{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:28:53Z","timestamp":1792740533890,"version":"4.5.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T00:00:00Z","timestamp":1338854400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0038408","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T21:00:24Z","timestamp":1338930024000},"page":"e38408","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":61,"title":["Heterogeneity of Multifunctional IL-17A Producing S. Typhi-Specific CD8+ T Cells in Volunteers following Ty21a Typhoid Immunization"],"prefix":"10.1371","volume":"7","author":[{"given":"Monica A.","family":"McArthur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo B.","family":"Sztein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1001\/jama.2009.1259","article-title":"Addressing the global disease burden of typhoid fever.","volume":"302","author":"ZA Bhutta","year":"2009","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1086\/649541","article-title":"Global trends in typhoid and paratyphoid Fever.","volume":"50","author":"JA Crump","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref3","article-title":"Emerging drug resistance and vaccination for typhoid fever.","volume":"580","author":"BL Atkins","year":"1998","journal-title":"JAMA 279: 579; author reply"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/adc.75.3.214","article-title":"Impact of age and drug resistance on mortality in typhoid fever.","volume":"75","author":"ZA Bhutta","year":"1996","journal-title":"Arch Dis Child"},{"key":"ref5","first-page":"346","article-title":"The global burden of typhoid fever.","volume":"82","author":"JA Crump","year":"2004","journal-title":"Bull World Health Organ"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.4103\/0255-0857.83904","article-title":"Antimicrobial resistance in typhoidal salmonellae.","volume":"29","author":"BN Harish","year":"2011","journal-title":"Indian J Med Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1001\/jama.2009.1229","article-title":"Typhoid fever in the United States, 1999\u20132006.","volume":"302","author":"MF Lynch","year":"2009","journal-title":"JAMA"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1099\/00222615-44-5-317","article-title":"Multi-drug resistant typhoid: a global problem.","volume":"44","author":"SH Mirza","year":"1996","journal-title":"J Med Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.4049\/jimmunol.173.9.5852","article-title":"Identification of a human HLA-E-restricted CD8+ T cell subset in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine.","volume":"173","author":"R Salerno-Goncalves","year":"2004","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.4049\/jimmunol.169.4.2196","article-title":"Characterization of CD8(+) effector T cell responses in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine.","volume":"169","author":"R Salerno-Goncalves","year":"2002","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e5879","DOI":"10.1371\/journal.pone.0005879","article-title":"Priming of Salmonella enterica serovar typhi-specific CD8(+) T cells by suicide dendritic cell cross-presentation in humans.","volume":"4","author":"R Salerno-Goncalves","year":"2009","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1128\/IAI.73.6.3521-3530.2005","article-title":"Immunization of volunteers with Salmonella enterica serovar Typhi strain Ty21a elicits the oligoclonal expansion of CD8+ T cells with predominant Vbeta repertoires.","volume":"73","author":"R Salerno-Goncalves","year":"2005","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1128\/CVI.00234-10","article-title":"Ex Vivo kinetics of early and long-term multifunctional human leukocyte antigen E-specific CD8+ cells in volunteers immunized with the Ty21a typhoid vaccine.","volume":"17","author":"R Salerno-Goncalves","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.4049\/jimmunol.170.5.2734","article-title":"Concomitant induction of CD4+ and CD8+ T cell responses in volunteers immunized with Salmonella enterica serovar typhi strain CVD 908-htrA.","volume":"170","author":"R Salerno-Goncalves","year":"2003","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1086\/518140","article-title":"Cell-mediated immunity and antibody responses elicited by attenuated Salmonella enterica Serovar Typhi strains used as live oral vaccines in humans.","volume":"45","author":"MB Sztein","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.vaccine.2006.10.040","article-title":"Cell-mediated immune responses in humans after immunization with one or two doses of oral live attenuated typhoid vaccine CVD 909.","volume":"25","author":"R Wahid","year":"2007","journal-title":"Vaccine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/mi.2008.30","article-title":"Generation of specific effector and memory T cells with gut- and secondary lymphoid tissue- homing potential by oral attenuated CVD 909 typhoid vaccine in humans.","volume":"1","author":"R Wahid","year":"2008","journal-title":"Mucosal Immunol"},{"key":"ref18","first-page":"3987","article-title":"Cytotoxic T lymphocytes after oral immunization with attenuated vaccine strains of Salmonella typhi in humans.","volume":"155","author":"MB Sztein","year":"1995","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4161\/viru.1.5.12862","article-title":"IL-17 in protective