{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:49:10Z","timestamp":1791132550918,"version":"4.1.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T00:00:00Z","timestamp":1339027200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0038336","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T21:13:09Z","timestamp":1339103589000},"page":"e38336","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Recruitment of Histone Deacetylase 3 to the Interferon-A Gene Promoters Attenuates Interferon Expression"],"prefix":"10.1371","volume":"7","author":[{"given":"Pierre","family":"G\u00e9nin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongtuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hiscott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Civas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,6,7]]},"reference":[{"key":"ref1","first-page":"447","article-title":"Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu. Rev. Biochem.","volume":"76","author":"MS Lee","year":"2007"},{"key":"ref2","first-page":"16","article-title":"Pathogen recognition by the innate immune system. Int. Rev. Immunol.","volume":"30","author":"H Kumar","year":"2011"},{"key":"ref3","first-page":"215","article-title":"RIG-I-like receptors: sensing and responding to RNA virus infection. Semin. Immunol.","volume":"21","author":"P Nakhaei","year":"2009"},{"key":"ref4","first-page":"221","article-title":"Pattern recognition receptors and control of adaptive immunity. Immunol. Rev.","volume":"227","author":"NW Palm","year":"2009"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1074-7613(00)00053-4","article-title":"Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-alpha\/beta Gene Induction.","volume":"13","author":"M Sato","year":"2000","journal-title":"Immunity"},{"key":"ref6","first-page":"644","article-title":"IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol.","volume":"6","author":"K Honda","year":"2006"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","article-title":"Type I interferon gene induction by the interferon regulatory factor family of transcription factors.","volume":"25","author":"K Honda","year":"2006","journal-title":"Immunity"},{"key":"ref8","first-page":"54","article-title":"RNA recognition and signal transduction by RIG-I-like receptors. Immunol. Rev.","volume":"227","author":"M Yoneyama","year":"2009"},{"key":"ref9","first-page":"489","article-title":"Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol. Immunother.","volume":"59","author":"D Savitsky","year":"2010"},{"key":"ref10","first-page":"1061","article-title":"Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol.","volume":"5","author":"T Kawai","year":"2004"},{"key":"ref11","first-page":"15416","article-title":"Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc. Natl. Acad. Sci.","volume":"101","author":"K Honda","year":"2004"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nature03464","article-title":"IRF-7 is the master regulator of type-I interferon-dependent immune responses.","volume":"434","author":"K Honda","year":"2005","journal-title":"Nature"},{"key":"ref13","first-page":"1","article-title":"Toll-like receptor and RIG-I-like receptor signaling. Ann. N. Y. Acad. Sci.","volume":"1143","author":"T Kawai","year":"2008"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2007.05.019","article-title":"An atomic model of the interferon-beta enhanceosome.","volume":"129","author":"D Panne","year":"2007","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cell.2008.05.052","article-title":"Virus Infection Induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression.","volume":"134","author":"E Apostolou","year":"2008","journal-title":"Cell"},{"key":"ref16","first-page":"71","article-title":"The receptor of the type I interferon family. Curr. Top. Microbiol. Immunol.","volume":"316","author":"G Uze","year":"2007"},{"key":"ref17","first-page":"975","article-title":"Interferons at age 50: past, current and future impact on biomedicine. Nat. Rev. Drug Discov.","volume":"6","author":"EC Borden","year":"2007"},{"key":"ref18","first-page":"307","article-title":"Type I interferons (alpha\/beta) in immunity and autoimmunity. Annu. Rev. Immunol.","volume":"23","author":"AN Theofilopoulos","year":"2005"},{"key":"ref19","first-page":"543","article-title":"TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat. Med.","volume":"13","author":"R Baccala","year":"2007"},{"key":"ref20","first-page":"3","article-title":"Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history. Cytokine Growth Factor Rev.","volume":"19","author":"P Fitzgerald-Bocarsly","year":"2008"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nature09386","article-title":"A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.","volume":"467","author":"M Heinig","year":"2010","journal-title":"Nature"},{"key":"ref22","first-page":"7799","article-title":"Postinduction repression of the beta-interferon gene is mediated through two positive regulatory domains. Proc. Natl. Acad. Sci.","volume":"87","author":"LA Whittemore","year":"1990"},{"key":"ref23","first-page":"3325","article-title":"Inducible processing of interferon regulatory factor-2. Mol. Cell. Biol.","volume":"12","author":"VJ Palombella","year":"1992"},{"key":"ref24","first-page":"125","article-title":"PRDI-BF1\/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes Dev.","volume":"13","author":"B Ren","year":"1999"},{"key":"ref25","first-page":"299","article-title":"PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Nat. Immunol.","volume":"5","author":"I