{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:41:44Z","timestamp":1792734104121,"version":"4.5.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0035675","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T21:12:39Z","timestamp":1334956359000},"page":"e35675","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Characterisation of Innate Fungal Recognition in the Lung"],"prefix":"10.1371","volume":"7","author":[{"given":"In\u00eas","family":"Faro-Trindade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet A.","family":"Willment","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Kerrigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Redelinghuys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabelo","family":"Hadebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delyth M.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naren","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Wainwright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk M.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon D.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-immunol-030409-101229","article-title":"Innate Antifungal Immunity: The Key Role of Phagocytes.","volume":"29","author":"GD Brown","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"ref2","article-title":"The role of Dectin-1 in the host defence against fungal infections.","author":"RA Drummond","year":"2011","journal-title":"Curr Opin Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.4049\/jimmunol.0804250","article-title":"Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus.","volume":"182","author":"JL Werner","year":"2009","journal-title":"J Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","article-title":"Recognition of microorganisms and activation of the immune response.","volume":"449","author":"R Medzhitov","year":"2007","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nri1528","article-title":"Immunoregulatory functions of surfactant proteins.","volume":"5","author":"JR Wright","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000272047","article-title":"Pulmonary surfactant: an immunological perspective.","volume":"25","author":"ZC Chroneos","year":"2010","journal-title":"Cell Physiol Biochem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1165\/ajrcmb.26.3.f227","article-title":"Distinct roles for lung collectins in pulmonary host defense.","volume":"26","author":"VL Shepherd","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0092-8674(03)00758-X","article-title":"By binding SIRPalpha or calreticulin\/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation.","volume":"115","author":"SJ Gardai","year":"2003","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nri1745","article-title":"Dectin-1: a signalling non-TLR pattern-recognition receptor.","volume":"6","author":"GD Brown","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1513\/pats.200701-018AW","article-title":"Immunomodulatory roles of surfactant proteins A and D: implications in lung disease.","volume":"4","author":"AM Pastva","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1128\/IAI.69.4.2037-2044.2001","article-title":"Interactions of surfactant proteins A and D with Saccharomyces cerevisiae and Aspergillus fumigatus.","volume":"69","author":"MJ Allen","year":"2001","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1128\/IAI.00243-06","article-title":"Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by surfactant protein D.","volume":"74","author":"M Lekkala","year":"2006","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ni1408","article-title":"Dectin-1 is required for beta-glucan recognition and control of fungal infection.","volume":"8","author":"PR Taylor","year":"2007","journal-title":"Nat Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/CMR.00055-08","article-title":"Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis.","volume":"22","author":"TR Dagenais","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1128\/IAI.65.8.3171-3179.1997","article-title":"Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages.","volume":"65","author":"T Madan","year":"1997","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1371\/journal.ppat.0010042","article-title":"The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus.","volume":"1","author":"C Steele","year":"2005","journal-title":"PLoS Pathog"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1462-5822.2006.00796.x","article-title":"Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2.","volume":"9","author":"K Luther","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.molimm.2010.02.027","article-title":"Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis.","volume":"47","author":"T Madan","year":"2010","journal-title":"Mol Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1067\/mai.2001.111591","article-title":"Pulmonary function response to EDTA, an additive in nebulized bronchodilators.","volume":"107","author":"MJ Asmus","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1513\/pats.200907-075AL","article-title":"Coping with Candida infections.","volume":"7","author":"SE Evans","year":"2010","journal-title":"Proc Am Thorac Soc"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1086\/315799","article-title":"Role of pulmonary surfactant protein D in innate defense against Candida albicans.","volume":"182","author":"BA van Rozendaal","year":"2000","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1165\/rcmb.2007-0045OC","article-title":"The lung responds to zymosan in a unique manner independent of toll-like receptors, complement, and dectin-1.","volume":"38","author":"MM Kelly","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1179\/096805103125001586","article-title":"Macrophage recognition of zymosan particles.","volume":"9","author":"DM Underhill","year":"2003","journal-title":"J Endotoxin Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1084\/jem.20082818","article-title":"Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.","volume":"206","author":"MJ Robinson","year":"2009","journal-title":"J Exp Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature08264","article-title":"Surface hydrophobin prevents immune recognition of airborne fungal spores.","volume":"460","author":"V Aimanianda","year":"2009","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1371\/journal.ppat.0010030","article-title":"Aspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific beta-Glucan Display.","volume":"1","author":"TM Hohl","year":"2005","journal-title":"PLoS Pathog"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1128\/IAI.71.6.3034-3042.2003","article-title":"Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates.","volume":"71","author":"B Philippe","year":"2003","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/eji.200838687","article-title":"Internalization of