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Mutat Res 569: 29\u201363.","author":"M Schroder","year":"2005"},{"key":"ref2","article-title":"Endoplasmic reticulum stress responses. Cell Mol Life Sci 65: 862\u2013894.","author":"M Schroder","year":"2008"},{"key":"ref3","article-title":"Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727\u2013730.","author":"MC Wei","year":"2001"},{"key":"ref4","article-title":"Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons. Cell Death Differ 14: 1011\u20131019.","author":"MI Smith","year":"2007"},{"key":"ref5","article-title":"The endoplasmic reticulum stress response in the pancreatic beta-cell. Diabetes Obes Metab 12 Suppl 2: 48\u201357.","author":"A Volchuk","year":"2010"},{"key":"ref6","article-title":"Ischemia-induced neuronal cell death and stress response. Antioxid Redox Signal 9: 573\u2013587.","author":"S Ogawa","year":"2007"},{"key":"ref7","article-title":"Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. J Cell Mol Med 15: 2025\u20132039.","author":"KM Doyle","year":"2011"},{"key":"ref8","article-title":"Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr Opin Immunol 19: 488\u2013496.","author":"JM Adams","year":"2007"},{"key":"ref9","article-title":"Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 17: 617\u2013625.","author":"SN Willis","year":"2005"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1242\/jcs.115.8.1567","article-title":"BH3-only proteins \u2013 evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death.","volume":"115","author":"P Bouillet","year":"2002","journal-title":"J Cell Sci"},{"key":"ref11","article-title":"BH3-Only proteins-essential initiators of apoptotic cell death. Cell 103: 839\u2013842.","author":"DC Huang","year":"2000"},{"key":"ref12","article-title":"BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415: 922\u2013926.","author":"P Bouillet","year":"2002"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.200305149","article-title":"Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3\/PUMA and activation of the mitochondrial apoptosis pathway. J Cell Biol 162: 587\u2013597.","author":"C Reimertz","year":"2003"},{"key":"ref14","article-title":"ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129: 1337\u20131349.","author":"H Puthalakath","year":"2007"},{"key":"ref15","article-title":"Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J Biol Chem 281: 7260\u20137270.","author":"J Li","year":"2006"},{"key":"ref16","article-title":"Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci 30: 16938\u201316948.","author":"Z Galehdar","year":"2010"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1101\/gad.12.7.982","article-title":"CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum.","volume":"12","author":"H Zinszner","year":"1998","journal-title":"Genes Dev"},{"key":"ref18","article-title":"Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109: 525\u2013532.","author":"S Oyadomari","year":"2002"},{"key":"ref19","article-title":"Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res 29: 1496\u20131503.","author":"C Ji","year":"2005"},{"key":"ref20","article-title":"CHOP\/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem 95: 974\u2013986.","author":"RM Silva","year":"2005"},{"key":"ref21","article-title":"Positive role of CCAAT\/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. Am J Pathol 174: 1786\u20131798.","author":"T Namba","year":"2009"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1101\/gad.6.3.439","article-title":"CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C\/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.","volume":"6","author":"D Ron","year":"1992","journal-title":"Genes Dev"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1042\/bj20020391","article-title":"Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J 366: 585\u2013594.","author":"T Okada","year":"2002"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1126\/science.272.5266.1347","article-title":"Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase.","volume":"272","author":"XZ Wang","year":"1996","journal-title":"Science"},{"key":"ref25","article-title":"Stress-inducible transcription factor CHOP\/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Exp Cell Res 267: 193\u2013204.","author":"EV Maytin","year":"2001"},{"key":"ref26","article-title":"Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857\u2013868.","author":"A Brunet","year":"1999"},{"key":"ref27","article-title":"Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol 11: 297\u2013305.","author":"A Brunet","year":"2001"},{"key":"ref28","article-title":"Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine\/threonine kinase Akt. Oncogene 18: 7328\u20137333.","author":"PL