{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:13:14Z","timestamp":1787242394549,"version":"build-2736575974"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T00:00:00Z","timestamp":1338422400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0038171","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T17:57:25Z","timestamp":1338487045000},"page":"e38171","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["Effect of Levels of Acetate on the Mevalonate Pathway of Borrelia burgdorferi"],"prefix":"10.1371","volume":"7","author":[{"given":"Tricia A.","family":"Van Laar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Han","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L. Rajasekhar","family":"Karna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Seshu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,5,31]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Summary of notifiable diseases \u2013 United States, 2009.","volume":"58","author":"CDC","year":"2011","journal-title":"Morb Mortal Wkly Rep"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S1470","DOI":"10.1093\/clinids\/11.Supplement_6.S1470","article-title":"The molecular biology of Borrelia.","volume":"11","author":"AG Barbour","year":"1989","journal-title":"Rev Infect Dis"},{"key":"ref3","first-page":"1","article-title":"Surveillance for Lyme disease\u2013United States, 1992\u20131998.","volume":"49","author":"KA Orloski","year":"2000","journal-title":"MMWR CDC Surveill Summ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1126\/science.8503006","article-title":"The biological and social phenomenon of Lyme disease.","volume":"260","author":"AG Barbour","year":"1993","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1365-2958.2008.06549.x","article-title":"sodA is essential for virulence of <italic>Borrelia burgdorferi<\/italic> in the murine model of Lyme disease.","volume":"71","author":"MD Esteve-Gassent","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1128\/IAI.00882-10","article-title":"CsrA modulates levels of lipoproteins and key regulators of gene expression critical for pathogenic mechanisms of <italic>Borrelia burgdorferi<\/italic>.","volume":"79","author":"SL Karna","year":"2011","journal-title":"Infect Immun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1128\/IAI.01118-07","article-title":"Role of the BBA64 locus of <italic>Borrelia burgdorferi<\/italic> in early stages of infectivity in a murine model of Lyme disease.","volume":"76","author":"M Maruskova","year":"2008","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1128\/IAI.00803-08","article-title":"Deletion of BBA64, BBA65, and BBA66 loci does not alter the infectivity of <italic>Borrelia burgdorferi<\/italic> in the murine model of Lyme disease.","volume":"76","author":"M Maruskova","year":"2008","journal-title":"Infect Immun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1128\/IAI.05234-11","article-title":"Oligopeptide permease A5 modulates vertebrate host-specific adaptation of <italic>Borrelia burgdorferi<\/italic>.","volume":"79","author":"BV Raju","year":"2011","journal-title":"Infect Immun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1128\/IAI.00673-09","article-title":"Overexpression of CsrA (BB0184) alters the morphology and antigen profiles of <italic>Borrelia burgdorferi<\/italic>.","volume":"77","author":"E Sanjuan","year":"2009","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI21681","article-title":"The emergence of Lyme disease.","volume":"113","author":"AC Steere","year":"2004","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S0025-6196(11)60731-3","article-title":"Diagnosis and treatment of Lyme disease.","volume":"83","author":"RL Bratton","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"ref13","article-title":"Erythema migrans.","volume":"vi","author":"P Dandache","year":"2008","journal-title":"Infect Dis Clin North Am 22: 235\u2013260,"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2217\/fmb.09.17","article-title":"Human Lyme disease vaccines: past and future concerns.","volume":"4","author":"DT Nardelli","year":"2009","journal-title":"Future Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1128\/IAI.55.9.2311-2313.1987","article-title":"Absence of lipopolysaccharide in the Lyme disease spirochete, <italic>Borrelia burgdorferi<\/italic>.","volume":"55","author":"K Takayama","year":"1987","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/37551","article-title":"Genomic sequence of a Lyme disease spirochaete, <italic>Borrelia burgdorferi<\/italic>.","volume":"390","author":"CM Fraser","year":"1997","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"7913","DOI":"10.1073\/pnas.1232451100","article-title":"A newly discovered cholesteryl galactoside from <italic>Borrelia burgdorferi<\/italic>.","volume":"100","author":"G Ben-Menachem","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"33645","DOI":"10.1074\/jbc.M305799200","article-title":"Acylated cholesteryl galactoside as a novel immunogenic motif in <italic>Borrelia burgdorferi<\/italic> sensu stricto.","volume":"278","author":"NW