{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:32:49Z","timestamp":1761708769016},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0039161","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T21:06:51Z","timestamp":1340053611000},"page":"e39161","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["UNC93B1 Mediates Innate Inflammation and Antiviral Defense in the Liver during Acute Murine Cytomegalovirus Infection"],"prefix":"10.1371","volume":"7","author":[{"given":"Meredith J.","family":"Crane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela J.","family":"Gaddi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais P.","family":"Salazar-Mather","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,6,18]]},"reference":[{"key":"ref1","article-title":"Pattern recognition receptors and inflammation. Cell 140: 805\u2013820.","author":"O Takeuchi","year":"2010"},{"key":"ref2","article-title":"Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci 1143: 1\u201320.","author":"T Kawai","year":"2008"},{"key":"ref3","article-title":"Antiviral responses: different roles for different tolls. Immunity 30: 173\u2013175.","author":"RW Finberg","year":"2009"},{"key":"ref4","article-title":"Cell type-specific involvement of RIG-I in antiviral response. Immunity 23: 19\u201328.","author":"H Kato","year":"2005"},{"key":"ref5","article-title":"The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol 177: 265\u2013275.","author":"MM Brinkmann","year":"2007"},{"key":"ref6","article-title":"Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A 101: 3516\u20133521.","author":"K Tabeta","year":"2004"},{"key":"ref7","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413: 732\u2013738.","author":"L Alexopoulou","year":"2001"},{"key":"ref8","article-title":"Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A 101: 5598\u20135603.","author":"JM Lund","year":"2004"},{"key":"ref9","article-title":"A Toll-like receptor recognizes bacterial DNA. Nature 408: 740\u2013745.","author":"H Hemmi","year":"2000"},{"key":"ref10","article-title":"Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198: 513\u2013520.","author":"J Lund","year":"2003"},{"key":"ref11","article-title":"Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways. Proc Natl Acad Sci U S A 101: 11416\u201311421.","author":"H Hochrein","year":"2004"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.4049\/jimmunol.169.12.6668","article-title":"Cutting edge: a novel Toll\/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.","volume":"169","author":"M Yamamoto","year":"2002","journal-title":"J Immunol"},{"key":"ref13","article-title":"Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol 5: 1061\u20131068.","author":"T Kawai","year":"2004"},{"key":"ref14","article-title":"Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A 101: 15416\u201315421.","author":"K Honda","year":"2004"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.4049\/jimmunol.169.8.4279","article-title":"Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection.","volume":"169","author":"KB Nguyen","year":"2002","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1084\/jem.185.7.1185","article-title":"Characterization of early cytokine responses and an interleukin (IL)-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infection.","volume":"185","author":"MC Ruzek","year":"1997","journal-title":"J Exp Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.4049\/jimmunol.156.12.4746","article-title":"Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection.","volume":"156","author":"JS Orange","year":"1996","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.4049\/jimmunol.156.3.1138","article-title":"An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.","volume":"156","author":"JS Orange","year":"1996","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.20011672","article-title":"Interferon alpha\/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo.","volume":"195","author":"M Dalod","year":"2002","journal-title":"J Exp Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.4049\/jimmunol.179.9.6176","article-title":"IFN-alphabeta-mediated inflammatory responses and antiviral defense in liver is TLR9-independent but MyD88-dependent during murine cytomegalovirus infection.","volume":"179","author":"KL Hokeness-Antonelli","year":"2007","journal-title":"J Immunol"},{"key":"ref21","first-page":"29","article-title":"Cytokine and chemokine networks: pathways to antiviral defense.","volume":"303","author":"TP Salazar-Mather","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.4049\/jimmunol.174.3.1549","article-title":"Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-alpha\/beta-induced inflammatory responses and antiviral defense in liver.","volume":"174","author":"KL Hokeness","year":"2005","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.187.1.1","article-title":"Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1alpha (MIP-1alpha)-dependent pathways.","volume":"187","author":"TP Salazar-Mather","year":"1998","journal-title":"J Exp Med"},{"key":"ref24","article-title":"A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense. J Clin Invest 105: 985\u2013993.","author":"TP Salazar-Mather","year":"2000"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1128\/JVI.71.1.267-275.1997","article-title":"Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells.","volume":"71","author":"CH Tay","year":"1997","journal-title":"J Virol"},{"key":"ref26","article-title":"CXCR3-dependent recruitment of antigen-specific T lymphocytes to the liver during murine cytomegalovirus infection. J Virol 81: 1241\u20131250.","author":"KL Hokeness","year":"2007"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1007\/s007050070010","article-title":"Immune responses and cytokine induction in the development of severe hepatitis during acute infections with murine cytomegalovirus.","volume":"145","author":"J Trgovcich","year":"2000","journal-title":"Arch Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2249.1994.tb05500.x","article-title":"Cytomegalovirus hepatitis: characterization of the inflammatory infiltrate in resistant and susceptible mice.","volume":"98","author":"SD Olver","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.4049\/jimmunol.176.6.3760","article-title":"Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus.","volume":"176","author":"MW Munks","year":"2006","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1128\/JVI.77.3.1703-1717.2003","article-title":"Vigorous innate and virus-specific cytotoxic T-lymphocyte responses to murine cytomegalovirus in the submaxillary salivary gland.","volume":"77","author":"VJ Cavanaugh","year":"2003","journal-title":"J Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.immuni.2004.06.007","article-title":"TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.","volume":"21","author":"A