immunity to intracellular pathogens.","volume":"1","author":"SA Khader","year":"2010","journal-title":"Virulence"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nm1743","article-title":"Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut.","volume":"14","author":"M Raffatellu","year":"2008","journal-title":"Nat Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.4049\/jimmunol.0900978","article-title":"Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity.","volume":"184","author":"G Sellge","year":"2010","journal-title":"J Immunol"},{"key":"ref22","article-title":"Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-gamma-mediated immunity.","author":"JM Marques","year":"2011"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/mi.2009.100","article-title":"Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa.","volume":"2","author":"SA Khader","year":"2009","journal-title":"Mucosal Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cytogfr.2010.11.002","article-title":"The role of Th17 cytokines in primary mucosal immunity.","volume":"21","author":"JK Kolls","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1073\/pnas.0914839107","article-title":"Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties.","volume":"107","author":"E Billerbeck","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.4049\/jimmunol.0801814","article-title":"Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.","volume":"182","author":"H Hamada","year":"2009","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.4049\/jimmunol.1000818","article-title":"Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype.","volume":"185","author":"N Yeh","year":"2010","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"745","DOI":"10.4049\/jimmunol.1002807","article-title":"Loss of IL-17-producing CD8 T cells during late chronic stage of pathogenic simian immunodeficiency virus infection.","volume":"186","author":"P Nigam","year":"2011","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nm1592","article-title":"Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major.","volume":"13","author":"PA Darrah","year":"2007","journal-title":"Nat Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1128\/JVI.00228-07","article-title":"Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells.","volume":"81","author":"S Kannanganat","year":"2007","journal-title":"J Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"12071","DOI":"10.1128\/JVI.01261-07","article-title":"Human immunodeficiency virus type 1 controllers but not noncontrollers maintain CD4 T cells coexpressing three cytokines.","volume":"81","author":"S Kannanganat","year":"2007","journal-title":"J Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1093\/infdis\/170.6.1508","article-title":"Cytokine production patterns and lymphoproliferative responses in volunteers orally immunized with attenuated vaccine strains of Salmonella typhi.","volume":"170","author":"MB Sztein","year":"1994","journal-title":"J Infect Dis"},{"key":"ref33","first-page":"4951","article-title":"HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences.","volume":"160","author":"N Lee","year":"1998","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.immunol.22.012703.104702","article-title":"Central memory and effector memory T cell subsets: function, generation, and maintenance.","volume":"22","author":"F Sallusto","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/00006454-198906000-00010","article-title":"Typhoid vaccines come of age.","volume":"8","author":"MM Levine","year":"1989","journal-title":"Pediatr Infect Dis J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1002\/cyto.b.20554","article-title":"Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data.","volume":"78","author":"Y Qian","year":"2010","journal-title":"Cytometry B Clin Cytom"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/intimm\/dxn069","article-title":"IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance.","volume":"20","author":"SM Schulz","year":"2008","journal-title":"Int Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.20070663","article-title":"Phenotypic and functional features of human Th17 cells.","volume":"204","author":"F Annunziato","year":"2007","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.4049\/jimmunol.165.11.6107","article-title":"Microbial lipopeptides induce the production of IL-17 in Th cells.","volume":"165","author":"C Infante-Duarte","year":"2000","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nri1635","article-title":"MHC class Ib molecules bridge innate and acquired immunity.","volume":"5","author":"JR Rodgers","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1146\/annurev.iy.12.040194.004203","article-title":"Antigen presentation by major histocompatibility complex class I-B molecules.","volume":"12","author":"SM Shawar","year":"1994","journal-title":"Annu Rev Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0038408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:52:31Z","timestamp":1588974751000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0038408"}},"subtitle":[],"editor":[{"given":"Mauricio Martins","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,5]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0038408","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,5]]}}}