Gyory","year":"2004"},{"key":"ref26","first-page":"931","article-title":"Gene repression by coactivator repulsion. Mol.","volume":"6","author":"K Senger","year":"2000","journal-title":"Cell"},{"key":"ref27","first-page":"453","article-title":"Targeting IRFs by ubiquitination: regulating antiviral responses. Biochem. Soc. Trans.","volume":"36","author":"R Higgs","year":"2008"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e11776","DOI":"10.1371\/journal.pone.0011776","article-title":"Self protection from anti-viral responses\u2013Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.","volume":"5","author":"R Higgs","year":"2010","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.immuni.2010.11.027","article-title":"The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.","volume":"33","author":"Y Yu","year":"2010","journal-title":"Immunity"},{"key":"ref30","first-page":"25660","article-title":"Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J. Biol. Chem.","volume":"283","author":"T Kubota","year":"2008"},{"key":"ref31","first-page":"1001","article-title":"Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses. J. Immunol.","volume":"186","author":"Q Liang","year":"2011"},{"key":"ref32","first-page":"4754","article-title":"Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7. J. Immunol.","volume":"187","author":"Q Liang","year":"2011"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e20681","DOI":"10.1371\/journal.pone.0020681","article-title":"Negative Regulation of Interferon-beta Gene Expression during Acute and Persistent Virus Infections.","volume":"6","author":"J Ye","year":"2011","journal-title":"PLoS One"},{"key":"ref34","first-page":"3435","article-title":"Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7. Mol. Cell. Biol.","volume":"29","author":"P Genin","year":"2009"},{"key":"ref35","first-page":"581","article-title":"A small domain of CBP\/p300 binds diverse proteins: solution structure and functional studies. Mol.","volume":"8","author":"CH Lin","year":"2001","journal-title":"Cell"},{"key":"ref36","first-page":"49417","article-title":"Acetylation of interferon regulatory factor-7 by p300\/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J. Biol. Chem.","volume":"277","author":"A Caillaud","year":"2002"},{"key":"ref37","first-page":"15495","article-title":"Interferon Regulatory Factor-7 Synergizes with Other Transcription Factors through Multiple Interactions with p300\/CBP Coactivators. J. Biol. Chem.","volume":"278","author":"H Yang","year":"2003"},{"key":"ref38","first-page":"61","article-title":"The Biology of HDAC3.","author":"E Seto","year":"2006"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/onc.2009.334","article-title":"Histone deacetylases and the immunological network: implications in cancer and inflammation.","volume":"29","author":"A Villagra","year":"2010","journal-title":"Oncogene"},{"key":"ref40","first-page":"282","article-title":"Selective and antagonistic functions of SWI\/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev.","volume":"20","author":"VR Ramirez-Carrozzi","year":"2006"},{"key":"ref41","first-page":"692","article-title":"Transcriptional control of the inflammatory response. Nat. Rev. Immunol.","volume":"9","author":"R Medzhitov","year":"2009"},{"key":"ref42","first-page":"4856","article-title":"Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon. J. Biol. Chem.","volume":"281","author":"A Civas","year":"2006"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.1062374","article-title":"Duration of nuclear NF-kappaB action regulated by reversible acetylation.","volume":"293","author":"L Chen","year":"2001","journal-title":"Science"},{"key":"ref44","first-page":"77","article-title":"Cloning and characterization of human histone deacetylase 8. FEBS Lett.","volume":"478","author":"I Van den Wyngaert","year":"2000"},{"key":"ref45","first-page":"6656","article-title":"Isolation and characterization of a novel class II histone deacetylase, HDAC10. J. Biol. Chem.","volume":"277","author":"DD Fischer","year":"2002"},{"key":"ref46","first-page":"261","article-title":"Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene. J. Mol. Biol.","volume":"393","author":"KM Makkonen","year":"2009"},{"key":"ref47","first-page":"473","article-title":"Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin. Mol.","volume":"8","author":"N Suka","year":"2001","journal-title":"Cell"},{"key":"ref48","first-page":"53","article-title":"Influence of combinatorial histone modifications on antibody and effector protein recognition. Curr. Biol.","volume":"21","author":"SM Fuchs","year":"2011"},{"key":"ref49","first-page":"780","article-title":"MAP kinase-mediated c-fos regulation relies on a histone acetylation relay switch. Mol.","volume":"29","author":"A O\u2019Donnell","year":"2008","journal-title":"Cell"},{"key":"ref50","first-page":"926","article-title":"Bypassing the requirements for epigenetic modifications in gene transcription by increasing enhancer strength. Mol. Cell. Biol.","volume":"28","author":"G Koutroubas","year":"2008"},{"key":"ref51","first-page":"755","article-title":"TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR\/SMRT transcriptional repression checkpoints. Mol.","volume":"29","author":"V Perissi","year":"2008","journal-title":"Cell"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature09607","article-title":"c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3\/NuRD repressor complex.","volume":"469","author":"C Aguilera","year":"2011","journal-title":"Nature"},{"key":"ref53","first-page":"687","article-title":"Diversity