del","year":"1999"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1073\/pnas.96.13.7421","article-title":"Protein kinase B\/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.","volume":"96","author":"WH Biggs III","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1128\/MCB.22.7.2025-2036.2002","article-title":"Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.","volume":"22","author":"GJ Kops","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref31","article-title":"FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162: 613\u2013622.","author":"J Gilley","year":"2003"},{"key":"ref32","article-title":"Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia. J Cereb Blood Flow Metab 29: 1903\u20131913.","author":"D Li","year":"2009"},{"key":"ref33","article-title":"Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells. Brain Res Mol Brain Res 126: 45\u201356.","author":"W Zhu","year":"2004"},{"key":"ref34","article-title":"FOXO3a-dependent regulation of Puma in response to cytokine\/growth factor withdrawal. J Exp Med 203: 1657\u20131663.","author":"H You","year":"2006"},{"key":"ref35","article-title":"PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01. Mol Cancer Ther 9: 2893\u20132902.","author":"C Dudgeon","year":"2010"},{"key":"ref36","article-title":"Myc and PI3K\/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression. Nucleic Acids Res 39: 9498\u20139507.","author":"S Amente","year":"2011"},{"key":"ref37","article-title":"p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036\u20131038.","author":"A Villunger","year":"2003"},{"key":"ref38","article-title":"Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735\u20131738.","author":"P Bouillet","year":"1999"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1523\/JNEUROSCI.16-05-01753.1996","article-title":"Apoptosis of bcl-x-deficient telencephalic cells in vitro.","volume":"16","author":"KA Roth","year":"1996","journal-title":"J Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1016\/S0021-9258(19)81080-3","article-title":"Relationship of the structure and biological activity of the natural homologues of tunicamycin.","volume":"257","author":"D Duksin","year":"1982","journal-title":"J Biol Chem"},{"key":"ref41","article-title":"BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. J Neurosci 26: 7257\u20137264.","author":"RS Akhtar","year":"2006"},{"key":"ref42","article-title":"PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7: 683\u2013694.","author":"K Nakano","year":"2001"},{"key":"ref43","article-title":"Ischemia-induced neuronal cell death and stress response. Antioxid Redox Signal 9: 573\u2013587.","author":"S Ogawa","year":"2007"},{"key":"ref44","article-title":"Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins. Exp Cell Res 314: 950\u2013960.","author":"S Reijonen","year":"2008"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1749-6632.2002.tb04837.x","article-title":"The unfolded protein response is involved in the pathology of Alzheimer's disease.","volume":"977","author":"T Kudo","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"ref46","article-title":"Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol Cell 36: 487\u2013499.","author":"H Kim","year":"2009"},{"key":"ref47","article-title":"The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons. J Neurochem 96: 1213\u20131226.","author":"A Wyttenbach","year":"2006"},{"key":"ref48","article-title":"Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol Biol 318: 1351\u20131365.","author":"Y Ma","year":"2002"},{"key":"ref49","article-title":"Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249\u20131259.","author":"KD McCullough","year":"2001"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1128\/MCB.16.4.1479","article-title":"Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element.","volume":"16","author":"M Ubeda","year":"1996","journal-title":"Mol Cell Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"7589","DOI":"10.1128\/MCB.19.11.7589","article-title":"CHOP enhancement of gene transcription by interactions with Jun\/Fos AP-1 complex proteins.","volume":"19","author":"M Ubeda","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref52","article-title":"C\/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell 8: 817\u2013828.","author":"H Wang","year":"2001"},{"key":"ref53","article-title":"hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ 11: 390-402.","author":"T Gotoh","year":"2004"},{"key":"ref54","article-title":"CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis. Am J Physiol Gastrointest Liver Physiol 299: G236-G243.","author":"SC Cazanave","year":"2010"},{"key":"ref55","article-title":"TRB3: a tribbles homolog that inhibits Akt\/PKB activation by insulin in liver. 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