{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:43:14Z","timestamp":1790476994248,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T00:00:00Z","timestamp":1338336000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0035772","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T21:45:20Z","timestamp":1338414320000},"page":"e35772","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["Glycans in Sera of Amyotrophic Lateral Sclerosis Patients and Their Role in Killing Neuronal Cells"],"prefix":"10.1371","volume":"7","author":[{"given":"Meital","family":"Edri-Brami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyamin","family":"Rosental","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Hayoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Welt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzhak","family":"Wirguin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Nefussy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian E.","family":"Drory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Porgador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel G.","family":"Lichtenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,5,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/0161-5890(91)90039-M","article-title":"Diversification of the IgG molecule by oligosaccharides.","volume":"28","author":"PM Rudd","year":"1991","journal-title":"Mol Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses.","volume":"8","author":"F Nimmerjahn","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev.immunol.25.022106.141702","article-title":"The impact of glycosylation on the biological function and structural of human immunoglobulins.","volume":"25","author":"JN Arnold","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.coi.2008.06.007","article-title":"Terminal sugars of Fc glycans influence antibody effector functions of IgGs.","volume":"20","author":"TS Raju","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0165-5728(84)90042-0","article-title":"Deposits of IgG and C3 in the spinal cord and motor cortex of ALS patients.","volume":"6","author":"H Donnenfeld","year":"1984","journal-title":"J. Neuroimmunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1001\/archneur.1990.00530110068019","article-title":"IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis.","volume":"47","author":"JI Engelhardt","year":"1990","journal-title":"Arch Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/jnr.10271","article-title":"Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons.","volume":"69","author":"HA Mohamed","year":"2002","journal-title":"J Neurosci Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/454284a","article-title":"Motor neuron disease: The curious ways of ALS.","volume":"454","author":"M Polymenidou","year":"2008","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1001\/archneur.1993.00540010026013","article-title":"Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis.","volume":"50","author":"JI Engelhardt","year":"1993","journal-title":"Arch Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1212\/WNL.57.7.1282","article-title":"Immune reactivity in a mouse model of familial ALS correlates with disease progression.","volume":"57","author":"ME Alexianu","year":"2001","journal-title":"Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/ana.10805","article-title":"Presence of dendritic cells, MCP-1 and activated microglia\/macrophages in amyotrophic lateral sclerosis spinal cord tissue.","volume":"55","author":"JS Henkel","year":"2004","journal-title":"Ann Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e2740","DOI":"10.1371\/journal.pone.0002740","article-title":"Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.","volume":"3","author":"R Banerjee","year":"2008","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15558","DOI":"10.1073\/pnas.0807419105","article-title":"CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.","volume":"105","author":"DR Beers","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrneurol.2010.71","article-title":"Systemic inflammatory cells fight off neurodegenerative disease.","volume":"6","author":"M Schwartz","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11481-009-9171-5","article-title":"Microglia in ALS: the good, the bad, and the resting.","volume":"4","author":"JS Henkel","year":"2009","journal-title":"J Neuroimmune Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1523\/JNEUROSCI.1090-04.2004","article-title":"Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.","volume":"24","author":"DM Wilcock","year":"2004","journal-title":"J Neurosci"},{"key":"ref17","first-page":"82","article-title":"Sequencing of N-glycan oligosaccharides directly from protein gels: In gel deglycosylation and analyzing in HPLC and MALDI-TOF MS.","volume":"250","author":"B K\u00fcster","year":"1997","journal-title":"Anal Biochem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s10719-009-9238-9","article-title":"Differences in the sialylation patterns of membrane stress proteins in chemical carcinogen-induced tumors developed in BALB\/c and IL-1alpha deficient mice.","volume":"26","author":"A Avidan","year":"2009","journal-title":"Glycoconj J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.4049\/jimmunol.0802806","article-title":"NKp44 receptor mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells.","volume":"183","author":"O Hershkovitz","year":"2009","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.4049\/jimmunol.1001635","article-title":"Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting.","volume":"185","author":"M Cohen","year":"2010","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s12031-008-9138-7","article-title":"DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS.","volume":"38","author":"N Lev","year":"2009","journal-title":"J Mol Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-0404.2005.00445.x","article-title":"Subcellular localization of IgG from the sera of ALS patients in the nervous system.","volume":"112","author":"JI Engelhardt","year":"2005","journal-title":"Acta Neurol Scand"},{"key":"ref23","first-page":"368","article-title":"Increased intracellular calcium triggered by immune mechanisms in amyotrophic lateral sclerosis.","volume":"3","author":"SH Appel","year":"1995","journal-title":"Clin Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/ana.410360608","article-title":"The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis.","volume":"36","author":"ME Alexianu","year":"1996","journal-title":"Ann Neurol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1471-4159.2005.03184.x","article-title":"ALS-IgG-induced selective motor neurone apoptosis in rat mixed primary spinal cord cultures.","volume":"94","author":"M Demestre","year":"2005","journal-title":"J Neurochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/35059110","article-title":"Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells.","volume":"409","author":"O Mandelboim","year":"2001","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1021\/pr070392+","article-title":"A two-dimensional array for simultaneous sequencing of N- and O-glycans and their glycoforms on specific glycosylation sites.","volume":"7","author":"Y Tzur","year":"2008","journal-title":"J Proteome Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.4049\/jimmunol.149.5.1751","article-title":"Protein tyrosine phosphorylation induced via the IgG receptors Fc gamma Ri and Fc gamma RII in the human monocytic cell line THP-1.","volume":"149","author":"PR Scholl","year":"1992","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/rheumatology\/ken081","article-title":"Sweet and sour: the impact of sugars on disease.","volume":"47","author":"A Alavi","year":"2008","journal-title":"Rheumatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1073\/pnas.0601279103","article-title":"Reelin expression and glycosylation patterns are altered in Alzheimer&apos;s disease.","volume":"103","author":"A Botella-L\u00f3pez","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1471-4159.2005.03514.x","article-title":"Altered glycosylation of acetylcholinesterase in Creutzfeldt-Jakob disease.","volume":"96","author":"MX Silveyra","year":"2006","journal-title":"J Neurochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1007\/s11064-008-9742-5","article-title":"Proteome analysis of cerebrospinal fluid in amyotrophic lateral sclerosis (ALS).","volume":"33","author":"J Brettschneider","year":"2008","journal-title":"Neurochem Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2009.10.053","article-title":"Proteome analysis reveals candidate markers of disease progression in amyotrophic lateral sclerosis (ALS).","volume":"468","author":"J Brettschneider","year":"2010","journal-title":"Neurosci Lett"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/glycob\/cwm100","article-title":"Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG.","volume":"17","author":"R Saldova","year":"2007","journal-title":"Glycobiology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/glycob\/cwn022","article-title":"The O-linked glycosylation of secretory\/shed MUC1 from an advanced breast cancer patient&apos;s serum.","volume":"18","author":"SJ Storr","year":"2008","journal-title":"Glycobiology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1002\/ijc.21728","article-title":"Fucosylated haptoglobin is a novel marker for pancreatic cancer: a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation.","volume":"118","author":"N Okuyama","year":"2006","journal-title":"Int J Cancer"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1021\/pr800752c","article-title":"Identification and development of fucosylated glycoproteins as biomarkers of primary hepatocellular carcinoma.","volume":"8","author":"MA Comunale","year":"2009","journal-title":"J Proteome Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cbpa.2009.08.015","article-title":"Glycomics and disease markers. Review.","volume":"13","author":"HJ An","year":"2009","journal-title":"Curr Opin Chem Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.1129594","article-title":"Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation.","volume":"313","author":"Y Kaneko","year":"2006","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1154315","article-title":"Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc.","volume":"320","author":"RM Anthony","year":"2008","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"26733","DOI":"10.1074\/jbc.M202069200","article-title":"Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity.","volume":"277","author":"RL Shields","year":"2002","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0022-510X(94)90171-6","article-title":"Evidence for autoimmunity in amyotrophic lateral sclerosis.","volume":"124","author":"SH Appel","year":"1994","journal-title":"Review J Neurol Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/316452a0","article-title":"Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG.","volume":"316","author":"RB Parekh","year":"1985","journal-title":"Nature"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/A:1018589704981","article-title":"The glycosylation pattern of humanized IgGI antibody (D1.3) expressed in CHO cells.","volume":"14","author":"FH Routier","year":"1997","journal-title":"Glycoconj J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"8433","DOI":"10.1073\/pnas.0702936104","article-title":"Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity.","volume":"104","author":"F Nimmerjahn","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/6179","article-title":"Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity.","volume":"17","author":"P Uma\u00f1a","year":"1999","journal-title":"Nat Biotechnol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"7934","DOI":"10.1158\/0008-5472.CAN-04-4212","article-title":"Improved effector functions of a therapeutic monoclonal Lewis Y-specific antibody by glycoform engineering.","volume":"65","author":"M Schuster","year":"2005","journal-title":"Cancer Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0165-5728(00)00288-5","article-title":"In vitro induction of neuronal apoptosis by anti-Fas antibody-containing sera from amyotrophic lateral sclerosis patients.","volume":"109","author":"FH Yi","year":"2000","journal-title":"J Neuroimmunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0022-510X(97)00219-0","article-title":"Serum autoantibodies to neurofilament proteins in sporadic amyotrophic lateral sclerosis.","volume":"154","author":"P Couratier","year":"1998","journal-title":"J Neurol Sci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0165-5728(03)00263-7","article-title":"Serum anti-Fas antibody levels in amyotrophic lateral sclerosis.","volume":"142","author":"IS Sengun","year":"2003","journal-title":"J Neuroimmunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/oxfordjournals.jbchem.a123148","article-title":"Monoclonal antibodies to disialogangliosides: characterization of antibody-mediated cytotoxicity against human melanoma and neuroblastoma cells in vitro.","volume":"108","author":"I Kawashima","year":"1990","journal-title":"J Biochem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0035772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:51:19Z","timestamp":1687481479000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0035772"}},"subtitle":[],"editor":[{"given":"Shaida A.","family":"Andrabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,30]]},"references-count":51,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0035772","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,30]]}}}