{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:44:26Z","timestamp":1791254666816,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T00:00:00Z","timestamp":1341878400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0039235","type":"journal-article","created":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T21:49:38Z","timestamp":1341956978000},"page":"e39235","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Increased Microparticle Production and Impaired Microvascular Endothelial Function in Aldosterone-Salt-Treated Rats: Protective Effects of Polyphenols"],"prefix":"10.1371","volume":"7","author":[{"given":"Natalia","family":"L\u00f3pez Andr\u00e9s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Tesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Regnault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huguette","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Cattan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon N.","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Labat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustine","family":"Kakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Tual-Chalot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Faure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Challande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Osborne-Pellegrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Carmen","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lacolley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramaroson","family":"Andriantsitohaina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.HYP.0000255636.11931.a2","article-title":"Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1.","volume":"49","author":"S Shibata","year":"2007","journal-title":"Hypertension"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1161\/01.CIR.0000039328.33137.6C","article-title":"Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone.","volume":"106","author":"P Lacolley","year":"2002","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1006\/jmcc.1993.1066","article-title":"Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism.","volume":"25","author":"CG Brilla","year":"1993","journal-title":"J Mol Cell Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/HYPERTENSIONAHA.107.103267","article-title":"Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients.","volume":"51","author":"C Savoia","year":"2008","journal-title":"Hypertension"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/01.HYP.0000201443.63240.a7","article-title":"Effects of aldosterone on the vasculature.","volume":"47","author":"EL Schiffrin","year":"2006","journal-title":"Hypertension"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.tips.2011.06.005","article-title":"Microparticles: targets and tools in cardiovascular disease.","volume":"32","author":"MC Martinez","year":"2011","journal-title":"Trends Pharmacol Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/jhh.2008.137","article-title":"Elevated circulating endothelial microparticles and brachial-ankle pulse wave velocity in well-controlled hypertensive patients.","volume":"23","author":"JM Wang","year":"2009","journal-title":"J Hum Hypertens"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2353\/ajpath.2008.080228","article-title":"Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome.","volume":"173","author":"A Agouni","year":"2008","journal-title":"Am J Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.HYP.38.2.159","article-title":"Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression.","volume":"38","author":"M Diebolt","year":"2001","journal-title":"Hypertension"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/sj.bjp.0701011","article-title":"Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta.","volume":"120","author":"E Andriambeloson","year":"1997","journal-title":"Br J Pharmacol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"H942","DOI":"10.1152\/ajpheart.00724.2001","article-title":"Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension.","volume":"282","author":"I Bernatova","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1097\/01.hjh.0000133734.32125.c7","article-title":"Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension.","volume":"22","author":"O Pechanova","year":"2004","journal-title":"J Hypertens"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1161\/HYPERTENSIONAHA.107.107672","article-title":"Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats.","volume":"51","author":"R Lopez-Sepulveda","year":"2008","journal-title":"Hypertension"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e8554","DOI":"10.1371\/journal.pone.0008554","article-title":"Estrogen receptor alpha as a key target of red wine polyphenols action on the endothelium.","volume":"5","author":"M Chalopin","year":"2010","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1161\/HYPERTENSIONAHA.107.087213","article-title":"Uninephrectomy in young age or chronic salt loading causes salt-sensitive hypertension in adult rats.","volume":"49","author":"M Carlstrom","year":"2007","journal-title":"Hypertension"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1161\/01.HYP.37.6.1444","article-title":"ET(A) receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats.","volume":"37","author":"JB Park","year":"2001","journal-title":"Hypertension"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1096\/fj.06-7782com","article-title":"Effects of red wine polyphenols on postischemic neovascularization model in rats: low doses are proangiogenic, high doses anti-angiogenic.","volume":"21","author":"C Baron-Menguy","year":"2007","journal-title":"Faseb J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1164\/rccm.200909-1347OC","article-title":"Circulating microparticles from pulmonary hypertensive rats induce endothelial dysfunction.","volume":"182","author":"S Tual-Chalot","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1088\/0143-0815\/12\/1\/003","article-title":"Non-invasive estimate of the mechanical properties of peripheral arteries from ultrasonic and photoplethysmographic measurements.","volume":"12","author":"Y Tardy","year":"1991","journal-title":"Clin Phys Physiol Meas"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/01.RES.82.8.879","article-title":"Protection of the arterial internal elastic lamina by inhibition of the renin-angiotensin system in the rat.","volume":"82","author":"W Huang","year":"1998","journal-title":"Circ Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1161\/01.CIR.92.7.1876","article-title":"In vivo spin trapping of glyceryl trinitrate-derived nitric oxide in rabbit blood vessels and organs.","volume":"92","author":"A Mulsch","year":"1995","journal-title":"Circulation"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jchromb.2006.10.006","article-title":"Electron paramagnetic resonance (EPR) spin trapping of biological nitric oxide.","volume":"851","author":"AL Kleschyov","year":"2007","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"H2342","DOI":"10.1152\/ajpheart.00511.2004","article-title":"Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function.","volume":"289","author":"P