{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:23:56Z","timestamp":1790843036369,"version":"4.1.0"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0034757","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T20:19:26Z","timestamp":1335298766000},"page":"e34757","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":66,"title":["A 6 Week Randomized Double-Blind Placebo-Controlled Trial of Ziprasidone for the Acute Depressive Mixed State"],"prefix":"10.1371","volume":"7","clinical-trial-number":[{"clinical-trial-number":"nct00490542","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Ashwin","family":"Patkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Gilmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-un","family":"Pae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"V\u00f6hringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ziffra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Pirok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Filkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Whitham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niki S.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sairah B.","family":"Thommi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Logvinenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Loebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Masand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Nassir","family":"Ghaemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/10673220216283","article-title":"Weygandt\u2019s On the Mixed States of Manic-Depressive Insanity: a translation and commentary on its significance in the evolution of the concept of bipolar disorder.","volume":"10","author":"P Salvatore","year":"2002","journal-title":"Harv Rev Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/10673220500174833","article-title":"Manic-depressive illness: evolution in Kraepelin\u2019s Textbook, 1883\u20131926.","volume":"13","author":"K Trede","year":"2005","journal-title":"Harv Rev Psychiatry"},{"key":"ref3","first-page":"3","article-title":"Diagnostic revisions for DSM-IV.","author":"D Dunner","year":"1998"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1176\/ajp.149.12.1633","article-title":"Clinical and research implications of the diagnosis of dysphoric or mixed mania or hypomania.","volume":"149","author":"SL McElroy","year":"1992","journal-title":"Am J Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1034\/j.1399-5618.2000.020405.x","article-title":"Depression, mania, and feeling bad: the role of dysphoria in mixed states.","volume":"2","author":"AC Swann","year":"2000","journal-title":"Bipolar Disord"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/15622970410029919","article-title":"Validating Kraepelin\u2019s two types of depressive mixed states: \u201cdepression with flight of ideas\u201d and \u201cexcited depression\u201d.","volume":"5","author":"HS Akiskal","year":"2004","journal-title":"World J Biol Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1046\/j.1440-1819.2001.00919.x","article-title":"Depressive mixed state: testing different definitions.","volume":"55","author":"F Benazzi","year":"2001","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0193-953X(05)70095-2","article-title":"Agitated depression as a mixed state and the problem of melancholia.","volume":"22","author":"A Koukopoulos","year":"1999","journal-title":"Psychiatr Clin North Am"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-0327(97)01446-8","article-title":"Clinical subtypes of bipolar mixed states: validating a broader European definition in 143 cases.","volume":"43","author":"G Perugi","year":"1997","journal-title":"J Affect Disord"},{"key":"ref10","article-title":"Structured Clinical Interview for DSM-IV Axis I Disorders \u2013 Patient Edition (SCID I-P, Version 2.0).","author":"M First","year":"1995"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00004850-199510030-00004","article-title":"Structural validity of MADRS during antidepressant treatment.","volume":"10","author":"A Galinowski","year":"1995","journal-title":"Int Clin Psychopharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: Reliability, validity, and sensitivity.","volume":"133","author":"RC Young","year":"1978","journal-title":"Br J Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0165-1781(97)00123-6","article-title":"Modification of the Clinical Global Impressions (CGI) scale for use in bipolar illness (BP): the CGI-BP.","volume":"73","author":"MK Spearing","year":"1997","journal-title":"Psychiatry Research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1192\/bjp.166.5.654","article-title":"A brief mental health outcome scale-reliability and validity of the Global Assessment of Functioning (GAF).","volume":"166","author":"SH Jones","year":"1995","journal-title":"Br J Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/0269881103174013","article-title":"The Barnes Akathisia Rating Scale\u2013revisited.","volume":"17","author":"TR Barnes","year":"2003","journal-title":"J Psychopharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0447.1970.tb02066.x","article-title":"A rating scale for extrapyramidal side effects.","volume":"Scand","author":"GM Simpson","year":"1970","journal-title":"Acta Psychiatr"},{"key":"ref17","article-title":"Manic Depressive Illness, 2nd edition.","author":"F Goodwin","year":"2007"},{"key":"ref18","first-page":"101","article-title":"Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity.","volume":"275","author":"TF Seeger","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"ref19","article-title":"(In press)) Efficacy and safety of adjunctive oral ziprasidone for acute treatment of depression in patients with bipolar I disorder Journal of Clinical Psychiatry","author":"G Sachs","year":"2010"},{"key":"ref20","article-title":"Sachs G, Lombardo I, Yang R, Kremer C. Lessons From the Ziprasidone Bipolar Depression Program; 2009 Jun 29\u2013Jul 2, 2009; Hollywood, FL"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.eurpsy.2007.07.003","article-title":"Reviewing the diagnostic validity and utility of mixed depression (depressive mixed states).","volume":"23","author":"F Benazzi","year":"2008","journal-title":"Eur Psychiatry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1176\/appi.ajp.161.7.1264","article-title":"The mood spectrum in unipolar and bipolar disorder: arguments for a unitary approach.","volume":"161","author":"GB Cassano","year":"2004","journal-title":"Am J Psychiatry"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0034757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:30:03Z","timestamp":1588962603000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0034757"}},"subtitle":[],"editor":[{"given":"Marianna","family":"Mazza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,24]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0034757","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,24]]}}}