{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:16:37Z","timestamp":1791270997153,"version":"4.1.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T00:00:00Z","timestamp":1333497600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0034772","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T21:08:03Z","timestamp":1333573683000},"page":"e34772","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Contribution by Polymorphonucleate Granulocytes to Elevated Gamma-Glutamyltransferase in Cystic Fibrosis Sputum"],"prefix":"10.1371","volume":"7","author":[{"given":"Alessandro","family":"Corti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Franzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Cianchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Bergamini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Lorenzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Melotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Paolicchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Paggiaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Pompella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/S0891-5849(01)00530-5","article-title":"Rethinking cystic fibrosis pathology: the critical role of abnormal reduced glutathione (GSH) transport caused by CFTR mutation.","volume":"30","author":"VM Hudson","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2006.09.022","article-title":"Antioxidants in cystic fibrosis. Conclusions from the CF antioxidant workshop, Bethesda, Maryland, November 11\u201312, 2003.","volume":"42","author":"AM Cantin","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"C323","DOI":"10.1152\/ajpcell.1998.275.1.C323","article-title":"Glutathione permeability of CFTR.","volume":"275","author":"P Linsdell","year":"1998","journal-title":"Am J Physiol"},{"key":"ref4","first-page":"L113","article-title":"Abnormal glutathione transport in cystic fibrosis airway epithelia.","volume":"277","author":"L Gao","year":"1999","journal-title":"Am J Physiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.prrv.2007.02.004","article-title":"Mucus structure and properties in cystic fibrosis.","volume":"8","author":"BK Rubin","year":"2007","journal-title":"Paediatr Respir Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/09629359990658","article-title":"Inflammation and CFTR: might neutrophils be the key in cystic fibrosis?","volume":"8","author":"V Witko-Sarsat","year":"1999","journal-title":"Mediators Inflamm"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1378\/chest.07-1631","article-title":"Airway inflammation in cystic fibrosis.","volume":"133","author":"A Elizur","year":"2008","journal-title":"Chest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1152\/jappl.1993.75.6.2419","article-title":"Systemic deficiency of glutathione in cystic fibrosis.","volume":"75","author":"JH Roum","year":"1993","journal-title":"J Appl Physiol"},{"key":"ref9","first-page":"571","article-title":"Subcellular localization of enzymes involved in leukotriene formation within human polymorphonuclear granulocytes.","volume":"51","author":"J Brom","year":"1984","journal-title":"Immunology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/bj3230477","article-title":"S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase.","volume":"323","author":"N Hogg","year":"1997","journal-title":"Biochem J"},{"key":"ref11","first-page":"1169","article-title":"Gamma-glutamyltransferase of Cancer Cells at the Crossroads of Tumor Progression, Drug Resistance and Drug Targeting.","volume":"30","author":"A Corti","year":"2010","journal-title":"Anticancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1089\/ars.2005.7.911","article-title":"The S-thiolating activity of membrane gammaglutamyltransferase: formation of cysteinyl-glycine mixed disulfides with cellular proteins and in the cell microenvironment.","volume":"7","author":"A Corti","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1165\/ajrcmb.11.5.7946387","article-title":"gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells.","volume":"11","author":"A Kugelman","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0891-5849(96)00375-9","article-title":"Increase in gamma-glutamyltransferase by glutathione depletion in rat type II pneumocytes.","volume":"22","author":"RJ van Klaveren","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/thx.52.6.557","article-title":"Pulmonary oxidative stress response in young children with cystic fibrosis.","volume":"52","author":"J Hull","year":"1997","journal-title":"Thorax"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1165\/rcmb.2008-0013OC","article-title":"Effects of Azithromycin (AZM) on Glutathione-S-Transferases (GST)s in Cystic Fibrosis Airway Cells.","volume":"41","author":"G Bergamini","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF01680457","article-title":"Cytochemistry of gamma-glutamyltransferase in haemic cells and malignancies.","volume":"19","author":"MR Khalaf","year":"1987","journal-title":"Histochem J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/intimm\/11.11.1791","article-title":"Gamma-glutamyl transpeptidase is up-regulated on memory T lymphocytes.","volume":"11","author":"DR Karp","year":"1999","journal-title":"Int Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ajh.2830210308","article-title":"Determination of ectoenzyme activities in leukemic cells and