{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:49:50Z","timestamp":1791618590133,"version":"4.3.4"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0035535","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T21:13:56Z","timestamp":1334956436000},"page":"e35535","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["IL-6 and Mouse Oocyte Spindle"],"prefix":"10.1371","volume":"7","author":[{"given":"Jashoman","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiman","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husam M.","family":"Abu-Soud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/ar1917","article-title":"Interleukin-6 and chronic inflammation.","volume":"8","author":"C Gabay","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.18553\/jmcp.2011.17.s9-b.S14","article-title":"Biologic agents in rheumatoid arthritis: an update for managed care professionals.","volume":"17","author":"SK Agarwal","year":"2011","journal-title":"J Manag Care Pharm"},{"key":"ref3","article-title":"Neuropathologic evidence of endothelial changes in cerebral small vessel disease.","author":"MO Giwa","year":"2012","journal-title":"Neurology"},{"key":"ref4","article-title":"Role of Interleukin 6 and Alpha-Globulins in Differentiating Alzheimer and Vascular Dementias.","author":"AA Helmy","year":"2012","journal-title":"Neurodegener Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S0002-9378(99)70329-7","article-title":"The association of interleukin 6 with clinical and laboratory parameters of acute pelvic inflammatory disease.","volume":"181","author":"HE Richter","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1600-0897.2009.00734.x","article-title":"Serum IL-6 level may have role in the pathophysiology of unexplained infertility.","volume":"62","author":"B Demir","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"ref7","first-page":"1118","article-title":"Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosis.","volume":"81","author":"JF Tseng","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/j.1600-0412.2011.01161.x","article-title":"Deep pelvic endometriosis negatively affects ovarian reserve and the number of oocytes retrieved for in vitro fertilization.","volume":"90","author":"E Papaleo","year":"2011","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/AOG.0b013e31822adfd1","article-title":"Clinical management of endometriosis.","volume":"118","author":"T Falcone","year":"2011","journal-title":"Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1242\/dev.113.2.551","article-title":"The origin of reactive oxygen species in mouse embryos cultured in vitro.","volume":"113","author":"MM Nasr-Esfahani","year":"1991","journal-title":"Development"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0891-5849(98)00216-0","article-title":"Mitochondrial damage induced by conditions of oxidative stress.","volume":"26","author":"AJ Kowaltowski","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/humrep\/13.4.998","article-title":"Detection of reactive oxygen species (ROS) and apoptosis in human fragmented embryos.","volume":"13","author":"HW Yang","year":"1998","journal-title":"Hum Reprod"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/mrd.20180","article-title":"Association of female aging with decreased parthenogenetic activation, raised MPF, and MAPKs activities and reduced levels of glutathione S-transferases activity and thiols in mouse oocytes.","volume":"69","author":"JJ Tarin","year":"2004","journal-title":"Mol Reprod Dev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1095\/biolreprod59.2.431","article-title":"Glutathione is present in reproductive tract secretions and improves development of mouse embryos after chemically induced glutathione depletion.","volume":"59","author":"CS Gardiner","year":"1998","journal-title":"Biol Reprod"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.freeradbiomed.2007.11.014","article-title":"Reactive oxygen species and oocyte aging: role of superoxide, hydrogen peroxide, and hypochlorous acid.","volume":"44","author":"AP Goud","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1056\/NEJM198803173181104","article-title":"Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis.","volume":"318","author":"JL Mills","year":"1988","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"11366","DOI":"10.1021\/bi060910e","article-title":"Activation of the cGMP signaling pathway is essential in delaying oocyte aging in diabetes mellitus.","volume":"45","author":"AP Goud","year":"2006","journal-title":"Biochemistry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000049424","article-title":"Endometriosis and oocyte quality.","volume":"53","author":"H Saito","year":"2002","journal-title":"Gynecol Obstet Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1472-6483(10)60497-X","article-title":"Spindles, mitochondria and redox potential in ageing oocytes.","volume":"8","author":"U Eichenlaub-Ritter","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/abbi.1998.0761","article-title":"Association between oxidative stress and cytokine production in nickel-treated rats.","volume":"356","author":"CY Chen","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0954-6111(98)90195-0","article-title":"Effect of hyperoxia on human macrophage cytokine response.","volume":"92","author":"P Desmarquest","year":"1998","journal-title":"Respir Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/cyto.2000.0789","article-title":"Chemioxyexcitation (delta pO2\/ROS)-dependent release of IL-1 beta, IL-6 and TNF-alpha: evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium.","volume":"13","author":"JJ Haddad","year":"2001","journal-title":"Cytokine"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.urology.2004.05.045","article-title":"Relationship of interleukin-6 with semen characteristics and oxidative stress in patients with varicocele.","volume":"64","author":"KP