{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:46:57Z","timestamp":1791316017497,"version":"4.3.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T00:00:00Z","timestamp":1341792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0038386","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T18:16:51Z","timestamp":1341857811000},"page":"e38386","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":94,"title":["Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment"],"prefix":"10.1371","volume":"7","clinical-trial-number":[{"clinical-trial-number":"nct00451828","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Miles","family":"Trupp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Wikoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Baillie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Bang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Karp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Fiehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Krauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Kaddurah-Daouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.0000133317.49796.0E","article-title":"Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.","volume":"110","author":"SM Grundy","year":"2004","journal-title":"Circulation"},{"key":"ref2","first-page":"483","article-title":"Statins: a new insight into their mechanisms of action and consequent pleiotropic effects.","volume":"59","author":"M Jasinska","year":"2007","journal-title":"Pharmacol Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCOUTCOMES.109.868299","article-title":"The JUPITER trial: results, controversies, and implications for prevention.","volume":"2","author":"PM Ridker","year":"2009","journal-title":"Circulation Cardiovascular quality and outcomes"},{"key":"ref4","first-page":"555","article-title":"Pharmacogenomics of statin response.","volume":"10","author":"LM Mangravite","year":"2008","journal-title":"Curr Opin Mol Ther"},{"key":"ref5","first-page":"193","article-title":"Major diet-drug interactions affecting the kinetic characteristics and hypolipidaemic properties of statins.","volume":"25","author":"MP Vaquero","year":"2010","journal-title":"Nutr Hosp"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.","volume":"359","author":"PM Ridker","year":"2008","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2133\/dmpk.25.62","article-title":"Ongoing challenges in drug interaction safety: from exposure to pharmacogenomics.","volume":"25","author":"JP Bai","year":"2010","journal-title":"Drug Metab Pharmacokinet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"14728","DOI":"10.1073\/pnas.0904489106","article-title":"Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism.","volume":"106","author":"TA Clayton","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e25482","DOI":"10.1371\/journal.pone.0025482","article-title":"Enteric microbiome metabolites correlate with response to simvastatin treatment.","volume":"6","author":"R Kaddurah-Daouk","year":"2011","journal-title":"PLoS ONE"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1146\/annurev.pharmtox.48.113006.094715","article-title":"Metabolomics: a global biochemical approach to drug response and disease.","volume":"48","author":"R Kaddurah-Daouk","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/npp.2008.174","article-title":"Metabolomics: a global biochemical approach to the study of central nervous system diseases.","volume":"34","author":"R Kaddurah-Daouk","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e21643","DOI":"10.1371\/journal.pone.0021643","article-title":"Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.","volume":"6","author":"X Han","year":"2011","journal-title":"PLoS ONE"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/mp.2009.33","article-title":"Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia.","volume":"15","author":"JK Yao","year":"2010","journal-title":"Mol Psychiatry"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e9508","DOI":"10.1371\/journal.pone.0009508","article-title":"Homeostatic imbalance of purine catabolism in first-episode neuroleptic-naive patients with schizophrenia.","volume":"5","author":"JK Yao","year":"2010","journal-title":"PLoS ONE"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2217\/pgs.10.157","article-title":"Pharmacometabonomics as an effector for personalized medicine.","volume":"12","author":"JK Nicholson","year":"2011","journal-title":"Pharmacogenomics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm.2307","article-title":"Metabolite profiles and the risk of developing diabetes.","volume":"17","author":"TJ Wang","year":"2011","journal-title":"Nat Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.","volume":"472","author":"Z Wang","year":"2011","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/clpt.2010.250","article-title":"Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram\/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics.","volume":"89","author":"Y Ji","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11306-010-0207-x","article-title":"Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study.","volume":"6","author":"R Kaddurah-Daouk","year":"2010","journal-title":"Metabolomics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1038\/tp.2011.22","article-title":"Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept.","volume":"1","author":"R Kaddurah-Daouk","year":"2011","journal-title":"Transl Psychiatry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.amjcard.2005.09.134","article-title":"Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study.","volume":"97","author":"JA Simon","year":"2006","journal-title":"Am J Cardiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1475-2891-2-3","article-title":"Alpha-tocopherol modulates the low density lipoprotein receptor of human HepG2 cells.","volume":"2","author":"S Pal","year":"2003","journal-title":"Nutr J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.bbrc.2008.02.132","article-title":"alpha-Tocopherol