{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:54:36Z","timestamp":1791888876493,"version":"4.3.4"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:00:00Z","timestamp":1334016000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0034641","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T17:09:37Z","timestamp":1334077777000},"page":"e34641","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":139,"title":["MiR-133a in Human Circulating Monocytes: A Potential Biomarker Associated with Postmenopausal Osteoporosis"],"prefix":"10.1371","volume":"7","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Hao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Lappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Recker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1158\/0008-5472.CAN-09-2792","article-title":"miR-146a suppresses invasion of pancreatic cancer cells.","volume":"70","author":"Y Li","year":"2010","journal-title":"Cancer Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature06174","article-title":"Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.","volume":"449","author":"L Ma","year":"2007","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11010-011-0727-3","article-title":"Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes.","volume":"351","author":"M Balasubramanyam","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature03076","article-title":"A pancreatic islet-specific microRNA regulates insulin secretion.","volume":"432","author":"MN Poy","year":"2004","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/nature07511","article-title":"MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.","volume":"456","author":"T Thum","year":"2008","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"13906","DOI":"10.1073\/pnas.0804438105","article-title":"A microRNA signature for a BMP2-induced osteoblast lineage commitment program.","volume":"105","author":"Z Li","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1073\/pnas.1016758108","article-title":"MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo.","volume":"108","author":"T Eskildsen","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/jbmr.377","article-title":"Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1.","volume":"26","author":"J Zhang","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"19879","DOI":"10.1073\/pnas.1007698107","article-title":"A network connecting Runx2, SATB2, and the miR-23a\u223c27a\u223c24-2 cluster regulates the osteoblast differentiation program.","volume":"107","author":"MQ Hassan","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"25221","DOI":"10.1074\/jbc.M110.116137","article-title":"miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop.","volume":"285","author":"K Kapinas","year":"2010","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/stem.288","article-title":"MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation.","volume":"28","author":"J Huang","year":"2010","journal-title":"Stem Cells"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bbrc.2008.01.073","article-title":"miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation.","volume":"368","author":"Y Mizuno","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1359\/jbmr.071011","article-title":"Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor.","volume":"23","author":"E Luzi","year":"2008","journal-title":"J Bone Miner Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"20794","DOI":"10.1073\/pnas.0909311106","article-title":"A microRNA regulatory mechanism of osteoblast differentiation.","volume":"106","author":"H Inose","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1359\/jbmr.081230","article-title":"miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue.","volume":"24","author":"YJ Kim","year":"2009","journal-title":"J Bone Miner Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1172\/JCI39832","article-title":"A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans.","volume":"119","author":"H Li","year":"2009","journal-title":"J Clin Invest"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/art.30321","article-title":"The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis.","volume":"63","author":"T Nakasa","year":"2011","journal-title":"Arthritis Rheum"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/jcb.21335","article-title":"MicroRNA-223 is a key factor in osteoclast differentiation.","volume":"101","author":"T Sugatani","year":"2007","journal-title":"J Cell Biochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1210\/endo.137.9.8756585","article-title":"The human osteoclast precursor circulates in the monocyte fraction.","volume":"137","author":"Y Fujikawa","year":"1996","journal-title":"Endocrinology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1359\/jbmr.1998.13.1.44","article-title":"Induction of human osteoclast-like cells by treatment of blood monocytes with anti-fusion regulatory protein-1\/CD98 monoclonal antibodies.","volume":"13","author":"S Higuchi","year":"1998","journal-title":"J Bone Miner Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"10785","DOI":"10.1073\/pnas.93.20.10785","article-title":"Human blood-mobilized hematopoietic precursors differentiate into osteoclasts in the absence of stromal cells.","volume":"93","author":"A Matayoshi","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1182\/blood.V87.5.1802.1802","article-title":"Normal human peripheral blood mononuclear cells mobilized with granulocyte colony-stimulating factor have increased osteoclastogenic potential compared to nonmobilized blood.","volume":"87","author":"LE Purton","year":"1996","journal-title":"Blood"},{"key":"ref23","first-page":"1648","article-title":"Peripheral monocyte culture supernatants of menopausal women can induce bone resorption: involvement of cytokines.","volume":"77","author":"ME Cohen-Solal","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/jcem.83.5.4808","article-title":"Increased bone resorbing activity of peripheral monocyte culture supernatants in elderly women.","volume":"83","author":"ME Cohen-Solal","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jbmr.5650110802","article-title":"Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis.","volume":"11","author":"R Pacifici","year":"1996","journal-title":"J Bone Miner Res"},{"key":"ref26","first-page":"M111","article-title":"Peripheral blood monocyte-expressed ANXA2 gene is involved in pathogenesis of osteoporosis in humans.","volume":"10","author":"FY Deng","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1359\/jbmr.090724","article-title":"Gene expression profiling in monocytes and SNP association suggest the importance of the STAT1 gene for osteoporosis in both Chinese and Caucasians.","volume":"25","author":"XD Chen","year":"2010","journal-title":"J Bone Miner Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"29011","DOI":"10.1074\/jbc.M501164200","article-title":"A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes.","volume":"280","author":"YZ Liu","year":"2005","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1359\/jbmr.080105","article-title":"In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis.","volume":"23","author":"P Xiao","year":"2008","journal-title":"J Bone Miner Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1590\/S0100-879X2000001200005","article-title":"Bone mineral density in Brazilian men 50 years and older.","volume":"33","author":"CA Zerbini","year":"2000","journal-title":"Braz J Med Biol Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/ng1798","article-title":"microRNA target predictions in animals.","volume":"38","author":"N Rajewsky","year":"2006","journal-title":"Nat Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation.","volume":"5","author":"L He","year":"2004","journal-title":"Nat Rev Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function.","volume":"116","author":"DP Bartel","year":"2004","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","article-title":"MicroRNA targeting specificity in mammals: determinants beyond seed pairing.","volume":"27","author":"A Grimson","year":"2007","journal-title":"Mol Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e1000977","DOI":"10.1371\/journal.pgen.1000977","article-title":"An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.","volume":"6","author":"YH Hsu","year":"2010","journal-title":"PLoS Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/hmg\/ddi088","article-title":"Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS study.","volume":"14","author":"SH Ralston","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1359\/jbmr.070303","article-title":"Bivariate whole genome linkage analysis for femoral neck geometric parameters and total body lean mass.","volume":"22","author":"FY Deng","year":"2007","journal-title":"J Bone Miner Res"},{"key":"ref38","first-page":"1362","article-title":"Genes influencing variation in serum osteocalcin concentrations are linked to markers on chromosomes 16q and 20q.","volume":"85","author":"BD Mitchell","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-2474-12-115","article-title":"Transgenic overexpression of miR-133a in skeletal muscle.","volume":"12","author":"Z Deng","year":"2011","journal-title":"BMC Musculoskelet Disord"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1152\/japplphysiol.00932.2006","article-title":"MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy.","volume":"102","author":"JJ McCarthy","year":"2007","journal-title":"J Appl Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"8721","DOI":"10.1073\/pnas.0602831103","article-title":"Myogenic factors that regulate expression of muscle-specific microRNAs.","volume":"103","author":"PK Rao","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e29173","DOI":"10.1371\/journal.pone.0029173","article-title":"Insulin-like growth factor-1 receptor is regulated by microRNA-133 during skeletal myogenesis.","volume":"6","author":"MB Huang","year":"2011","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ng1725","article-title":"The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation.","volume":"38","author":"JF Chen","year":"2006","journal-title":"Nat Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000268088","article-title":"MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction.","volume":"115","author":"E