and relatedness among the type I interferons. J. Interferon Cytokine Res.","volume":"24","author":"J Chen","year":"2004"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cytogfr.2009.07.005","article-title":"The role of differential expression of human interferon\u2013a genes in antiviral immunity.","volume":"20","author":"P Genin","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.cell.2004.05.023","article-title":"Mapping global histone acetylation patterns to gene expression.","volume":"117","author":"SK Kurdistani","year":"2004","journal-title":"Cell"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2005.06.026","article-title":"Genome-wide map of nucleosome acetylation and methylation in yeast.","volume":"122","author":"DK Pokholok","year":"2005","journal-title":"Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cell.2007.05.042","article-title":"A chromatin landmark and transcription initiation at most promoters in human cells.","volume":"130","author":"MG Guenther","year":"2007","journal-title":"Cell"},{"key":"ref58","first-page":"693","article-title":"Structure and function of histone acetyltransferases. Cell. Mol. Life Sci.","volume":"58","author":"R Marmorstein","year":"2001"},{"key":"ref59","first-page":"559","article-title":"Histones: annotating chromatin. Annu. Rev. Genet.","volume":"43","author":"EI Campos","year":"2009"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0092-8674(02)01077-2","article-title":"Deciphering the transcriptional histone acetylation code for a human gene.","volume":"111","author":"T Agalioti","year":"2002","journal-title":"Cell"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.bbagrm.2010.01.010","article-title":"The transcriptional code of human IFN-beta gene expression.","volume":"1799","author":"E Ford","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"ref62","first-page":"743","article-title":"Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors. Genes Dev.","volume":"16","author":"Y Katan-Khaykovich","year":"2002"},{"key":"ref63","first-page":"289","article-title":"Enhanced histone acetylation and transcription: a dynamic perspective. Mol.","volume":"23","author":"AL Clayton","year":"2006","journal-title":"Cell"},{"key":"ref64","first-page":"3106","article-title":"Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol. Cell. Biol.","volume":"26","author":"I Nusinzon","year":"2006"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2010.01.020","article-title":"RIG-I detects viral genomic RNA during negative-strand RNA virus infection.","volume":"140","author":"J Rehwinkel","year":"2010","journal-title":"Cell"},{"key":"ref66","first-page":"e1000734","article-title":"Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. PLoS Pathog.","volume":"6","author":"L Gitlin","year":"2010"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.gene.2007.03.018","article-title":"Evolution of the interferon alpha gene family in eutherian mammals.","volume":"397","author":"CH Woelk","year":"2007","journal-title":"Gene"},{"key":"ref68","first-page":"41629","article-title":"Recruitment of multiple interferon regulatory factors and histone acetyltransferase to the transcriptionally active interferon a promoters. J. Biol. Chem.","volume":"276","author":"WC Au","year":"2001"},{"key":"ref69","first-page":"6342","article-title":"Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha\/beta interferon genes by interferon regulatory factors 3 and 7. Mol. Cell. Biol.","volume":"20","author":"R Lin","year":"2000"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0092-8674(00)00169-0","article-title":"Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter.","volume":"103","author":"T Agalioti","year":"2000","journal-title":"Cell"},{"key":"ref71","first-page":"7809","article-title":"Post-TATA binding protein recruitment clearance of Gcn5-dependent histone acetylation within promoter nucleosomes. Mol. Cell. Biol.","volume":"23","author":"I Topalidou","year":"2003"},{"key":"ref72","first-page":"618","article-title":"Fast signals and slow marks: the dynamics of histone modifications. Trends Biochem. Sci.","volume":"35","author":"TK Barth","year":"2010"},{"key":"ref73","first-page":"3686","article-title":"JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun. EMBO J.","volume":"22","author":"C Weiss","year":"2003"},{"key":"ref74","first-page":"549","article-title":"Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation. J. Mol. Med.","volume":"81","author":"LF Chen","year":"2003"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1038\/sj.onc.1210612","article-title":"HDAC3: taking the SMRT-N-CoRrect road to repression.","volume":"26","author":"P Karagianni","year":"2007","journal-title":"Oncogene"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1038\/onc.2008.181","article-title":"p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc.","volume":"27","author":"N Sankar","year":"2008","journal-title":"Oncogene"},{"key":"ref77","first-page":"19254","article-title":"Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14. Proc. Natl. Acad. Sci.","volume":"107","author":"WR Luebben","year":"2010"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0038336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T07:04:24Z","timestamp":1540364664000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0038336"}},"subtitle":[],"editor":[{"given":"Earl G.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,7]]},"references-count":77,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0038336","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,7]]}}}