{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:30:10Z","timestamp":1791153010080,"version":"4.1.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T00:00:00Z","timestamp":1336348800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0036705","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T03:31:38Z","timestamp":1336447898000},"page":"e36705","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Role of the Polarity Protein Scribble for Podocyte Differentiation and Maintenance"],"prefix":"10.1371","volume":"7","author":[{"given":"Bj\u00f6rn","family":"Hartleben","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Widmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Wanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Schmidts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dontscho","family":"Kerjaschki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Miner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Walz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias B.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,5,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00020.2002","article-title":"Cell biology of the glomerular podocyte.","volume":"83","author":"H Pavenstadt","year":"2003","journal-title":"Physiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"23033","DOI":"10.1074\/jbc.M803143200","article-title":"Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.","volume":"283","author":"B Hartleben","year":"2008","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"F589","DOI":"10.1152\/ajprenal.00615.2010","article-title":"Protein complexes that control renal epithelial polarity.","volume":"300","author":"J Pieczynski","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2009.04.017","article-title":"A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier.","volume":"334","author":"L Ebarasi","year":"2009","journal-title":"Dev Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1681\/ASN.2008080871","article-title":"Loss of podocyte aPKClambda\/iota causes polarity defects and nephrotic syndrome.","volume":"20","author":"TB Huber","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e4194","DOI":"10.1371\/journal.pone.0004194","article-title":"An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms.","volume":"4","author":"T Hirose","year":"2009","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"E114","DOI":"10.1038\/35017119","article-title":"Collective nomenclature for LAP proteins.","volume":"2","author":"D Bilder","year":"2000","journal-title":"Nat Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/sj.embor.7400006","article-title":"Basolateral targeting by leucine-rich repeat domains in epithelial cells.","volume":"4","author":"R Legouis","year":"2003","journal-title":"EMBO Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1038\/sj.onc.1208632","article-title":"Junctional recruitment of mammalian Scribble relies on E-cadherin engagement.","volume":"24","author":"C Navarro","year":"2005","journal-title":"Oncogene"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1083\/jcb.200506094","article-title":"The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin.","volume":"171","author":"Y Qin","year":"2005","journal-title":"J Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1038\/sj.onc.1210016","article-title":"The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge.","volume":"26","author":"LE Dow","year":"2007","journal-title":"Oncogene"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/hmg\/ddg014","article-title":"Disruption of <italic>scribble<\/italic> (<italic>Scrb1<\/italic>) causes severe neural tube defects in the <italic>circletail<\/italic> mouse.","volume":"12","author":"JN Murdoch","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"E219","DOI":"10.1371\/journal.pbio.0020219","article-title":"A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.","volume":"2","author":"K Zarbalis","year":"2004","journal-title":"PLoS Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/dbio.1994.1230","article-title":"Developmental basis of severe neural tube defects in the <italic>loop-tail<\/italic> (<italic>Lp<\/italic>) mutant mouse: use of microsatellite DNA markers to identify embryonic genotype.","volume":"165","author":"AJ Copp","year":"1994","journal-title":"Dev Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/90081","article-title":"Ltap, a mammalian homolog of Drosophila Strabismus\/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.","volume":"28","author":"Z Kibar","year":"2001","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1093\/hmg\/10.22.2593","article-title":"Severe neural tube defects in the loop-tail mouse result from mutation of <italic>Lpp1<\/italic>, a novel gene involved in floor plate specification.","volume":"10","author":"JN Murdoch","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/geno.2001.6638","article-title":"Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation.","volume":"78","author":"JN Murdoch","year":"2001","journal-title":"Genomics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature01618","article-title":"Identification of <italic>Vangl2<\/italic> and <italic>Scrb1<\/italic> as planar polarity genes in mammals.","volume":"423","author":"M Montcouquiol","year":"2003","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/jcb.20992","article-title":"Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains.","volume":"99","author":"LM Kallay","year":"2006","journal-title":"J Cell Biochem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8244","DOI":"10.1128\/MCB.20.21.8244-8253.2000","article-title":"Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase.","volume":"20","author":"S Nakagawa","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/sj.bjc.6601465","article-title":"Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix.","volume":"90","author":"S Nakagawa","year":"2004","journal-title":"Br J Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cell.2008.09.045","article-title":"Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.","volume":"135","author":"L Zhan","year":"2008","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1172\/JCI58509","article-title":"SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.","volume":"121","author":"HB Pearson","year":"2011","journal-title":"J Clin Invest"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/gene.10164","article-title":"Podocyte-specific expression of cre recombinase in transgenic mice.","volume":"35","author":"MJ Moeller","year":"2003","journal-title":"Genesis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1681\/ASN.V133788","article-title":"Glomerular-specific gene excision in vivo.","volume":"13","author":"V Eremina","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1083\/jcb.111.3.1255","article-title":"The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium.","volume":"111","author":"E Schnabel","year":"1990","journal-title":"J Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1128\/MCB.23.12.4267-4282.2003","article-title":"JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1.","volume":"23","author":"S Hirabayashi","year":"2003","journal-title":"Mol Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1681\/ASN.V1111","article-title":"The glomerular slit diaphragm is a modified adherens junction.","volume":"11","author":"J Reiser","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"8579","DOI":"10.1073\/pnas.0811691106","article-title":"Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development.","volume":"106","author":"K Skouloudaki","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1093\/nar\/23.24.5080","article-title":"A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.","volume":"23","author":"F Schwenk","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1172\/JCI118828","article-title":"Conditional gene targeting.","volume":"98","author":"K Rajewsky","year":"1996","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1681\/ASN.2004050387","article-title":"Heparan sulfate of perlecan is involved in glomerular filtration.","volume":"16","author":"H Morita","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"ref33","first-page":"64","article-title":"The pathophysiology of protein-overload proteinuria.","volume":"129","author":"JJ Weening","year":"1987","journal-title":"Am J Pathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1046\/j.1523-1755.2000.00342.x","article-title":"Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events.","volume":"58","author":"Y Wang","year":"2000","journal-title":"Kidney Int"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0022-5347(17)52273-9","article-title":"An organ culture model for the study of metanephric development.","volume":"129","author":"ED Avner","year":"1983","journal-title":"J Urol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1083\/jcb.102.2.484","article-title":"Endothelial cell membranes contain podocalyxin\u2013the major sialoprotein of visceral glomerular epithelial cells.","volume":"102","author":"R Horvat","year":"1986","journal-title":"J Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1242\/jcs.01163","article-title":"Enhanced podocalyxin expression alters the structure of podocyte basal surface.","volume":"117","author":"CG Economou","year":"2004","journal-title":"J Cell Sci"}],"updated-by":[{"DOI":"10.1371\/annotation\/2c0c1c61-0627-4794-b6f2-01fc4db84dcb","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T00:00:00Z","timestamp":1388707200000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0036705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T03:32:23Z","timestamp":1642217543000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0036705"}},"subtitle":[],"editor":[{"given":"Jean-Claude","family":"Dussaule","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,7]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0036705","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,7]]}}}