{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T11:08:33Z","timestamp":1772622513628,"version":"3.50.1"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:00:00Z","timestamp":1335484800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0036316","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T21:10:42Z","timestamp":1335561042000},"page":"e36316","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Soluble Cytokine Receptors (sIL-2R\u03b1, sIL-2R\u03b2) Induce Subunit-Specific Behavioral Responses and Accumulate in the Cerebral Cortex and Basal Forebrain"],"prefix":"10.1371","volume":"7","author":[{"given":"Steven S.","family":"Zalcman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchika","family":"Mohla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3000281","article-title":"Soluble receptors for cytokines and growth factors: generation and biological function.","volume":"300","author":"S Rose-John","year":"1994","journal-title":"The Biochemical Journal"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cytogfr.2007.06.024","article-title":"The tale of soluble receptors and binding proteins: from bench to bedside.","volume":"18","author":"D Novick","year":"2007","journal-title":"Cytokine Growth Factor Reviews"},{"key":"ref3","first-page":"77","article-title":"Molecular mechanisms of soluble cytokine receptor generation.","volume":"283","author":"SJ Levin","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.mad.2006.01.025","article-title":"Cytokine receptor signalling and aging.","volume":"127","author":"T Fulop","year":"2006","journal-title":"Mechanisms of Ageing and Development"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0165-0173(95)00015-1","article-title":"Interleukin-2 as a neuroregulatory cytokine.","volume":"21","author":"UK Hanisch","year":"1995","journal-title":"Brain Research Reviews"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.4049\/jimmunol.145.12.4131","article-title":"Identification of a soluble IL-2 receptor beta-chain from human lymphoid cell line cells.","volume":"145","author":"M Honda","year":"1990","journal-title":"Journal of Immunology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1586\/14737159.8.2.189","article-title":"Cytokines and their receptors as biomarkers of systemic lupus erythematosus.","volume":"8","author":"CH Suh","year":"2008","journal-title":"Expert Review of Molecular Diagnostics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13547500701674063","article-title":"Serum soluble interleukin 2 receptor alpha in human cancer of adults and children: a review.","volume":"13","author":"E Bien","year":"2008","journal-title":"Biomarkers"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1155\/S0962935193000018","article-title":"Biological significance of soluble IL-2 receptor.","volume":"2","author":"C Caruso","year":"1993","journal-title":"Mediators of Inflammation"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1176\/ajp.150.9.1408","article-title":"Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients.","volume":"150","author":"J Licinio","year":"1993","journal-title":"American Journal of Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0278-5846(97)00082-1","article-title":"An association between increased serum-soluble interleukin-2 receptors and a disturbance in muscle force in schizophrenic patients.","volume":"21","author":"MH Rapaport","year":"1997","journal-title":"Progress in neuro-psychopharmacology & biological psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3109\/15622970009150591","article-title":"In-vitro immunomodulatory effects of haloperidol and perazine in schizophrenia.","volume":"1","author":"J Kowalski","year":"2000","journal-title":"The World Journal of Biological Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1177\/147323000203000313","article-title":"Serum interleukin 1 alpha and interleukin 2 levels in patients with schizophrenia.","volume":"30","author":"S Ebrin\u00e7","year":"2002","journal-title":"The Journal of international medical research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1017\/S1461145709000315","article-title":"Persistently increased serum soluble interleukin-2 receptors in continuously ill patients with schizophrenia.","volume":"12","author":"C Bresee","year":"2009","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.biopsych.2007.09.024","article-title":"Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review.","volume":"63","author":"S Potvin","year":"2008","journal-title":"Biological Psychiatry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0920-9964(97)00008-X","article-title":"CSF IL-1 and IL-2 in medicated schizophrenic patients and normal volunteers.","volume":"25","author":"MH Rapaport","year":"1997","journal-title":"Schizophrenia Research"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1600-0447.1994.tb01599.x","article-title":"Serum-soluble interleukin-2 receptors in neuroleptic-naive schizophrenic subjects and in medicated schizophrenic subjects with and without tardive dyskinesia.","volume":"90","author":"MH Rapaport","year":"1994","journal-title":"Acta psychiatrica Scandinavica"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0022-3956(94)00049-W","article-title":"Interleukin-2 and interleukin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers.","volume":"29","author":"M Maes","year":"1995","journal-title":"Journal of Psychiatric Research"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0165-0327(00)00252-4","article-title":"Effects of symptomatic severity on elevation of plasma soluble interleukin-2 receptor in bipolar mania.","volume":"64","author":"SY Tsai","year":"2001","journal-title":"Journal of Affective Disorders"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(01)02090-X","article-title":"Interleukin-2 potentiates novelty- and GBR 12909-induced exploratory activity.","volume":"899","author":"SS Zalcman","year":"2001","journal-title":"Brain Research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0006-8993(02)02740-3","article-title":"Interleukin-2-induced increases in climbing behavior: inhibition by dopamine D-1 and D-2 receptor antagonists.","volume":"19; 944","author":"SS Zalcman","year":"2002","journal-title":"Brain Research"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1046\/j.1440-1711.2002.01097.x","article-title":"Possible mechanism for the alpha subunit of the interleukin-2 receptor (CD25) to influence interleukin-2 receptor signal transduction.","volume":"80","author":"JM Ellery","year":"2002","journal-title":"Immunology and Cell Biology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13547500701674063","article-title":"Serum soluble interleukin-2 receptor alpha in human cancer of adults and children: a review.","volume":"13","author":"E Bien","year":"2008","journal-title":"Biomarkers"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jneuroim.2006.11.027","article-title":"Soluble TNFR1 inhibits the development of experimental autoimmune neuritis by modulating blood-nerve-barrier permeability and inflammation.","volume":"183","author":"JM Taylor","year":"2007","journal-title":"Journal of Neuroimmunology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0036316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:04:40Z","timestamp":1713917080000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0036316"}},"subtitle":[],"editor":[{"given":"Shu-min","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,27]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0036316","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,27]]}}}