disturbs macrophage LXRalpha regulation of ABCA1\/G1 and cholesterol handling.","volume":"369","author":"S Rode","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0022-2275(20)31160-3","article-title":"Alpha-tocopherol decreases CD36 expression in human monocyte-derived macrophages.","volume":"42","author":"S Devaraj","year":"2001","journal-title":"J Lipid Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1161\/01.CIR.102.1.82","article-title":"Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells.","volume":"102","author":"R Ricciarelli","year":"2000","journal-title":"Circulation"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0009-8981(97)06557-1","article-title":"The effect of Simvastatin on the plasma antioxidant concentrations in patients with hypercholesterolaemia.","volume":"263","author":"JA Human","year":"1997","journal-title":"Clin Chim Acta"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1080\/07853890410018844","article-title":"Effect of 12-month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations.","volume":"36","author":"T Vasankari","year":"2004","journal-title":"Ann Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0735-1097(98)00295-2","article-title":"Additional benefit of vitamin E supplementation to simvastatin therapy on vasoreactivity of the brachial artery of hypercholesterolemic men.","volume":"32","author":"T Neunteufl","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"ref29","article-title":"Effects of simvastatin on carotenoid status in plasma.","author":"M Ryden","year":"2010"},{"key":"ref30","first-page":"37","article-title":"Effect of simvastatin on trioleylglycerol hydrolysis and transacylation with cholesterol in serum of outpatients with coronary heart disease.","volume":"29","author":"M Piorunska-Stolzmann","year":"2003","journal-title":"Drugs Exp Clin Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1053\/j.ajkd.2004.11.015","article-title":"First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease.","volume":"45","author":"C Baigent","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.atherosclerosis.2008.11.010","article-title":"Effect of simvastatin on kidney function loss in patients with coronary heart disease: findings from the Scandinavian Simvastatin Survival Study (4S).","volume":"205","author":"J Huskey","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/08860220601038892","article-title":"Improvement of endothelial dysfunction with simvastatin in patients with autosomal dominant polycystic kidney disease.","volume":"29","author":"S Namli","year":"2007","journal-title":"Ren Fail"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1074\/mcp.M900140-MCP200","article-title":"Quantification of cardiovascular biomarkers in patient plasma by targeted mass spectrometry and stable isotope dilution.","volume":"8","author":"H Keshishian","year":"2009","journal-title":"Mol Cell Proteomics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"80re82","DOI":"10.1126\/scitranslmed.3002043","article-title":"Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss.","volume":"3","author":"B Laferrere","year":"2011","journal-title":"Sci Transl Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"902","DOI":"10.2310\/JIM.0b013e3181bca50c","article-title":"Allopurinol, xanthine oxidase, and cardiac ischemia.","volume":"57","author":"BE Lee","year":"2009","journal-title":"J Investig Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1124\/pr.58.1.6","article-title":"Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol.","volume":"58","author":"P Pacher","year":"2006","journal-title":"Pharmacol Rev"},{"key":"ref38","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2125.2006.02785.x","article-title":"Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease?","author":"J Dawson","year":"2006"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000320356","article-title":"Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats.","volume":"48","author":"IF Schwartz","year":"2011","journal-title":"J Vasc Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1039\/C0MB00023J","article-title":"Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro.","volume":"7","author":"AM Aura","year":"2011","journal-title":"Mol Biosyst"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-313X.2007.03387.x","article-title":"Quality control for plant metabolomics: reporting MSI-compliant studies.","volume":"53","author":"O Fiehn","year":"2008","journal-title":"Plant J"},{"key":"ref42","first-page":"224","article-title":"Setup and annotation of metabolomic experiments by integrating biological and mass spectrometric metadata.","volume":"3615","author":"O Fiehn","year":"2005","journal-title":"Proc Lect Notes Bioinformatics"},{"key":"ref43","first-page":"169","article-title":"SetupX\u2013a public study design database for metabolomic projects.","author":"M Scholz","year":"2007"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies.","volume":"100","author":"JD Storey","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1000479","DOI":"10.1371\/journal.pgen.1000479","article-title":"Modulated modularity clustering as an exploratory tool for functional genomic inference.","volume":"5","author":"EA Stone","year":"2009","journal-title":"PLoS Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/cem.695","article-title":"Orthogonal projections to latent structures (O-PLS).","volume":"16","author":"J Trygg","year":"2002","journal-title":"Journal of Chemometrics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0038386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T13:56:25Z","timestamp":1642686985000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0038386"}},"subtitle":[],"editor":[{"given":"Matej","family":"Oresic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,9]]},"references-count":46,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0038386","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.724156960.793534132","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,9]]}}}