{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:08:50Z","timestamp":1792652930240,"version":"4.5.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:00:00Z","timestamp":1337126400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0037026","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T09:24:38Z","timestamp":1337246678000},"page":"e37026","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["Non-Invasive Quantification of White and Brown Adipose Tissues and Liver Fat Content by Computed Tomography in Mice"],"prefix":"10.1371","volume":"7","author":[{"given":"Marko","family":"Lubura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deike","family":"Hesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Scherneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Wiedmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Sch\u00fcrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"97S","DOI":"10.1038\/oby.2002.202","article-title":"The obesity epidemic: pathophysiology and consequences of obesity.","volume":"10","author":"FX Pi-Sunyer","year":"2002","journal-title":"Obes Res"},{"key":"ref2","article-title":"Obesity and overweight.","year":"2006"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/35007508","article-title":"Obesity as a medical problem.","volume":"404","author":"PG Kopelman","year":"2000","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/00000441-200604000-00002","article-title":"Overweight and obesity: prevalence, consequences, and causes of a growing public health problem.","volume":"331","author":"SB Wyatt","year":"2006","journal-title":"Am J Med Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/jn\/137.4.1087","article-title":"Improvements in body composition, glucose tolerance, and insulin action induced by increasing energy expenditure or decreasing energy intake.","volume":"137","author":"EP Weiss","year":"2007","journal-title":"J Nutr"},{"key":"ref6","first-page":"39","article-title":"Ectopic fat accumulation: an important cause of insulin resistance in humans.","volume":"95","author":"H Yki-Jarvinen","year":"2002","journal-title":"J R Soc Med"},{"key":"ref7","first-page":"9","article-title":"Non alcoholic fatty liver disease and metabolic syndrome.","volume":"13","author":"P Paschos","year":"2009","journal-title":"Hippokratia"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/206201b0","article-title":"Non-shivering thermogenesis and brown adipose tissue in the human new-born infant.","volume":"206","author":"MJ Dawkins","year":"1965","journal-title":"Nature"},{"key":"ref9","first-page":"300","article-title":"Respiration under control of uncoupling proteins: Clinical perspective.","volume":"65","author":"T Nubel","year":"2006","journal-title":"Horm Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1096\/fj.09-133546","article-title":"The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.","volume":"23","author":"MC Zingaretti","year":"2009","journal-title":"FASEB J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1038\/ijo.2010.179","article-title":"Brown fat thermogenesis and body weight regulation in mice: relevance to humans.","volume":"34","author":"LP Kozak","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans.","volume":"360","author":"AM Cypess","year":"2009","journal-title":"New England Journal of Medicine"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.2337\/db09-0833","article-title":"Brown adipose tissue and seasonal variation in humans.","volume":"58","author":"IT Au-Yong","year":"2009","journal-title":"Diabetes"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","article-title":"Cold-activated brown adipose tissue in healthy men.","volume":"360","author":"WD van Marken Lichtenbelt","year":"2009","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1751-2980.2009.00402.x","article-title":"Nonalcoholic fatty liver disease: quantitative assessment of liver fat content by computed tomography, magnetic resonance imaging and proton magnetic resonance spectroscopy.","volume":"10","author":"L Zhong","year":"2009","journal-title":"J Dig Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/153537020222700806","article-title":"Determinants affecting physical activity levels in animal models.","volume":"227","author":"JC Tou","year":"2002","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s00216-003-2224-3","article-title":"Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis.","volume":"377","author":"GZ Taicher","year":"2003","journal-title":"Anal Bioanal Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bone.2010.07.002","article-title":"Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl\/6 mice: modulation by diet-induced obesity.","volume":"47","author":"A Bartelt","year":"2010","journal-title":"Bone"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.medengphy.2008.03.006","article-title":"In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model.","volume":"31","author":"Y Luu","year":"2009","journal-title":"Medical Eng Phys"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ymeth.2009.05.017","article-title":"Quantification of adiposity in small rodents using micro-CT.","volume":"50","author":"S Judex","year":"2010","journal-title":"Methods"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/oby.2009.341","article-title":"Validation of computed tomographic estimates of intra-abdominal and subcutaneous adipose tissue in rats and mice.","volume":"18","author":"JJ Hillebrand","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00125-010-1973-8","article-title":"Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.","volume":"54","author":"O Kluth","year":"2011","journal-title":"Diabetologia"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/sj.ijo.0801921","article-title":"A novel method of measuring intra-abdominal fat volume using helical computed tomography.","volume":"26","author":"J Kobayashi","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/oby.2007.629","article-title":"Estimating abdominal adipose tissue with DXA and anthropometry.","volume":"15","author":"AM Hill","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1071\/RD9951351","article-title":"Circulatory responses to acute asphyxia in intact and chemodenervated fetal sheep near term.","volume":"7","author":"A Jensen","year":"1995","journal-title":"Reprod Fertil Dev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2214\/ajr.170.2.9456958","article-title":"Using quantitative CT to assess adipose distribution in adult men with acquired hypogonadism.","volume":"170","author":"L Katznelson","year":"1998","journal-title":"AJR Am J Roentgenol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.2214\/AJR.06.0992","article-title":"Comparison of CT methods for determining the fat content of the liver.","volume":"188","author":"Y Kodama","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00268-007-9197-x","article-title":"Liver volumetry plug and play: do it yourself with ImageJ.","volume":"31","author":"SA Dello","year":"2007","journal-title":"World J Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/ajcn\/80.2.271","article-title":"Visceral adipose tissue: relations between single-slice areas and total volume.","volume":"80","author":"W Shen","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejrad.2006.11.005","article-title":"Imaging of hepatic steatosis and fatty sparing.","volume":"61","author":"M Karcaaltincaba","year":"2007","journal-title":"Eur J Radiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00125-004-1637-7","article-title":"Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study.","volume":"48","author":"MB Snijder","year":"2005","journal-title":"Diabetologia"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"8456","DOI":"10.1074\/jbc.275.12.8456","article-title":"Mechanism of insulin resistance in A-ZIP\/F-1 fatless mice.","volume":"275","author":"JK Kim","year":"2000","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/07853890510037383","article-title":"Fat in the liver and insulin resistance.","volume":"37","author":"H Yki-Jarvinen","year":"2005","journal-title":"Ann Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1194\/jlr.D400001-JLR200","article-title":"In vivo MRS measurement of liver lipid levels in mice.","volume":"45","author":"JR Garbow","year":"2004","journal-title":"J Lipid Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1148\/rg.296095513","article-title":"Diffuse liver disease: strategies for hepatic CT and MR imaging.","volume":"29","author":"D Boll","year":"2009","journal-title":"Radiographics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2967\/jnumed.109.068775","article-title":"CT Hounsfield units of brown adipose tissue increase with activation: preclinical and clinical studies.","volume":"51","author":"S Baba","year":"2010","journal-title":"J Nucl Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1172\/JCI60433","article-title":"Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans.","volume":"122","author":"V Ouellet","year":"2012","journal-title":"The Journal of clinical investigation"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nm.2297","article-title":"Brown adipose tissue activity controls triglyceride clearance.","volume":"17","author":"A Bartelt","year":"2011","journal-title":"Nature medicine"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0037026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T16:43:14Z","timestamp":1561740194000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0037026"}},"subtitle":[],"editor":[{"given":"Anita Magdalena","family":"Hennige","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,16]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0037026","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,16]]}}}