{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:59:42Z","timestamp":1792166382713,"version":"4.4.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,18]],"date-time":"2012-05-18T00:00:00Z","timestamp":1337299200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0037395","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T11:46:59Z","timestamp":1337514419000},"page":"e37395","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":62,"title":["A Panel of Serum MicroRNAs as Specific Biomarkers for Diagnosis of Compound- and Herb-Induced Liver Injury in Rats"],"prefix":"10.1371","volume":"7","author":[{"given":"Yu-Wen","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Zhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Yue","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1056\/NEJMra021844","article-title":"Drug-induced hepatotoxicity.","volume":"349","author":"WM Lee","year":"2003","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.2174\/138161205774414510","article-title":"Why drugs fail\u2013a study on side effects in new chemical entities.","volume":"11","author":"D Schuster","year":"2005","journal-title":"Curr Pharm Des"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity.","volume":"245","author":"J Ozer","year":"2008","journal-title":"Toxicology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1001\/jama.280.18.1569","article-title":"Trends in Alternative Medicine Use in the United States, 1990\u20131997.","volume":"280","author":"DM Eisenberg","year":"1998","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3109\/15563650.2010.537662","article-title":"Causality assessment of herb-induced liver injury using multidisciplinary approach and Roussel Uclaf Causality Assessment Method (RUCAM).","volume":"49","author":"T Nin Chau","year":"2011","journal-title":"Clin Toxicol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1353\/hpu.2011.0002","article-title":"Trends in the use of complementary and alternative medicine in the United States: 2002\u20132007.","volume":"22","author":"D Su","year":"2011","journal-title":"J Health Care Poor Underserved"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1053\/j.gastro.2008.09.011","article-title":"Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States.","volume":"135","author":"N Chalasani","year":"2008","journal-title":"Gastroenterology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1478-3231.2007.01461.x","article-title":"Drug-induced liver injury at an Asian center: a prospective study.","volume":"27","author":"CT Wai","year":"2007","journal-title":"Liver Int"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cld.2007.06.006","article-title":"Acetaminophen hepatotoxicity.","volume":"11","author":"AM Larson","year":"2007","journal-title":"Clin Liver Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1248\/bpb.25.1241","article-title":"Antitumor-promoting constituents from Dioscorea bulbifera L. in JB6 mouse epidermal cells.","volume":"25","author":"H Gao","year":"2002","journal-title":"Biol Pharm Bull"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0031-9422(00)80394-5","article-title":"Diosbulbin d and 8-epidiosbulbin e acetate, norclerodane diterpenoids from dioscorea bulbifera tubers.","volume":"23","author":"RDH Murray","year":"1984","journal-title":"Phytochemistry"},{"key":"ref12","first-page":"79","article-title":"Study of the hepatotoxicity induced by Dioscorea bulbifera L. rhizome in mice.","volume":"4","author":"J Wang","year":"2010","journal-title":"Biosci Trends"},{"key":"ref13","first-page":"102","article-title":"Review on clinical application and adverse reaction of Dioscorea bulbifera. rhizome.","volume":"23","author":"H Yang","year":"2004","journal-title":"Tradit Chinese Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/hep.22109","article-title":"Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease.","volume":"47","author":"WR Kim","year":"2008","journal-title":"Hepatology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/hep.20548","article-title":"Serum alanine aminotransferase in skeletal muscle diseases.","volume":"41","author":"RA Nathwani","year":"2005","journal-title":"Hepatology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/RHU.0b013e318190b4a6","article-title":"Elevated alanine aminotransferase levels associated with polymyositis: can this be due to muscle injury?","volume":"14","author":"HA Shabaneh Al-Tamimi","year":"2008","journal-title":"J Clin Rheumatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1081\/BIO-200027429","article-title":"Review of hemoglobin-induced myocardial lesions.","volume":"32","author":"K Burhop","year":"2004","journal-title":"Artif Cells Blood Substit Immobil Biotechnol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.taap.2010.02.011","article-title":"The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity.","volume":"245","author":"DE Amacher","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases.","volume":"18","author":"X