Schroder","year":"2003","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13326","DOI":"10.1074\/jbc.M809575200","article-title":"Acylated cholesteryl galactosides are specific antigens of borrelia causing lyme disease and frequently induce antibodies in late stages of disease.","volume":"284","author":"G Stubs","year":"2009","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.chom.2010.09.001","article-title":"Cholesterol lipids of <italic>Borrelia burgdorferi<\/italic> form lipid rafts and are required for the bactericidal activity of a complement-independent antibody.","volume":"8","author":"TJ LaRocca","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/mgme.1998.2786","article-title":"Sequence comparisons reveal two classes of 3-hydroxy-3-methylglutaryl coenzyme A reductase.","volume":"66","author":"DA Bochar","year":"1999","journal-title":"Mol Genet Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1110\/ps.03597504","article-title":"Inhibition of the class II HMG-CoA reductase of <italic>Pseudomonas mevalonii<\/italic>.","volume":"13","author":"M Hedl","year":"2004","journal-title":"Protein Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"14397","DOI":"10.1021\/bi0614636","article-title":"Characterization of an HMG-CoA reductase from <italic>Listeria monocytogenes<\/italic> that exhibits dual coenzyme specificity.","volume":"45","author":"AE Theivagt","year":"2006","journal-title":"Biochemistry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1128\/JB.186.1.61-67.2004","article-title":"<italic>Staphylococcus aureus<\/italic> mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway.","volume":"186","author":"NE Voynova","year":"2004","journal-title":"J Bacteriol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1128\/JB.182.15.4319-4327.2000","article-title":"Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci.","volume":"182","author":"EI Wilding","year":"2000","journal-title":"J Bacteriol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1128\/JB.182.18.5147-5152.2000","article-title":"Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of <italic>Staphylococcus aureus<\/italic>.","volume":"182","author":"EI Wilding","year":"2000","journal-title":"J Bacteriol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"13172","DOI":"10.1073\/pnas.240454797","article-title":"Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes.","volume":"97","author":"BM Lange","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"663","DOI":"10.18388\/abp.2001_3901","article-title":"Isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate\/2-C-methyl-D-erythritol 4-phosphate (DOXP\/MEP) pathway.","volume":"48","author":"M Wanke","year":"2001","journal-title":"Acta Biochim Pol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/gb-2004-5-11-248","article-title":"The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.","volume":"5","author":"JA Friesen","year":"2004","journal-title":"Genome Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1059344","article-title":"Structural mechanism for statin inhibition of HMG-CoA reductase.","volume":"292","author":"ES Istvan","year":"2001","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0022-2275(20)41379-3","article-title":"The discovery and development of HMG-CoA reductase inhibitors.","volume":"33","author":"A Endo","year":"1992","journal-title":"J Lipid Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0165-6147(97)01147-4","article-title":"Hydrophilicity\/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors.","volume":"19","author":"BA Hamelin","year":"1998","journal-title":"Trends Pharmacol Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrd1112","article-title":"Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors.","volume":"2","author":"JA Tobert","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"III50","DOI":"10.1161\/01.CIR.0000131519.15067.1f","article-title":"Safety of statins: focus on clinical pharmacokinetics and drug interactions.","volume":"109","author":"S Bellosta","year":"2004","journal-title":"Circulation"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0195-668X(02)00419-0","article-title":"Statin effects beyond lipid lowering\u2013are they clinically relevant?","volume":"24","author":"PO Bonetti","year":"2003","journal-title":"Eur Heart J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev.micro.112408.134040","article-title":"Gene regulation in <italic>Borrelia burgdorferi<\/italic>.","volume":"65","author":"DS Samuels","year":"2011","journal-title":"Annu Rev Microbiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1128\/IAI.00871-10","article-title":"Inactivation of bb0184, which encodes carbon storage regulator A, represses the infectivity of <italic>Borrelia burgdorferi<\/italic>.","volume":"79","author":"CW","year":"2011","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1365-2958.2011.07853.x","article-title":"Carbon storage regulator A (CsrA(Bb) ) is a repressor of <italic>Borrelia burgdorferi<\/italic> flagellin protein FlaB.","volume":"82","author":"CW