Krug","year":"2004","journal-title":"Immunity"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.4049\/jimmunol.175.10.6723","article-title":"MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.","volume":"175","author":"T Delale","year":"2005","journal-title":"J Immunol"},{"key":"ref33","first-page":"5799","article-title":"Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.","volume":"180","author":"N Zucchini","year":"2008"},{"key":"ref34","article-title":"UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 452: 234\u2013238.","author":"Y-M Kim","year":"2008"},{"key":"ref35","article-title":"The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 7: 156\u2013164.","author":"K Tabeta","year":"2006"},{"key":"ref36","article-title":"Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1alpha delivery to the liver. J Clin Invest 110: 321\u2013330.","author":"TP Salazar-Mather","year":"2002"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"9248","DOI":"10.1128\/JVI.71.12.9248-9258.1997","article-title":"Mechanisms for virus-induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection.","volume":"71","author":"JS Orange","year":"1997","journal-title":"J Virol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.22034","article-title":"Liver: An organ with predominant innate immunity.","volume":"47","author":"B Gao","year":"2008","journal-title":"Hepatology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1002\/hep.21060","article-title":"The liver as an immunological organ.","volume":"43","author":"V Racanelli","year":"2006","journal-title":"Hepatology"},{"key":"ref40","first-page":"47","article-title":"The hepatic immune system.","volume":"22","author":"MJ Wick","year":"2002","journal-title":"Crit Rev Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1053\/j.gastro.2006.01.038","article-title":"Toll-like receptor signaling in the liver.","volume":"130","author":"RF Schwabe","year":"2006","journal-title":"Gastroenterology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/hep.21308","article-title":"Pattern recognition receptors: a contemporary view on liver diseases.","volume":"44","author":"G Szabo","year":"2006","journal-title":"Hepatology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.virol.2004.01.033","article-title":"Does Toll-like receptor 3 play a biological role in virus infections?","volume":"322","author":"KH Edelmann","year":"2004","journal-title":"Virology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/intimm\/dxm119","article-title":"Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection.","volume":"20","author":"N Zucchini","year":"2008","journal-title":"Int Immunol"},{"key":"ref45","article-title":"Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303: 1529\u20131531.","author":"SS Diebold","year":"2004"},{"key":"ref46","article-title":"Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103: 1433\u20131437.","author":"A Krug","year":"2004"},{"key":"ref47","article-title":"Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev 234: 142\u2013162.","author":"M Swiecki","year":"2010"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.immuni.2010.11.020","article-title":"Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual.","volume":"33","author":"M Swiecki","year":"2010","journal-title":"Immunity"},{"key":"ref49","first-page":"1011","article-title":"Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nat. Immunol.","volume":"6","author":"CE Andoniou","year":"2005"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.virol.2011.02.003","article-title":"Innate immune sensing of DNA viruses.","volume":"411","author":"VA Rathinam","year":"2011","journal-title":"Virology"},{"key":"ref51","article-title":"A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. Proc Natl Acad Sci U S A 106: 17870\u201317875.","author":"MK Choi","year":"2009"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1128\/JVI.79.5.2689-2699.2005","article-title":"Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I.","volume":"79","author":"R Sumpter Jr","year":"2005","journal-title":"J Virol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.chom.2011.04.008","article-title":"IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.","volume":"19","author":"N Kerur","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/ni.2091","article-title":"The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells.","volume":"12","author":"Z Zhang","year":"2011","journal-title":"Nat Immunol"},{"key":"ref55","first-page":"8913","article-title":"Activation of the interferon response by human cytomegalovirus occurs via cytoplasmic double-stranded DNA but not glycoprotein B. J Virol","volume":"84","author":"VR DeFilippis","year":"2010"},{"key":"ref56","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20021522","article-title":"Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha\/beta. J Exp Med 197: 885\u2013898.","author":"M Dalod","year":"2003"},{"key":"ref57","first-page":"2552","article-title":"Role of IL-12-independent and IL-12-dependent pathways in regulating generation of the IFN-gamma component of T cell responses to Salmonella typhimurium.","volume":"2545","author":"B John","year":"2002","journal-title":"J Immunol 169"},{"key":"ref58","first-page":"188","article-title":"Generation of a protective T-cell response following coronavirus infection of the central nervous system is not dependent on IL-12\/23 signaling.","volume":"173","author":"KS Held","year":"2008","journal-title":"Virol Immunol 21"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.4049\/jimmunol.1102335","article-title":"Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.","volume":"187","author":"JJ Obar","year":"2011","journal-title":"J Immunol"},{"key":"ref60","article-title":"AID-IMMU3048&amp;#62; 3.0.CO; 2-1","author":"HC Su","year":"2001"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1084\/jem.20091193","article-title":"Innate immunity defines the capacity of antiviral T cells to limit persistent infection.","volume":"207","author":"DM Andrews","year":"2010","journal-title":"J Exp Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1128\/JVI.06042-11","article-title":"The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response.","volume":"86","author":"M Mitrovic","year":"2012","journal-title":"J Virol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0039161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T20:40:09Z","timestamp":1714077609000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0039161"}},"subtitle":[],"editor":[{"given":"Karin E.","family":"Peterson","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,18]]},"references-count":62,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0039161","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,18]]}}}