{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:16:15Z","timestamp":1789208175580,"version":"build-2803163510"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T00:00:00Z","timestamp":1335744000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0036489","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T20:55:20Z","timestamp":1335819320000},"page":"e36489","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["RAB-7 Antagonizes LET-23 EGFR Signaling during Vulva Development in Caenorhabditis elegans"],"prefix":"10.1371","volume":"7","author":[{"given":"Olga","family":"Skorobogata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian E.","family":"Rocheleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1895\/wormbook.1.80.1","article-title":"RTK\/Ras\/MAPK signaling.","author":"MV Sundaram","year":"2006"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0014-4827(02)00094-0","article-title":"Signaling by the Drosophila epidermal growth factor receptor pathway during development.","volume":"284","author":"BZ Shilo","year":"2003","journal-title":"Exp Cell Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gde.2006.12.004","article-title":"Deregulated Ras signaling in developmental disorders: new tricks for an old dog.","volume":"17","author":"S Schubbert","year":"2007","journal-title":"Curr Opin Genet Dev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrc2109","article-title":"Hyperactive Ras in developmental disorders and cancer.","volume":"7","author":"S Schubbert","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.gene.2005.10.018","article-title":"Epidermal growth factor receptor (EGFR) signaling in cancer.","volume":"366","author":"N Normanno","year":"2006","journal-title":"Gene"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00114-8","article-title":"Cell signaling by receptor tyrosine kinases.","volume":"103","author":"J Schlessinger","year":"2000","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.yexcr.2008.07.029","article-title":"Endocytosis and intracellular trafficking of ErbBs.","volume":"315","author":"A Sorkin","year":"2009","journal-title":"Exp Cell Res"},{"key":"ref8","first-page":"987","article-title":"Regulation of EGFR endocytic trafficking by rab proteins.","volume":"21","author":"BP Ceresa","year":"2006","journal-title":"Histol Histopathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/35042605","article-title":"The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.","volume":"408","author":"L Lanzetti","year":"2000","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1083\/jcb.151.3.539","article-title":"Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a.","volume":"151","author":"MA Barbieri","year":"2000","journal-title":"J Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"50996","DOI":"10.1074\/jbc.M204869200","article-title":"Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre.","volume":"277","author":"L Martinu","year":"2002","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1534-5807(01)00008-9","article-title":"Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.","volume":"1","author":"GG Tall","year":"2001","journal-title":"Dev Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1398-9219.2004.00204.x","article-title":"Continual expression of Rab5(Q79L) causes a ligand-independent EGFR internalization and diminishes EGFR activity.","volume":"5","author":"JL Dinneen","year":"2004","journal-title":"Traffic"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(04)00117-5","article-title":"APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.","volume":"116","author":"M Miaczynska","year":"2004","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1091\/mbc.E07-02-0098","article-title":"Late endosomal traffic of the epidermal growth factor receptor ensures spatial and temporal fidelity of mitogen-activated protein kinase signaling.","volume":"18","author":"N Taub","year":"2007","journal-title":"Mol Biol Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1074\/jbc.M504175200","article-title":"rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome.","volume":"281","author":"BP Ceresa","year":"2006","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"12110","DOI":"10.1074\/jbc.M809277200","article-title":"Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration.","volume":"284","author":"PA Vanlandingham","year":"2009","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1895\/wormbook.1.6.1","article-title":"Vulval development.","author":"PW Sternberg","year":"2005"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of <italic>Caenorhabditis elegans<\/italic>.","volume":"77","author":"S Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e1001055","DOI":"10.1371\/journal.pgen.1001055","article-title":"Multivesicular body formation requires OSBP-related proteins and cholesterol.","volume":"6","author":"H Kobuna","year":"2010","journal-title":"PLoS Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0092-8674(00)81186-1","article-title":"MAP kinase signaling specificity mediated by the LIN-1 Ets\/LIN-31 WH transcription factor complex during <italic>C. elegans<\/italic> vulval induction.","volume":"93","author":"PB Tan","year":"1998","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in <italic>C. elegans<\/italic>: extrachromosomal maintenance and integration of transforming sequences.","volume":"10","author":"CC Mello","year":"1991","journal-title":"EMBO J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1091\/mbc.E05-08-0787","article-title":"RAB-10 Is Required for Endocytic Recycling in the <italic>Caenorhabditis elegans<\/italic> Intestine.","volume":"17","author":"CC Chen","year":"2006","journal-title":"Mol Biol Cell"},{"key":"ref24","first-page":"RESEARCH0002","article-title":"Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in <italic>Caenorhabditis elegans<\/italic>.","volume":"2","author":"RS Kamath","year":"2001","journal-title":"Genome Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-1119(00)00579-5","article-title":"Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in <italic>Caenorhabditis elegans<\/italic>.","volume":"263","author":"L Timmons","year":"2001","journal-title":"Gene"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Post-embryonic cell lineages of the nematode, <italic>Caenorhabditis