Sze","year":"2011","journal-title":"Mol Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e1001104","DOI":"10.1371\/journal.ppat.1001104","article-title":"Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in <italic>Borrelia burgdorferi<\/italic>.","volume":"6","author":"H Xu","year":"2010","journal-title":"PLoS Pathogens"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"12724","DOI":"10.1073\/pnas.231442498","article-title":"Expression of <italic>Borrelia burgdorferi<\/italic> OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway.","volume":"98","author":"A Hubner","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1365-2958.2007.05716.x","article-title":"Temperature-induced regulation of RpoS by a small RNA in <italic>Borrelia burgdorferi<\/italic>.","volume":"64","author":"MC Lybecker","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/j.1365-2958.2009.06621.x","article-title":"Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of <italic>Borrelia burgdorferi<\/italic> core cellular functions.","volume":"71","author":"EA Rogers","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1073\/pnas.92.7.2909","article-title":"Induction of an outer surface protein on <italic>Borrelia burgdorferi<\/italic> during tick feeding.","volume":"92","author":"TG Schwan","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1128\/IAI.63.11.4535-4539.1995","article-title":"Temperature-related differential expression of antigens in the Lyme disease spirochete, <italic>Borrelia burgdorferi<\/italic>.","volume":"63","author":"B Stevenson","year":"1995","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"11001","DOI":"10.1073\/pnas.1834315100","article-title":"The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in <italic>Borrelia burgdorferi<\/italic>.","volume":"100","author":"XF Yang","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1099\/mic.0.024604-0","article-title":"The <italic>Borrelia burgdorferi<\/italic> outer-surface protein ErpX binds mammalian laminin.","volume":"155","author":"CA Brissette","year":"2009","journal-title":"Microbiology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/JB.06394-11","article-title":"BpaB and EbfC DNA-binding proteins regulate production of the Lyme disease spirochete&apos;s infection-associated Erp surface proteins.","volume":"194","author":"BL Jutras","year":"2012","journal-title":"J Bacteriol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e15830","DOI":"10.1371\/journal.pone.0015830","article-title":"Outer surface protein C is a dissemination-facilitating factor of <italic>Borrelia burgdorferi<\/italic> during mammalian infection.","volume":"5","author":"SV Seemanapalli","year":"2010","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/IAI.69.1.446-455.2001","article-title":"Decreased infectivity in <italic>Borrelia burgdorferi<\/italic> strain B31 is associated with loss of linear plasmid 25 or 28\u20131.","volume":"69","author":"M Labandeira-Rey","year":"2001","journal-title":"Infect Immun"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1128\/IAI.01193-08","article-title":"OspC-independent infection and dissemination by host-adapted <italic>Borrelia burgdorferi<\/italic>.","volume":"77","author":"K Tilly","year":"2009","journal-title":"Infect Immun"},{"key":"ref51","first-page":"521","article-title":"Isolation and cultivation of Lyme disease spirochetes.","volume":"57","author":"AG Barbour","year":"1984","journal-title":"Yale J Biol Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1128\/JVI.01880-08","article-title":"Impaired cholesterol biosynthesis in a neuronal cell line persistently infected with measles virus.","volume":"83","author":"S Robinzon","year":"2009","journal-title":"J Virol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0167-4889(97)00091-8","article-title":"Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells.","volume":"1359","author":"PM Ghosh","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/j.1365-2958.2004.04352.x","article-title":"A conservative amino acid change alters the function of BosR, the redox regulator of <italic>Borrelia burgdorferi<\/italic>.","volume":"54","author":"J Seshu","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/j.1365-2958.2007.05593.x","article-title":"Artificial regulation of ospC expression in <italic>Borrelia burgdorferi<\/italic>.","volume":"63","author":"MA Gilbert","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1365-2958.2010.07374.x","article-title":"Identification and function of the RNA chaperone Hfq in the Lyme disease spirochete <italic>Borrelia burgdorferi<\/italic>.","volume":"78","author":"MC Lybecker","year":"2010","journal-title":"Mol Microbiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/j.1365-2958.2005.05042.x","article-title":"Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of <italic>Borrelia burgdorferi<\/italic>.","volume":"59","author":"J Seshu","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref58","first-page":"253","article-title":"Electrotransformation of the spirochete <italic>Borrelia burgdorferi<\/italic>.","volume":"74","author":"DS Samuels","year":"1995","journal-title":"Methods