Nallella","year":"2004","journal-title":"Urology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/15362300260339557","article-title":"Spindle observation in living mammalian oocytes with the polarization microscope and its practical use.","volume":"4","author":"WH Wang","year":"2002","journal-title":"Cloning Stem Cells"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.fertnstert.2009.09.043","article-title":"Endometriosis-induced alterations in mouse metaphase II oocyte microtubules and chromosomal alignment: a possible cause of infertility.","volume":"94","author":"G Mansour","year":"2010","journal-title":"Fertil Steril"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.fertnstert.2007.02.067","article-title":"Oxidative stress and tumor necrosis factor-alpha-induced alterations in metaphase II mouse oocyte spindle structure.","volume":"88","author":"WJ Choi","year":"2007","journal-title":"Fertil Steril"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jvs.2010.04.085","article-title":"Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells.","volume":"52","author":"WJ Lee","year":"2010","journal-title":"J Vasc Surg"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.freeradbiomed.2010.05.019","article-title":"Differential inflammatory responses in aging and disease: TNF-alpha and IL-6 as possible biomarkers.","volume":"49","author":"D de Gonzalo-Calvo","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1600-079X.2010.00821.x","article-title":"Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-kappaB and Nrf2 cascades.","volume":"50","author":"G Negi","year":"2011","journal-title":"J Pineal Res"},{"key":"ref30","first-page":"2665","article-title":"Combined treatment with antioxidants and immunosuppressants on cytokine release by human peripheral blood mononuclear cells - chemically injured keratocyte reaction.","volume":"17","author":"K Yi","year":"2011","journal-title":"Mol Vis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12263-010-0195-5","article-title":"Lycopene inhibits IL-6 expression in cerulein-stimulated pancreatic acinar cells.","volume":"6","author":"M Kang","year":"2011","journal-title":"Genes Nutr"},{"key":"ref32","author":"J Banerjee","year":"2012"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0002-9378(97)70553-2","article-title":"Increased interleukin-6 levels in peritoneal fluid of infertile patients with active endometriosis.","volume":"176","author":"T Harada","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.fertnstert.2005.11.060","article-title":"Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis.","volume":"85","author":"CM Kyama","year":"2006","journal-title":"Fertil Steril"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/S0002-9378(96)70600-2","article-title":"Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis.","volume":"174","author":"J Punnonen","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0015-0282(99)00466-5","article-title":"Vascular endothelial growth factor and interleukin-6 in peritoneal fluid of women with endometriosis.","volume":"73","author":"JL Mahnke","year":"2000","journal-title":"Fertil Steril"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1189\/jlb.1105674","article-title":"Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.","volume":"80","author":"S Rose-John","year":"2006","journal-title":"J Leukoc Biol"},{"key":"ref38","article-title":"Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro.","author":"JJ Bromfield","year":"2011","journal-title":"Endocrinology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.fertnstert.2008.02.097","article-title":"L-carnitine supplementation reduces oocyte cytoskeleton damage and embryo apoptosis induced by incubation in peritoneal fluid from patients with endometriosis.","volume":"91","author":"G Mansour","year":"2009","journal-title":"Fertil Steril"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/bjc.1995.482","article-title":"Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock.","volume":"72","author":"BK Winter","year":"1995","journal-title":"Br J Cancer"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/humupd\/6.1.67","article-title":"Follicular hormonal environment and embryo quality in women with endometriosis.","volume":"6","author":"N Garrido","year":"2000","journal-title":"Hum Reprod Update"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0015-0282(98)00204-0","article-title":"The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production.","volume":"70","author":"A Pellicer","year":"1998","journal-title":"Fertil Steril"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1210\/en.2008-1532","article-title":"Interleukin-6: an autocrine regulator of the mouse cumulus cell-oocyte complex expansion process.","volume":"150","author":"Z Liu","year":"2009","journal-title":"Endocrinology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/infdis\/174.3.647","article-title":"Analysis of lymphocyte phenotype and cytokine activity in the inflammatory infiltrates of the upper genital tract of female macaques infected with Chlamydia trachomatis.","volume":"174","author":"WC Van Voorhis","year":"1996","journal-title":"J Infect Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.fertnstert.2007.07.1379","article-title":"The effect of interleukin-6 on ciliary beat frequency in the human fallopian tube.","volume":"90","author":"A Papathanasiou","year":"2008","journal-title":"Fertil Steril"}],"updated-by":[{"DOI":"10.1371\/annotation\/947afede-1969-4061-a535-164655e9de72","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T00:00:00Z","timestamp":1337212800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0035535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T16:01:09Z","timestamp":1713888069000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0035535"}},"subtitle":[],"editor":[{"given":"Pierre","family":"Bob\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,20]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0035535","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,20]]}}}