{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:40:06Z","timestamp":1773060006359,"version":"3.50.1"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:00:00Z","timestamp":1335484800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0035632","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T17:21:26Z","timestamp":1335547286000},"page":"e35632","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Promyelocytic Leukemia Zinc Finger Protein Activates GATA4 Transcription and Mediates Cardiac Hypertrophic Signaling from Angiotensin II Receptor 2"],"prefix":"10.1371","volume":"7","author":[{"given":"Ning","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald D.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronghua","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongjia","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amita","family":"Rachakonda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Paolo","family":"Pandolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Senbonmatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin J.","family":"Landon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Inagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,4,27]]},"reference":[{"key":"ref1","first-page":"415","article-title":"de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T( 2000) International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev.","volume":"52"},{"key":"ref2","first-page":"958","article-title":"The angiotensin II type 2 (AT<sub>2<\/sub>) receptor: an enigmatic seven transmembrane receptor. Front Biosci.","volume":"14","author":"ER Porrello","year":"2009"},{"key":"ref3","first-page":"C8297","article-title":"Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol.","volume":"292","author":"PK Mehta","year":"2007"},{"key":"ref4","first-page":"499","article-title":"Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol.","volume":"6","author":"Y Zou","year":"2004"},{"key":"ref5","first-page":"1952","article-title":"Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice. Circulation.","volume":"97","author":"K Harada","year":"1998"},{"key":"ref6","article-title":"Acute pressure overload could induce hypertrophic responses in the heart of angiotensin II type 1a knockout mice. Circ Res.","volume":"779\u2013785","author":"K Harada","year":"1998","journal-title":"82,"},{"key":"ref7","first-page":"H868","article-title":"Pressure-overload hypertrophy is unabated in mice devoid of AT<sub>1a<\/sub> receptors. Am J Physiol.","volume":"274","author":"M Hamawaki","year":"1998"},{"key":"ref8","first-page":"24037","article-title":"Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice. J Biol Chem.","volume":"273","author":"S Kudoh","year":"1998"},{"key":"ref9","first-page":"346","article-title":"Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation.","volume":"104","author":"S Ichihara","year":"2001"},{"key":"ref10","first-page":"R25","article-title":"Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest.","volume":"106","author":"T Senbonmatsu","year":"2000"},{"key":"ref11","first-page":"17985","article-title":"Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A.","volume":"103","author":"SD Crowley","year":"2006"},{"key":"ref12","first-page":"1347","article-title":"The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy. Hypertension.","volume":"46","author":"A D\u2019Amore","year":"2005"},{"key":"ref13","first-page":"863","article-title":"Pivotal role of tyrosine phosphatase SHP-1 in AT<sub>2<\/sub> receptor-mediated apoptosis in rat fetal vascular smooth muscle cell. Cardiovasc Res.","volume":"49","author":"T Cui","year":"2001"},{"key":"ref14","first-page":"449","article-title":"Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase.","volume":"2)","author":"K Bedecs","year":"1997","journal-title":"Biochem J. 325 ( Pt"},{"key":"ref15","first-page":"6471","article-title":"A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. EMBO J.","volume":"22","author":"T Senbonmatsu","year":"2003"},{"key":"ref16","first-page":"3609","article-title":"All in the family: the BTB\/POZ, KRAB, and SCAN domains. Mol Cell Biol.","volume":"21","author":"T Collins","year":"2001"},{"key":"ref17","first-page":"166","article-title":"Plzf regulates limb and axial skeletal patterning. Nat Genet.","volume":"25","author":"M Barna","year":"2000"},{"key":"ref18","first-page":"653","article-title":"Essential role of Plzf in maintenance of spermatogonial stem cells. Nat Genet.","volume":"36","author":"JA Costoya","year":"2004"},{"key":"ref19","first-page":"925","article-title":"Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Oncogene.","volume":"18","author":"PL Yeyati","year":"1999"},{"key":"ref20","first-page":"9375","article-title":"Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expression. Mol Cell Biol.","volume":"23","author":"MJ McConnell","year":"2003"},{"key":"ref21","first-page":"6770","article-title":"Repression of kit expression by Plzf in germ cells. Mol Cell Biol.","volume":"27","author":"D Filipponi","year":"2007"},{"key":"ref22","first-page":"1355","article-title":"A novel signal transduction cascade involving direct physical interaction of the renin\/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res.","volume":"99","author":"JH Schefe","year":"2006"},{"key":"ref23","first-page":"757","article-title":"PLZF outreach: a finger in interferon\u2019s pie. Immunity.","volume":"30","author":"K Ozato","year":"2009"},{"key":"ref24","first-page":"802","article-title":"Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity. Immunity.","volume":"30","author":"D Xu","year":"2009"},{"key":"ref25","first-page":"771","article-title":"Understanding PLZF. Cell Cycle.","volume":"10","author":"M Kolesnichenko","year":"2011"},{"key":"ref26","first-page":"38949","article-title":"The zinc finger-containing transcription factors GATA-4,-5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. J Biol Chem.","volume":"275","author":"JD Molkentin","year":"2000"},{"key":"ref27","first-page":"4648","article-title":"The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Mol Cell Biol.","volume":"16","author":"D Durocher","year":"1996"},{"key":"ref28","first-page":"C1248","article-title":"Involvement