Bostjancic","year":"2010","journal-title":"Cardiology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/hrt.2010.220418","article-title":"Myocardial gene expression of microRNA-133a and myosin heavy and light chains, in conjunction with clinical parameters, predict regression of left ventricular hypertrophy after valve replacement in patients with aortic stenosis.","volume":"97","author":"AV Villar","year":"2011","journal-title":"Heart"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/CIRCRESAHA.111.240150","article-title":"MicroRNA-133 controls vascular smooth muscle cell phenotypic switch in vitro and vascular remodeling in vivo.","volume":"109","author":"D Torella","year":"2011","journal-title":"Circ Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"20844","DOI":"10.1073\/pnas.0710558105","article-title":"An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133.","volume":"104","author":"N Liu","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"9863","DOI":"10.1073\/pnas.1018493108","article-title":"A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2.","volume":"108","author":"Y Zhang","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bbrc.2010.11.079","article-title":"Ibandronate promotes osteogenic differentiation of periodontal ligament stem cells by regulating the expression of microRNAs.","volume":"404","author":"Q Zhou","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1261\/rna.965408","article-title":"miRDB: a microRNA target prediction and functional annotation database with a wiki interface.","volume":"14","author":"X Wang","year":"2008","journal-title":"RNA"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/bioinformatics\/btm595","article-title":"Prediction of both conserved and nonconserved microRNA targets in animals.","volume":"24","author":"X Wang","year":"2008","journal-title":"Bioinformatics"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.","volume":"120","author":"BP Lewis","year":"2005","journal-title":"Cell"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","article-title":"MicroRNA targeting specificity in mammals: determinants beyond seed pairing.","volume":"27","author":"A Grimson","year":"2007","journal-title":"Mol Cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/nsmb.2115","article-title":"Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs.","volume":"18","author":"DM Garcia","year":"2011","journal-title":"Nat Struct Mol Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs.","volume":"19","author":"RC Friedman","year":"2009","journal-title":"Genome Res"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"11917","DOI":"10.1073\/pnas.0502188102","article-title":"Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.","volume":"102","author":"LF Coelho","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00418-003-0587-3","article-title":"Human osteoclasts express different CXC chemokines depending on cell culture substrate: molecular and immunocytochemical evidence of high levels of CXCL10 and CXCL12.","volume":"120","author":"F Grassi","year":"2003","journal-title":"Histochem Cell Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0946-672X(99)80019-4","article-title":"Skeletal effects of zinc deficiency in growing rats.","volume":"13","author":"J Eberle","year":"1999","journal-title":"J Trace Elem Med Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/07315724.1996.10718608","article-title":"Zinc and growth.","volume":"15","author":"Y Nishi","year":"1996","journal-title":"J Am Coll Nutr"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bone.2005.04.035","article-title":"Expression of the zinc transporter ZIP1 in osteoclasts.","volume":"37","author":"MA Khadeer","year":"2005","journal-title":"Bone"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1359\/jbmr.051002","article-title":"Molecular genetic studies of gene identification for osteoporosis: a 2004 update.","volume":"21","author":"YJ Liu","year":"2006","journal-title":"J Bone Miner Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1359\/jbmr.090724","article-title":"Gene expression profiling in monocytes and SNP association suggest the importance of the STAT1 gene for osteoporosis in both Chinese and Caucasians.","volume":"25","author":"XD Chen","year":"2010","journal-title":"J Bone Miner Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1055\/s-2002-38250","article-title":"Differential gene expression between visceral and subcutaneous fat depots.","volume":"34","author":"G Atzmon","year":"2002","journal-title":"Horm Metab Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1194\/jlr.M300256-JLR200","article-title":"Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women.","volume":"45","author":"K Linder","year":"2004","journal-title":"J Lipid Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0034641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T11:18:12Z","timestamp":1641986292000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0034641"}},"subtitle":[],"editor":[{"given":"Qingyang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,10]]},"references-count":64,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0034641","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,10]]}}}