{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:33:30Z","timestamp":1770435210873,"version":"3.49.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T00:00:00Z","timestamp":1334534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0034912","type":"journal-article","created":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T20:54:42Z","timestamp":1334609682000},"page":"e34912","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Identification of JAK2 as a Mediator of FIP1L1-PDGFRA-Induced Eosinophil Growth and Function in CEL"],"prefix":"10.1371","volume":"7","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangsen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faqing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingchen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuchu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaojun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.","volume":"348","author":"J Cools","year":"2003","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1182\/blood-2003-01-0006","article-title":"Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness.","volume":"101","author":"AD Klion","year":"2003","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/leu.2008.310","article-title":"The molecular anatomy of the FIP1L1-PDGFRA fusion gene.","volume":"23","author":"C Walz","year":"2009","journal-title":"Leukemia"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1038\/leu.2008.287","article-title":"Five years since the discovery of FIP1L1-PDGFRA: what we have learned about the fusion and other molecularly defined eosinophilias.","volume":"22","author":"J Gotlib","year":"2008","journal-title":"Leukemia"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1158\/0008-5472.CAN-06-4183","article-title":"Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation.","volume":"67","author":"M Buitenhuis","year":"2007","journal-title":"Cancer Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1074\/jbc.M807489200","article-title":"FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem\/progenitor cells.","volume":"284","author":"K Fukushima","year":"2009","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbrc.2007.12.063","article-title":"Mechanisms for the proliferation of eosinophilic leukemia cells by FIP1L1-PDGFRalpha.","volume":"366","author":"K Ishihara","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1021\/pr100836p","article-title":"Comparative proteomic analysis of blood eosinophils reveals redox signaling modifications in patients with FIP1L1-PDGFRA-associated chronic eosinophilic leukemia.","volume":"10","author":"JE Kahn","year":"2011","journal-title":"J Proteome Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.exphem.2008.04.017","article-title":"Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha.","volume":"36","author":"C Baumgartner","year":"2008","journal-title":"Exp Hematol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1177\/1947601910372232","article-title":"Destabilization of Bcr-Abl\/Jak2 Network by a Jak2\/Abl Kinase Inhibitor ON044580 Overcomes Drug Resistance in Blast Crisis Chronic Myelogenous Leukemia (CML).","volume":"1","author":"AK Samanta","year":"2010","journal-title":"Genes Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1038\/onc.2009.7","article-title":"Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients.","volume":"28","author":"AK Samanta","year":"2009","journal-title":"Oncogene"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1002\/eji.200635943","article-title":"cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis.","volume":"36","author":"EM Vassina","year":"2006","journal-title":"Eur J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e14676","DOI":"10.1371\/journal.pone.0014676","article-title":"Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor.","volume":"6","author":"J Putters","year":"2011","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1358\/dnp.2005.18.4.908658","article-title":"JAK\/STAT-dependent gene regulation by cytokines.","volume":"18","author":"D Hebenstreit","year":"2005","journal-title":"Drug News Perspect"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/jcb.22069","article-title":"JAK pathway induction of c-Myc critical to IL-5 stimulation of cell proliferation and inhibition of apoptosis.","volume":"106","author":"WH Lee","year":"2009","journal-title":"J Cell Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1182\/blood-2005-08-3153","article-title":"The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)\/chronic eosinophilic leukemia (CEL)-like disease.","volume":"107","author":"Y Yamada","year":"2006","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.4049\/jimmunol.159.8.4024","article-title":"Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor.","volume":"159","author":"J Monahan","year":"1997","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1182\/blood-2009-03-209262","article-title":"The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes.","volume":"114","author":"JW Vardiman","year":"2009","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-197501000-00001","article-title":"The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature.","volume":"54","author":"MJ Chusid","year":"1975","journal-title":"Medicine (Baltimore)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1182\/blood-2003-07-2479","article-title":"The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.","volume":"103","author":"J Cools","year":"2004","journal-title":"Blood"},{"key":"ref21","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.","volume":"97","author":"A Boyum","year":"1968","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e23720","DOI":"10.1371\/journal.pone.0023720","article-title":"Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK\/ERK\/JNK and JAK2\/STAT3\/AKT signalings.","volume":"6","author":"J Zhu","year":"2011","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0022-1759(85)90242-X","article-title":"Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors.","volume":"83","author":"M Strath","year":"1985","journal-title":"J