in established hematopoietic cell lines.","volume":"21","author":"A Morell","year":"1986","journal-title":"Am J Hematol"},{"key":"ref20","first-page":"135","article-title":"Metabolism of leukotrienes by L-gamma-glutamyl-transpeptidase and dipeptidase from human polymorphonuclear granulocytes.","volume":"55","author":"M Raulf","year":"1985","journal-title":"Immunology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1183\/09031936.04.00139503","article-title":"Granulocyte markers in hypertonic and isotonic saline-induced sputum of asthmatic subjects.","volume":"24","author":"S Cianchetti","year":"2004","journal-title":"Eur Respir J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.4049\/jimmunol.163.8.4564","article-title":"Ectosomes released by human neutrophils are specialized functional units.","volume":"163","author":"C Hess","year":"1999","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0022-1759(99)00171-4","article-title":"Subcellular fractionation of human neutrophils on Percoll density gradients.","volume":"232","author":"L Kjeldsen","year":"1999","journal-title":"J Immunol Methods"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ab.2007.10.025","article-title":"A high performance gel-filtration chromatography method for gammaglutamyltransferase fraction analysis.","volume":"374","author":"M Franzini","year":"2008","journal-title":"Anal Biochem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cca.2008.06.005","article-title":"Fractions of plasma gamma-glutamyltransferase in healthy individuals: reference values.","volume":"395","author":"M Franzini","year":"2008","journal-title":"Clin Chim Acta"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1165\/ajrcmb\/4.4.313","article-title":"A cystic fibrosis bronchial epithelial cell line: immortalization by adeno-12-SV40 infection.","volume":"4","author":"PL Zeitlin","year":"1991","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/jnci\/51.5.1417","article-title":"In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.","volume":"51","author":"DJ Giard","year":"1973","journal-title":"J Natl Cancer Inst"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1177\/44.10.8813074","article-title":"Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissue.","volume":"44","author":"MH Hanigan","year":"1996","journal-title":"J Histochem Cytochem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/00365517409049892","article-title":"Practical points regarding routine determination of gamma-glutamyl transferase (gamma-GT) in serum with a kinetic method at 37 degrees C.","volume":"34","author":"NE Huseby","year":"1974","journal-title":"Scand J Clin Lab Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.freeradbiomed.2004.07.027","article-title":"Reevaluating gel-forming mucins' roles in cystic fibrosis lung disease.","volume":"37","author":"J Perez-Vilar","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1189\/jlb.1204697","article-title":"Myeloperoxidase: friend and foe.","volume":"77","author":"SJ Klebanoff","year":"2005","journal-title":"J Leukoc Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0009-8981(92)90330-S","article-title":"Characterization of the carbohydrate moiety of human gamma-glutamyltransferases using lectin-blotting and glycosidase treatment.","volume":"209","author":"G Evjen","year":"1992","journal-title":"Clin Chim Acta"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"14219","DOI":"10.1016\/S0021-9258(17)36777-7","article-title":"Synthesis and release of amphipathic gamma-glutamyl transferase by the pulmonary alveolar type 2 cell. Its redistribution throughout the gas exchange portion of the lung indicates a new role for surfactant.","volume":"269","author":"M Joyce-Brady","year":"1994","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1023\/A:1007092529261","article-title":"Alveolar type II cell abnormalities and peroxide formation in lungs of rats given IL-1 intratracheally.","volume":"24","author":"BM Hybertson","year":"2000","journal-title":"Inflammation"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1161\/01.CIR.0000120558.41356.E6","article-title":"Images in cardiovascular medicine. Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity.","volume":"109","author":"A Paolicchi","year":"2004","journal-title":"Circulation"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1164\/ajrccm.152.2.7633718","article-title":"Increased degranulation of eosinophil and neutrophil granulocytes in cystic fibrosis.","volume":"152","author":"DY Koller","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tcb.2008.11.003","article-title":"Shedding microvesicles: artefacts no more.","volume":"19","author":"E Cocucci","year":"2009","journal-title":"Trends Cell Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1182\/blood-2004-01-0361","article-title":"Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis.","volume":"104","author":"O Gasser","year":"2004","journal-title":"Blood"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0034772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T20:21:59Z","timestamp":1713817319000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0034772"}},"subtitle":[],"editor":[{"given":"Dominik","family":"Hartl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,4]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0034772","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,4]]}}}