOI":"10.1152\/ajpregu.00201.2009","article-title":"The timing of \u201ccatch-up growth\u201d affects metabolism and appetite regulation in male rats born with intrauterine growth restriction.","volume":"297","author":"B Coupe","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"e14398","DOI":"10.1371\/journal.pone.0014398","article-title":"Sex- and diet-specific changes of imprinted gene expression and dna methylation in mouse placenta under a high-fat diet.","volume":"5","author":"C Gallou-Kabani","year":"2010","journal-title":"PLoS One"},{"issue":"23","key":"ref22","doi-asserted-by":"crossref","first-page":"R1014","DOI":"10.1016\/j.cub.2004.11.027","article-title":"How cells coordinate growth and division.","volume":"14","author":"P Jorgensen","year":"2004","journal-title":"Curr Biol"},{"issue":"5937","key":"ref23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1126\/science.1174294","article-title":"Cell growth and size homeostasis in proliferating animal cells.","volume":"325","author":"A Tzur","year":"2009","journal-title":"Science"},{"issue":"24","key":"ref24","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1101\/gad.12.24.3777","article-title":"Polo-like kinases: a team that plays throughout mitosis.","volume":"12","author":"D Glover","year":"1998","journal-title":"Genes Dev"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0955-0674(98)80121-X","article-title":"Polo-like kinases: positive regulators of cell division from start to finish.","volume":"10","author":"E Nigg","year":"1998","journal-title":"Curr Opin Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1079\/BJN20051447","article-title":"The expression of growth- arrest genes in the liver and kidney of the protein-restricted rat fetus.","volume":"94","author":"C Maloney","year":"2005","journal-title":"Br J Nutr"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s00125-003-1208-3","article-title":"Intrauterine programming of fetal islet gene expression in rats\u2013effects of maternal protein restriction during gestation revealed by proteome analysis.","volume":"46","author":"T Sparre","year":"2003","journal-title":"Diabetologia"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1095\/biolreprod.104.034561","article-title":"Effect of maternal nutrient restriction in sheep on the development of fetal skeletal muscle.","volume":"71","author":"M Zhu","year":"2004","journal-title":"Biol Reprod"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"e31390","DOI":"10.1371\/journal.pone.0031390","article-title":"Intrauterine growth retarded progeny of pregnant sows fed high protein:low carbohydrate diet is related to metabolic energy deficit.","volume":"7","author":"C Metges","year":"2012","journal-title":"PLoS One"},{"key":"ref30","article-title":"High protein : low carbohydrate diet during pregnancy alters maternal composition and placental uptake but not fetal composition of plasma amino acid concentrations in a porcine model.","author":"B Metzler-Zebeli","year":"2012","journal-title":"Br J Nutr manuscript under review (second revision)"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1210\/endo.140.10.7042","article-title":"A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor-ii.","volume":"140","author":"J Petrik","year":"1999","journal-title":"Endocrinology"},{"issue":"15","key":"ref32","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1007\/s00018-007-6568-2","article-title":"Spatial control of mitosis by the gtpase ran.","volume":"64","author":"M Ciciarello","year":"2007","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1469-7580.2005.00494.x","article-title":"Fetal programming of fat and collagen in porcine skeletal muscles.","volume":"207","author":"J Karunaratne","year":"2005","journal-title":"J Anat"},{"key":"ref34","first-page":"19","article-title":"Prenatal undernutrition increases fat deposition and collagen content within skeletal muscle in the porcine fetus.","volume":"49","author":"J Karunaratne","year":"2006","journal-title":"Arch Tierz Dummerstorf"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mito.2009.09.006","article-title":"Energetics, epigenetics, mitochondrial genetics.","volume":"10","author":"D Wallace","year":"2010","journal-title":"Mitochondrion"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.exger.2010.03.014","article-title":"How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis).","volume":"45","author":"M Ristow","year":"2010","journal-title":"Exp Gerontol"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00109-010-0663-9","article-title":"Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease.","volume":"88","author":"J Ren","year":"2010","journal-title":"J Mol Med"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0098-2997(99)00008-4","article-title":"Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms.","volume":"20","author":"V Skulachev","year":"1999","journal-title":"Mol Aspects Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"R1516","DOI":"10.1152\/ajpregu.00280.2009","article-title":"Maternal low-protein diet alters pancreatic islet mitochondrial function in a sex-specific manner in the adult rat.","volume":"297","author":"N Theys","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1186\/1423-0127-17-S1-S38","article-title":"A maternal low protein diet has pronounced effects on mitochondrial gene expression in offspring liver and skeletal muscle; protective effect of taurine.","volume":"17","author":"O Mortensen","year":"2010","journal-title":"J Biomed Sci"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"e24068","DOI":"10.1371\/journal.pone.0024068","article-title":"Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial sirt3 expression in rat offspring at weaning.","volume":"6","author":"LFSJ Borengasser","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"E130","DOI":"10.1152\/ajpendo.00322.2002","article-title":"Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats.","volume":"285","author":"M Selak","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/01.RES.0000256090.42690.05","article-title":"Amp-activated protein kinase in metabolic control and insulin signaling.","volume":"100","author":"M Towler","year":"2007","journal-title":"Circ Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/jn\/135.6.1382","article-title":"Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring.","volume":"135","author":"K Lillycrop","year":"2005","journal-title":"J Nutr"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1017\/S000711450769196X","article-title":"Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced dna methyltransferase-1 expression is involved in impaired dna methylation and changes in histone modifications.","volume":"97","author":"K Lillycrop","year":"2007","journal-title":"Br J Nutr"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1210\/endo.142.7.8238","article-title":"The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11beta-hydroxysteroid dehydrogenase: potential molecular mechanisms underlying the programming of hypertension in utero.","volume":"142","author":"C Bertram","year":"2001","journal-title":"Endocrinology"},{"key":"ref47","article-title":"The R-Project website."},{"issue":"16","key":"ref48","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies.","volume":"100","author":"J Storey","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","article-title":"The Ingenuity Pathway Analysis website."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0034519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T02:57:39Z","timestamp":1561604259000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0034519"}},"subtitle":[],"editor":[{"given":"Shree Ram","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,9]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0034519","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,9]]}}}