Immunol Methods"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e12165","DOI":"10.1371\/journal.pone.0012165","article-title":"JAK2 exon 14 deletion in patients with chronic myeloproliferative neoplasms.","volume":"5","author":"W Ma","year":"2010","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e22148","DOI":"10.1371\/journal.pone.0022148","article-title":"JAK2 V617F-dependent upregulation of PU.1 expression in the peripheral blood of myeloproliferative neoplasm patients.","volume":"6","author":"T Irino","year":"2011","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ejphar.2007.12.024","article-title":"The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.","volume":"582","author":"E Kudlacz","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1111\/j.1349-7006.2009.01283.x","article-title":"Triptolide abrogates oncogene FIP1L1-PDGFRalpha addiction and induces apoptosis in hypereosinophilic syndrome.","volume":"100","author":"Y Jin","year":"2009","journal-title":"Cancer Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/sj.leu.2404714","article-title":"The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha-expressing cells through caspase-3-mediated cleavage of Mcl-1.","volume":"21","author":"J Pan","year":"2007","journal-title":"Leukemia"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.leukres.2006.07.011","article-title":"Imatinib-induced apoptosis in the eosinophils of patients with a hypereosinophilic syndrome: a surrogate marker of response?","volume":"31","author":"V Pitini","year":"2007","journal-title":"Leuk Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/leu.2010.23","article-title":"JAK2 mutation and disease phenotype: a double L611V\/V617F in cis mutation of JAK2 is associated with isolated erythrocytosis and increased activation of AKT and ERK1\/2 rather than STAT5.","volume":"24","author":"C Cleyrat","year":"2010","journal-title":"Leukemia"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/sj.leu.2403266","article-title":"TEL-Syk fusion constitutively activates PI3-K\/Akt, MAPK and JAK2-independent STAT5 signal pathways.","volume":"18","author":"T Kanie","year":"2004","journal-title":"Leukemia"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ccr.2009.10.015","article-title":"The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.","volume":"16","author":"M Hedvat","year":"2009","journal-title":"Cancer Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.leukres.2005.11.011","article-title":"FIP1L1-PDGFRA in eosinophilic disorders: prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature.","volume":"30","author":"A Pardanani","year":"2006","journal-title":"Leuk Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1038\/sj.leu.2404977","article-title":"The severity of FIP1L1-PDGFRA-positive chronic eosinophilic leukaemia is associated with polymorphic variation at the IL5RA locus.","volume":"21","author":"S Burgstaller","year":"2007","journal-title":"Leukemia"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3109\/10428194.2010.534210","article-title":"Concomitant FIP1L1-PDGFRA fusion gene and T-cell clonality in a case of chronic eosinophilic leukemia with clonal evolution and an incomplete response to imatinib.","volume":"52","author":"K Burbury","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"ref36","first-page":"17","article-title":"Cell clonality in hypereosinophilic syndrome: what pathogenetic role?","volume":"25","author":"S Galimberti","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000312134","article-title":"FIP1L1\/PDGFR alpha-associated systemic mastocytosis.","volume":"152","author":"Y Yamada","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1365-2222.2003.01585.x","article-title":"Tumour necrosis factor-alpha-induced expression of intercellular adhesion molecule-1 on human eosinophilic leukaemia EoL-1 cells is mediated by the activation of nuclear factor-kappaB pathway.","volume":"33","author":"WK Ip","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1007\/s11033-009-9687-z","article-title":"Leukotactin-1\/CCL15 induces cell migration and differentiation of human eosinophilic leukemia EoL-1 cells through PKCdelta activation.","volume":"37","author":"JS Lee","year":"2010","journal-title":"Mol Biol Rep"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cyto.2009.07.008","article-title":"The roles of MCP-1 and protein kinase C delta activation in human eosinophilic leukemia EoL-1 cells.","volume":"48","author":"JS Lee","year":"2009","journal-title":"Cytokine"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/leu.2008.26","article-title":"Contributions of the Raf\/MEK\/ERK, PI3K\/PTEN\/Akt\/mTOR and Jak\/STAT pathways to leukemia.","volume":"22","author":"LS Steelman","year":"2008","journal-title":"Leukemia"},{"key":"ref42","article-title":"PI3-Kinase Regulates Eosinophil and Neutrophil Degranulation in Patients with Allergic Rhinitis and Allergic Asthma Irrespective of Allergen Challenge Model.","author":"M Kampe","year":"2011","journal-title":"Inflammation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"516","DOI":"10.4049\/jimmunol.1000955","article-title":"Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils.","volume":"186","author":"Y Zhu","year":"2011","journal-title":"J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cytogfr.2009.11.005","article-title":"Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer.","volume":"21","author":"SI Grivennikov","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref45","article-title":"Dual inhibition of Jak2 and STAT5 enhances killing of myeloproliferative neoplasia cells.","author":"M Bar-Natan","year":"2011","journal-title":"Leukemia"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0034912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T09:07:43Z","timestamp":1713863263000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0034912"}},"subtitle":[],"editor":[{"given":"Kevin D.","family":"Bunting","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,16]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0034912","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,16]]}}}