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Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.","volume":"24","author":"K Tamura","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/BF02102193","article-title":"A fast unbiased comparison of protein structures by means of the Needleman-Wunsch algorithm.","volume":"32","author":"J Rose","year":"1991","journal-title":"J Mol Evol"},{"key":"ref48","author":"AB Drummond AJ","year":"2011"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0014-4894(02)00008-5","article-title":"Immunoaffinity-isolated antigens induce protective immunity against larval <italic>Strongyloides stercoralis<\/italic> in mice.","volume":"100","author":"DR Herbert","year":"2002","journal-title":"Exp 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Wang","year":"2003","journal-title":"Development"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e18086","DOI":"10.1371\/journal.pone.0018086","article-title":"Sensitive and precise quantification of insulin-like mRNA expression in <italic>Caenorhabditis elegans<\/italic>.","volume":"6","author":"LR Baugh","year":"2011","journal-title":"PLoS One"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1126\/science.290.5489.147","article-title":"Regulation of <italic>C. elegans<\/italic> life-span by insulinlike signaling in the nervous system.","volume":"290","author":"CA Wolkow","year":"2000","journal-title":"Science"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1371\/journal.pbio.0050237","article-title":"High-throughput in vivo analysis of gene expression in <italic>Caenorhabditis elegans<\/italic>.","volume":"5","author":"R Hunt-Newbury","year":"2007","journal-title":"PLoS 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