elegans<\/italic>.","volume":"56","author":"JE Sulston","year":"1977","journal-title":"Dev Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s004380100523","article-title":"LG II balancer chromosomes in <italic>Caenorhabditis elegans<\/italic>: <italic>mT1(II;III)<\/italic> and the <italic>mIn1<\/italic> set of dominantly and recessively marked inversions.","volume":"266","author":"ML Edgley","year":"2001","journal-title":"Mol Genet Genomics"},{"key":"ref28","doi-asserted-by":"crossref","DOI":"10.1895\/wormbook.1.105.1","article-title":"Immunohistochemistry.","author":"JS Duerr","year":"2006"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1083\/jcb.114.3.465","article-title":"Muscle cell attachment in <italic>Caenorhabditis elegans<\/italic>.","volume":"114","author":"R Francis","year":"1991","journal-title":"J Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1371\/journal.pbio.0060061","article-title":"Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells.","volume":"6","author":"X Yu","year":"2008","journal-title":"Plos Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/genetics\/110.1.17","article-title":"Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode <italic>Caenorhabditis elegans<\/italic>.","volume":"110","author":"EL Ferguson","year":"1985","journal-title":"Genetics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1097-2765(05)00001-8","article-title":"ARK-1 inhibits EGFR signaling in <italic>C. elegans<\/italic>.","volume":"6","author":"NA Hopper","year":"2000","journal-title":"Mol Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1101\/gad.333505","article-title":"The <italic>C. elegans<\/italic> homolog of the mammalian tumor suppressor Dep-1\/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.","volume":"19","author":"TA Berset","year":"2005","journal-title":"Genes Dev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0092-8674(00)81227-1","article-title":"SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in <italic>C. elegans<\/italic>.","volume":"94","author":"DS Sieburth","year":"1998","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"11757","DOI":"10.1073\/pnas.0500937102","article-title":"<italic>Caenorhabditis elegans<\/italic> CNK-1 promotes Raf activation but is not essential for Ras\/Raf signaling.","volume":"102","author":"CE Rocheleau","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/genetics\/146.2.553","article-title":"Mechanism of activation of the <italic>Caenorhabditis elegans<\/italic> ras homologue <italic>let- 60<\/italic> by a novel, temperature-sensitive, gain-of-function mutation.","volume":"146","author":"DM Eisenmann","year":"1997","journal-title":"Genetics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.7652556","article-title":"Similarity of <italic>sli-1<\/italic>, a regulator of vulval development in <italic>C. elegans<\/italic>, to the mammalian proto-oncogene c-cbl.","volume":"269","author":"CH Yoon","year":"1995","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1093\/genetics\/139.4.1553","article-title":"<italic>sli-1<\/italic>, a negative regulator of <italic>let-23<\/italic>-mediated signaling in <italic>C. elegans<\/italic>.","volume":"139","author":"GD Jongeward","year":"1995","journal-title":"Genetics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1101\/gad.11.20.2715","article-title":"Inhibition of <italic>Caenorhabditis elegans<\/italic> vulval induction by <italic>gap-1<\/italic> and by <italic>let-23<\/italic> receptor tyrosine kinase.","volume":"11","author":"A Hajnal","year":"1997","journal-title":"Genes Dev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1126\/science.1055642","article-title":"Notch Inhibition of RAS Signaling Through MAP Kinase Phosphatase LIP-1 During <italic>C. elegans<\/italic> Vulval Development.","volume":"291","author":"T Berset","year":"2001","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1126\/science.1091639","article-title":"Crosstalk between the EGFR and LIN-12\/Notch pathways in <italic>C. elegans<\/italic> vulval development.","volume":"303","author":"AS Yoo","year":"2004","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.200806088","article-title":"Mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in <italic>Caenorhabditis elegans<\/italic>.","volume":"183","author":"M Gu","year":"2008","journal-title":"J Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1101\/gad.8.1.60","article-title":"<italic>unc-101<\/italic>, a gene required for many aspects of <italic>Caenorhabditis elegans<\/italic> development and behavior, encodes a clathrin-associated protein.","volume":"8","author":"J Lee","year":"1994","journal-title":"Genes Dev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tcb.2004.02.002","article-title":"Adaptable adaptors for coated vesicles.","volume":"14","author":"MS Robinson","year":"2004","journal-title":"Trends Cell Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1242\/dev.125.6.1083","article-title":"EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in <italic>C. elegans<\/italic>.","volume":"125","author":"RD Burdine","year":"1998","journal-title":"Development"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0092-8674(00)81735-3","article-title":"The LIN-2\/LIN-7\/LIN-10 complex mediates basolateral membrane localization of the <italic>C. elegans<\/italic> EGF receptor LET-23 in vulval epithelial cells.","volume":"94","author":"SM Kaech","year":"1998","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1091\/mbc.10.6.2087","article-title":"Basolateral localization of the <italic>Caenorhabditis elegans<\/italic> epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10.","volume":"10","author":"CW Whitfield","year":"1999","journal-title":"Mol Biol Cell"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0012-1606(81)90427-9","article-title":"Abnormal cell lineages in mutants of the nematode <italic>Caenorhabditis elegans<\/italic>.","volume":"82","author":"JE Sulston","year":"1981","journal-title":"Dev Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/genetics\/128.2.251","article-title":"Multiple functions of <italic>let-23<\/italic>, a <italic>Caenorhabditis elegans<\/italic> receptor tyrosine kinase gene required for vulval induction.","volume":"128","author":"RV Aroian","year":"1991","journal-title":"Genetics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0092-8674(00)81096-X","article-title":"LET-23 