Ohlmann","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3324\/haematol.12364","article-title":"The effect of platelet activation on the hypercoagulability induced by murine monoclonal antiphospholipid antibodies.","volume":"93","author":"A Membre","year":"2008","journal-title":"Haematologica"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1097\/HJH.0b013e328337fe42","article-title":"Vascular effects of cardiotrophin-1: a role in hypertension?","volume":"28","author":"N Lopez-Andres","year":"2010","journal-title":"J Hypertens"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/HYPERTENSIONAHA.108.117531","article-title":"Cross-talk between mineralocorticoid and angiotensin II signaling for cardiac remodeling.","volume":"52","author":"A Di Zhang","year":"2008","journal-title":"Hypertension"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2353\/ajpath.2006.051351","article-title":"MDM2: a novel mineralocorticoid-responsive gene involved in aldosterone-induced human vascular structural remodeling.","volume":"169","author":"Y Nakamura","year":"2006","journal-title":"Am J Pathol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cardiores.2006.08.008","article-title":"Carotid arterial stiffness, elastic fibre network and vasoreactivity in semicarbazide-sensitive amine-oxidase null mouse.","volume":"72","author":"N Mercier","year":"2006","journal-title":"Cardiovasc Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/01.HYP.0000049760.15764.2D","article-title":"Effects of severe hypertension on endothelial and platelet microparticles.","volume":"41","author":"RA Preston","year":"2003","journal-title":"Hypertension"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"H1004","DOI":"10.1152\/ajpheart.00842.2004","article-title":"Shed membrane microparticles from circulating and vascular cells in regulating vascular function.","volume":"288","author":"MC Martinez","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1161\/hc4701.100516","article-title":"Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction.","volume":"104","author":"CM Boulanger","year":"2001","journal-title":"Circulation"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"694","DOI":"10.2337\/db08-1524","article-title":"Increased vitreous shedding of microparticles in proliferative diabetic retinopathy stimulates endothelial proliferation.","volume":"59","author":"S Chahed","year":"2010","journal-title":"Diabetes"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1161\/01.CIR.0000124065.31211.6E","article-title":"Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression.","volume":"109","author":"S Martin","year":"2004","journal-title":"Circulation"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.4049\/jimmunol.161.8.4382","article-title":"Endothelial cell activation by leukocyte microparticles.","volume":"161","author":"M Mesri","year":"1998","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"974","DOI":"10.2353\/ajpath.2010.091252","article-title":"Endothelial dysfunction and circulating microparticles from patients with obstructive sleep apnea.","volume":"177","author":"P Priou","year":"2010","journal-title":"Am J Pathol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.2353\/ajpath.2006.051304","article-title":"Shed membrane particles from preeclamptic women generate vascular wall inflammation and blunt vascular contractility.","volume":"169","author":"F Meziani","year":"2006","journal-title":"Am J Pathol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1210\/en.2005-1318","article-title":"Protective effect of spironolactone on endothelial cell apoptosis.","volume":"147","author":"TA Williams","year":"2006","journal-title":"Endocrinology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/sj.bjp.0705347","article-title":"Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis.","volume":"139","author":"S Martin","year":"2003","journal-title":"Br J Pharmacol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1073\/pnas.0804037106","article-title":"Aldosterone activates endothelial exocytosis.","volume":"106","author":"Y Jeong","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00239-003-0634-7","article-title":"Intracellular calcium: a prerequisite for aldosterone action.","volume":"196","author":"C Schafer","year":"2003","journal-title":"J Membr Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/00005344-199604000-00002","article-title":"Cell membrane cation transport systems during aldorsterone antagonism.","volume":"27","author":"P Lijnen","year":"1996","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1161\/01.CIR.103.23.2792","article-title":"Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release.","volume":"103","year":"2001","journal-title":"Circulation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"909","DOI":"10.2147\/VHRM.S8123","article-title":"Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea.","volume":"5","author":"S Jelic","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/01.HYP.0000259667.22309.df","article-title":"In vivo shear stress determines circulating levels of endothelial microparticles in end-stage renal disease.","volume":"49","author":"CM Boulanger","year":"2007","journal-title":"Hypertension"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1161\/01.HYP.4.3.374","article-title":"Aldosterone infusion into the rat and dose-dependent changes in blood pressure and arterial ionic transport.","volume":"4","author":"ET Garwitz","year":"1982","journal-title":"Hypertension"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0008-6363(97)00097-7","article-title":"Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion.","volume":"35","author":"Y Sun","year":"1997","journal-title":"Cardiovasc Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.freeradbiomed.2007.05.007","article-title":"Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase.","volume":"43","author":"R Jimenez","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"H336","DOI":"10.1152\/ajpheart.01307.2005","article-title":"Ang II-induced cardiac molecular and cellular events: role of aldosterone.","volume":"291","author":"W Zhao","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/01.HYP.0000154365.30593.d3","article-title":"Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src.","volume":"45","author":"GE Callera","year":"2005","journal-title":"Hypertension"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"H1008","DOI":"10.1152\/ajpheart.00114.2008","article-title":"NAD(P)H oxidase-derived peroxide mediates elevated basal and impaired flow-induced NO production in SHR mesenteric arteries in vivo.","volume":"295","author":"X Zhou","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0039235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T17:59:21Z","timestamp":1714154361000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0039235"}},"subtitle":[],"editor":[{"given":"Philippe","family":"Rouet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,10]]},"references-count":50,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0039235","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,10]]}}}