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Pharmacol Ther.","volume":"123","author":"KE Porter","year":"2009"},{"key":"ref2","first-page":"25796","article-title":"Cardiac fibroblasts arrest at the G1\/S restriction point in response to interleukin (IL)-1beta. Evidence for IL-1beta-induced hypophosphorylation of the retinoblastoma protein. J Biol Chem.","volume":"273","author":"F Koudssi","year":"1998"},{"key":"ref3","first-page":"H220","article-title":"Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts. Am J Physiol.","volume":"272","author":"MH Soonpaa","year":"1997"},{"key":"ref4","first-page":"845","article-title":"Regenerating the heart. Nat Biotechnol.","volume":"23","author":"MA Laflamme","year":"2005"},{"key":"ref5","first-page":"521","article-title":"Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev.","volume":"87","author":"P Ahuja","year":"2007"},{"key":"ref6","first-page":"1750","article-title":"Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med.","volume":"344","author":"AP Beltrami","year":"2001"},{"key":"ref7","first-page":"1360","article-title":"Cardiomyocyte proliferation: a platform for mammalian cardiac repair. Cell Cycle.","volume":"4","author":"FB Engel","year":"2005"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","article-title":"Neuregulin1\/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.","volume":"138","author":"K Bersell","year":"2009","journal-title":"Cell"},{"key":"ref9","first-page":"303","article-title":"Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart. Cardiovasc Res.","volume":"83","author":"R Granata","year":"2009"},{"key":"ref10","first-page":"323","article-title":"The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival. Cell Cycle.","volume":"4","author":"RS Gupte","year":"2005"},{"key":"ref11","first-page":"227","article-title":"The PCNA-RFC families of DNA clamps and clamp loaders. Prog Nucleic Acid Res Mol Biol.","volume":"78","author":"J Majka","year":"2004"},{"key":"ref12","first-page":"677","article-title":"Localization of proliferating cell nuclear antigen in the developing and mature rat heart cell. Anat Rec.","volume":"245","author":"TA Marino","year":"1996"},{"key":"ref13","first-page":"24","article-title":"Biochemical characterization and development of DNA polymerases alpha and delta in the neonatal rat heart. Arch Biochem Biophys.","volume":"252","author":"SJ Zhang","year":"1987"},{"key":"ref14","first-page":"533","article-title":"Expression of replication factor C 40-kDa subunit is down-regulated during neonatal development in rat ventricular myocardium. J Cell Biochem.","volume":"78","author":"SS Chim","year":"2000"},{"key":"ref15","first-page":"794","article-title":"The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. Chest.","volume":"135","author":"HJ Bogaard","year":"2009"},{"key":"ref16","first-page":"1951","article-title":"Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure. Circulation.","volume":"120","author":"HJ Bogaard","year":"2009"},{"key":"ref17","first-page":"1050","article-title":"End-stage cardiac failure in humans is coupled with the induction of proliferating cell nuclear antigen and nuclear mitotic division in ventricular myocytes. Circ Res.","volume":"75","author":"F Quaini","year":"1994"},{"key":"ref18","first-page":"286","article-title":"Chronic right ventricular pressure overload results in a hyperplastic rather than a hypertrophic myocardial response. J Anat.","volume":"212","author":"BP Leeuwenburgh","year":"2008"},{"key":"ref19","first-page":"116","article-title":"Endomitosis and polyploidization of myocardial cells in the periphery of human acute myocardial infarction. Cardiovasc Res.","volume":"67","author":"PC Meckert","year":"2005"},{"key":"ref20","first-page":"1545","article-title":"Activation of cyclins and cyclin-dependent kinases, DNA synthesis, and myocyte mitotic division in pacing-induced heart failure in dogs. Lab Invest.","volume":"79","author":"M Setoguchi","year":"1999"},{"issue":"182","key":"ref21","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1164\/rccm.201003-0335OC","article-title":"Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats.","volume":"Med","author":"HJ Bogaard","year":"2010","journal-title":"Am J Respir Crit Care"},{"issue":"121","key":"ref22","first-page":"2747","article-title":"Formation of plexiform lesions in experimental severe pulmonary arterial hypertension.","volume":"Circulation","author":"K Abe","year":"2010"},{"key":"ref23","first-page":"H285","article-title":"Cholesterol depletion modulates basal L-type Ca2+ current and abolishes its -adrenergic enhancement in ventricular myocytes. Am J Physiol Heart Circ Physiol.","volume":"294","author":"H Tsujikawa","year":"2008"},{"key":"ref24","first-page":"898","article-title":"The structural determinants of checkpoint activation. Genes Dev.","volume":"21","author":"CA MacDougall","year":"2007"},{"key":"ref25","first-page":"2636","article-title":"Incorporation of reporter molecule-labeled nucleotides by DNA polymerases. II. High-density labeling of natural DNA. Nucleic Acids Res.","volume":"31","author":"T Tasara","year":"2003"},{"key":"ref26","first-page":"3883","article-title":"Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, alpha and delta. EMBO J.","volume":"8","author":"T Tsurimoto","year":"1989"},{"key":"ref27","first-page":"289","article-title":"DNA synthesis in adult feline ventricular myocytes. Comparison of hypoxic and normoxic states. Circ Res.","volume":"78","author":"PL Kozlovskis","year":"1996"},{"key":"ref28","first-page":"2223","article-title":"Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids.","volume":"42","author":"CJ Jong","year":"2012"},{"key":"ref29","first-page":"1051","article-title":"Origin of cells cultured in vitro from human breast carcinomas traced by cyclin D1 and HER2\/neu FISH signal numbers. Anticancer Res.","volume":"25","author":"E Matouskova","year":"2005"},{"key":"ref30","first-page":"901","article-title":"Various hypertrophic stimuli induce distinct phenotypes in cardiomyocytes. J Mol Med.","volume":"75","author":"MC Schaub","year":"1997"},{"key":"ref31","first-page":"5156","article-title":"Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants. Mol Cell Biol.","volume":"21","author":"SA Krause","year":"2001"},{"key":"ref32","first-page":"365","article-title":"Cardiomyocyte cell cycle control and growth estimation in vivo\u2013an analysis based on cardiomyocyte nuclei. Cardiovasc Res.","volume":"86","author":"S Walsh","year":"2010"},{"key":"ref33","first-page":"536","article-title":"Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties. Circ Res.","volume":"100","author":"X Chen","year":"2007"},{"key":"ref34","first-page":"1270","article-title":"Re-expression of proteins involved in cytokinesis during cardiac hypertrophy. Exp Cell Res.","volume":"313","author":"P Ahuja","year":"2007"},{"key":"ref35","first-page":"52630","article-title":"Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure. J Biol Chem.","volume":"279","author":"S Sarkar","year":"2004"},{"key":"ref36","first-page":"8801","article-title":"Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci U S A.","volume":"95","author":"J Kajstura","year":"1998"},{"key":"ref37","first-page":"27","article-title":"Polyploidy of myocyte nuclei in pressure overloaded human hearts: a flow cytometric study in left and right ventricular myocardium. Am J Cardiovasc Pathol.","volume":"5","author":"HW Vliegen","year":"1995"},{"key":"ref38","first-page":"497","article-title":"Nuclear DNA content and nucleation patterns in rat cardiac myocytes from different models of cardiac hypertrophy. J Mol Cell Cardiol.","volume":"24","author":"S Kellerman","year":"1992"},{"key":"ref39","first-page":"203","article-title":"Changes in nuclear size of cardiac myocytes during the development and progression of hypertrophy in rats. Cardioscience.","volume":"5","author":"AM Gerdes","year":"1994"},{"key":"ref40","first-page":"2461","article-title":"Endoreplication: polyploidy with purpose. Genes Dev.","volume":"23","author":"HO Lee","year":"2009"},{"key":"ref41","first-page":"989","article-title":"Hemodynamic support by left ventricular assist devices reduces cardiomyocyte DNA content in the failing human heart. Circulation.","volume":"121","author":"J Wohlschlaeger","year":"2010"},{"key":"ref42","first-page":"4","article-title":"When 2+2 = 5: the origins and fates of aneuploid and tetraploid cells. Biochim Biophys Acta.","volume":"1786","author":"RW King","year":"2008"},{"key":"ref43","first-page":"10454","article-title":"Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. J Neurosci.","volume":"23","author":"AH Yang","year":"2003"},{"key":"ref44","first-page":"167","article-title":"Chromosome missegregation and trisomy 21 mosaicism in Alzheimer\u2019s disease. Neurobiol Dis.","volume":"6","author":"LN Geller","year":"1999"},{"key":"ref45","first-page":"6859","article-title":"Aneuploidy and DNA replication in the normal human brain and Alzheimer\u2019s disease. J Neurosci.","volume":"27","author":"B Mosch","year":"2007"},{"key":"ref46","first-page":"2661","article-title":"DNA replication precedes neuronal cell death in Alzheimer\u2019s disease. J Neurosci.","volume":"21","author":"Y Yang","year":"2001"},{"key":"ref47","first-page":"1038","article-title":"Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature.","volume":"437","author":"Q Shi","year":"2005"},{"key":"ref48","first-page":"1583","article-title":"Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. Curr Biol.","volume":"13","author":"P Kanellis","year":"2003"},{"key":"ref49","first-page":"3547","article-title":"Sister-chromatid cohesion mediated by the alternative RF-CCtf18\/Dcc1\/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II. J Cell Sci.","volume":"17","author":"M Petronczki","year":"2004"},{"key":"ref50","first-page":"959","article-title":"Identification of RFC (Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell.","volume":"7","author":"ML Mayer","year":"2001"},{"key":"ref51","first-page":"56","article-title":"Mechanism of pressure-overload right ventricular hypertrophy in infant rabbits. Int Heart J.","volume":"52","author":"S Minegishi","year":"2011"},{"key":"ref52","first-page":"169","article-title":"Myocyte cell death and ventricular remodeling. Curr Opin Nephrol Hypertens.","volume":"6","author":"P Anversa","year":"1997"},{"key":"ref53","first-page":"15","article-title":"Selective cell death of hyperploid neurons in Alzheimer\u2019s disease. Am J Pathol.","volume":"177","author":"T Arendt","year":"2010"},{"key":"ref54","first-page":"185","article-title":"Cell cycle reactivation in mature neurons: a link with brain plasticity, neuronal injury and neurodegenerative diseases? Neurosci Bull.","volume":"27","author":"K Hern\u00e1ndez-Ortega","year":"2011"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0039009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T03:01:46Z","timestamp":1540350106000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0039009"}},"subtitle":[],"editor":[{"given":"Emanuele","family":"Buratti","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,14]]},"references-count":54,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0039009","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,14]]}}}