{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:51:13Z","timestamp":1790859073185,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0037055","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T21:29:27Z","timestamp":1337030967000},"page":"e37055","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Plasticity of Adult Human Pancreatic Duct Cells by Neurogenin3-Mediated Reprogramming"],"prefix":"10.1371","volume":"7","author":[{"given":"Nathalie","family":"Swales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert A.","family":"Martens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bonn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Heremans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehannah","family":"Borup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Van de Casteele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pipeleers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ravassard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Heimberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/dev.129.10.2447","article-title":"Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors.","volume":"129","author":"G Gu","year":"2002","journal-title":"Development"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.97.4.1607","article-title":"neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.","volume":"97","author":"G Gradwohl","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1172\/JCI37028","article-title":"The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.","volume":"119","author":"JM Oliver-Krasinski","year":"2009","journal-title":"J Clin Invest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s001250050960","article-title":"Extra-insular beta cells associated with ductules are frequent in adult human pancreas.","volume":"41","author":"L Bouwens","year":"1998","journal-title":"Diabetologia"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1073\/pnas.97.14.7999","article-title":"In vitro cultivation of human islets from expanded ductal tissue.","volume":"97","author":"S Bonner-Weir","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1083\/jcb.200203074","article-title":"Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.","volume":"159","author":"Y Heremans","year":"2002","journal-title":"J Cell Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/labinvest.3700204","article-title":"EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK\/ERK cascade.","volume":"85","author":"C Rescan","year":"2005","journal-title":"Lab Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.2337\/db06-1670","article-title":"Differentiation of affinity-purified human pancreatic duct cells to beta-cells.","volume":"56","author":"S Yatoh","year":"2007","journal-title":"Diabetes"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3727\/000000006783981431","article-title":"Induction of pancreatic stem\/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology.","volume":"15","author":"H Noguchi","year":"2006","journal-title":"Cell Transplant"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-213X-7-63","article-title":"Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas.","volume":"7","author":"J Ahnfelt-Ronne","year":"2007","journal-title":"BMC Dev Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1242\/dev.00921","article-title":"Global expression analysis of gene regulatory pathways during endocrine pancreatic development.","volume":"131","author":"G Gu","year":"2004","journal-title":"Development"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ydbio.2008.02.052","article-title":"Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation.","volume":"317","author":"S Wang","year":"2008","journal-title":"Dev Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.mod.2007.08.004","article-title":"Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.","volume":"124","author":"S Wang","year":"2007","journal-title":"Mech Dev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","article-title":"In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.","volume":"455","author":"Q Zhou","year":"2008","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A gene atlas of the mouse and human protein-encoding transcriptomes.","volume":"101","author":"AI Su","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","author":"GA Martens","year":"4134"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1210\/me.2003-0037","article-title":"Neurogenin3 activates the islet differentiation program while repressing its own expression.","volume":"18","author":"SB Smith","year":"2004","journal-title":"Mol Endocrinol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1128\/MCB.20.9.3292-3307.2000","article-title":"Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3.","volume":"20","author":"HP Huang","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"38254","DOI":"10.1074\/jbc.M302229200","article-title":"Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4.","volume":"278","author":"SB Smith","year":"2003","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"17130","DOI":"10.1074\/jbc.M213196200","article-title":"Distinct gene expression programs function in progenitor and mature islet cells.","volume":"278","author":"H Watada","year":"2003","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/sj.emboj.7601011","article-title":"IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.","volume":"25","author":"G Mellitzer","year":"2006","journal-title":"EMBO J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1007\/s00125-006-0428-8","article-title":"Evidence for the homeostatic regulation of induced beta cell mass expansion.","volume":"49","author":"MA Lipsett","year":"2006","journal-title":"Diabetologia"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.2337\/diabetes.52.8.2007","article-title":"Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture.","volume":"52","author":"R Gao","year":"2003","journal-title":"Diabetes"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.2337\/diab.45.8.1108","article-title":"Ductal cyst formation in collagen-embedded adult human islet preparations. A means to the reproduction of nesidioblastosis in vitro.","volume":"45","author":"J Kerr-Conte","year":"1996","journal-title":"Diabetes"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"19915","DOI":"10.1073\/pnas.0805803105","article-title":"Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth.","volume":"105","author":"A Inada","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.cmet.2009.12.005","article-title":"Kushner JA, Weir GC, Bonner-Weir S Ductal origin hypothesis of pancreatic regeneration under attack.","volume":"11","journal-title":"Cell Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.devcel.2009.11.003","article-title":"Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.","volume":"17","author":"M Solar","year":"2009","journal-title":"Dev Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1101\/gr.101709.109","article-title":"van Arensbergen J, Garcia-Hurtado J, Moran I, Maestro MA, Xu X, et al. Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program.","volume":"20","journal-title":"Genome Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/mcne.1996.0060","article-title":"neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS.","volume":"8","author":"L Sommer","year":"1996","journal-title":"Mol Cell Neurosci"},{"key":"ref30","author":"J Simon-Areces","year":"1814"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1242\/dev.127.16.3533","article-title":"Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.","volume":"127","author":"VM Schwitzgebel","year":"2000","journal-title":"Development"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/dbio.2002.0868","article-title":"Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord.","volume":"253","author":"J Lee","year":"2003","journal-title":"Dev Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrn874","article-title":"Proneural genes and the specification of neural cell types.","volume":"3","author":"N Bertrand","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"13245","DOI":"10.1073\/pnas.0405301101","article-title":"Proendocrine genes coordinate the pancreatic islet differentiation program in vitro.","volume":"101","author":"R Gasa","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1101\/gad.846001","article-title":"Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes.","volume":"15","author":"A Grapin-Botton","year":"2001","journal-title":"Genes Dev"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/23716","article-title":"Notch signalling controls pancreatic cell differentiation.","volume":"400","author":"A Apelqvist","year":"1999","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.devcel.2007.02.010","article-title":"Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.","volume":"12","author":"KA Johansson","year":"2007","journal-title":"Dev Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.95.5.2509","article-title":"A simplified system for generating recombinant adenoviruses.","volume":"95","author":"TC He","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2337\/diabetes.49.4.571","article-title":"Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1.","volume":"49","author":"H Heimberg","year":"2000","journal-title":"Diabetes"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF00269546","article-title":"Cytochemical localization of NADPH-diaphorase in the four types of pancreatic islet cell.","volume":"101","author":"L Bouwens","year":"1994","journal-title":"Histochemistry"},{"key":"ref41","first-page":"RESEARCH0032","article-title":"Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application.","volume":"2","author":"C Li","year":"2001","journal-title":"Genome Biol"},{"key":"ref42","author":"JCV Oliveros","year":"2007"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0037055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T17:04:07Z","timestamp":1642266247000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0037055"}},"subtitle":[],"editor":[{"given":"Patrick","family":"Callaerts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,14]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0037055","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,14]]}}}