{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:15:26Z","timestamp":1791065726891,"version":"4.1.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T00:00:00Z","timestamp":1340323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0039580","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T23:32:45Z","timestamp":1340407965000},"page":"e39580","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Chronic VEGF Blockade Worsens Glomerular Injury in the Remnant Kidney Model"],"prefix":"10.1371","volume":"7","author":[{"given":"Flavia G.","family":"Machado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Semedo","family":"Kuriki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice K.","family":"Fujihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Fanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone C. A.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M. A. C.","family":"Malheiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels O. S.","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Zatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.2479987","article-title":"Vascular permeability factor, an endothelial cell mitogen related to PDGF.","volume":"246","author":"PJ Keck","year":"1989","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.2479986","article-title":"Vascular endothelial growth factor is a secreted angiogenic mitogen.","volume":"246","author":"DW Leung","year":"1989","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1002\/j.1460-2075.1989.tb08557.x","article-title":"Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.","volume":"8","author":"J Plouet","year":"1989","journal-title":"EMBO J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.6823562","article-title":"Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.","volume":"219","author":"DR Senger","year":"1983","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1111\/j.1523-1755.2004.00621.x","article-title":"The role of vascular endothelial growth factor (VEGF) in renal pathophysiology.","volume":"65","author":"BF Schrijvers","year":"2004","journal-title":"Kidney Int"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"F422","DOI":"10.1152\/ajprenal.00448.2005","article-title":"Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP.","volume":"291","author":"F Guan","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/j.ajkd.2007.04.025","article-title":"Angiogenesis inhibitor therapies: focus on kidney toxicity and hypertension.","volume":"50","author":"H Izzedine","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00280-006-0376-5","article-title":"Sunitinib malate.","volume":"60","author":"H Izzedine","year":"2007","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref9","first-page":"327","article-title":"In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic\/pharmacodynamic relationship.","volume":"9","author":"DB Mendel","year":"2003","journal-title":"Clin Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ejca.2009.11.001","article-title":"VEGF signalling inhibition-induced proteinuria: Mechanisms, significance and management.","volume":"46","author":"H Izzedine","year":"2010","journal-title":"Eur J Cancer"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1111\/j.1523-1755.2005.09909.x","article-title":"Role of hypoxia in the pathogenesis of renal disease.","author":"KU Eckardt","year":"2005"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/MNH.0b013e3283328eed","article-title":"The role of hypoxia, increased oxygen consumption, and hypoxia-inducible factor-1 alpha in progression of chronic kidney disease.","volume":"19","author":"T Tanaka","year":"2010","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nrneph.2010.124","article-title":"The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease.","volume":"6","author":"I Mimura","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"F191","DOI":"10.1152\/ajprenal.0197.2001","article-title":"Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats.","volume":"282","author":"B Rodriguez-Iturbe","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"p32","DOI":"10.1159\/000101798","article-title":"Role of the VEGF\u2013a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier.","volume":"106","author":"V Eremina","year":"2007","journal-title":"Nephron Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1097\/HJH.0b013e3283309b59","article-title":"Cardiovascular and renal toxicity during angiogenesis inhibition: clinical and mechanistic aspects.","volume":"27","author":"MH Kappers","year":"2009","journal-title":"J Hypertens"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"13313","DOI":"10.1074\/jbc.273.21.13313","article-title":"Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells.","volume":"273","author":"HP Gerber","year":"1998","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1006\/jmcc.1996.0365","article-title":"Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: balance between growth and death signals.","volume":"29","author":"I Spyridopoulos","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e13663","DOI":"10.1371\/journal.pone.0013663","article-title":"A new mouse model to explore therapies for preeclampsia.","volume":"5","author":"A Ahmed","year":"2010","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/ki.1992.441","article-title":"Vascular permeability factor mRNA and protein expression in human kidney.","volume":"42","author":"LF Brown","year":"1992","journal-title":"Kidney Int"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1523-1755.2000.00139.x","article-title":"Hypoxia and interleukin-1beta stimulate vascular endothelial growth factor production in human proximal tubular cells.","volume":"58","author":"B El Awad","year":"2000","journal-title":"Kidney Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1681\/ASN.2010030295","article-title":"Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling.","volume":"21","author":"K Sison","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","article-title":"VEGF inhibition and renal thrombotic microangiopathy.","volume":"358","author":"V Eremina","year":"2008","journal-title":"N Engl J Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.semnephrol.2010.09.006","article-title":"Biology of anti-angiogenic therapy-induced thrombotic microangiopathy.","volume":"30","author":"V Eremina","year":"2010","journal-title":"Semin Nephrol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/HYPERTENSIONAHA.109.149690","article-title":"Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endothelin-1 levels.","volume":"56","author":"MH Kappers","year":"2010","journal-title":"Hypertension"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1089\/thy.2010.0028","article-title":"Hematologic toxicity in patients treated with sunitinib for advanced thyroid