receptor localization by the cell junction protein LIN-7 during <italic>C. elegans<\/italic> vulval induction.","volume":"85","author":"JS Simske","year":"1996","journal-title":"Cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/j.1460-2075.1994.tb06269.x","article-title":"Mutations in the <italic>Caenorhabditis elegans let-23<\/italic> EGFR-like gene define elements important for cell-type specificity and function.","volume":"13","author":"RV Aroian","year":"1994","journal-title":"EMBO J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1242\/dev.00924","article-title":"A cell-specific enhancer that specifies <italic>lin-3<\/italic> expression in the <italic>C. elegans<\/italic> anchor cell for vulval development.","volume":"131","author":"BJ Hwang","year":"2004","journal-title":"Development"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/sj.embor.7400019","article-title":"Hrs mediates downregulation of multiple signalling receptors in Drosophila.","volume":"4","author":"G Jekely","year":"2003","journal-title":"EMBO Rep"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0092-8674(02)00611-6","article-title":"Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila.","volume":"108","author":"TE Lloyd","year":"2002","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1034\/j.1600-0854.2000.010307.x","article-title":"Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking.","volume":"1","author":"M Babst","year":"2000","journal-title":"Traffic"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/ncb1101-983","article-title":"Cooperative regulation of AJM-1 controls junctional integrity in <italic>Caenorhabditis elegans<\/italic> epithelia.","volume":"3","author":"M Koppen","year":"2001","journal-title":"Nat Cell Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.devcel.2004.11.015","article-title":"<italic>lin-35<\/italic> Rb acts in the major hypodermis to oppose ras-mediated vulval induction in <italic>C. elegans<\/italic>.","volume":"8","author":"TR Myers","year":"2005","journal-title":"Dev Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/ncb1261","article-title":"<italic>Caenorhabditis elegans<\/italic> RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit.","volume":"7","author":"M Sato","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1101\/gad.384506","article-title":"<italic>C. elegans<\/italic> GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival.","volume":"20","author":"EA Kritikou","year":"2006","journal-title":"Genes Dev"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1534\/genetics.106.063990","article-title":"<italic>sli-3<\/italic> negatively regulates the LET-23\/epidermal growth factor receptor-mediated vulval induction pathway in <italic>Caenorhabditis elegans<\/italic>.","volume":"174","author":"BP Gupta","year":"2006","journal-title":"Genetics"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1091\/mbc.11.8.2743","article-title":"Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode <italic>Caenorhabditis elegans<\/italic>.","volume":"11","author":"J Shim","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.cub.2009.09.048","article-title":"An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.","volume":"19","author":"G Tarcic","year":"2009","journal-title":"Curr Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature07961","article-title":"The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.","volume":"458","author":"C Raiborg","year":"2009","journal-title":"Nature"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1083\/jcb.131.6.1435","article-title":"Rab 7: an important regulator of late endocytic membrane traffic.","volume":"131","author":"Y Feng","year":"1995","journal-title":"J Cell Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1083\/jcb.140.5.1075","article-title":"Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartment.","volume":"140","author":"B Press","year":"1998","journal-title":"J Cell Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.1371\/journal.pbio.0030233","article-title":"Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes.","volume":"3","author":"A Vonderheit","year":"2005","journal-title":"PLoS Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.cell.2005.06.043","article-title":"Rab conversion as a mechanism of progression from early to late endosomes.","volume":"122","author":"J Rink","year":"2005","journal-title":"Cell"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1091\/mbc.11.2.467","article-title":"Rab7: a key to lysosome biogenesis.","volume":"11","author":"C Bucci","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1242\/jcs.106.3.823","article-title":"Involvement of Ypt7p, a small GTPase, in traffic from late endosome to the vacuole in yeast.","volume":"106","author":"F Schimmoller","year":"1993","journal-title":"J Cell Sci"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1242\/jcs.108.11.3349","article-title":"The rab7 GTPase resides on a vesicular compartment connected to lysosomes.","volume":"108","author":"S Meresse","year":"1995","journal-title":"J Cell Sci"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/ncb1269","article-title":"Endosome-to-cytosol transport of viral nucleocapsids.","volume":"7","author":"I Le Blanc","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1534\/genetics.107.084608","article-title":"The <italic>Caenorhabditis elegans ekl<\/italic> (enhancer of <italic>ksr-1<\/italic> lethality) genes include putative components of a germline small RNA pathway.","volume":"178","author":"CE Rocheleau","year":"2008","journal-title":"Genetics"},{"key":"ref73","article-title":"A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal.","author":"T Wang","year":"2011","journal-title":"J Cell Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0036489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T14:59:56Z","timestamp":1642172396000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0036489"}},"subtitle":[],"editor":[{"given":"Anna Maria","family":"Delprato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,4,30]]},"references-count":73,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,4,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0036489","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,30]]}}}