Chen","year":"2008","journal-title":"Cell Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection.","volume":"105","author":"PS Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function.","volume":"116","author":"DP Bartel","year":"2004","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/med.20215","article-title":"Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers.","volume":"32","author":"K Zen","year":"2010","journal-title":"Med Res Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1373\/clinchem.2009.131797","article-title":"Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury.","volume":"55","author":"OF Laterza","year":"2009","journal-title":"Clin Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1373\/clinchem.2010.147850","article-title":"Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases.","volume":"56","author":"Y Zhang","year":"2010","journal-title":"Clin Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1093\/nar\/gni178","article-title":"Real-time quantification of microRNAs by stem-loop RT-PCR.","volume":"33","author":"C Chen","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref26","first-page":"145","article-title":"Quantitative Stem-Loop RT-PCR for Detection of MicroRNAs.","author":"E Varkonyi-Gasic","year":"2011"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1073\/pnas.0813371106","article-title":"Circulating microRNAs, potential biomarkers for drug-induced liver injury.","volume":"106","author":"K Wang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1373\/clinchem.2009.125310","article-title":"Plasma miR-208 as a Biomarker of Myocardial Injury.","volume":"55","author":"X Ji","year":"2009","journal-title":"Clin Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e23925","DOI":"10.1371\/journal.pone.0023925","article-title":"Early Second-Trimester Serum MiRNA Profiling Predicts Gestational Diabetes Mellitus.","volume":"6","author":"C Zhao","year":"2011","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/sj.bjc.6605608","article-title":"Circulating microRNAs in plasma of patients with gastric cancers.","volume":"102","author":"M Tsujiura","year":"2010","journal-title":"Br J Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1124\/jpet.106.102681","article-title":"Alterations in the rat serum proteome during liver injury from acetaminophen exposure.","volume":"318","author":"BA Merrick","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/0192623308329287","article-title":"The liver toxicity biomarker study: phase I design and preliminary results.","volume":"37","author":"RN McBurney","year":"2009","journal-title":"Toxicol Pathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrc1997","article-title":"MicroRNA signatures in human cancers.","volume":"6","author":"GA Calin","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs - microRNAs with a role in cancer.","volume":"6","author":"A Esquela-Kerscher","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.jhep.2008.01.019","article-title":"miR-122, a paradigm for the role of microRNAs in the liver.","volume":"48","author":"M Girard","year":"2008","journal-title":"J Hepatol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1471-2164-8-166","article-title":"Characterization of microRNA expression profiles in normal human tissues.","volume":"8","author":"Y Liang","year":"2007","journal-title":"BMC Genomics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1373\/clinchem.2010.157198","article-title":"Analysis of Circulating MicroRNA: Preanalytical and Analytical Challenges.","volume":"57","author":"JS McDonald","year":"2011","journal-title":"Clin Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/CS20100297","article-title":"Serum microRNA characterization identifies miR-885-5p as a potential marker for detecting liver pathologies.","volume":"120","author":"J Gui","year":"2011","journal-title":"Clin Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"9798","DOI":"10.1158\/0008-5472.CAN-10-1001","article-title":"Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma.","volume":"70","author":"LM Li","year":"2010","journal-title":"Cancer Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/MCG.0b013e3181f18ac2","article-title":"Circulating microRNAs as biomarkers for hepatocellular carcinoma.","volume":"45","author":"KZ Qu","year":"2011","journal-title":"J Clin Gastroenterol"},{"key":"ref41","first-page":"499","article-title":"MicroRNAs in Cancer Translational Research.","author":"X Chen","year":"2011"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0037395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T20:59:19Z","timestamp":1687467559000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0037395"}},"subtitle":[],"editor":[{"given":"Ioannis P.","family":"Androulakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,18]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0037395","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,18]]}}}