cancer.","volume":"20","author":"A Gkountouvas","year":"2010","journal-title":"Thyroid"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJMoa065044","article-title":"Sunitinib versus interferon alfa in metastatic renal-cell carcinoma.","volume":"356","author":"RJ Motzer","year":"2007","journal-title":"N Engl J Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1101\/gad.1071203","article-title":"The bloody fate of endothelial stem cells.","volume":"17","author":"H Kubo","year":"2003","journal-title":"Genes Dev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ar.a.10131","article-title":"Hemangioblasts, angioblasts, and adult endothelial cell progenitors.","volume":"276","author":"GC Schatteman","year":"2004","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1681\/ASN.V1271434","article-title":"Impaired angiogenesis in the remnant kidney model: I. Potential role of vascular endothelial growth factor and thrombospondin-1.","volume":"12","author":"DH Kang","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000092032","article-title":"Microvasculature change and placenta growth factor expression in the early stage of a rat remnant kidney model.","volume":"26","author":"Q Wu","year":"2006","journal-title":"Am J Nephrol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ki.1992.42","article-title":"Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model.","volume":"41","author":"J Floege","year":"1992","journal-title":"Kidney Int"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1046\/j.1523-1755.1998.00138.x","article-title":"Mycophenolate mofetil attenuates renal injury in the rat remnant kidney.","volume":"54","author":"CK Fujihara","year":"1998","journal-title":"Kidney Int"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/ndt\/13.8.1967","article-title":"Local macrophage and myofibroblast proliferation in progressive renal injury in the rat remnant kidney.","volume":"13","author":"N Yang","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/ndt\/gfg176","article-title":"Vascular endothelial growth factor expression and glomerular endothelial cell loss in the remnant kidney model.","volume":"18","author":"DJ Kelly","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ki.2008.183","article-title":"The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease.","volume":"74","author":"KS Eardley","year":"2008","journal-title":"Kidney Int"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1097\/01.ASN.0000125614.35046.10","article-title":"Evidence of tubular hypoxia in the early phase in the remnant kidney model.","volume":"15","author":"K Manotham","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1172\/JCI112013","article-title":"Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass.","volume":"76","author":"S Anderson","year":"1985","journal-title":"J Clin Invest"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"F1810","DOI":"10.1152\/ajprenal.00521.2006","article-title":"Losartan-hydrochlorothiazide association promotes lasting blood pressure normalization and completely arrests long-term renal injury in the 5\/6 ablation model.","volume":"292","author":"CK Fujihara","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1159\/000086034","article-title":"Pathophysiological role of vascular endothelial growth factor in the remnant kidney.","volume":"101","author":"BF Schrijvers","year":"2005","journal-title":"Nephron Exp Nephrol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"E362","DOI":"10.1152\/ajpendo.00007.2002","article-title":"Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent.","volume":"283","author":"A Flyvbjerg","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/ki.1992.222","article-title":"Effects of salt restriction on renal growth and glomerular injury in rats with remnant kidneys.","volume":"41","author":"DS Lax","year":"1992","journal-title":"Kidney Int"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1172\/JCI116874","article-title":"Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.","volume":"92","author":"Y Isaka","year":"1993","journal-title":"J Clin Invest"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ki.1992.272","article-title":"Glomerular damage after uninephrectomy in young rats. II. Mechanical stress on podocytes as a pathway to sclerosis.","volume":"42","author":"M Nagata","year":"1992","journal-title":"Kidney Int"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1681\/ASN.2005020159","article-title":"Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria.","volume":"16","author":"D Yu","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"ref46","first-page":"S159","article-title":"Detection of multiple vascular endothelial growth factor splice isoforms in single glomerular podocytes.","author":"M Kretzler","year":"1998"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"F1263","DOI":"10.1152\/ajprenal.00276.2002","article-title":"Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes.","volume":"284","author":"RR Foster","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrm1911","article-title":"VEGF receptor signalling - in control of vascular function.","volume":"7","author":"AK Olsson","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/ndt\/gfn657","article-title":"Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib.","volume":"24","author":"G Bollee","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/ndt\/gfp666","article-title":"Inhibition of tyrosine kinases by sunitinib associated with focal segmental glomerulosclerosis lesion in addition to thrombotic microangiopathy.","volume":"25","author":"O Costero","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF00430245","article-title":"Interstitial fibrosis of the renal cortex in minimal change lesion and its correlation with renal function. A quantitative study.","volume":"383","author":"FL Jepsen","year":"1979","journal-title":"Virchows Arch A Pathol Anat Histol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ki.1982.82","article-title":"Development of glomerular lesions in experimental long-term diabetes in the rat.","volume":"21","author":"K Hirose","year":"1982","journal-title":"Kidney Int"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.47.1.1","article-title":"Some statistical methods useful in circulation research.","volume":"47","author":"S Wallenstein","year":"1980","journal-title":"Circ Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0039580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T10:40:36Z","timestamp":1642588836000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0039580"}},"subtitle":[],"editor":[{"given":"Nick","family":"Ashton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,22]]},"references-count":53,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0039580","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,22]]}}}