Mol Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1046\/j.1523-1755.2003.00041.x","article-title":"HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia.","volume":"64","author":"K Liang","year":"2003","journal-title":"Kidney Int"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.abb.2010.09.028","article-title":"Enzymes of the mevalonate pathway of isoprenoid biosynthesis.","volume":"505","author":"HM Miziorko","year":"2011","journal-title":"Arch Biochem Biophys"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1128\/JB.181.4.1256-1263.1999","article-title":"Purification, characterization, and cloning of a eubacterial 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme involved in biosynthesis of terpenoids.","volume":"181","author":"S Takahashi","year":"1999","journal-title":"J Bacteriol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1172\/JCI2325","article-title":"A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state.","volume":"101","author":"DR Akins","year":"1998","journal-title":"J Clin Invest"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1128\/IAI.67.7.3181-3187.1999","article-title":"Effects of environmental pH on membrane proteins in <italic>Borrelia burgdorferi<\/italic>.","volume":"67","author":"JA Carroll","year":"1999","journal-title":"Infect Immun"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S1286-4579(01)01435-6","article-title":"Analysis of <italic>Borrelia burgdorferi<\/italic> gene expression during life cycle phases of the tick vector <italic>Ixodes scapularis<\/italic>.","volume":"3","author":"RD Gilmore","year":"2001","journal-title":"Microbe Infect"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1128\/IAI.69.4.2739-2742.2001","article-title":"<italic>Borrelia burgdorferi<\/italic> proteins whose expression is similarly affected by culture temperature and pH.","volume":"69","author":"R Ramamoorthy","year":"2001","journal-title":"Infect Immun"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/JCM.38.1.382-388.2000","article-title":"Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, <italic>Borrelia burgdorferi<\/italic>, during the chain of infection in ticks and mice.","volume":"38","author":"TG Schwan","year":"2000","journal-title":"J Clin Microbiol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1128\/IAI.05153-11","article-title":"Analysis of the HD-GYP domain cyclic dimeric GMP phosphodiesterase reveals a role in motility and the enzootic life cycle of <italic>Borrelia burgdorferi<\/italic>.","volume":"79","author":"SZ Sultan","year":"2011","journal-title":"Infect Immun"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1128\/IAI.00075-11","article-title":"Analysis of the <italic>Borrelia burgdorferi<\/italic> cyclic-di-GMP-binding protein PlzA reveals a role in motility and virulence.","volume":"79","author":"JE Pitzer","year":"2011","journal-title":"Infect Immun"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1128\/IAI.72.3.1580-1586.2004","article-title":"Dissolved oxygen levels alter gene expression and antigen profiles in <italic>Borrelia burgdorferi<\/italic>.","volume":"72","author":"J Seshu","year":"2004","journal-title":"Infect Immun"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2958.2011.07822.x","article-title":"CsrA-FliW interaction governs flagellin homeostasis and a checkpoint on flagellar morphogenesis in <italic>Bacillus subtilis<\/italic>.","volume":"82","author":"S Mukherjee","year":"2011","journal-title":"Mol Microbiol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1128\/IAI.70.4.2139-2150.2002","article-title":"Clonal polymorphism of <italic>Borrelia burgdorferi<\/italic> strain B31 MI: implications for mutagenesis in an infectious strain background.","volume":"70","author":"AF Elias","year":"2002","journal-title":"Infect Immun"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1128\/jb.178.1.19-23.1996","article-title":"3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: purification, characterization, and expression in <italic>Escherichia coli<\/italic>.","volume":"178","author":"KM Bischoff","year":"1996","journal-title":"J Bacteriol"},{"key":"ref73","first-page":"149","article-title":"Biosynthesis and characterization of (S)-and (R)-3-hydroxy-3-methylglutaryl coenzyme A. Biochem Med Meta Biol","volume":"48","author":"KM Bischoff","year":"1992"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.1523-1747.1998.00246.x","article-title":"The activity of HMG-CoA reductase and acetyl-CoA carboxylase in human apocrine sweat glands, sebaceous glands, and hair follicles is regulated by phosphorylation and by exogenous cholesterol.","volume":"111","author":"CD Smythe","year":"1998","journal-title":"The J Invest Derma"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0038171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T09:42:04Z","timestamp":1642326124000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0038171"}},"subtitle":[],"editor":[{"given":"Brian","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,31]]},"references-count":74,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0038171","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,31]]}}}