of oxidants and AP-1 in angiotensin II-activated NFAT3 transcription factor. Am J Physiol Cell Physiol.","volume":"292","author":"VC Tu","year":"2007"},{"key":"ref29","first-page":"324","article-title":"Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med.","volume":"13","author":"CM Trivedi","year":"2007"},{"key":"ref30","first-page":"978","article-title":"A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell.","volume":"133","author":"T Ago","year":"2008"},{"key":"ref31","first-page":"1922","article-title":"Gene regulatory networks in the evolution and development of the heart. Science.","volume":"313","author":"EN Olson","year":"2006"},{"key":"ref32","first-page":"1937","article-title":"Sizing up the heart: development redux in disease. Genes Dev.","volume":"17","author":"EN Olson","year":"2003"},{"key":"ref33","first-page":"748","article-title":"Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature.","volume":"377","author":"T Ichiki","year":"1995"},{"key":"ref34","first-page":"326","article-title":"Alteration of angiotensin II receptor contents in hypertrophied hearts. Biochem Biophys Res Commun.","volume":"212","author":"N Fujii","year":"1995"},{"key":"ref35","first-page":"410","article-title":"GATA-4 gene organization and analysis of its promoter. Biol Pharm Bull.","volume":"29","author":"Y Ohara","year":"2006"},{"key":"ref36","first-page":"22447","article-title":"Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein. J Biol Chem.","volume":"272","author":"JY Li","year":"1997"},{"key":"ref37","first-page":"2933","article-title":"MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics.","volume":"21","author":"K Cartharius","year":"2005"},{"key":"ref38","first-page":"1079","article-title":"Roles of cardiac transcription factors in cardiac hypertrophy. Circ Res.","volume":"92","author":"H Akazawa","year":"2003"},{"key":"ref39","first-page":"2702","article-title":"Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev.","volume":"15","author":"F Charron","year":"2001"},{"key":"ref40","first-page":"2249","article-title":"Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. Proc Natl Acad Sci U S A.","volume":"92","author":"M Cook","year":"1995"},{"key":"ref41","first-page":"611","article-title":"Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression. J Mol Cell Cardiol.","volume":"34","author":"Q Liang","year":"2002"},{"key":"ref42","first-page":"837","article-title":"Cardiac-specific deletion of GATA4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ Res.","volume":"98","author":"T Oka","year":"2006"},{"key":"ref43","first-page":"559","article-title":"GAGA protein: a multi-faceted transcription factor. Biochem Cell Biol.","volume":"84","author":"NL Adkins","year":"2006"},{"key":"ref44","first-page":"250","article-title":"Combinatorial interactions regulating cardiac transcription. Dev Genet.","volume":"22","author":"D Durocher","year":"1998"},{"key":"ref45","first-page":"177","article-title":"GATA factors and transcriptional regulation of cardiac natriuretic peptide genes. Regul Pept.","volume":"128","author":"R Temsah","year":"2005"},{"key":"ref46","first-page":"28586","article-title":"Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes. J Biol Chem.","volume":"276","author":"C Morisco","year":"2001"},{"key":"ref47","first-page":"1182","article-title":"Pathophysiological Role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ Res.","volume":"83","author":"H Matsubara","year":"1998"},{"key":"ref48","first-page":"2355","article-title":"Angiotensin AT<sub>1<\/sub> receptor inhibition in pacing induced heart failure: effects on left ventricular myocardial collagen content and composition. J Mol Cell Cardiol.","volume":"30","author":"MJ Clair","year":"1998"},{"key":"ref49","first-page":"H2179","article-title":"Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice. Am J Physiol Heart Circ Physiol.","volume":"285","author":"X Yan","year":"2003"},{"key":"ref50","first-page":"175","article-title":"Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium. Basic Res Cardiol.","volume":"106","author":"T Hasin","year":"2011"},{"key":"ref51","first-page":"3759","article-title":"Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart.","volume":"Endocrinology.150","author":"Y Li","year":"2009"},{"key":"ref52","first-page":"887","article-title":"Mechanical stretch induces enhanced expression of angiotensin II receptor subtypes in neonatal rat cardiac myocytes.","volume":"Res.79","author":"K Kijima","year":"1996","journal-title":"Circ"},{"key":"ref53","first-page":"736","article-title":"Up-regulation of angiotensin II type 2 receptor in rat thoracic aorta by pressure overload. J Pharmacol Exp Ther.","volume":"308","author":"K Yayama","year":"2004"},{"key":"ref54","first-page":"1347","article-title":"The AT<sub>2<\/sub> receptor causes constitutive growth of cardiomyocytes and does not antagonize AT<sub>1<\/sub> receptor-mediated hypertrophy. Hypertension.","volume":"46","author":"A D\u2019Amore","year":"2005"},{"key":"ref55","first-page":"384390","article-title":"AT<sub>1<\/sub> and AT<sub>2<\/sub> receptor blockade and epinephrine release during insulin-induced hypoglycemia. Hypertension.","volume":"31","author":"RH Worck","year":"1998"},{"key":"ref56","first-page":"367","article-title":"Comparison of angiotensin II type-1 and type-2 receptor antagonists on angiotensin II-induced IP3 generation in cardiomyocytes. Gen pharmacol.","volume":"30","author":"V Goutsouliak","year":"1998"},{"key":"ref57","first-page":"7543","article-title":"Angiotensin II type 1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proc Natl Acad Sci U S A.","volume":"94","author":"TC Herzig","year":"1997"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0035632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T02:46:47Z","timestamp":1540349207000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0035632"}},"subtitle":[],"editor":[{"given":"Leon J.","family":"de Windt","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,27]]},"references-count":57,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0035632","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,27]]}}}