Dectin-1 terminates induction of inflammatory responses.","volume":"39","author":"P Hernanz-Falcon","year":"2009","journal-title":"Eur J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1128\/IAI.71.2.891-903.2003","article-title":"Phagocytosis and intracellular fate of Aspergillus fumigatus conidia in alveolar macrophages.","volume":"71","author":"O Ibrahim-Granet","year":"2003","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fmicb.2011.00096","article-title":"Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway.","volume":"2","author":"A Thywissen","year":"2011","journal-title":"Front Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.1096158","article-title":"Regulation of phagosome maturation by signals from toll-like receptors.","volume":"304","author":"JM Blander","year":"2004","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1000218","DOI":"10.1371\/journal.ppat.1000218","article-title":"Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis.","volume":"4","author":"SE Heinsbroek","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrmicro2128","article-title":"Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.","volume":"7","author":"RS Flannagan","year":"2009","journal-title":"Nature Reviews Microbiology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/eji.200737741","article-title":"Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.","volume":"38","author":"KM Dennehy","year":"2008","journal-title":"Eur J Immunol"},{"key":"ref35","article-title":"Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.","author":"SI Gringhuis","year":"2009","journal-title":"Nat Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature04926","article-title":"Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.","volume":"442","author":"O Gross","year":"2006","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4049\/jimmunol.182.2.1146","article-title":"Differential use of CARD9 by Dectin-1 in macrophages and dendritic cells.","volume":"182","author":"HS Goodridge","year":"2009","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1084\/jem.20021890","article-title":"Dectin-1 mediates the biological effects of beta-glucan.","volume":"197","author":"GD Brown","year":"2003","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1084\/jem.20020470","article-title":"Dectin-1 is a major beta-glucan receptor on macrophages.","volume":"296","author":"GD Brown","year":"2002","journal-title":"J Exp Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.physiol.63.1.521","article-title":"Surfactant proteins a and d and pulmonary host defense.","volume":"63","author":"E Crouch","year":"2001","journal-title":"Annu Rev Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000121454","article-title":"Surfactant collectins and innate immunity.","volume":"93","author":"HP Haagsman","year":"2008","journal-title":"Neonatology"},{"key":"ref42","first-page":"151","article-title":"Collectins and Pentraxins.","author":"U Kishore","year":"2007"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1128\/IAI.67.9.4563-4569.1999","article-title":"Binding of rat and human surfactant proteins A and D to Aspergillus fumigatus conidia.","volume":"67","author":"MJ Allen","year":"1999","journal-title":"Infect Immun"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.molimm.2009.03.019","article-title":"Therapeutic effects of recombinant forms of full-length and truncated human surfactant protein D in a murine model of invasive pulmonary aspergillosis.","volume":"46","author":"M Singh","year":"2009","journal-title":"Mol Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1073\/pnas.0805177106","article-title":"C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia.","volume":"106","author":"S Yamasaki","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature07405","article-title":"The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.","volume":"456","author":"SE Ewald","year":"2008","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1128\/IAI.00047-08","article-title":"Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA.","volume":"76","author":"ZG Ramirez-Ortiz","year":"2008","journal-title":"Infect Immun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"7614","DOI":"10.4049\/jimmunol.1002760","article-title":"TLR9 is actively recruited to Aspergillus fumigatus phagosomes and requires the N-terminal proteolytic cleavage domain for proper intracellular trafficking.","volume":"185","author":"PV Kasperkovitz","year":"2010","journal-title":"J Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.4049\/jimmunol.1000110","article-title":"Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus.","volume":"184","author":"WK Ip","year":"2010","journal-title":"J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.chom.2009.12.008","article-title":"Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion.","volume":"7","author":"T Shimada","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nprot.2007.8","article-title":"A method to enable the investigation of murine bronchial immune cells, their cytokines and mediators.","volume":"2","author":"JH Maxeiner","year":"2007","journal-title":"Nat Protoc"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.4049\/jimmunol.160.11.5514","article-title":"Nonopsonic and opsonic association of Mycobacterium tuberculosis with resident alveolar macrophages is inefficient.","volume":"160","author":"RW Stokes","year":"1998","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/eji.200324003","article-title":"Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo.","volume":"33","author":"PR Taylor","year":"2003","journal-title":"Eur J Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1128\/IAI.00233-09","article-title":"Complement C3 plays an essential role in the control of opportunistic fungal infections.","volume":"77","author":"SV Tsoni","year":"2009","journal-title":"Infect Immun"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1600-0854.2005.00304.x","article-title":"Maturation of Rhodococcus equi-containing vacuoles is arrested after completion of the early endosome stage.","volume":"6","author":"E Fernandez-Mora","year":"2005","journal-title":"Traffic"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jim.2006.05.013","article-title":"Soluble Dectin-1 as a tool to detect beta-glucans.","volume":"314","author":"LM Graham","year":"2006","journal-title":"J Immunol Methods"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0035675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T04:41:42Z","timestamp":1687408902000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0035675"}},"subtitle":[],"editor":[{"given":"Robert A.","family":"Cramer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,20]]},"references-count":56,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0035675","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,20]]}}}