{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:57:56Z","timestamp":1792173476069,"version":"4.4.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T00:00:00Z","timestamp":1340236800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0039526","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T10:24:58Z","timestamp":1340360698000},"page":"e39526","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":119,"title":["Electrical Stimulation to Conductive Scaffold Promotes Axonal Regeneration and Remyelination in a Rat Model of Large Nerve Defect"],"prefix":"10.1371","volume":"7","author":[{"given":"Jinghui","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,6,21]]},"reference":[{"key":"ref1","first-page":"769","article-title":"PLGA conduit seeded with olfactory ensheathing cells for bridging sciatic nerve defect of rats.","volume":"94","author":"BC Li","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1089\/ten.tea.2009.0017","article-title":"A novel scaffold with longitudinally oriented micro-channels promotes peripheral nerve regeneration.","volume":"15","author":"X Hu","year":"2009","journal-title":"Tissue Eng Part A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1085-9489.2003.03029.x","article-title":"Experimental strategies to promote functional recovery after peripheral nerve injuries.","volume":"8","author":"T Gordon","year":"2003","journal-title":"J Peripher Nerv Syst"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1523\/JNEUROSCI.15-05-03876.1995","article-title":"Contributing factors to poor functional recovery after delayed nerve repair: prolonged axotomy.","volume":"15","author":"SY Fu","year":"1995","journal-title":"J Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1523\/JNEUROSCI.15-05-03886.1995","article-title":"Contributing factors to poor functional recovery after delayed nerve repair: prolonged denervation.","volume":"15","author":"SY Fu","year":"1995","journal-title":"J Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1523\/JNEUROSCI.22-15-06631.2002","article-title":"Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron.","volume":"22(15)","author":"TM Brushart","year":"2002","journal-title":"J Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1523\/JNEUROSCI.20-07-02602.2000","article-title":"Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration.","volume":"20","author":"AA Al Majed","year":"2000","journal-title":"J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.expneurol.2007.08.005","article-title":"One hour electrical stimulation accelerates functional recovery after femoral nerve repair.","volume":"208","author":"P Ahlborn","year":"2007","journal-title":"Exp Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1089\/neu.2008.0732","article-title":"Electrical stimulation accelerates motor functional recovery in autograft-repaired 10 mm femoral nerve gap in rats.","volume":"26","author":"J Huang","year":"2009","journal-title":"J Neurotrauma"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1006\/exnr.2001.7778","article-title":"Nerve growth factor- and neurotrophin-3-releasing guidance channels promote regeneration of the transected rat dorsal root.","volume":"172","author":"J Bloch","year":"2001","journal-title":"Exp Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"8948","DOI":"10.1073\/pnas.94.17.8948","article-title":"Stimulation of neurite outgrowth using an electrically conducting polymer.","volume":"94","author":"CE Schmidt","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1523\/JNEUROSCI.02-04-00483.1982","article-title":"Orientation of neurite growth by extracellular electric fields.","volume":"2(4)","author":"N Patel","year":"1982","journal-title":"J Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.actbio.2010.10.013","article-title":"Material properties and electrical stimulation regimens of polycaprolactone fumarate-polypyrrole scaffolds as potential conductive nerve conduits.","volume":"7","author":"P Moroder","year":"2011","journal-title":"Acta Biomater"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/bem.20214","article-title":"Short-duration, DC electrical stimulation increases chick embryo DRG neurite outgrowth.","volume":"27(4)","author":"M Wood","year":"2006","journal-title":"Bioelectromagnetics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1525-1594.2007.00335.x","article-title":"Electrically conductive biodegradable polymer composite for nerve regeneration: electricity-stimulated neurite outgrowth and axon regeneration.","volume":"31","author":"Z Zhang","year":"2007","journal-title":"Artif Organs"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0896-6273(01)00217-3","article-title":"Electrical activity modulates growth cone guidance by diffusible factors.","volume":"29","author":"G Ming","year":"2001","journal-title":"Neuron"},{"key":"ref17","first-page":"2323","article-title":"Trophically and topographically functionalized silk fibroin nerve conduits for guided peripheral nerve regeneration.","volume":"31","author":"S Madduri","year":"2010","journal-title":"Biomaterials 2010"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1055\/s-2003-42502","article-title":"Histologic analysis of Schwann cell migration and peripheral nerve regeneration in the autogenous venous nerve conduit (AVNC).","volume":"19","author":"CY Tseng","year":"2003","journal-title":"J Reconstr Microsurg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/107632700320748","article-title":"A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration.","volume":"6","author":"T Hadlock","year":"2000","journal-title":"Tissue Eng"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.3171\/FOC.2009.26.2.E4","article-title":"Transplantation of autologous Schwann cells for the repair of segmental peripheral nerve defects.","volume":"26","author":"B Hood","year":"2009","journal-title":"Neurosurg Focus"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.expneurol.2008.02.015","article-title":"Chick embryonic Schwann cells migrate anodally in small electrical fields.","volume":"211","author":"MJ McKasson","year":"2008","journal-title":"Exp Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/glia.20766","article-title":"Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease.","volume":"56","author":"R Martini","year":"2008","journal-title":"Glia"},{"key":"ref23","first-page":"397","article-title":"Schwann cells, neurotrophic factors, and peripheral nerve regeneration.","volume":"18","author":"SP Frostick","year":"1998","journal-title":"Microsurgery 1998"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0079-6123(03)46029-9","article-title":"Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord.","volume":"146","author":"WT Hendriks","year":"2004","journal-title":"Prog Brain Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/glia.20951","article-title":"Electrical stimulation induces calcium-dependent release of NGF from Cultured Schwann cells.","volume":"58","author":"J Huang","year":"2010","journal-title":"Glia"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jbm.a.32511","article-title":"Electrical regulation of Schwann cells using conductive polypyrrole\/chitosan polymers.","volume":"93","author":"J Huang","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ng1195-281","article-title":"Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies.","volume":"11","author":"R Martini","year":"1995","journal-title":"Nat Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1126\/science.1134069","article-title":"The polarity protein Par-3 directly interacts with p75NTR to regulate myelination.","volume":"314","author":"JR Chan","year":"2006","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00006534-199202000-00009","article-title":"Walking track analysis: a long-term assessment of peripheral nerve recovery.","volume":"89","author":"GM Hare","year":"1992","journal-title":"Plast Reconstr Surg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jneumeth.2005.04.023","article-title":"An improved test of neurological dysfunction following transient focal cerebral ischemia in rats.","volume":"151","author":"ME Sughrue","year":"2006","journal-title":"J Neurosci Methods"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1038\/nprot.2007.359","article-title":"Neurologic assessment of somatosensory dysfunction following an experimental rodent model of cerebral ischemia.","volume":"2","author":"RJ Komotar","year":"2007","journal-title":"Nat Protoc"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1177\/1545968310368686","article-title":"Electrical stimulation accelerates motor functional recovery in the rat model of 15 mm sciatic nerve gap bridged by scaffolds with longitudinally oriented micro-channels.","volume":"24","author":"J Huang","year":"2010","journal-title":"Neurorehab Neural Re"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0039526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T20:09:09Z","timestamp":1714075749000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0039526"}},"subtitle":[],"editor":[{"given":"Fabrizio","family":"Gelain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,21]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0039526","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,21]]}}}